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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:toluene 2,4-diisocyanate
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Accession:CHEBI:53556 term browser browse the term
Definition:A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Synonyms:exact_synonym: 2,4-diisocyanato-1-methylbenzene
 related_synonym: 2,4-Diisocyanatotoluene;   2,4-TDI;   4-Methyl-m-phenylene diisocyanate;   Formula=C9H6N2O2;   InChI=1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3;   InChIKey=DVKJHBMWWAPEIU-UHFFFAOYSA-N;   Isocyanic acid, 4-methyl-m-phenylene ester;   SMILES=Cc1ccc(cc1N=C=O)N=C=O;   TDI;   Toluylene-2,4-diisocyanate;   Tolylene-2,4-diisocyanate;   toluene-2,4-diyl diisocyanate
 xref: Beilstein:744602;   CAS:584-84-9
 xref_mesh: MESH:D014051
 xref: PMID:17042142;   PMID:19647056;   PMID:21725071;   PMID:21878336;   PMID:22151392;   PMID:22206939;   PMID:22229538;   PMID:24572447;   PMID:24950844;   PMID:25042713;   PMID:6296214;   PMID:9811173;   Reaxys:744602;   Wikipedia:Toluene_diisocyanate



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toluene 2,4-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acyp1 acylphosphatase 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ACYP1 mRNA CTD PMID:11379042 NCBI chr12:85,319,172...85,335,257
Ensembl chr12:85,319,172...85,335,212
JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif 15 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ADAMTS15 mRNA CTD PMID:19647056 NCBI chr 9:30,810,451...30,833,853
Ensembl chr 9:30,810,451...30,833,748
JBrowse link
G Adcy6 adenylate cyclase 6 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ADCY6 mRNA CTD PMID:11379042 NCBI chr15:98,484,982...98,508,119
Ensembl chr15:98,487,854...98,507,957
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression
EXP
ISO
FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]
AGER protein affects the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]
CTD PMID:28329851 PMID:30261222 PMID:33075463 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of AKT1 protein] CTD PMID:26089345 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT14 mRNA; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT19 mRNA; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; IL1B protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein] CTD PMID:9124697 PMID:14676436 PMID:15478392 PMID:16908450 PMID:17030242 More... NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Ankrd2 ankyrin repeat domain 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ANKRD2 mRNA CTD PMID:19647056 NCBI chr19:42,024,358...42,033,550
Ensembl chr19:42,024,439...42,033,549
JBrowse link
G Asns asparagine synthetase increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ASNS mRNA CTD PMID:18242016 NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Axl AXL receptor tyrosine kinase decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of AXL mRNA CTD PMID:11379042 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130
JBrowse link
G Bpifa2 BPI fold containing family A, member 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of BPIFA2 mRNA CTD PMID:11379042 NCBI chr 2:153,850,196...153,857,993
Ensembl chr 2:153,850,185...153,857,999
JBrowse link
G Bspry B-box and SPRY domain containing increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of BSPRY mRNA CTD PMID:18242016 NCBI chr 4:62,398,248...62,415,537
Ensembl chr 4:62,398,290...62,415,535
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of BST2 mRNA CTD PMID:19647056 NCBI chr 8:71,986,899...71,990,116
Ensembl chr 8:71,986,899...71,990,100
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of BUB1 mRNA CTD PMID:21404309 NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of BUB1B mRNA CTD PMID:21404309 NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072
JBrowse link
G Cacnb3 calcium channel, voltage-dependent, beta 3 subunit increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CACNB3 mRNA CTD PMID:11379042 NCBI chr15:98,526,317...98,542,410
Ensembl chr15:98,528,721...98,542,410
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CAD mRNA CTD PMID:21404309 NCBI chr 5:31,211,964...31,235,823
Ensembl chr 5:31,212,124...31,235,823
JBrowse link
G Casp1 caspase 1 multiple interactions
increases cleavage
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased cleavage of CASP1 protein]; belnacasan inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein] CTD PMID:25929181 PMID:31070765 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions
increases phosphorylation
ISO
EXP
AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of CAV1 protein]; CAV1 protein mutant form inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; CAV1 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of CAV1 protein]
Toluene 2,4-Diisocyanate results in increased phosphorylation of CAV1 protein
FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of CAV1 protein]
CTD PMID:29940203 PMID:30261222 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions
increases expression
EXP
ISO
BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]
Toluene 2,4-Diisocyanate results in increased expression of CCL11 mRNA
CTD PMID:15823807 PMID:17015710 PMID:20219652 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781
JBrowse link
G Ccl12 C-C motif chemokine ligand 12 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCL12 mRNA CTD PMID:19647056 NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions
increases expression
EXP diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein]
Toluene 2,4-Diisocyanate results in increased expression of CCL17 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein
CTD PMID:15491423 PMID:21404309 NCBI chr 8:95,535,996...95,538,666
Ensembl chr 8:95,537,081...95,538,664
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
EXP
ISO
Toluene 2,4-Diisocyanate results in increased expression of CCL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL2 protein
CCL2 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]
CTD PMID:19647056 PMID:20219652 PMID:21404309 PMID:26072274 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl21b C-C motif chemokine ligand 21B (leucine) decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CCL21B mRNA CTD PMID:21404309 NCBI chr 4:42,173,120...42,256,825
Ensembl chr 4:42,255,693...42,256,825
JBrowse link
G Ccl21d C-C motif chemokine ligand 21D decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CCL21D mRNA CTD PMID:18242016 NCBI chr 4:41,896,187...41,904,743
Ensembl chr 4:41,903,610...41,904,743
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCL22 mRNA CTD PMID:21404309 NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCL3 mRNA CTD PMID:19647056 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCL4 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL4 protein CTD PMID:19647056 PMID:20219652 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects response to substance
multiple interactions
increases expression
decreases expression
ISO
EXP
CCL5 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]
BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA]
Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein
Toluene 2,4-Diisocyanate results in decreased expression of CCL5 mRNA
