Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,5-hexanedione
go back to main search page
Accession:CHEBI:85014 term browser browse the term
Definition:A diketone that is hexane substituted by oxo groups at positions 2 and 5. It is a toxic metabolite of hexane and of 2-hexanone
Synonyms:related_synonym: 1,2-Diacetylethane;   2,5-Diketohexane;   2,5-Hexadione;   Acetonyl acetone;   CH3COCH2CH2COCH3;   Formula=C6H10O2;   InChI=1S/C6H10O2/c1-5(7)3-4-6(2)8/h3-4H2,1-2H3;   InChIKey=OJVAMHKKJGICOG-UHFFFAOYSA-N;   NSC 7621;   SMILES=CC(=O)CCC(C)=O;   acetonylacetone;   alpha,beta-diacetylethane;   hexane-2,5-dione
 xref: CAS:110-13-4
 xref_mesh: MESH:C011269
 xref: MetaCyc:CPD-15521;   PMID:1781736;   PMID:24634916;   PMID:25549948;   Reaxys:506525;   Wikipedia:Hexane-2\,5-dione


show annotations for term's descendants           Sort by:
2,5-hexanedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 increases expression EXP 2,5-hexanedione results in increased expression of ABI2 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699 		JBrowse link
G Aco2 aconitase 2 increases expression EXP 2,5-hexanedione results in increased expression of ACO2 protein CTD PMID:19033394 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions		 EXP 2,5-hexanedione results in increased expression of AIF1 protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]		 CTD PMID:32522579 PMID:32860822 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases expression		 ISO 2,5-hexanedione results in decreased phosphorylation of AKT1 protein
2,5-hexanedione results in increased expression of AKT1 mRNA		 CTD PMID:33197454 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B decreases expression EXP 2,5-hexanedione results in decreased expression of ALOX15B mRNA CTD PMID:22952946 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
G Angptl4 angiopoietin-like 4 affects expression EXP 2,5-hexanedione affects the expression of ANGPTL4 mRNA CTD PMID:20616210 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Arg1 arginase 1 decreases expression
multiple interactions		 EXP 2,5-hexanedione results in decreased expression of ARG1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]		 CTD PMID:32522579 PMID:32860822 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP		 2,5-hexanedione results in increased expression of BAX mRNA; 2,5-hexanedione results in increased expression of BAX protein CTD PMID:17492505 PMID:21901545 PMID:22337490 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression		 EXP
ISO		 2,5-hexanedione results in increased expression of BCL2 protein
2,5-hexanedione results in decreased expression of BCL2 mRNA; 2,5-hexanedione results in decreased expression of BCL2 protein		 CTD PMID:17492505 PMID:21901545 PMID:22337490 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l14 Bcl2-like 14 increases expression EXP 2,5-hexanedione results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression EXP 2,5-hexanedione results in decreased expression of BDNF protein CTD PMID:31760062 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bfar bifunctional apoptosis regulator increases expression EXP 2,5-hexanedione results in increased expression of BFAR mRNA CTD PMID:22952946 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038 		JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions
increases expression		 EXP 2,5-hexanedione results in increased cleavage of CASP1 protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]
2,5-hexanedione results in increased expression of CASP1 mRNA		 CTD PMID:32522579 PMID:32860822 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases expression ISO
EXP		 2,5-hexanedione results in increased expression of CASP3 mRNA; 2,5-hexanedione results in increased expression of CASP3 protein alternative form CTD PMID:17492505 PMID:21901545 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression ISO 2,5-hexanedione results in decreased expression of CASP8 protein CTD PMID:33197454 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccdc171 coiled-coil domain containing 171 increases expression EXP 2,5-hexanedione results in increased expression of CCDC171 mRNA CTD PMID:22952946 NCBI chr 5:97,919,965...98,403,853
Ensembl chr 5:97,920,002...98,282,833 		JBrowse link
G Ccdc191 coiled-coil domain containing 191 increases expression EXP 2,5-hexanedione results in increased expression of CCDC191 mRNA CTD PMID:22952946 NCBI chr11:56,735,655...56,806,372
Ensembl chr11:56,735,652...56,806,375 		JBrowse link
G Cdin1 CDAN1 interacting nuclease 1 increases expression EXP 2,5-hexanedione results in increased expression of CDIN1 mRNA CTD PMID:22952946 NCBI chr 3:102,441,553...102,646,935
Ensembl chr 3:102,441,704...102,646,682 		JBrowse link
G Cep112 centrosomal protein 112 increases expression EXP 2,5-hexanedione results in increased expression of CEP112 mRNA CTD PMID:22952946 NCBI chr10:93,366,059...93,833,133
Ensembl chr10:93,366,136...93,833,131 		JBrowse link
