Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,3-dinitrobenzene | decreases expression | EXP | | 6480464 | 3-dinitrobenzene results in decreased expression of TBC1D5 mRNA | CTD | PMID:21983209 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of TBC1D5 mRNA | CTD | PMID:35192832 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tbc1d5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TBC1D5 mRNA | CTD | PMID:21570461 | 2,5-hexanedione | increases expression | EXP | | 6480464 | 2 and 5-hexanedione results in increased expression of TBC1D5 mRNA | CTD | PMID:22952946 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D5 mRNA | CTD | PMID:28628672 | 7,12-dimethyltetraphene | decreases expression | ISO | Tbc1d5 (Mus musculus) | 6480464 | 9 more ... | CTD | PMID:32553695 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of TBC1D5 mRNA | CTD | PMID:31881176 | aconitine | decreases expression | EXP | | 6480464 | Aconitine results in decreased expression of TBC1D5 protein | CTD | PMID:33236894 | acrolein | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TBC1D5 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TBC1D5 mRNA | CTD | PMID:32699268 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of TBC1D5 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases expression | ISO | Tbc1d5 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of TBC1D5 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of TBC1D5 intron | CTD | PMID:30157460 | aflatoxin B1 | increases methylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of TBC1D5 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of TBC1D5 mRNA | CTD | PMID:15498508 | alpha-pinene | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TBC1D5 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TBC1D5 mRNA | CTD | PMID:32699268 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of TBC1D5 mRNA | CTD | PMID:30779732 | aristolochic acid A | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of TBC1D5 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to TBC1D5 mRNA] | CTD | PMID:32406909 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of TBC1D5 gene | CTD | PMID:28931070 | benzo[a]pyrene | decreases expression | ISO | Tbc1d5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of TBC1D5 mRNA | CTD | PMID:19770486 and PMID:21715664 | benzo[a]pyrene | increases methylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of TBC1D5 5' UTR and Benzo(a)pyrene results in increased methylation of TBC1D5 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of TBC1D5 exon | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | Tbc1d5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of TBC1D5 intron | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of TBC1D5 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | increases expression | ISO | Tbc1d5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of TBC1D5 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | benzo[e]pyrene | increases methylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of TBC1D5 intron | CTD | PMID:30157460 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of TBC1D5 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of TBC1D5 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TBC1D5 mRNA | CTD | PMID:30816183 and PMID:32528016 | bisphenol A | increases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of TBC1D5 mRNA | CTD | PMID:29275510 | bisphenol A | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of TBC1D5 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D5 mRNA | CTD | PMID:28628672 and PMID:31601247 | butanal | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of TBC1D5 mRNA | CTD | PMID:26079696 | caffeine | affects phosphorylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of TBC1D5 protein | CTD | PMID:35688186 | carbamazepine | affects expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of TBC1D5 mRNA | CTD | PMID:25979313 | carbendazim | decreases expression | EXP | | 6480464 | carbendazim results in decreased expression of TBC1D5 mRNA | CTD | PMID:27466211 | CGP 52608 | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TBC1D5 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | Tbc1d5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D5 gene | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of TBC1D5 mRNA | CTD | PMID:27594783 | coumarin | affects phosphorylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of TBC1D5 protein | CTD | PMID:35688186 | dexamethasone | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D5 mRNA | CTD | PMID:28628672 | diquat | decreases expression | ISO | Tbc1d5 (Mus musculus) | 6480464 | Diquat results in decreased expression of TBC1D5 protein | CTD | PMID:36851058 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of TBC1D5 mRNA | CTD | PMID:29391264 | enzyme inhibitor | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TBC1D5 protein | CTD | PMID:23301498 | ethanol | increases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Ethanol results in increased expression of TBC1D5 mRNA | CTD | PMID:28986285 | fenthion | decreases expression | ISO | Tbc1d5 (Mus musculus) | 6480464 | Fenthion results in decreased expression of TBC1D5 mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | ISO | Tbc1d5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D5 gene | CTD | PMID:20938992 | FR900359 | affects phosphorylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of TBC1D5 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of TBC1D5 gene | CTD | PMID:31601247 | glyphosate | decreases methylation | EXP | | 6480464 | Glyphosate results in decreased methylation of TBC1D5 gene | CTD | PMID:31011160 | hexadecanoic acid | decreases phosphorylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | Palmitic Acid results in decreased phosphorylation of TBC1D5 protein | CTD | PMID:28073184 | hydrogen peroxide | multiple interactions | ISO | Tbc1d5 (Mus musculus) | 6480464 | [Hydrogen Peroxide co-treated with N-(oxo-5 more ... | CTD | PMID:31494107 | indometacin | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D5 mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of TBC1D5 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Tbc1d5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D5 gene | CTD | PMID:20938992 | methapyrilene | increases methylation | ISO | TBC1D5 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of TBC1D5 intron | CTD | PMID:30157460 | ochratoxin A | increases methylation | EXP | | 6480464 | ochratoxin A results in increased methylation of TBC1D5 gene | CTD | PMID:26431795 | ozone | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TBC1D5 mRNA more ... | CTD | PMID:32699268 | paracetamol | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of TBC1D5 mRNA | CTD | PMID:21420995 | resveratrol | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | resveratrol results in decreased expression of TBC1D5 mRNA | CTD | PMID:25888808 | silicon dioxide | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of TBC1D5 mRNA | CTD | PMID:25351596 | sodium arsenite | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of TBC1D5 protein | CTD | PMID:21925251 | sodium arsenite | multiple interactions | ISO | TBC1D5 (Homo sapiens) | 6480464 | sodium arsenite promotes the reaction [TBC1D5 protein binds to CAPRIN1 protein] | CTD | PMID:33939924 | sodium dichromate | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | sodium bichromate results in decreased expression of TBC1D5 mRNA | CTD | PMID:17685462 | succimer | multiple interactions | ISO | Tbc1d5 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TBC1D5 mRNA | CTD | PMID:21641980 | sunitinib | increases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of TBC1D5 mRNA | CTD | PMID:31533062 | tamibarotene | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | tamibarotene results in decreased expression of TBC1D5 mRNA | CTD | PMID:15498508 | testosterone | decreases expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of TBC1D5 mRNA | CTD | PMID:33359661 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TBC1D5 mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of TBC1D5 mRNA | CTD | PMID:34492290 | tungsten | decreases expression | ISO | Tbc1d5 (Mus musculus) | 6480464 | Tungsten results in decreased expression of TBC1D5 mRNA | CTD | PMID:30912803 | valproic acid | affects expression | ISO | TBC1D5 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TBC1D5 mRNA | CTD | PMID:25979313 | |