CTD PMID:11467998 PMID:12356572 PMID:15491423 PMID:15823807 PMID:16908450 More... NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCL6 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCL7 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351
JBrowse link
G Ccl8 C-C motif chemokine ligand 8 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCL8 mRNA CTD PMID:19647056 NCBI chr11:82,006,011...82,007,625
Ensembl chr11:82,006,011...82,007,625
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCL9 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462
JBrowse link
G Ccna2 cyclin A2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCNA2 mRNA CTD PMID:21404309 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
JBrowse link
G Ccnb2 cyclin B2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCNB2 mRNA CTD PMID:21404309 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
JBrowse link
G Ccne1 cyclin E1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCNE1 mRNA CTD PMID:21404309 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Ccnf cyclin F increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCNF mRNA CTD PMID:18242016 NCBI chr17:24,441,518...24,470,333
Ensembl chr17:24,441,172...24,470,458
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CCR2 mRNA CTD PMID:19647056 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression
decreases expression
EXP Toluene 2,4-Diisocyanate results in increased expression of CCR6 protein
Toluene 2,4-Diisocyanate results in decreased expression of CCR6 mRNA
CTD PMID:21404309 PMID:27103660 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973
JBrowse link
G Cd24a CD24a antigen decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CD24A mRNA CTD PMID:21404309 NCBI chr10:43,454,433...43,460,261
Ensembl chr10:43,454,280...43,460,261
JBrowse link
G Cd36 CD36 molecule decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CD36 mRNA CTD PMID:21404309 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cd4 CD4 antigen multiple interactions EXP CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA] CTD PMID:15590890 NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184
JBrowse link
G Cd40 CD40 antigen increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CD40 mRNA CTD PMID:19647056 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CD47 mRNA CTD PMID:11379042 NCBI chr16:49,671,691...49,732,799
Ensembl chr16:49,620,896...49,735,373
JBrowse link
G Cd55 CD55 molecule, decay accelerating factor for complement decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CD55 mRNA CTD PMID:21404309 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481
JBrowse link
G Cd55b CD55 molecule, decay accelerating factor for complement B decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CD55B mRNA CTD PMID:21404309 NCBI chr 1:130,316,263...130,350,831
Ensembl chr 1:130,316,274...130,350,746
JBrowse link
G Cd8b1 CD8 subunit beta 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CD8B1 mRNA CTD PMID:21404309 NCBI chr 6:71,299,772...71,314,476
Ensembl chr 6:71,299,772...71,314,478
JBrowse link
G Cdc20 cell division cycle 20 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDC20 mRNA CTD PMID:21404309 NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549
JBrowse link
G Cdc25a cell division cycle 25A increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDC25A mRNA CTD PMID:21404309 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963
JBrowse link
G Cdc25b cell division cycle 25B increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDC25B mRNA CTD PMID:21404309 NCBI chr 2:131,028,356...131,040,431
Ensembl chr 2:131,028,869...131,040,417
JBrowse link
G Cdc25c cell division cycle 25C increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDC25C mRNA CTD PMID:21404309 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
JBrowse link
G Cdc45 cell division cycle 45 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDC45 mRNA CTD PMID:21404309 NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737
JBrowse link
G Cdc6 cell division cycle 6 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDC6 mRNA CTD PMID:21404309 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
JBrowse link
G Cdc7 cell division cycle 7 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDC7 mRNA CTD PMID:21404309 NCBI chr 5:107,112,201...107,132,298
Ensembl chr 5:107,112,188...107,132,298
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDCA2 mRNA CTD PMID:18242016 NCBI chr14:67,910,629...67,953,290
Ensembl chr14:67,913,780...67,953,290
JBrowse link
G Cdh1 cadherin 1 multiple interactions
affects localization
EXP 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CDH1 protein CTD PMID:26089345 PMID:30517707 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdk1 cyclin dependent kinase 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDK1 mRNA CTD PMID:21404309 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDK2 mRNA CTD PMID:21404309 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CDKN1A mRNA CTD PMID:21404309 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CDKN1B mRNA CTD PMID:21404309 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cdkn1c cyclin dependent kinase inhibitor 1C decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CDKN1C mRNA CTD PMID:21404309 NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787
JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CNTF mRNA CTD PMID:21404309 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996
JBrowse link
G Commd3 COMM domain containing 3 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of COMMD3 mRNA CTD PMID:21404309 NCBI chr 2:18,677,246...18,681,042
Ensembl chr 2:18,677,234...18,681,042
JBrowse link
G Cox8b cytochrome c oxidase subunit 8B increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of COX8B mRNA CTD PMID:11379042 NCBI chr 7:140,478,855...140,480,359
Ensembl chr 7:140,478,858...140,480,359
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein] CTD PMID:16908450 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CSF2RB2 mRNA CTD PMID:19647056 NCBI chr15:78,166,707...78,189,921
Ensembl chr15:78,166,707...78,189,921
JBrowse link
G Csf3r colony stimulating factor 3 receptor increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CSF3R mRNA CTD PMID:19647056 NCBI chr 4:125,917,241...125,938,233
Ensembl chr 4:125,918,343...125,938,233
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CTLA4 protein CTD PMID:27103660 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases phosphorylation
affects localization
EXP
ISO
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of CTNNB1 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CTNNB1 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein]; Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein; Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein
Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein
AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; AGER protein affects the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; CAV1 protein mutant form inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]
CTD PMID:26089345 PMID:30261222 PMID:30517707 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CXCL10 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CXCL12 mRNA CTD PMID:21404309 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CXCL13 mRNA CTD PMID:21404309 NCBI chr 5:96,104,785...96,108,927