G Cfap221 cilia and flagella associated protein 221 increases expression EXP 2,5-hexanedione results in increased expression of CFAP221 mRNA CTD PMID:22952946 NCBI chr13:31,046,550...31,118,141
Ensembl chr13:31,046,535...31,116,899 		JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 increases expression EXP 2,5-hexanedione results in increased expression of CKMT1B protein CTD PMID:19033394 NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758 		JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199 		JBrowse link
G Clu clusterin decreases expression
increases expression		 EXP 2,5-hexanedione results in decreased expression of CLU mRNA
2,5-hexanedione results in increased expression of CLU mRNA		 CTD PMID:22952946 PMID:27466211 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Ctxn1 cortexin 1 increases expression EXP 2,5-hexanedione results in increased expression of CTXN1 mRNA CTD PMID:22952946 NCBI chr12:2,610,465...2,612,076 JBrowse link
G Dcn decorin increases expression EXP 2,5-hexanedione results in increased expression of DCN mRNA CTD PMID:22952946 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Dennd1a DENN domain containing 1A increases expression EXP 2,5-hexanedione results in increased expression of DENND1A mRNA CTD PMID:22952946 NCBI chr 3:21,564,749...22,052,057
Ensembl chr 3:21,564,749...22,052,062 		JBrowse link
G Dicer1 dicer 1 ribonuclease III increases expression ISO 2,5-hexanedione results in increased expression of DICER1 mRNA CTD PMID:33197454 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Dnaaf11 dynein axonemal assembly factor 11 increases expression EXP 2,5-hexanedione results in increased expression of DNAAF11 mRNA CTD PMID:22952946 NCBI chr 7:98,141,525...98,245,906
Ensembl chr 7:98,144,763...98,245,837 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP 2,5-hexanedione results in increased expression of DNAJB4 mRNA CTD PMID:22952946 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases expression EXP 2,5-hexanedione results in decreased expression of DPYSL2 protein CTD PMID:19033394 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP 2,5-hexanedione results in increased expression of EGFR mRNA CTD PMID:16141653 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 increases expression EXP 2,5-hexanedione results in increased expression of ERC1 mRNA CTD PMID:22952946 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639 		JBrowse link
G Faslg Fas ligand increases expression EXP 2,5-hexanedione results in increased expression of FASLG mRNA CTD PMID:22337490 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP 2,5-hexanedione results in decreased expression of FASN protein CTD PMID:19033394 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fcer1g Fc epsilon receptor Ig increases expression EXP 2,5-hexanedione results in increased expression of FCER1G mRNA CTD PMID:22952946 NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
decreases expression		 ISO 2,5-hexanedione results in increased phosphorylation of FOXO3 protein
2,5-hexanedione results in decreased expression of FOXO3 mRNA		 CTD PMID:33197454 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP 2,5-hexanedione results in increased expression of GADD45 mRNA CTD PMID:16141653 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gas2 growth arrest-specific 2 increases expression EXP 2,5-hexanedione results in increased expression of GAS2 mRNA CTD PMID:22952946 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression		 EXP 2,5-hexanedione results in decreased expression of GFAP protein
2,5-hexanedione results in increased expression of GFAP protein		 CTD PMID:19033394 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Ghsr growth hormone secretagogue receptor affects expression EXP 2,5-hexanedione affects the expression of GHSR mRNA CTD PMID:20616210 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression EXP 2,5-hexanedione results in increased expression of GLUD1 protein CTD PMID:19033394 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Gsdmd gasdermin D multiple interactions
increases cleavage		 EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein] CTD PMID:32522579 PMID:32860822 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression EXP 2,5-hexanedione results in decreased expression of GSK3B protein CTD PMID:31760062 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsn gelsolin decreases expression EXP 2,5-hexanedione results in decreased expression of GSN protein CTD PMID:19033394 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Gstm5l glutathione S-transferase, mu 5-like decreases expression EXP 2,5-hexanedione results in decreased expression of GSTM5 protein CTD PMID:19033394 NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP 2,5-hexanedione results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hdgfl1 HDGF like 1 decreases expression EXP 2,5-hexanedione results in decreased expression of HDGFL1 mRNA CTD PMID:22952946 NCBI chr17:38,207,906...38,209,902 JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP 2,5-hexanedione results in increased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Ier3 immediate early response 3 affects expression EXP 2,5-hexanedione affects the expression of IER3 mRNA CTD PMID:20616210 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ift81 intraflagellar transport 81 increases expression EXP 2,5-hexanedione results in increased expression of IFT81 mRNA CTD PMID:22952946 NCBI chr12:33,957,744...34,037,164
