Sppl3 (signal peptide peptidase like 3)

Gene: Sppl3 (signal peptide peptidase like 3) Rattus norvegicus

Analyze

Symbol:

Sppl3

Name:

signal peptide peptidase like 3

RGD ID:

1562826

Description:

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and proteolysis. Predicted to be located in endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment membrane; and plasma membrane. Predicted to be active in Golgi-associated vesicle membrane. Orthologous to human SPPL3 (signal peptide peptidase like 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; bisphenol A.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC360822; RGD1562826; signal peptide peptidase 3; signal peptide peptidase-like 3; signal peptide peptidase-like 3, pseudogene 1; similar to Hypothetical protein MGC75937; Sppl3-ps1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPPL3 (signal peptide peptidase like 3)	RGD	RGD
Mus musculus (house mouse):	Sppl3 (signal peptide peptidase 3)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Sppl3 (signal peptide peptidase like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SPPL3 (signal peptide peptidase like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPPL3 (signal peptide peptidase like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sppl3 (signal peptide peptidase like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SPPL3 (signal peptide peptidase like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SPPL3 (signal peptide peptidase like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sppl3 (signal peptide peptidase like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SPPL3 (signal peptide peptidase like 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sppl3 (signal peptide peptidase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sppl3 (signal peptide peptidase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	SppL	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sppl3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	47,176,317 - 47,260,756 (-)	NCBI		GRCr8
mRatBN7.2	12	41,515,635 - 41,600,079 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,515,640 - 41,600,126 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	12	47,276,485 - 47,360,552 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,276,476 - 47,360,507 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	49,071,961 - 49,156,613 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	42,788,576 - 42,882,650 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	43,134,305 - 43,170,708 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,5-hexanedione (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

dexamethasone (ISO)

dioxygen (ISO)

doxorubicin (ISO)

fenthion (ISO)

indometacin (ISO)

methapyrilene (ISO)

methidathion (ISO)

methoxychlor (EXP)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

silver atom (ISO)

silver(0) (ISO)

Soman (EXP)

sunitinib (ISO)

testosterone (ISO)

titanium dioxide (ISO)

topotecan (EXP)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

membrane protein ectodomain proteolysis (ISO)

membrane protein proteolysis (IBA,ISO)

positive regulation of calcineurin-NFAT signaling cascade (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of protein dephosphorylation (ISO)

signal peptide processing (IBA)

T cell receptor signaling pathway (ISO)

Cellular Component

cytoplasmic side of endoplasmic reticulum membrane (ISO)

endoplasmic reticulum-Golgi intermediate compartment membrane (ISO)

Golgi-associated vesicle membrane (IBA,ISO)

intracellular membrane-bounded organelle (ISO)

lumenal side of endoplasmic reticulum membrane (ISO)

membrane (ISO)

plasma membrane (IEA,ISO)

rough endoplasmic reticulum (ISO)

Molecular Function

aspartic endopeptidase activity, intramembrane cleaving (IBA,ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2313285	PMID:15385547	PMID:15998642	PMID:16778019	PMID:16829952	PMID:16873890	PMID:17965014	PMID:25384971

Genomics

Comparative Map Data

Sppl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	47,176,317 - 47,260,756 (-)	NCBI		GRCr8
mRatBN7.2	12	41,515,635 - 41,600,079 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,515,640 - 41,600,126 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	12	47,276,485 - 47,360,552 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,276,476 - 47,360,507 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	49,071,961 - 49,156,613 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	42,788,576 - 42,882,650 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	43,134,305 - 43,170,708 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

SPPL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	120,762,510 - 120,904,358 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	120,762,510 - 120,904,358 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	121,200,313 - 121,342,161 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	119,685,418 - 119,826,534 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	120,835,168 - 120,976,050 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	118,209,451 - 118,351,576 (-)	NCBI		HuRef
CHM1_1	12	121,169,084 - 121,310,844 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	120,751,646 - 120,893,446 (-)	NCBI		T2T-CHM13v2.0