Ensembl chr 5:96,104,810...96,108,927
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of CXCL8 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; IL1B protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein] CTD PMID:14676436 PMID:16908450 PMID:24964617 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CXCL16 mRNA CTD PMID:19647056 NCBI chr11:70,345,215...70,350,810
Ensembl chr11:70,344,809...70,350,810
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
EXP AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]
Toluene 2,4-Diisocyanate results in increased expression of CXCL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein
CTD PMID:12956900 PMID:16963530 PMID:17014439 PMID:17980417 PMID:28826779 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CXCL1 mRNA CTD PMID:19647056 PMID:28826779 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Cxcl5 C-X-C motif chemokine ligand 5 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CXCL5 mRNA CTD PMID:19647056 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression
increases expression
EXP Toluene 2,4-Diisocyanate results in decreased expression of CXCL9 mRNA
Toluene 2,4-Diisocyanate results in increased expression of CXCL9 mRNA
CTD PMID:11379042 PMID:19647056 PMID:21404309 PMID:28826779 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CXCR3 mRNA CTD PMID:21404309 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of CXCR4 mRNA CTD PMID:11379042 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CXCR6 mRNA CTD PMID:21404309 NCBI chr 9:123,635,542...123,640,819
Ensembl chr 9:123,635,540...123,640,825
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects response to substance
multiple interactions
increases expression
ISO
EXP
CYP1A1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
Toluene 2,4-Diisocyanate results in increased expression of and results in decreased activity of CYP1A1 protein
Toluene 2,4-Diisocyanate results in increased expression of CYP1A1 mRNA
CTD PMID:12415424 PMID:18447907 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp2f2 cytochrome P450, family 2, subfamily f, polypeptide 2 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of CYP2F2 mRNA CTD PMID:11379042 NCBI chr 7:26,819,380...26,833,085
Ensembl chr 7:26,819,334...26,833,085
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of DACT1 mRNA CTD PMID:18242016 NCBI chr12:71,356,658...71,366,881
Ensembl chr12:71,356,658...71,366,881
JBrowse link
G Dbf4 DBF4 zinc finger increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of DBF4 mRNA CTD PMID:21404309 NCBI chr 5:8,446,969...8,472,789
Ensembl chr 5:8,446,973...8,472,716
JBrowse link
G Dcpp2 demilune cell and parotid protein 2 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of DCPP2 mRNA CTD PMID:11379042 NCBI chr17:24,117,696...24,119,762
Ensembl chr17:24,099,854...24,119,762
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of DNAJB6 mRNA CTD PMID:11379042 NCBI chr 5:29,940,896...29,991,476
Ensembl chr 5:29,940,686...30,023,132
JBrowse link
G Dntt deoxynucleotidyltransferase, terminal decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of DNTT mRNA CTD PMID:21404309 NCBI chr19:41,017,701...41,047,964
Ensembl chr19:41,017,714...41,047,964
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of DPYD mRNA CTD PMID:21404309 NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573
JBrowse link
G Dtymk deoxythymidylate kinase increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of DTYMK mRNA CTD PMID:21404309 NCBI chr 1:93,720,298...93,730,246
Ensembl chr 1:93,720,298...93,729,656
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of DUSP4 mRNA CTD PMID:18242016 NCBI chr 8:35,274,448...35,289,106
Ensembl chr 8:35,274,451...35,287,048
JBrowse link
G Dut deoxyuridine triphosphatase increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of DUT mRNA CTD PMID:18242016 PMID:21404309 NCBI chr 2:125,089,168...125,100,969
Ensembl chr 2:125,089,110...125,100,528
JBrowse link
G E2f1 E2F transcription factor 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of E2F1 mRNA CTD PMID:21404309 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G E2f2 E2F transcription factor 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of E2F2 mRNA CTD PMID:21404309 NCBI chr 4:135,899,585...135,923,368
Ensembl chr 4:135,899,705...135,923,368
JBrowse link
G Ear2 eosinophil-associated, ribonuclease A family, member 2 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of EAR2 mRNA CTD PMID:18242016 NCBI chr14:44,340,111...44,340,988
Ensembl chr14:44,340,111...44,340,991
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein] CTD PMID:16908450 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO 2',3'-dialdehyde ATP inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; Acetylcysteine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; CAV1 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; CCL2 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; coomassie Brilliant Blue inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; KN 62 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; P2RX4 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein; Toluene 2,4-Diisocyanate results in increased secretion of and results in increased expression of ENPP2 protein CTD PMID:26072274 PMID:29940203 NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288
JBrowse link
G Epor erythropoietin receptor decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of EPOR mRNA CTD PMID:21404309 NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802
JBrowse link
G Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 like increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ERCC6L mRNA CTD PMID:18242016 NCBI chr  X:101,186,426...101,200,697
Ensembl chr  X:101,185,322...101,200,697
JBrowse link
G Fabp1 fatty acid binding protein 1, liver decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of FABP1 mRNA CTD PMID:18242016 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
JBrowse link
G Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of FCER2A mRNA CTD PMID:21404309 NCBI chr 8:3,730,280...3,744,174
Ensembl chr 8:3,731,737...3,744,175
JBrowse link
G Ffar2 free fatty acid receptor 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of FFAR2 mRNA CTD PMID:18242016 NCBI chr 7:30,517,778...30,523,200
Ensembl chr 7:30,517,773...30,523,200
JBrowse link
G Fus fused in sarcoma decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of FUS mRNA CTD PMID:11379042 NCBI chr 7:127,565,276...127,581,204
Ensembl chr 7:127,566,629...127,584,873
JBrowse link
G Grap2 GRB2-related adaptor protein 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of GRAP2 mRNA CTD PMID:21404309 NCBI chr15:80,456,798...80,537,055
Ensembl chr15:80,456,795...80,537,055
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
EXP 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein] CTD PMID:26089345 PMID:30517707 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases response to substance
decreases expression
ISO
EXP
GSTM1 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate
Toluene 2,4-Diisocyanate results in decreased expression of GSTM1 mRNA; Toluene 2,4-Diisocyanate results in decreased expression of GSTM5 mRNA