Ensembl chr12:33,957,806...34,037,057 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression EXP 2,5-hexanedione results in decreased expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP 2,5-hexanedione results in increased expression of IL1B mRNA; 2,5-hexanedione results in increased expression of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]		 CTD PMID:16141653 PMID:32522579 PMID:32860822 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha decreases expression EXP 2,5-hexanedione results in decreased expression of INA protein CTD PMID:19033394 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330 		JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions		 ISO
EXP		 2,5-hexanedione results in increased expression of ITGAM protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein]		 CTD PMID:19464574 PMID:32522579 PMID:32860822 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP 2,5-hexanedione results in decreased expression of ITGB1 mRNA CTD PMID:16141653 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Kiaa0930 KIAA0930 homolog increases expression EXP 2,5-hexanedione results in increased expression of KIAA0930 mRNA CTD PMID:22952946 NCBI chr 7:116,067,974...116,107,678
Ensembl chr 7:116,071,447...116,107,727 		JBrowse link
G Kiaa1328 KIAA1328 homolog increases expression EXP 2,5-hexanedione results in increased expression of KIAA1328 mRNA CTD PMID:22952946 NCBI chr18:16,488,569...16,776,373
Ensembl chr18:16,489,408...16,775,548 		JBrowse link
G Kif6 kinesin family member 6 increases expression EXP 2,5-hexanedione results in increased expression of KIF6 mRNA CTD PMID:22952946 NCBI chr 9:11,076,203...11,373,205
Ensembl chr 9:11,072,824...11,373,006 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions		 EXP 2,5-hexanedione results in decreased expression of KIT protein
resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]		 CTD PMID:17725299 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Loxl1 lysyl oxidase-like 1 increases expression
multiple interactions		 EXP 2,5-hexanedione results in increased expression of LOXL1 protein
2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA		 CTD PMID:22382377 NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356 		JBrowse link
G Lrrc69 leucine rich repeat containing 69 increases expression EXP 2,5-hexanedione results in increased expression of LRRC69 mRNA CTD PMID:22952946 NCBI chr 5:28,023,591...28,181,963
Ensembl chr 5:28,023,593...28,214,384 		JBrowse link
G Lyz2 lysozyme 2 decreases expression
increases expression		 EXP 2,5-hexanedione results in decreased expression of LYZ2 mRNA
2,5-hexanedione results in increased expression of LYZ2 mRNA		 CTD PMID:22952946 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106 		JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 increases expression
multiple interactions		 EXP 2,5-hexanedione results in increased expression of MACROD1 mRNA
[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA		 CTD PMID:22382377 NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716 		JBrowse link
G Map1a microtubule-associated protein 1A decreases expression EXP 2,5-hexanedione results in decreased expression of MAP1A protein CTD PMID:20554699 NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899 		JBrowse link
G Map1b microtubule-associated protein 1B decreases expression EXP 2,5-hexanedione results in decreased expression of MAP1B protein; 2,5-hexanedione results in decreased expression of MAP1B protein modified form CTD PMID:20554699 PMID:31760062 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317 		JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP 2,5-hexanedione results in decreased expression of MAP2 protein modified form CTD PMID:20554699 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP 2,5-hexanedione results in increased expression of MAP3K1 protein CTD PMID:31760062 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression EXP 2,5-hexanedione results in decreased expression of MAPT protein modified form CTD PMID:20554699 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mbp myelin basic protein multiple interactions
decreases expression		 EXP Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein] CTD PMID:32522579 PMID:32860822 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression EXP 2,5-hexanedione results in increased expression of MDH1 protein CTD PMID:19033394 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mfap3l microfibril associated protein 3 like increases expression EXP 2,5-hexanedione results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr16:29,411,643...29,454,665