Sppl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	115,149,204 - 115,236,849 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	115,149,196 - 115,236,849 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	115,011,524 - 115,098,790 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	115,011,137 - 115,098,790 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	115,461,533 - 115,548,799 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	115,272,523 - 115,359,789 (+)	NCBI		MGSCv36	mm8
Celera	5	112,107,828 - 112,194,819 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	55.99	NCBI

Sppl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	10,760,804 - 10,907,024 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	10,849,627 - 10,905,515 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPPL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	128,837,951 - 128,976,306 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	128,834,324 - 128,972,679 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	118,351,199 - 118,489,579 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	121,723,881 - 121,858,502 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	121,723,881 - 121,773,429 (-)	Ensembl	panpan1.1		panPan2

SPPL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	16,620,236 - 16,760,616 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	16,621,455 - 16,760,623 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	16,622,725 - 16,762,963 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	16,886,222 - 17,026,542 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	16,887,266 - 17,026,468 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	16,847,005 - 16,987,200 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	16,922,683 - 17,062,392 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	16,965,017 - 17,105,003 (-)	NCBI		UU_Cfam_GSD_1.0

Sppl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	145,694,867 - 145,731,325 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	193,723 - 231,088 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	193,753 - 229,859 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPPL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	40,699,937 - 40,822,761 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	40,699,931 - 40,870,288 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	43,167,682 - 43,217,584 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPPL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	116,125,042 - 116,267,226 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	116,124,221 - 116,267,108 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	128,831,057 - 128,972,698 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sppl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	12,795,563 - 12,928,649 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	12,795,803 - 12,925,319 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sppl3
352 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	135
Count of miRNA genes:	110
Interacting mature miRNAs:	123
Transcripts:	ENSRNOT00000001562
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	32103174	45899022	Rat

Markers in Region

RH128470

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,515,820 - 41,516,008 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	47,276,671 - 47,276,858	NCBI	Rnor6.0
Rnor_5.0	12	49,072,147 - 49,072,334	UniSTS	Rnor5.0
RGSC_v3.4	12	42,787,814 - 42,788,001	UniSTS	RGSC3.4
Celera	12	43,134,491 - 43,134,678	UniSTS
RH 3.4 Map	12	778.12	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	49	33	19	33	1	2	74	35	41	11	1
Low		9	8	8		8	7	9					7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003751200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006221425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC105804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ741246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000001562 ⟹ ENSRNOP00000001562

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	41,515,640 - 41,600,126 (-)	Ensembl
Rnor_6.0 Ensembl	12	47,276,476 - 47,360,507 (-)	Ensembl

RefSeq Acc Id:

XM_003751200 ⟹ XP_003751248

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	47,176,317 - 47,260,756 (-)	NCBI
mRatBN7.2	12	41,515,635 - 41,600,071 (-)	NCBI
Rnor_6.0	12	47,276,485 - 47,360,552 (-)	NCBI
Rnor_5.0	12	49,071,961 - 49,156,613 (-)	NCBI

Sequence:

show sequence

CGGAGCCCGAGTGCCCGTCCGCCGTGCGAGCGAGCCGCCGGGCCCCCGGCCGCGCCCTCTGCCG
CCGGCCGAGCGAGCCGCGGAGCCCCGAGAGGCAGCACCATGGCGGAGCAGACCTATTCGTGGGC
CTATTCCCTGGTGGATTCCAGTCAAGTGTCGACATTTCTGATATCCATTCTTCTGATAGTCTAT
GGTAGTTTCAGGTCTCTTAATATGGACTTTGAGAACCAAGATAAGGAGAAAGACAGCAGCAGTA
GTTCTGGCCCTTTCAACGGCAGCAGCACCAATAACAGCATTCAGACCATTGACTCCACCCAAGC
TCTGTTCCTTCCGATTGGAGCGTCCGTCTCTCTCCTAGTCATGTTCTTCTTCTTTGACTCAGTT
CAAGTCGTTTTCACAATATGTACAGCAGTTCTTGCAACAATAGCTTTTGCTTTTCTTCTTCTCC
CAATGTGCCAGTATTTAACAAGACCCTGCTCACCTCAGAATAAGATTTCCTTCGGTTGCTGTGG
GCGTTTCACTGCTGCCGAGCTGCTGTCCTTCTCCCTGTCAGTCATGCTTGTCCTCATCTGGGTT
CTCACTGGACACTGGCTTCTTATGGACGCTCTGGCCATGGGTCTCTGTGTCGCCATGATCGCCT
TCGTCCGCCTGCCAAGCCTCAAGGTTTCCTGCCTGCTTCTCTCAGGGCTTCTCATCTACGATGT
CTTCTGGGTGTTTTTCTCGGCCTACATCTTCAACAGCAATGTCATGGTGAAAGTGGCCACACAG
CCAGCTGACAATCCCCTCGACGTTCTGTCCCGCAAGCTCCACCTGGGACCCAATGTGGGGCGTG
ATGTTCCTCGCCTGTCTTTGCCTGGAAAGTTGGTCTTCCCAAGCTCCACGGGCAGTCACTTCTC
TATGTTGGGCATCGGGGACATTGTGATGCCCGGCCTCCTGTTATGCTTTGTTCTTCGCTACGAC
AACTACAAGAAACAAGCCAGCGGCGACTCCTGTGGGGCCCCTGGCCCGGCAAACATCTCTGGGC
GCATGCAGAGGGTCTCCTACTTCCACTGCACCCTCATCGGGTACTTTGTAGGTCTGCTCACCGC
AACTGTGGCGTCTCGCATCCACCGGGCCGCCCAGCCAGCCCTCCTCTACTTGGTGCCATTCACC
TTATTGCCGCTCCTCACCATGGCCTACTTAAAGGGTGACTTACGAAGGATGTGGTCTGAGCCAT
TCCACTCCAAGTCCAGCAGCTCCCGCTTCCTGGAAGTATGATGGGCAGTGTGAGAAGGGACCAG
AGCGCCGGCTCCGCCCTGTTCTCTCACCACGTGGTTTTGTTCTCTCTACAAGCTGGCCTGGACT
CAAGAGGCACGCCTGCTCACAGAACTGCGGTGTGGCTGCAGTCTGCGTCTGAGGGTAGCGTTCC
CAGAGGGTGCTGGAGCCCTGCCGAGGGAGCCTTCTCTTCTGTGCTCTGGGAGAGTGGACCCTTG
AGAAGGGGCAGGCCCTCCGGTGCTCCTTCTGTCTTCATGGATCTGCACCAGACTGTTAACTTGT
GGGGAGAAGTTGACTTATTTAAAAACTACAAAAAGCAAGGAGTTGTTCTAGAACTTTGAACACT
AAACGGTCGAAAATCAGTGAACCCCAAAACTTTGGGGCCAGTTTTCCTCGGGGGCTCCACTTCA
GAGACCTAGGGCCGAACATCTCGTCTGCCCTATTCTTTTCTTTTTCTTTTTTTCTTTTGGATTT
ATTAAATATTTTCTGTGGTGTGAAGTGACTTATTAAATCCACAGACATTGAATGACTTCTTACA
ACGTACACATAAGAATTTGTTGTAATGACTGTGTCCAACCGTGTTGGCAGTGAGCAGGACACGG
TTTTATACATACGTACATATATATATATATATACGTGCACATAGATACCTATGAGTAAACAGCC
ACTAAACCTGCTAAGATCATGCCGTGTAGCAGACGGGCTTGCTGTCATTTGAGCATGTAGAACA
GTTTACCGTGGCTTCCTCGCATAAGCTGCCGTCTCCTGTGTGAGTCACGTGCAGTTGTAAGCTG
TGGGCGCGTTGAACTGATACTCGTGGGCTGTGGGGGCTCCTTCTTTTGATCAGTGTAGCAAAAT
TAGGGATGAAAAGTTTGAACTTTTTGACCCTTTTCTTTTTACAGGCTTCTTCCTCGCAGTTTTT
AGTAACCGCCTCTTGAACCAGTGCATGTATTATAGCAGTCTTTGTGCTTTCTGATCATAGTAAC
AGACTACCTGTAAATACATTTTTCTATTTTATATTTTTTTGTATTTTTTTTGACATTTTGTTTC
ATTGGTGCGCTGTATTTTCCATGCCCTCAGACCCTTAGAAGAAAAAAAAAAACAGAAAAGCAGC
GCAATGCTGTCCTTGCTGTTGTGATTACAGTCTCAGCTTACCTGTGGTGACAGCTGGGCTTTGG
GGACAGATGTCAGTTACCTCTGCAAATGGAACTGATGTCCAGGAGCTGGAGACAGAGCAGGCTG
CTACTGTGACTTCAGAACCTGGCCCCGCGCTGTCCGTGGGCGTGCAGAGTCTGGTGTGACCTCA
CCTTCATCTCAGACTGGTAAGCTGCTGCTGCCCCCCCGGGGGGTGAGACGGCAGAGTACACAGC
CTGAGCCCGGCGTGTCAACGGAGCAGCGTGCCGCCATGCTGTTGGTTCCTCTGTCCTCCTCAAA
CTCTGCCGAAGGGTTTGAAGGGTTGGTTTTGTCTCTAATAAATGACTCCTTTTTCTA