CTD PMID:11927838 PMID:21404309 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of GSTM3 mRNA CTD PMID:21404309 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002
JBrowse link
G Gsto2 glutathione S-transferase omega 2 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of GSTO2 mRNA CTD PMID:21404309 NCBI chr19:47,853,879...47,874,747
Ensembl chr19:47,853,973...47,874,763
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 affects response to substance
affects metabolic processing
ISO GSTP1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
GSTP1 gene polymorphism affects the metabolism of Toluene 2,4-Diisocyanate
CTD PMID:20032816 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of GSTT2 mRNA CTD PMID:21404309 NCBI chr10:75,667,676...75,673,253
Ensembl chr10:75,666,948...75,673,258
JBrowse link
G Gzma granzyme A increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of GZMA mRNA CTD PMID:18242016 NCBI chr13:113,230,358...113,237,515
Ensembl chr13:113,230,359...113,237,515
JBrowse link
G Gzmb granzyme B decreases expression
increases expression
EXP Toluene 2,4-Diisocyanate results in decreased expression of GZMB mRNA
Toluene 2,4-Diisocyanate results in increased expression of GZMB mRNA
CTD PMID:11379042 PMID:18652873 NCBI chr14:56,496,293...56,499,791
Ensembl chr14:56,496,295...56,499,717
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of H2-AA mRNA CTD PMID:21404309 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 affects response to substance ISO HLA-DQB1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate CTD PMID:18447907 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
JBrowse link
G Hdc histidine decarboxylase multiple interactions
increases activity
increases expression
ISO Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased activity of HDC protein]; Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA] CTD PMID:15054596 PMID:18360087 PMID:19050374 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein] CTD PMID:25929181 PMID:28329851 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of HNRNPLL mRNA CTD PMID:21404309 NCBI chr17:80,336,916...80,369,697
Ensembl chr17:80,336,916...80,369,697
JBrowse link
G Hrh1 histamine receptor H1 multiple interactions
increases expression
ISO Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein]
Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of HRH1 protein
CTD PMID:15054595 PMID:15513549 PMID:18360087 PMID:19050374 PMID:19075512 More... NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of HSP90AB1 mRNA CTD PMID:11379042 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
JBrowse link
G Hspa4 heat shock protein 4 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of HSPA4 mRNA CTD PMID:11379042 NCBI chr11:53,150,641...53,191,306
Ensembl chr11:53,150,641...53,191,284
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
ISO
EXP
Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]
Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein
CTD PMID:11698162 PMID:12789230 PMID:16210060 PMID:17014439 PMID:17015710 More... NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Icos inducible T cell co-stimulator increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ICOS protein CTD PMID:27103660 NCBI chr 1:60,999,909...61,039,481
Ensembl chr 1:61,017,086...61,039,479
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IFI27 mRNA CTD PMID:18242016 NCBI chr12:103,400,448...103,406,504
Ensembl chr12:103,400,470...103,406,498
JBrowse link
G Ifi44l interferon-induced protein 44 like increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IFI44L mRNA CTD PMID:18242016 NCBI chr 3:151,464,374...151,468,528
Ensembl chr 3:151,464,374...151,468,529
JBrowse link
G Ifit1 interferon-induced protein with tetratricopeptide repeats 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IFIT1 mRNA CTD PMID:19647056 NCBI chr19:34,618,289...34,627,409
Ensembl chr19:34,618,271...34,627,409
JBrowse link
G Ifnb1 interferon beta 1, fibroblast increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IFNB1 mRNA CTD PMID:11379042 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
affects secretion
increases expression
increases secretion
EXP CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]
Toluene 2,4-Diisocyanate results in decreased expression of IFNG mRNA; Toluene 2,4-Diisocyanate results in decreased expression of IFNG protein
Toluene 2,4-Diisocyanate affects the secretion of IFNG protein
Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA; Toluene 2,4-Diisocyanate results in increased expression of IFNG protein
CTD PMID:10637130 PMID:11243917 PMID:12356572 PMID:12884401 PMID:15588918 More... NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression
decreases expression
EXP Toluene 2,4-Diisocyanate results in increased expression of IFNGR2 mRNA
Toluene 2,4-Diisocyanate results in decreased expression of IFNGR2 mRNA
CTD PMID:19647056 PMID:21404309 NCBI chr16:91,343,947...91,360,895
Ensembl chr16:91,343,960...91,362,511
JBrowse link
G Il10 interleukin 10 increases expression
decreases secretion
multiple interactions
EXP Toluene 2,4-Diisocyanate results in increased expression of IL10 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL10 protein
Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein
5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]
CTD PMID:11243917 PMID:12884401 PMID:16940033 PMID:19422874 PMID:19428947 More... NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of IL11RA1 mRNA CTD PMID:21404309 NCBI chr 4:41,760,443...41,769,473
Ensembl chr 4:41,699,989...41,769,474
JBrowse link
G Il12b interleukin 12b increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL12B mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL12B protein CTD PMID:11379042 PMID:18652873 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il12rb1 interleukin 12 receptor, beta 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL12RB1 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr 8:71,261,005...71,276,186
Ensembl chr 8:71,261,093...71,274,068
JBrowse link
G Il13 interleukin 13 multiple interactions
increases expression
increases secretion
EXP 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]
Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL13 protein
CTD PMID:11243917 PMID:15590890 PMID:16940033 PMID:17015710 PMID:17641053 More... NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il15 interleukin 15 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL15 mRNA CTD PMID:11243917 PMID:11379042 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
decreases expression
increases secretion
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL17A protein]; Wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]
Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL17A protein
Toluene 2,4-Diisocyanate results in decreased expression of IL17A protein
CTD PMID:17982072 PMID:28826779 PMID:31577921 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il18 interleukin 18 multiple interactions
increases secretion
increases expression
EXP 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]; belnacasan inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein] CTD PMID:30517707 PMID:31070765 PMID:33711354 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il19 interleukin 19 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL19 mRNA CTD PMID:19647056 NCBI chr 1:130,860,393...130,873,194