Ensembl chr16:29,415,849...29,430,863 		JBrowse link
G Mir10b microRNA 10b increases expression EXP 2,5-hexanedione results in increased expression of MIR10B mRNA CTD PMID:31760062 NCBI chr 3:59,628,438...59,628,546
Ensembl chr 3:59,628,438...59,628,546 		JBrowse link
G Mir1224 microRNA 1224 increases expression EXP 2,5-hexanedione results in increased expression of MIR1224 mRNA CTD PMID:31760062 NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986 		JBrowse link
G Mir125a microRNA 125a increases expression
decreases expression		 EXP 2,5-hexanedione results in increased expression of MIR125A mRNA
2,5-hexanedione results in decreased expression of MIR125A mRNA		 CTD PMID:31760062 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir130b microRNA 130b decreases expression EXP 2,5-hexanedione results in decreased expression of MIR130B mRNA CTD PMID:31760062 NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244 		JBrowse link
G Mir134 microRNA 134 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR134 mRNA CTD PMID:31760062 NCBI chr 6:128,748,908...128,748,980 JBrowse link
G Mir155 microRNA 155 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR155 mRNA CTD PMID:31760062 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir183 microRNA 183 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR183 mRNA CTD PMID:31760062 NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723 		JBrowse link
G Mir193 microRNA 193 increases expression EXP 2,5-hexanedione results in increased expression of MIR193 mRNA CTD PMID:31760062 NCBI chr10:64,672,354...64,672,439 JBrowse link
G Mir193a microRNA 193a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR193A mRNA CTD PMID:31760062 NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454 		JBrowse link
G Mir194-2 microRNA 194-2 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR194-2 mRNA CTD PMID:31760062 NCBI chr 1:203,564,761...203,564,845
Ensembl chr 1:203,564,761...203,564,845 		JBrowse link
G Mir196a microRNA 196a increases expression EXP 2,5-hexanedione results in increased expression of MIR196A mRNA CTD PMID:31760062 NCBI chr 7:134,110,400...134,110,509
Ensembl chr 7:134,110,400...134,110,509 		JBrowse link
G Mir196c microRNA 196c increases expression EXP 2,5-hexanedione results in increased expression of MIR196C mRNA CTD PMID:31760062 NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085 		JBrowse link
G Mir199a2 microRNA 199a-2 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR199A-2 mRNA; 2,5-hexanedione results in decreased expression of MIR199A2 mRNA CTD PMID:31760062 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063 		JBrowse link
G Mir200c microRNA 200c decreases expression EXP 2,5-hexanedione results in decreased expression of MIR200C mRNA CTD PMID:31760062 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mir202 microRNA 202 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR202 mRNA CTD PMID:31760062 NCBI chr 1:194,754,730...194,754,801
Ensembl chr 1:194,754,730...194,754,801 		JBrowse link
G Mir206 microRNA 206 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR206 mRNA CTD PMID:31760062 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir208a microRNA 208a increases expression EXP 2,5-hexanedione results in increased expression of MIR208A mRNA CTD PMID:31760062 NCBI chr15:28,425,570...28,425,652 JBrowse link
G Mir20a microRNA 20a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR20A mRNA CTD PMID:31760062 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir21 microRNA 21 increases expression
decreases expression		 EXP 2,5-hexanedione results in increased expression of MIR21 mRNA
2,5-hexanedione results in decreased expression of MIR21 mRNA		 CTD PMID:31760062 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir212 microRNA 212 increases expression EXP 2,5-hexanedione results in increased expression of MIR212 mRNA CTD PMID:31760062 NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513 		JBrowse link
G Mir214 microRNA 214 increases expression ISO 2,5-hexanedione results in increased expression of MIR214 mRNA CTD PMID:33197454 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir22 microRNA 22 increases expression EXP 2,5-hexanedione results in increased expression of MIR22 mRNA CTD PMID:31760062 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mir223 microRNA 223 increases expression EXP 2,5-hexanedione results in increased expression of MIR223 mRNA CTD PMID:31760062 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir224 microRNA 224 increases expression EXP 2,5-hexanedione results in increased expression of MIR224 mRNA CTD PMID:31760062 NCBI chr  X:150,065,088...150,065,169
Ensembl chr  X:150,065,088...150,065,169 		JBrowse link
