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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | increases expression | ISO | RGD:2560 | 6480464 | Pilocarpine results in increased expression of EPOR mRNA | CTD | PMID:17166730 | 17beta-estradiol | increases expression | ISO | RGD:736105 | 6480464 | Estradiol results in increased expression of EPOR mRNA | CTD | PMID:16705744 | 17beta-estradiol | affects expression | ISO | RGD:736105 | 6480464 | Estradiol affects the expression of EPOR mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of EPOR mRNA | CTD | PMID:21570461 | 2,6-di-tert-butyl-4-methylphenol | increases expression | EXP | | 6480464 | Butylated Hydroxytoluene results in increased expression of EPOR mRNA | CTD | PMID:19925653 | 2,6-dinitrotoluene | affects expression | ISO | RGD:2560 | 6480464 | 2,6-dinitrotoluene affects the expression of EPOR mRNA | CTD | PMID:21346803 | 2-butoxyethanol | increases expression | EXP | | 6480464 | n-butoxyethanol results in increased expression of EPOR mRNA | CTD | PMID:19812364 | 5-fluorouracil | affects response to substance | EXP | | 6480464 | EPOR gene mutant form affects the susceptibility to Fluorouracil | CTD | PMID:16511603 | all-trans-retinoic acid | increases expression | ISO | RGD:736105 | 6480464 | Tretinoin results in increased expression of EPOR mRNA | CTD | PMID:21934132 | aluminium atom | affects expression | ISO | RGD:736105 | 6480464 | Aluminum affects the expression of EPOR protein | CTD | PMID:15777837 | aluminium(0) | affects expression | ISO | RGD:736105 | 6480464 | Aluminum affects the expression of EPOR protein | CTD | PMID:15777837 | ammonium chloride | affects expression | ISO | RGD:2560 | 6480464 | Ammonium Chloride affects the expression of EPOR mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of EPOR mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of EPOR mRNA | CTD | PMID:17942131 more ... | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of EPOR mRNA | CTD | PMID:17942131 PMID:21569818 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of EPOR mRNA | CTD | PMID:17942131 | bis(2-chloroethyl) sulfide | increases expression | EXP | | 6480464 | Mustard Gas results in increased expression of EPOR mRNA | CTD | PMID:15674844 | C60 fullerene | decreases expression | ISO | RGD:2560 | 6480464 | fullerene C60 results in decreased expression of EPOR mRNA | CTD | PMID:19167457 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of EPOR mRNA; more ... | CTD | PMID:17603282 | clofibrate | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of EPOR mRNA; more ... | CTD | PMID:17585979 | cobalt dichloride | increases expression | ISO | RGD:2560 | 6480464 | cobaltous chloride results in increased expression of EPOR protein | CTD | PMID:21116766 | cobalt dichloride | multiple interactions | ISO | RGD:2560 | 6480464 | EPO protein inhibits the reaction [cobaltous chloride results in increased expression of EPOR protein] | CTD | PMID:21116766 | copper(2+) sulfate | decreases expression | ISO | RGD:736105 | 6480464 | Copper Sulfate results in decreased expression of EPOR mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of EPOR mRNA | CTD | PMID:17942131 | dioxygen | increases expression | ISO | RGD:2560 | 6480464 | Oxygen deficiency results in increased expression of EPOR mRNA; more ... | CTD | PMID:19497871 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of EPOR protein | CTD | PMID:16449733 | doxorubicin | multiple interactions | EXP | | 6480464 | EPO protein inhibits the reaction [Doxorubicin results in decreased expression of EPOR protein] | CTD | PMID:16449733 | enalapril | multiple interactions | ISO | RGD:2560 | 6480464 | Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; more ... | CTD | PMID:19958114 | gefitinib | increases expression | ISO | RGD:736105 | 6480464 | gefitinib results in increased expression of EPOR mRNA | CTD | PMID:16685379 | genistein | increases expression | ISO | RGD:736105 | 6480464 | Genistein results in increased expression of EPOR mRNA | CTD | PMID:16705744 | hydrogen peroxide | affects expression | ISO | RGD:736105 | 6480464 | Hydrogen Peroxide affects the expression of EPOR mRNA | CTD | PMID:20044591 | methamphetamine | decreases expression | ISO | RGD:2560 | 6480464 | Methamphetamine results in decreased expression of EPOR mRNA | CTD | PMID:15644446 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of