Ensembl chr 1:130,860,393...130,867,852
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases secretion
EXP
ISO
IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]
Toluene 2,4-Diisocyanate results in increased secretion of IL1A protein
CTD PMID:1699434 PMID:16210060 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
ISO
EXP
[Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of IL1B protein; IL1B protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; belnacasan inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein
Toluene 2,4-Diisocyanate results in increased expression of IL1B mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL1B protein
Toluene 2,4-Diisocyanate results in increased secretion of IL1B protein
CTD PMID:1699434 PMID:11379042 PMID:12098602 PMID:12789230 PMID:14676436 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of IL1RL1 mRNA CTD PMID:11379042 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
JBrowse link
G Il2 interleukin 2 decreases expression
increases expression
EXP Toluene 2,4-Diisocyanate results in decreased expression of IL2 mRNA
Toluene 2,4-Diisocyanate results in increased expression of IL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL2 protein
CTD PMID:11379042 PMID:18652873 PMID:22381623 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il24 interleukin 24 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL24 mRNA CTD PMID:19647056 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL2RA mRNA CTD PMID:21404309 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004
JBrowse link
G Il2rb interleukin 2 receptor, beta chain increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL2RB mRNA CTD PMID:19647056 PMID:21404309 NCBI chr15:78,363,456...78,396,569
Ensembl chr15:78,363,456...78,379,471
JBrowse link
G Il3 interleukin 3 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL3 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL3 protein CTD PMID:11379042 PMID:16271432 PMID:18652873 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103
JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression
EXP 2,3-bis(4-hydroxyphenyl)-propionitrile inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; [2,3-bis(4-hydroxyphenyl)-propionitrile co-treated with Toluene 2,4-Diisocyanate] results in increased expression of IL33 protein; [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol co-treated with Toluene 2,4-Diisocyanate] results in increased expression of IL33 protein; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL33 protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL33 protein CTD PMID:29846729 PMID:30017638 PMID:30445053 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Il4 interleukin 4 multiple interactions
affects secretion
increases expression
increases secretion
EXP
ISO
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; [Toluene 2,4-Diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 protein; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
Toluene 2,4-Diisocyanate affects the secretion of IL4 protein
Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL4 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]
CTD PMID:10637130 PMID:11243917 PMID:11467998 PMID:11708898 PMID:11758997 More... NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il4ra interleukin 4 receptor, alpha increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL4RA mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL4RA protein CTD PMID:19647056 PMID:22381623 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646
JBrowse link
G Il5 interleukin 5 multiple interactions
increases expression
increases secretion
EXP
ISO
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]
Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL5 protein
sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA]
CTD PMID:15590890 PMID:16271432 PMID:16516891 PMID:17014439 PMID:17015710 More... NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression
EXP
ISO
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]
Toluene 2,4-Diisocyanate results in increased expression of IL6 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL6 protein
[Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of IL6 protein
CTD PMID:1699434 PMID:11758997 PMID:12956900 PMID:18652873 PMID:19647056 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Il7 interleukin 7 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of IL7 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
JBrowse link
G Il7r interleukin 7 receptor decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of IL7R mRNA CTD PMID:21404309 NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262
JBrowse link
G Il9 interleukin 9 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of IL9 mRNA CTD PMID:11243917 NCBI chr13:56,627,090...56,630,070
Ensembl chr13:56,627,090...56,630,059
JBrowse link
G Inhba inhibin beta-A increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of INHBA mRNA CTD PMID:19647056 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of ISG15 mRNA CTD PMID:11379042 NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253
JBrowse link
G Itgae integrin alpha E, epithelial-associated increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ITGAE protein CTD PMID:27103660 NCBI chr11:72,981,396...73,038,272
Ensembl chr11:72,981,409...73,038,272
JBrowse link
G Kitl kit ligand decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of KITL mRNA CTD PMID:21404309 NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
JBrowse link
G Klra6 killer cell lectin-like receptor, subfamily A, member 6 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of KLRA6 mRNA CTD PMID:11379042 NCBI chr 6:129,989,993...130,003,917
Ensembl chr 6:129,989,996...130,003,917
JBrowse link
G Krt14 keratin 14 multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT14 mRNA CTD PMID:15478392 NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374
JBrowse link
G Krt19 keratin 19 multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT19 mRNA CTD PMID:15478392 NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491
JBrowse link
G Lig1 ligase I, DNA, ATP-dependent increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of LIG1 mRNA CTD PMID:21404309 NCBI chr 7:13,011,101...13,045,351
Ensembl chr 7:13,011,239...13,045,350
JBrowse link
G Lta lymphotoxin A multiple interactions
increases expression
EXP TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTA mRNA] CTD PMID:12356572 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327
JBrowse link
G Ltb lymphotoxin B multiple interactions
increases expression
EXP TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTB mRNA] CTD PMID:11467998 PMID:12356572 PMID:19647056 NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296
JBrowse link
G Ly6i lymphocyte antigen 6 family member I increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of LY6I mRNA CTD PMID:18242016 NCBI chr15:74,851,383...74,855,279
Ensembl chr15:74,851,383...74,855,279
JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of MAP3K7 mRNA CTD PMID:11379042 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK1 protein]
CTD PMID:16908450 PMID:26089345 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK3 protein]
