RGD Reference Report - IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C. - Rat Genome Database

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IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C.

Authors: He, Yongchao  Zhang, Hongwei  Yin, Jianhua  Xie, Jiaxin  Tan, Xiaojie  Liu, Shijian  Zhang, Qian  Li, Chengzhong  Zhao, Jun  Wang, Hongyang  Cao, Guangwen 
Citation: He Y, etal., Carcinogenesis. 2009 Nov;30(11):1916-22. doi: 10.1093/carcin/bgp226. Epub 2009 Oct 1.
RGD ID: 40400751
Pubmed: PMID:19797428   (View Abstract at PubMed)
PMCID: PMC2783005   (View Article at PubMed Central)
DOI: DOI:10.1093/carcin/bgp226   (Journal Full-text)

Genetic predisposition of nuclear factor-kappa B (NF-kappaB)-signaling pathways linking inflammation to hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remains unresolved. We conducted a case-control study to determine the associations of the polymorphisms within the promoter regions of NFKB1 encoding NF-kappaB1 and NFKBIA encoding IkappaBalpha with the development of HCC. A total of 404 healthy controls, 482 non-HCC subjects with HBV infection and 202 patients with HCC were included. NFKB1 -94ATTG2 allele and GG allele in the 3'-untranslated region of NFKBIA were more prevalent in HCC patients than in the healthy controls. NFKBIA -826CT and NFKBIA -881AG allelic carriages were more prevalent in HCC patients than in the non-HCC subjects with HBV infection. The estimated haplotype frequency of NFKBIA promoter -881G-826T-519C was significantly higher in the patients with HCC than in the HBV-infected subjects without HCC (odds ratio = 3.142, P = 0.002). As compared with the HBV-infected subjects without HCC, NFKBIA -826 T and NFKBIA -881AG allelic carriages were only associated with HCC risk in the subjects with HBV genotype C. The association of NFKBIA -881AG allelic carriage with HCC risk was not affected by liver cirrhosis (LC) status, alanine aminotransferase level and hepatitis B e antigen status. By multivariate regression analysis, NFKB1 -94ATTG2, NFKBIA -826T, NFKBIA -881AG and HBV genotype C were independently associated with an increased risk of HCC. In conclusion, NFKB1 -94ATTG2 allele and haplotype -881G-826T-519C in NFKBIA promoter were associated with hepatocarcinogenesis. NFKBIA -826T and -881AG were associated with the risk of HCC in the subjects infected with HBV genotype C.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma disease_progressionIAGP 40400751associated with Chronic Hepatitis B and DNA:insertion/deletion:3'utr: -94ins/delATTG (rs28720239) (human)RGD 
hepatocellular carcinoma disease_progressionIAGP 40400751associated with Chronic Hepatitis B more ...RGD 
hepatocellular carcinoma disease_progressionISONFKB1 (Homo sapiens)40400751; 40400751associated with Chronic Hepatitis B and DNA:insertion/deletion:3'utr: -94ins/delATTG (rs28720239) (human)RGD 
hepatocellular carcinoma disease_progressionISONFKBIA (Homo sapiens)40400751; 40400751associated with Chronic Hepatitis B more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nfkb1  (nuclear factor kappa B subunit 1)
Nfkbia  (NFKB inhibitor alpha)

Genes (Mus musculus)
Nfkb1  (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105)
Nfkbia  (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha)

Genes (Homo sapiens)
NFKB1  (nuclear factor kappa B subunit 1)
NFKBIA  (NFKB inhibitor alpha)


Additional Information