EPOR mRNA | CTD | PMID:17942915 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of EPOR mRNA] | CTD | PMID:17942915 | paracetamol | multiple interactions | EXP | | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EPOR mRNA] | CTD | PMID:17585979 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of EPOR mRNA | CTD | PMID:17942131 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of EPOR mRNA | CTD | PMID:17562736 | phenylhydrazine | affects response to substance | EXP | | 6480464 | EPOR gene mutant form affects the susceptibility to phenylhydrazine | CTD | PMID:16511603 | raloxifene | affects expression | ISO | RGD:736105 | 6480464 | Raloxifene affects the expression of EPOR mRNA | CTD | PMID:14699072 | resveratrol | increases expression | ISO | RGD:2560 | 6480464 | resveratrol results in increased expression of EPOR mRNA | CTD | PMID:19228061 | simvastatin | multiple interactions | ISO | RGD:2560 | 6480464 | Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPOR protein]; more ... | CTD | PMID:20821229 | streptozocin | multiple interactions | ISO | RGD:2560 | 6480464 | Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; more ... | CTD | PMID:19958114 | streptozocin | increases expression | ISO | RGD:2560 | 6480464 | Streptozocin results in increased expression of EPOR mRNA | CTD | PMID:19958114 PMID:20821229 | streptozocin | increases expression | ISO | RGD:2560 | 6480464 | Streptozocin results in increased expression of EPOR protein | CTD | PMID:19958114 | streptozocin | increases expression | ISO | RGD:2560 | 6480464 | Streptozocin results in increased expression of EPOR mRNA | CTD | PMID:20821229 PMID:19958114 | streptozocin | decreases expression | ISO | RGD:2560 | 6480464 | Streptozocin results in decreased expression of EPOR protein | CTD | PMID:20821229 | streptozocin | multiple interactions | ISO | RGD:2560 | 6480464 | Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPOR protein]; more ... | CTD | PMID:20821229 | tamoxifen | affects response to substance | ISO | RGD:736105 | 6480464 | EPOR protein affects the susceptibility to Tamoxifen | CTD | PMID:19706814 | trans-resveratrol | increases expression | ISO | RGD:2560 | 6480464 | resveratrol results in increased expression of EPOR mRNA | CTD | PMID:19228061 | trimellitic anhydride | decreases expression | EXP | | 6480464 | trimellitic anhydride results in decreased expression of EPOR mRNA | CTD | PMID:19042947 | uranium atom | decreases expression | ISO | RGD:2560 | 6480464 | Uranium results in decreased expression of EPOR mRNA | CTD | PMID:18375546 | valproic acid | increases expression | ISO | RGD:736105 | 6480464 | Valproic Acid results in increased expression of EPOR mRNA | CTD | PMID:19101580 | wortmannin | multiple interactions | ISO | RGD:736105 | 6480464 | wortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA] | CTD | PMID:20189893 | zidovudine | multiple interactions | EXP | | 6480464 | EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; more ... | CTD | PMID:7646543 | zidovudine | decreases expression | EXP | | 6480464 | Zidovudine results in decreased expression of EPOR mRNA | CTD | PMID:1417927 PMID:7646543 | zidovudine | decreases expression | EXP | | 6480464 | Zidovudine results in decreased expression of EPOR protein | CTD | PMID:1417927 | zidovudine | decreases expression | EXP | | 6480464 | Zidovudine results in decreased expression of EPOR mRNA | CTD | PMID:7646543 PMID:1417927 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Hematopoietic cell lineage | |
| Jak-STAT signaling pathway | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | EPO signaling pathway (PID:200183) |
| Signaling events mediated by Stem cell factor receptor (c-Kit) (PID:200181) | |
Phenotype Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Hematopoietic cell lineage | |
| Jak-STAT signaling pathway | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | EPO signaling pathway (PID:200183) |
| Signaling events mediated by Stem cell factor receptor (c-Kit) (PID:200181) | |
Phenotype Annotations
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References - curated| 1. |
MGD and Homologene mouse data transfer |
| 2. |
MGD data from the GO Consortium |
| 3. |
MGD IEA |
| 4. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 5. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 6. |
RGD automated import pipeline |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