CTD PMID:16908450 PMID:26089345 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP
ISO
pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK8 protein] CTD PMID:33075463 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
EXP
ISO
Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK9 protein
pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK9 protein]
CTD PMID:33075463 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of MCM2 mRNA CTD PMID:21404309 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of MCM3 mRNA CTD PMID:21404309 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of MCM4 mRNA CTD PMID:21404309 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of MCM5 mRNA CTD PMID:21404309 NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of MCM6 mRNA CTD PMID:21404309 NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of MCM7 mRNA CTD PMID:21404309 NCBI chr 5:138,162,845...138,170,675
Ensembl chr 5:138,162,845...138,170,684
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of MGST1 mRNA CTD PMID:21404309 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of MGST2 mRNA CTD PMID:21404309 NCBI chr 3:51,544,179...51,590,096
Ensembl chr 3:51,567,781...51,590,098
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
increases activity
increases expression
ISO
EXP
Toluene 2,4-Diisocyanate results in decreased expression of MMP9 protein
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of MMP9 protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of MMP9 protein
Toluene 2,4-Diisocyanate results in increased activity of MMP9 protein
Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA; Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein
CTD PMID:11742282 PMID:12534559 PMID:12789230 PMID:14987308 PMID:15131573 More... NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mtcp1 mature T cell proliferation 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of MTCP1 mRNA CTD PMID:11379042 NCBI chr  X:74,454,048...74,460,190
Ensembl chr  X:74,454,050...74,460,194
JBrowse link
G Mup4 major urinary protein 4 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of MUP4 mRNA CTD PMID:11379042 NCBI chr 4:59,956,804...59,960,667
Ensembl chr 4:59,956,804...59,960,710
JBrowse link
G Mx1 MX dynamin-like GTPase 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of MX2 mRNA CTD PMID:19647056 NCBI chr16:97,248,235...97,264,106
Ensembl chr16:97,248,235...97,264,107
JBrowse link
G Nat1 N-acetyl transferase 1 affects response to substance
increases response to substance
ISO NAT1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
NAT1 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate
CTD PMID:11927838 PMID:18447907 NCBI chr 8:67,943,620...67,945,183
Ensembl chr 8:67,933,573...67,944,756
JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate CTD PMID:11927838 NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236
JBrowse link
G Ndp Norrie disease (pseudoglioma) (human) increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of NDP mRNA CTD PMID:11379042 NCBI chr  X:16,751,760...16,778,013
Ensembl chr  X:16,751,760...16,778,013
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
ISO NGF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]
Toluene 2,4-Diisocyanate results in increased expression of NGF protein
CTD PMID:14672914 PMID:16020193 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased activity of NLRP3 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of NLRP3 protein CTD PMID:31070765 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NOS2 protein CTD PMID:12974195 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NOS3 protein CTD PMID:12974195 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Nrp1 neuropilin 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of NRP1 protein CTD PMID:27103660 NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844
JBrowse link
G Oasl2 2'-5' oligoadenylate synthetase-like 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of OASL2 mRNA CTD PMID:19647056 NCBI chr 5:115,034,995...115,050,306
Ensembl chr 5:115,034,997...115,050,295
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ODC1 mRNA CTD PMID:21404309 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ORC1 mRNA CTD PMID:21404309 NCBI chr 4:108,436,651...108,472,030
Ensembl chr 4:108,436,620...108,472,030
JBrowse link
G Orc6 origin recognition complex, subunit 6 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ORC6 mRNA CTD PMID:21404309 NCBI chr 8:86,026,261...86,034,908
Ensembl chr 8:86,026,261...86,034,907
JBrowse link
G Osm oncostatin M increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of OSM mRNA CTD PMID:19647056 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 multiple interactions ISO P2RX4 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein] CTD PMID:26072274 NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions
affects response to substance
ISO P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]
P2RX7 gene SNP affects the susceptibility to Toluene 2,4-Diisocyanate
CTD PMID:26072274 PMID:29940203 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PCNA mRNA CTD PMID:21404309 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pf4 platelet factor 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PF4 mRNA CTD PMID:19647056 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242
JBrowse link
G Phf11d PHD finger protein 11D increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PHF11 mRNA CTD PMID:19647056 NCBI chr14:59,584,646...59,608,004
Ensembl chr14:59,584,856...59,602,919
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta multiple interactions
increases expression
EXP IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CD protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CD protein] CTD PMID:33711354 NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma increases expression
multiple interactions
EXP Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein
IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein]
CTD PMID:33711354 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PKMYT1 mRNA CTD PMID:21404309 NCBI chr17:23,945,385...23,955,709
Ensembl chr17:23,945,310...23,955,709
JBrowse link
G Plk1 polo like kinase 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PLK1 mRNA CTD PMID:21404309 NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096
JBrowse link
G Pola1 polymerase (DNA directed), alpha 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of POLA1 mRNA CTD PMID:21404309 NCBI chr  X:92,348,372...92,675,993
Ensembl chr  X:92,348,373...92,675,761
JBrowse link
G Pola2 polymerase (DNA directed), alpha 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of POLA2 mRNA CTD PMID:21404309 NCBI chr19:5,990,574...6,014,266
Ensembl chr19:5,990,570...6,014,230
JBrowse link
G Pold1 polymerase (DNA directed), delta 1, catalytic subunit increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of POLD1 mRNA CTD PMID:21404309 NCBI chr 7:44,182,168...44,198,239
Ensembl chr 7:44,182,170...44,198,273
JBrowse link
G Pold3 polymerase (DNA-directed), delta 3, accessory subunit increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of POLD3 mRNA CTD PMID:21404309 NCBI chr 7:99,731,317...99,770,709
Ensembl chr 7:99,731,318...99,770,772
JBrowse link
G Pole polymerase (DNA directed), epsilon increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of POLE mRNA CTD PMID:21404309 NCBI chr 5:110,434,185...110,485,319