hide sequence

RefSeq Acc Id:

XR_010056808

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	47,179,403 - 47,260,749 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003751248	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM13911	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001562
	ENSRNOP00000001562.7

RefSeq Acc Id:

XP_003751248 ⟸ XM_003751200

- UniProtKB:

D3ZY49 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEQTYSWAYSLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKEKDSSSSSGPFNGSSTNNS
IQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQYLTRPCSPQ
NKISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAFVRLPSLKVSCLL
LSGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPNVGRDVPRLSLPGKLVF
PSSTGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAPGPANISGRMQRVSYFHCTLI
GYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV

hide sequence

RefSeq Acc Id:

ENSRNOP00000001562 ⟸ ENSRNOT00000001562

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZY49-F1-model_v2	AlphaFold	D3ZY49	1-384	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562826	AgrOrtholog
BioCyc Gene	G2FUF-18971	BioCyc
Ensembl Genes	ENSRNOG00000001178	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001562.8	UniProtKB/TrEMBL
InterPro	Peptidase_A22	UniProtKB/TrEMBL
	Peptidase_A22B_SPP	UniProtKB/TrEMBL
KEGG Report	rno:360822	UniProtKB/TrEMBL
NCBI Gene	360822	ENTREZGENE
PANTHER	Peptidase_A22B	UniProtKB/TrEMBL
	SIGNAL PEPTIDE PEPTIDASE-LIKE 3	UniProtKB/TrEMBL
Pfam	Peptidase_A22B	UniProtKB/TrEMBL
PhenoGen	Sppl3	PhenoGen
RatGTEx	ENSRNOG00000001178	RatGTEx
SMART	PSN	UniProtKB/TrEMBL
UniProt	D3ZY49	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-03-07	Sppl3	signal peptide peptidase-like 3	Sppl3-ps1	signal peptide peptidase-like 3, pseudogene 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-03-07	Sppl3	signal peptide peptidase like 3	Sppl3	signal peptide peptidase-like 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-06-09	Sppl3-ps1	signal peptide peptidase-like 3, pseudogene 1	Sppl3	signal peptide peptidase 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-29	Sppl3	signal peptide peptidase 3	RGD1562826_predicted	similar to Hypothetical protein MGC75937 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1562826_predicted	similar to Hypothetical protein MGC75937 (predicted)	LOC360822	similar to Hypothetical protein MGC75937	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC360822	similar to Hypothetical protein MGC75937			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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