| 8. |
RGD Automated Pipelines |
References - uncurated| PubMed | 10349636 |
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RGD Disease Portals| Epor has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Epor (Mus musculus) |
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| EPOR (Homo sapiens) |
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| Epor (Rattus norvegicus) |
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Position Markers| Epor |
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| D9Mit86 |
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| PMC14696P1 |
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| PMC150206P1 |
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| PMC150350P1 |
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| Epor |
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| Epor |
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| Epor |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_010149 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01076453 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC163623 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK010968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK139031 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BB842890 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC003953 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC046282 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466522 | (Get FASTA) | Search GEO for Microarray Profiles | |
| J04843 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M38133 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M62360 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X53081 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_010149 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_034279 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_034279 | (Get FASTA) |
| GenBank Protein | AAA37571 | (Get FASTA) |
| AAA37572 | (Get FASTA) | |
| AAA37582 | (Get FASTA) | |
| AAH03953 | (Get FASTA) | |
| AAH46282 | (Get FASTA) | |
| BAE23871 | (Get FASTA) | |
| CAA37248 | (Get FASTA) | |
| EDL25236 | (Get FASTA) | |
| P14753 | (Get FASTA) |
Promoters| RGD ID: | 6848406 | ||||||||||
| Promoter ID: | MM_ACW:49834 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain, Kidney, Lung | ||||||||||
| Transcripts: | EPOR.DSEP07-UNSPLICED | ||||||||||
| Position: |
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| RGD ID: | 6848409 | ||||||||||
| Promoter ID: | MM_ACW:49835 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Kidney, Spleen | ||||||||||
| Transcripts: | EPOR.ASEP07, EPOR.CSEP07 | ||||||||||
| Position: |
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| RGD ID: | 6883006 | ||||||||||
| Promoter ID: | EPDNEW_M4954 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Epor_1 | ||||||||||
| Description: | erythropoietin receptor | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000006235 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000006397 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000006397 | ENTREZGENE |
| Entrez Gene | 13857 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| Germonline | ENSMUSG00000006235 | |
| HomoloGene Group ID | 95 | ENTREZGENE |
| InterPro | Erythropoietin_rcpt | UniProtKB/Swiss-Prot |
| Fibronectin_type3 | UniProtKB/Swiss-Prot | |
| Growth/epo_recpt_lig-bind | UniProtKB/Swiss-Prot | |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Long_hematopoietin_rcpt_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00129864 | UniProtKB/Swiss-Prot |
| IPI00408736 | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:13857 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:95408 | ENTREZGENE |
| PANTHER | PTHR23037:SF10 | UniProtKB/Swiss-Prot |
| Pfam | EpoR_lig-bind | UniProtKB/Swiss-Prot |
| fn3 | UniProtKB/Swiss-Prot | |
| PIRSF | EPO_receptor | UniProtKB/Swiss-Prot |
| PROSITE | FN3 | UniProtKB/Swiss-Prot |
| HEMATOPO_REC_L_F1 | UniProtKB/Swiss-Prot | |
| SMART | FN3 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | FN_III-like | UniProtKB/Swiss-Prot |
| UniGene | Mm.2653 | ENTREZGENE |
| UniProt | EPOR_MOUSE | UniProtKB/Swiss-Prot |
| Q3UTV9_MOUSE | UniProtKB/TrEMBL |
| More on Epor | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 10532 |
| Created: | 2000-05-25 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