G Mir27a microRNA 27a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR27A mRNA CTD PMID:31760062 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mir27b microRNA 27b increases expression EXP 2,5-hexanedione results in increased expression of MIR27B mRNA CTD PMID:31760062 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Mir300 microRNA 300 increases expression EXP 2,5-hexanedione results in increased expression of MIR300 mRNA CTD PMID:31760062 NCBI chr 6:128,738,513...128,738,591
Ensembl chr 6:128,738,505...128,738,594 		JBrowse link
G Mir30a microRNA 30a increases expression EXP 2,5-hexanedione results in increased expression of MIR30A mRNA CTD PMID:31760062 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670 		JBrowse link
G Mir32 microRNA 32 increases expression EXP 2,5-hexanedione results in increased expression of MIR32 mRNA CTD PMID:31760062 NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152 		JBrowse link
G Mir320a microRNA 320a increases expression EXP 2,5-hexanedione results in increased expression of MIR320A mRNA CTD PMID:31760062 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mir323 microRNA 323 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR323 mRNA CTD PMID:31760062 NCBI chr 6:128,725,539...128,725,624
Ensembl chr 6:128,725,539...128,725,624 		JBrowse link
G Mir326 microRNA 326 increases expression EXP 2,5-hexanedione results in increased expression of MIR326 mRNA CTD PMID:31760062 NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123 		JBrowse link
G Mir33 microRNA 33 increases expression EXP 2,5-hexanedione results in increased expression of MIR33 mRNA CTD PMID:31760062 NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923 		JBrowse link
G Mir330 microRNA 330 increases expression EXP 2,5-hexanedione results in increased expression of MIR330 mRNA CTD PMID:31760062 NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274 		JBrowse link
G Mir331 microRNA 331 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR331 mRNA CTD PMID:31760062 NCBI chr 7:28,527,390...28,527,485
Ensembl chr 7:28,527,390...28,527,485 		JBrowse link
G Mir339 microRNA 339 increases expression EXP 2,5-hexanedione results in increased expression of MIR339 mRNA CTD PMID:31760062 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir344-1 microRNA 344-1 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR344-1 mRNA CTD PMID:31760062 NCBI chr 1:115,306,861...115,306,958 JBrowse link
G Mir345 microRNA 345 increases expression EXP 2,5-hexanedione results in increased expression of MIR345 mRNA CTD PMID:31760062 NCBI chr 6:127,754,027...127,754,122
Ensembl chr 6:127,754,027...127,754,122 		JBrowse link
G Mir3556a microRNA 3556a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3556A mRNA CTD PMID:31760062 NCBI chr 4:59,650,596...59,650,713
Ensembl chr 4:59,650,596...59,650,713 		JBrowse link
G Mir3558 microRNA 3558 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3558 mRNA CTD PMID:31760062 NCBI chr 6:7,181,751...7,181,864
Ensembl chr 6:7,181,751...7,181,864 		JBrowse link
G Mir3560 microRNA 3560 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3560 mRNA CTD PMID:31760062 NCBI chr  X:15,255,308...15,255,419
Ensembl chr  X:15,255,308...15,255,419 		JBrowse link
G Mir3573 microRNA 3573 increases expression EXP 2,5-hexanedione results in increased expression of MIR3573 mRNA CTD PMID:31760062 NCBI chr  X:64,259,096...64,259,167
Ensembl chr  X:64,259,096...64,259,167 		JBrowse link
G Mir3580 microRNA 3580 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3580 mRNA CTD PMID:31760062 NCBI chr  X:145,445,018...145,445,098
Ensembl chr  X:145,445,018...145,445,098 		JBrowse link
G Mir3593 microRNA 3593 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3593 mRNA CTD PMID:31760062 NCBI chr 6:73,252,647...73,252,737
Ensembl chr 6:73,252,647...73,252,737 		JBrowse link
G Mir370 microRNA 370 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR370 mRNA CTD PMID:31760062 NCBI chr 6:128,572,257...128,572,335
Ensembl chr 6:128,572,257...128,572,335 		JBrowse link
G Mir375 microRNA 375 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR375 mRNA CTD PMID:31760062 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985 		JBrowse link
G Mir412 microRNA 412 increases expression EXP 2,5-hexanedione results in increased expression of MIR412 mRNA CTD PMID:31760062 NCBI chr 6:128,757,932...128,758,001
Ensembl chr 6:128,757,926...128,758,005 		JBrowse link
G Mir423 microRNA 423 increases expression EXP 2,5-hexanedione results in increased expression of MIR423 mRNA CTD PMID:31760062 NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226 		JBrowse link
G Mir433 microRNA 433 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR433 mRNA CTD PMID:31760062 NCBI chr 6:128,545,119...128,545,211
Ensembl chr 6:128,545,112...128,545,217 		JBrowse link
G Mir450a1 microRNA 450a-1 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR450A1 mRNA CTD PMID:31760062 NCBI chr  X:132,801,380...132,801,470
Ensembl chr  X:132,801,380...132,801,470 		JBrowse link
G Mir487b microRNA 487b increases expression EXP 2,5-hexanedione results in increased expression of MIR487B mRNA CTD PMID:31760062 NCBI chr 6:128,741,485...128,741,566
Ensembl chr 6:128,741,485...128,741,566 		JBrowse link
