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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1affects localizationISONfkb1 (Mus musculus)6480464CTDMethamphetamine affects the localization of NFKB1 proteinPMID:30394308
Nfkb1increases activityISONFKB1 (Homo sapiens)6480464CTDMethamphetamine results in increased activity of NFKB1 proteinPMID:11746378
Nfkb1increases expressionISONfkb1 (Mus musculus)6480464CTDMethamphetamine results in increased expression of NFKB1 mRNA; Methamphetamine results in increased expression of NFKB1 proteinPMID:26307267 PMID:32569805
Nfkb1multiple interactionsISONfkb1 (Mus musculus)6480464CTD[SNCA protein co-treated with Methamphetamine] results in increased expression of NFKB1 protein; Methamphetamine promotes the reaction [NFKB1 protein binds to MIR143 promoter]; NFKB1 protein affects the reaction [Methamphetamine results in decreased expression of MIR143 mRNA]PMID:30394308 PMID:32569805
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