Ensembl chr 5:110,434,172...110,485,340
JBrowse link
G Polr1b polymerase (RNA) I polypeptide B increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of POLR1B mRNA CTD PMID:21404309 NCBI chr 2:128,942,891...128,969,980
Ensembl chr 2:128,942,915...128,968,514
JBrowse link
G Ppa1 pyrophosphatase (inorganic) 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PPA1 mRNA CTD PMID:18242016 NCBI chr10:61,484,400...61,509,944
Ensembl chr10:61,484,331...61,509,947
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases localization
EXP pioglitazone promotes the reaction [Toluene 2,4-Diisocyanate results in increased localization of PPARG protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; rosiglitazone promotes the reaction [Toluene 2,4-Diisocyanate results in increased localization of PPARG protein] CTD PMID:17015710 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppbp pro-platelet basic protein increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PPBP mRNA CTD PMID:19647056 NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PPP2R3A mRNA CTD PMID:11379042 NCBI chr 9:100,982,188...101,129,031
Ensembl chr 9:100,982,283...101,128,994
JBrowse link
G Prim1 DNA primase, p49 subunit increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PRIM1 mRNA CTD PMID:21404309 NCBI chr10:127,851,084...127,865,899
Ensembl chr10:127,851,041...127,865,906
JBrowse link
G Prl2c3 prolactin family 2, subfamily c, member 3 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PRL2C3 mRNA CTD PMID:19647056 NCBI chr13:12,805,705...12,814,982
Ensembl chr13:12,805,705...12,814,968
JBrowse link
G Prol1 proline rich, lacrimal 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of PROL1 mRNA CTD PMID:11379042 NCBI chr 5:88,465,171...88,476,676
Ensembl chr 5:88,465,171...88,476,673
JBrowse link
G Psme4 proteasome (prosome, macropain) activator subunit 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PSME4 mRNA CTD PMID:21404309 NCBI chr11:30,721,753...30,831,150
Ensembl chr11:30,721,726...30,830,361
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Toluene 2,4-Diisocyanate results in decreased expression of and results in decreased activity of PTEN protein CTD PMID:17982072 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Pttg1 pituitary tumor-transforming gene 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of PTTG1 mRNA CTD PMID:21404309 NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RBL1 mRNA CTD PMID:11379042 NCBI chr 2:156,987,813...157,046,454
Ensembl chr 2:156,987,813...157,046,454
JBrowse link
G Rcc1 regulator of chromosome condensation 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RCC1 mRNA CTD PMID:18242016 NCBI chr 4:132,059,230...132,073,061
Ensembl chr 4:132,059,230...132,080,916
JBrowse link
G Rcn1 reticulocalbin 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of RCN1 mRNA CTD PMID:11379042 NCBI chr 2:105,216,293...105,229,664
Ensembl chr 2:105,216,636...105,229,664
JBrowse link
G Recql4 RecQ protein-like 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RECQL4 mRNA CTD PMID:18242016 NCBI chr15:76,587,753...76,594,820
Ensembl chr15:76,587,753...76,594,748
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases localization
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein] CTD PMID:17015710 PMID:17982072 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rfc3 replication factor C (activator 1) 3 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RFC3 mRNA CTD PMID:21404309 NCBI chr 5:151,566,282...151,574,673
Ensembl chr 5:151,566,221...151,574,707
JBrowse link
G Rfc4 replication factor C (activator 1) 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RFC4 mRNA CTD PMID:21404309 NCBI chr16:22,932,698...22,946,480
Ensembl chr16:22,932,693...22,946,487
JBrowse link
G Rfc5 replication factor C (activator 1) 5 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RFC5 mRNA CTD PMID:21404309 NCBI chr 5:117,517,210...117,527,088
Ensembl chr 5:117,516,168...117,527,112
JBrowse link
G Rhoa ras homolog family member A decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of RHOA mRNA CTD PMID:11379042 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rnase2a ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin) decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of RNASE2A mRNA CTD PMID:18242016 NCBI chr14:51,492,718...51,493,569
Ensembl chr14:51,492,719...51,493,569
JBrowse link
G Rnaseh2b ribonuclease H2, subunit B increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RNASEH2B mRNA CTD PMID:21404309 NCBI chr14:62,569,517...62,610,445
Ensembl chr14:62,530,038...62,610,441
JBrowse link
G Rorc RAR-related orphan receptor gamma multiple interactions
increases expression
EXP TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of RORC mRNA alternative form] CTD PMID:31577921 NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583
JBrowse link
G Rrm1 ribonucleotide reductase M1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RRM1 mRNA CTD PMID:21404309 NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978
JBrowse link
G Rrm2 ribonucleotide reductase M2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RRM2 mRNA CTD PMID:21404309 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
JBrowse link
G Rrm2b ribonucleotide reductase M2 B (TP53 inducible) decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of RRM2B mRNA CTD PMID:21404309 NCBI chr15:37,924,196...37,961,562
Ensembl chr15:37,924,196...37,961,562
JBrowse link
G Rtp4 receptor transporter protein 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of RTP4 mRNA CTD PMID:18242016 PMID:19647056 NCBI chr16:23,338,976...23,432,972
Ensembl chr16:23,339,041...23,432,972
JBrowse link
G Sftpd surfactant associated protein D increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of SFTPD mRNA CTD PMID:11379042 NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106
JBrowse link
G Skp2 S-phase kinase-associated protein 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of SKP2 mRNA CTD PMID:21404309 NCBI chr15:9,112,070...9,155,512
Ensembl chr15:9,112,073...9,155,512
JBrowse link
G Smad1 SMAD family member 1 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of SMAD1 mRNA CTD PMID:11379042 NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147
JBrowse link
G Sqle squalene epoxidase increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of SQLE mRNA CTD PMID:18242016 NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041
JBrowse link
G Src Rous sarcoma oncogene multiple interactions
increases phosphorylation
EXP
ISO
FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of SRC protein]
AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of SRC protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of SRC protein]
CTD PMID:30261222 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
JBrowse link
G Srsf7 serine and arginine-rich splicing factor 7 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of SRSF7 mRNA CTD PMID:11379042 NCBI chr17:80,507,509...80,514,734
Ensembl chr17:80,507,509...80,514,736
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions EXP Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein] CTD PMID:28329851 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions EXP Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein] CTD PMID:28329851 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550