G Mir488 microRNA 488 increases expression EXP 2,5-hexanedione results in increased expression of MIR488 mRNA CTD PMID:31760062 NCBI chr13:70,683,064...70,683,142
Ensembl chr13:70,683,064...70,683,142 		JBrowse link
G Mir497 microRNA 497 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR497 mRNA CTD PMID:31760062 NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584 		JBrowse link
G Mir503 microRNA 503 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR503 mRNA CTD PMID:31760062 NCBI chr  X:132,806,303...132,806,373
Ensembl chr  X:132,806,303...132,806,373 		JBrowse link
G Mir541 microRNA 541 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR541 mRNA CTD PMID:31760062 NCBI chr 6:128,757,016...128,757,105
Ensembl chr 6:128,757,016...128,757,105 		JBrowse link
G Mir542 microRNA 542 increases expression EXP 2,5-hexanedione results in increased expression of MIR542 mRNA CTD PMID:31760062 NCBI chr  X:132,802,623...132,802,701
Ensembl chr  X:132,802,623...132,802,701 		JBrowse link
G Mir551b microRNA 551b decreases expression EXP 2,5-hexanedione results in decreased expression of MIR551B mRNA CTD PMID:31760062 NCBI chr 2:113,989,203...113,989,300
Ensembl chr 2:113,989,203...113,989,300 		JBrowse link
G Mir582 microRNA 582 increases expression EXP 2,5-hexanedione results in increased expression of MIR582 mRNA CTD PMID:31760062 NCBI chr 2:40,928,571...40,928,651
Ensembl chr 2:40,928,571...40,928,651 		JBrowse link
G Mir652 microRNA 652 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR652 mRNA CTD PMID:31760062 NCBI chr  X:106,343,293...106,343,373
Ensembl chr  X:106,343,293...106,343,373 		JBrowse link
G Mir653 microRNA 653 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR653 mRNA CTD PMID:31760062 NCBI chr 4:31,692,714...31,692,810
Ensembl chr 4:31,692,714...31,692,810 		JBrowse link
G Mir665 microRNA 665 increases expression EXP 2,5-hexanedione results in increased expression of MIR665 mRNA CTD PMID:31760062 NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533 		JBrowse link
G Mir675 microRNA 675 increases expression EXP 2,5-hexanedione results in increased expression of MIR675 mRNA CTD PMID:31760062 NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358 		JBrowse link
G Mir743a microRNA 743a increases expression EXP 2,5-hexanedione results in increased expression of MIR743A mRNA CTD PMID:31760062 NCBI chr  X:145,402,692...145,402,767
Ensembl chr  X:145,402,692...145,402,767 		JBrowse link
G Mir760 microRNA 760 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR760 mRNA CTD PMID:31760062 NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695 		JBrowse link
G Mir770 microRNA 770 increases expression EXP 2,5-hexanedione results in increased expression of MIR770 mRNA CTD PMID:31760062 NCBI chr 6:128,515,843...128,515,918
Ensembl chr 6:128,515,835...128,515,928 		JBrowse link
G Mir8 microRNA 8 increases expression EXP 2,5-hexanedione results in increased expression of MIR8 mRNA CTD PMID:31760062 NCBI chr 1:132,806,420...132,806,514
Ensembl chr 1:132,806,420...132,806,514 		JBrowse link
G Mir873 microRNA 873 increases expression EXP 2,5-hexanedione results in increased expression of MIR873 mRNA CTD PMID:31760062 NCBI chr 5:51,356,919...51,356,995
Ensembl chr 5:51,356,919...51,356,995 		JBrowse link
G Mir877 microRNA 877 increases expression EXP 2,5-hexanedione results in increased expression of MIR877 mRNA CTD PMID:31760062 NCBI chr20:2,811,476...2,811,560
Ensembl chr20:2,811,476...2,811,560 		JBrowse link
G Mir883 microRNA 883 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR883 mRNA CTD PMID:31760062 NCBI chr  X:145,410,566...145,410,642
Ensembl chr  X:145,410,566...145,410,642 		JBrowse link
G Mirlet7b microRNA let-7b increases expression EXP 2,5-hexanedione results in increased expression of MIRLET7B mRNA CTD PMID:31760062 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mirlet7f-1 microRNA let7f-1 decreases expression EXP 2,5-hexanedione results in decreased expression of MIRLET7F1 mRNA CTD PMID:31760062 NCBI chr17:16,114,130...16,114,226
Ensembl chr17:16,114,130...16,114,226 		JBrowse link
G Mirlet7i microRNA let-7i increases expression EXP 2,5-hexanedione results in increased expression of MIRLET7I mRNA CTD PMID:31760062 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571 		JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression
multiple interactions		 EXP 2,5-hexanedione results in decreased expression of MRC1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA]		 CTD PMID:32522579 PMID:32860822 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Mtm1 myotubularin 1 increases expression EXP 2,5-hexanedione results in increased expression of MTM1 mRNA CTD PMID:22952946 NCBI chr 6:488,923...506,882
Ensembl chr 6:488,969...506,860 		JBrowse link
G Napa NSF attachment protein alpha decreases expression EXP 2,5-hexanedione results in decreased expression of NAPA protein CTD PMID:19033394 NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869 		JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 increases expression
decreases expression		 EXP 2,5-hexanedione results in increased expression of NDUFA10 protein
2,5-hexanedione results in decreased expression of NDUFA10 protein		 CTD PMID:19033394 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560 		JBrowse link
G Nefh neurofilament heavy chain decreases expression EXP 2,5-hexanedione results in decreased expression of NEFH protein CTD PMID:19033394 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain decreases expression
multiple interactions		 EXP 2,5-hexanedione results in decreased expression of NEFL protein
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein]		 CTD PMID:19033394 PMID:32522579 PMID:32860822 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain decreases expression EXP 2,5-hexanedione results in decreased expression of NEFM protein CTD PMID:19033394 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression		 EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]
2,5-hexanedione results in increased expression of NLRP3 mRNA; 2,5-hexanedione results in increased expression of NLRP3 protein		 CTD PMID:32522579 PMID:32860822 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP 2,5-hexanedione results in increased expression of NOS2 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]		 CTD PMID:32522579 PMID:32860822 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression EXP 2,5-hexanedione results in decreased expression of NSF protein CTD PMID:19033394 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
G Nupr2 nuclear protein 2, transcriptional regulator increases expression EXP 2,5-hexanedione results in increased expression of NUPR2 mRNA CTD PMID:22952946 NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP 2,5-hexanedione results in decreased expression of PDIA3 protein CTD PMID:19033394 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP 2,5-hexanedione results in decreased expression of PDLIM3 protein CTD PMID:19033394 NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression EXP 2,5-hexanedione results in increased expression of PGAM1 protein CTD PMID:19033394 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 increases expression EXP 2,5-hexanedione results in increased expression of PHOSPHO1 mRNA CTD PMID:22952946 NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO 2,5-hexanedione results in decreased expression of PIK3CA mRNA CTD PMID:33197454 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO 2,5-hexanedione results in decreased expression of PIK3R1 protein CTD PMID:33197454 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression EXP 2,5-hexanedione results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP 2,5-hexanedione results in increased expression of PKM protein CTD PMID:19033394 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression EXP 2,5-hexanedione results in increased expression of POU2F1 mRNA CTD PMID:22952946 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363 		JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II decreases expression EXP 2,5-hexanedione results in decreased expression of PRKCSH protein CTD PMID:19033394 NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492 		JBrowse link
G Ptgds prostaglandin D2 synthase increases expression EXP 2,5-hexanedione results in increased expression of PTGDS mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Pycard PYD and CARD domain containing increases expression EXP 2,5-hexanedione results in increased expression of PYCARD mRNA; 2,5-hexanedione results in increased expression of PYCARD protein CTD PMID:32860822 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Pygb glycogen phosphorylase B decreases expression EXP 2,5-hexanedione results in decreased expression of PYGB protein CTD PMID:19033394 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553 		JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression EXP 2,5-hexanedione results in decreased expression of PYGM protein CTD PMID:19033394 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368 		JBrowse link
G Ralgapa2 Ral GTPase activating protein catalytic subunit alpha 2 increases expression EXP 2,5-hexanedione results in increased expression of RALGAPA2 mRNA CTD PMID:22952946 NCBI chr 3:133,658,725...133,938,821
Ensembl chr 3:133,659,761...133,938,916 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2,5-hexanedione results in decreased expression of and affects the localization of RELA protein CTD PMID:22337490 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rtkn2 rhotekin 2 increases expression EXP 2,5-hexanedione results in increased expression of RTKN2 mRNA CTD PMID:22952946 NCBI chr20:20,536,628...20,609,951
Ensembl chr20:20,525,256...20,609,951 		JBrowse link
G S100z S100 calcium binding protein Z increases expression EXP 2,5-hexanedione results in increased expression of S100Z mRNA CTD PMID:22952946 NCBI chr 2:26,737,796...26,753,611
Ensembl chr 2:26,738,776...26,752,390 		JBrowse link