JBrowse link
G Tac1 tachykinin 1 multiple interactions
increases expression
ISO [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 mRNA; [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 protein; NGF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]; staurosporine aglycone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein] CTD PMID:10673198 PMID:14672914 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tfdp1 transcription factor Dp 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TFDP1 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr 8:13,388,273...13,428,448
Ensembl chr 8:13,388,751...13,428,448
JBrowse link
G Tfec transcription factor EC increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TFEC mRNA CTD PMID:19647056 NCBI chr 6:16,830,926...16,898,463
Ensembl chr 6:16,833,372...16,898,440
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein] CTD PMID:17015710 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of TGFBR2 mRNA CTD PMID:21404309 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions
increases expression
ISO
EXP
Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of TIMP1 protein
Toluene 2,4-Diisocyanate results in increased expression of TIMP1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of TIMP1 protein
CTD PMID:12534559 PMID:14987308 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tk1 thymidine kinase 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TK1 mRNA CTD PMID:21404309 NCBI chr11:117,706,345...117,716,913
Ensembl chr11:117,706,352...117,716,918
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TNF protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTA mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTB mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of XCL1 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TNF protein
Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA; Toluene 2,4-Diisocyanate results in increased expression of TNF protein
[Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of TNF protein
CTD PMID:11467998 PMID:12356572 PMID:12789230 PMID:16516891 PMID:17014439 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TNFRSF12A mRNA CTD PMID:19647056 NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442
JBrowse link
G Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TNFRSF19 mRNA CTD PMID:21404309 NCBI chr14:61,201,283...61,284,304
Ensembl chr14:61,201,324...61,283,939
JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TNFRSF4 mRNA CTD PMID:21404309 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069
JBrowse link
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of TNFSF13 mRNA CTD PMID:21404309 NCBI chr11:69,573,403...69,576,380
Ensembl chr11:69,573,672...69,576,610
JBrowse link
G Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of TNFSF13B mRNA CTD PMID:21404309 NCBI chr 8:10,056,637...10,086,000
Ensembl chr 8:10,056,467...10,089,072
JBrowse link
G Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TNFSF14 mRNA CTD PMID:19647056 NCBI chr17:57,496,437...57,501,182
Ensembl chr17:57,496,492...57,501,177
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 increases expression
multiple interactions
EXP Toluene 2,4-Diisocyanate results in increased expression of TRPV4 protein
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TRPV4 protein]
CTD PMID:30517707 NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions
increases secretion
EXP
ISO
Toluene 2,4-Diisocyanate results in increased expression of TSLP mRNA; Toluene 2,4-Diisocyanate results in increased expression of TSLP protein
bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TSLP protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TSLP protein; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of RORC mRNA alternative form]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL17A protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]
Toluene 2,4-Diisocyanate results in increased secretion of TSLP protein
CTD PMID:19647056 PMID:28329851 PMID:29846729 PMID:30017638 PMID:31577921 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TXN1 mRNA CTD PMID:19647056 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Tyms thymidylate synthase increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of TYMS mRNA CTD PMID:21404309 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615
JBrowse link
G Uck2 uridine-cytidine kinase 2 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of UCK2 mRNA CTD PMID:21404309 NCBI chr 1:167,050,464...167,112,657
Ensembl chr 1:167,050,452...167,112,889
JBrowse link
G Upb1 ureidopropionase, beta decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of UPB1 mRNA CTD PMID:21404309 NCBI chr10:75,242,745...75,277,513
Ensembl chr10:75,236,949...75,277,513
JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of USP18 mRNA CTD PMID:19647056 NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876
JBrowse link
G Usp8 ubiquitin specific peptidase 8 decreases expression EXP Toluene 2,4-Diisocyanate results in decreased expression of USP8 mRNA CTD PMID:11379042 NCBI chr 2:126,549,280...126,601,234
Ensembl chr 2:126,549,248...126,601,217
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP
ISO
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]
Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein
CTD PMID:12789230 PMID:15823807 PMID:16210060 PMID:17015710 PMID:17641053 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP
Toluene 2,4-Diisocyanate results in increased expression of VEGFA mRNA alternative form
Toluene 2,4-Diisocyanate results in increased expression of VEGFA protein
CTD PMID:11907124 PMID:18250044 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Xcl1 chemokine (C motif) ligand 1 multiple interactions
increases expression
EXP TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of XCL1 mRNA] CTD PMID:11467998 PMID:12356572 NCBI chr 1:164,759,216...164,763,094
Ensembl chr 1:164,759,213...164,763,096
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of YWHAQ mRNA CTD PMID:11379042 NCBI chr12:21,440,330...21,467,437
Ensembl chr12:21,440,072...21,467,638
JBrowse link
G Zbp1 Z-DNA binding protein 1 increases expression EXP Toluene 2,4-Diisocyanate results in increased expression of ZBP1 mRNA CTD PMID:18242016 PMID:19647056 NCBI chr 2:173,048,405...173,060,715
Ensembl chr 2:173,048,405...173,060,716
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22205
    role 22190
      biological role 22189
        hapten 3140
          toluene 2,4-diisocyanate 269
Path 2
Term Annotations click to browse term
  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    p-block element atom 22131
                      carbon group element atom 21928
                        carbon atom 21854
                          organic molecular entity 21854
                            heteroorganic entity 21512
                              organochalcogen compound 21001
                                organooxygen compound 20845
                                  isocyanates 362
                                    diisocyanate 324
                                      toluene meta-diisocyanate 269
                                        toluene 2,4-diisocyanate 269
paths to the root