G Sclt1 sodium channel and clathrin linker 1 increases expression EXP 2,5-hexanedione results in increased expression of SCLT1 mRNA CTD PMID:22952946 NCBI chr 2:124,605,445...124,763,964
Ensembl chr 2:124,605,658...124,764,065 		JBrowse link
G Septin8 septin 8 decreases expression EXP 2,5-hexanedione results in decreased expression of SEPTIN8 protein CTD PMID:19033394 NCBI chr10:37,684,649...37,713,704
Ensembl chr10:37,684,639...37,713,174 		JBrowse link
G Sh2d4a SH2 domain containing 4A decreases expression EXP 2,5-hexanedione results in decreased expression of SH2D4A mRNA CTD PMID:22952946 NCBI chr16:21,339,010...21,409,360
Ensembl chr16:21,340,015...21,409,260 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Sil1 SIL1 nucleotide exchange factor increases expression EXP 2,5-hexanedione results in increased expression of SIL1 mRNA CTD PMID:22952946 NCBI chr18:26,872,423...27,104,365
Ensembl chr18:26,872,429...27,104,332 		JBrowse link
G Slc10a7 solute carrier family 10, member 7 increases expression EXP 2,5-hexanedione results in increased expression of SLC10A7 mRNA CTD PMID:22952946 NCBI chr19:29,183,143...29,407,470
Ensembl chr19:29,183,155...29,407,464 		JBrowse link
G Sltm SAFB-like, transcription modulator increases expression EXP 2,5-hexanedione results in increased expression of SLTM mRNA CTD PMID:22952946 NCBI chr 8:71,215,995...71,261,821
Ensembl chr 8:71,216,612...71,261,825 		JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP 2,5-hexanedione results in increased expression of SOD3 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sppl3 signal peptide peptidase like 3 increases expression EXP 2,5-hexanedione results in increased expression of SPPL3 mRNA CTD PMID:22952946 NCBI chr12:41,515,635...41,600,079
Ensembl chr12:41,515,640...41,600,126 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 decreases expression EXP 2,5-hexanedione results in decreased expression of SPTAN1 protein CTD PMID:19033394 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Stmn1 stathmin 1 decreases expression EXP 2,5-hexanedione results in decreased expression of STMN1 mRNA CTD PMID:22952946 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression EXP 2,5-hexanedione results in increased expression of STRBP mRNA CTD PMID:22952946 NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 increases expression EXP 2,5-hexanedione results in increased expression of STYXL1 mRNA CTD PMID:22952946 NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 increases expression EXP 2,5-hexanedione results in increased expression of TAX1BP1 mRNA CTD PMID:22952946 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100 		JBrowse link
G Tbc1d5 TBC1 domain family, member 5 increases expression EXP 2,5-hexanedione results in increased expression of TBC1D5 mRNA CTD PMID:22952946 NCBI chr 9:3,503,328...4,017,131
Ensembl chr 9:3,513,623...4,016,913 		JBrowse link
G Tmem192 transmembrane protein 192 increases expression EXP 2,5-hexanedione results in increased expression of TMEM192 mRNA CTD PMID:22952946 NCBI chr16:24,740,166...24,760,994
Ensembl chr16:24,740,124...24,761,021 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP 2,5-hexanedione results in increased expression of TPI1 mRNA; 2,5-hexanedione results in increased expression of TPI1 protein CTD PMID:19033394 PMID:22952946 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 increases expression EXP 2,5-hexanedione results in increased expression of UBA1 protein CTD PMID:19033394 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636 		JBrowse link
G Ubn2 ubinuclein 2 increases expression EXP 2,5-hexanedione results in increased expression of UBN2 mRNA CTD PMID:22952946 NCBI chr 4:67,165,278...67,251,562
Ensembl chr 4:67,166,346...67,230,491 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression EXP 2,5-hexanedione results in decreased expression of UQCRC2 mRNA CTD PMID:22952946 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453 		JBrowse link
G Vim vimentin multiple interactions ISO 2,5-hexanedione promotes the reaction [VIM protein binds to VIM protein] CTD PMID:6361548 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression EXP 2,5-hexanedione results in decreased expression of XIAP mRNA CTD PMID:22337490 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Zfp169 zinc finger protein 169 decreases expression EXP 2,5-hexanedione results in decreased expression of ZFP169 protein CTD PMID:19033394 NCBI chr17:16,139,204...16,167,242
Ensembl chr17:16,139,253...16,169,914 		JBrowse link
G Zfp407 zinc finger protein 407 increases expression EXP 2,5-hexanedione results in increased expression of ZFP407 mRNA CTD PMID:22952946 NCBI chr18:77,571,140...77,970,282
Ensembl chr18:77,571,204...77,974,129 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        aetiopathogenetic role 19166
          neurotoxin 18155
            2,5-hexanedione 198
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      diketone 1261
                                        2,5-hexanedione 198
paths to the root