Mcm3 (minichromosome maintenance complex component 3) - Rat Genome Database

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Gene: Mcm3 (minichromosome maintenance complex component 3) Mus musculus
Analyze
Symbol: Mcm3
Name: minichromosome maintenance complex component 3
RGD ID: 1313037
MGI Page MGI
Description: Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within DNA replication. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; limb; myocardium layer; neural ectoderm; and retina. Orthologous to human MCM3 (minichromosome maintenance complex component 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AL033361; C80350; DNA polymerase alpha holoenzyme-associated protein P1; DNA replication licensing factor MCM3; Mcmd; mini chromosome maintenance deficient; minichromosome maintenance deficient 3; P; P1; P1-MCM3; p1.; p1.m
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,873,188 - 20,890,536 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl120,873,192 - 20,890,536 (-)EnsemblGRCm39 Ensembl
GRCm38120,802,966 - 20,820,312 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,802,968 - 20,820,312 (-)EnsemblGRCm38mm10GRCm38
MGSCv37120,793,095 - 20,810,294 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36120,788,165 - 20,805,364 (-)NCBIMGSCv36mm8
Celera120,676,980 - 20,695,949 (-)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dioxane  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (ISO)
aminoglutethimide  (ISO)
amphetamine  (ISO)
anthracene-1,8,9-triol  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bromobenzene  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CGP 52608  (ISO)
chlorpromazine  (ISO)
cholic acid  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
FR900359  (ISO)
furan  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (EXP)
iron trichloride  (EXP)
iron(III) nitrilotriacetate  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methylseleninic acid  (ISO)
Mezerein  (EXP)
miconazole  (EXP)
N-(6-acetamidohexyl)acetamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
palytoxin  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (EXP)
pentachlorophenol  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
saccharin  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
sodium nitrite  (EXP)
styrene oxide  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO)
chromosome  (IEA)
CMG complex  (ISO)
cytoplasm  (IDA)
MCM complex  (IBA,ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO,NAS)
perinuclear region of cytoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. Thommes P, etal., Nucleic Acids Res 1992 Mar 11;20(5):1069-74.
Additional References at PubMed
PMID:7610039   PMID:7622621   PMID:7671812   PMID:7925275   PMID:8265339   PMID:8575467   PMID:8838817   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11389549   PMID:12167160   PMID:12477932   PMID:12520002   PMID:14996723   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16420439   PMID:17157410   PMID:17244605  
PMID:17967808   PMID:18023262   PMID:18524952   PMID:18590716   PMID:18635963   PMID:19433082   PMID:19521500   PMID:20059953   PMID:20838603   PMID:21185283   PMID:21220507   PMID:21267068  
PMID:21589869   PMID:21873635   PMID:22354170   PMID:22474384   PMID:22560297   PMID:23341629   PMID:24457600   PMID:24662053   PMID:24821722   PMID:26336360   PMID:26370502   PMID:26456157  
PMID:26496610   PMID:27034005   PMID:27757957   PMID:28378742   PMID:28671696   PMID:29955894   PMID:29967292   PMID:30069701   PMID:30108253   PMID:30196744   PMID:30457570   PMID:30550785  
PMID:30595499   PMID:30787433   PMID:31601942   PMID:33590678   PMID:34162889   PMID:34321999   PMID:35920641   PMID:36114006  


Genomics

Comparative Map Data
Mcm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,873,188 - 20,890,536 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl120,873,192 - 20,890,536 (-)EnsemblGRCm39 Ensembl
GRCm38120,802,966 - 20,820,312 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,802,968 - 20,820,312 (-)EnsemblGRCm38mm10GRCm38
MGSCv37120,793,095 - 20,810,294 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36120,788,165 - 20,805,364 (-)NCBIMGSCv36mm8
Celera120,676,980 - 20,695,949 (-)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.5NCBI
MCM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,264,015 - 52,284,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,264,014 - 52,284,881 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,128,813 - 52,149,540 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,236,771 - 52,257,541 (-)NCBINCBI36Build 36hg18NCBI36
Build 34652,236,770 - 52,257,541NCBI
Celera653,789,937 - 53,810,711 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef651,960,041 - 51,980,910 (-)NCBIHuRef
CHM1_1652,131,052 - 52,151,919 (-)NCBICHM1_1
T2T-CHM13v2.0652,102,764 - 52,123,487 (-)NCBIT2T-CHM13v2.0
Mcm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,715,602 - 30,733,746 (-)NCBIGRCr8
mRatBN7.2923,219,169 - 23,237,314 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,219,169 - 23,237,314 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx931,708,279 - 31,726,367 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,828,996 - 36,847,084 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,144,261 - 35,162,350 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,914,057 - 26,932,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,914,057 - 26,932,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,770,288 - 25,788,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,536,922 - 19,554,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1919,534,642 - 19,552,122 (-)NCBI
Celera920,794,785 - 20,812,805 (-)NCBICelera
Cytogenetic Map9q13NCBI
Mcm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554115,814,041 - 5,832,796 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554115,800,800 - 5,832,713 (+)NCBIChiLan1.0ChiLan1.0
MCM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2566,732,230 - 66,754,058 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1662,609,065 - 62,629,834 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0651,816,615 - 51,837,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1653,084,657 - 53,105,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl653,085,231 - 53,105,344 (-)Ensemblpanpan1.1panPan2
MCM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11219,924,017 - 19,945,576 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,920,210 - 19,945,605 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,821,166 - 19,842,529 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,422,999 - 20,444,648 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1220,422,997 - 20,444,648 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11219,928,809 - 19,950,166 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01220,031,993 - 20,053,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,170,450 - 20,191,818 (-)NCBIUU_Cfam_GSD_1.0
Mcm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494655,412,234 - 55,429,506 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364768,530,688 - 8,547,978 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364768,530,614 - 8,547,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,084,662 - 46,104,375 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,084,648 - 46,104,425 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,534,805 - 52,554,554 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11720,222,440 - 20,243,807 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1720,222,590 - 20,243,809 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604452,162,228 - 52,183,499 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,806,553 - 3,827,873 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,806,273 - 3,825,143 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcm3
824 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:183
Interacting mature miRNAs:192
Transcripts:ENSMUST00000053266
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412226Alpq4_malcohol preference QTL 4 (mouse)Not determined1122976684Mouse
1301891Alcp25_malcohol preference locus 25 (mouse)Not determined1125203185Mouse
1300834Cia20_mcollagen induced arthritis 20 (mouse)Not determined1125203185Mouse
1301482Morph1_mmorphine antinociception 1 (mouse)Not determined1130367747Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
4141646Fecq3_mfecundity QTL 3 (mouse)Not determined11291692026517685Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse

Markers in Region
RH124239  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera120,677,129 - 20,677,233UniSTS
Cytogenetic Map1A3-A5UniSTS
X62154  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38120,803,178 - 20,803,273UniSTSGRCm38
MGSCv37120,793,259 - 20,793,354UniSTSGRCm37
Celera120,677,144 - 20,677,239UniSTS
Cytogenetic Map1A3-A5UniSTS
Whitehead/MRC_RH1385.72UniSTS
Mcm3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1A3-A5UniSTS
cM Map1 UniSTS
RH126856  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38120,803,063 - 20,803,267UniSTSGRCm38
MGSCv37120,793,144 - 20,793,348UniSTSGRCm37
Celera120,677,029 - 20,677,233UniSTS
Cytogenetic Map1A3-A5UniSTS
Whitehead/MRC_RH1385.82UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC156980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D26088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH769480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000053266   ⟹   ENSMUSP00000059192
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl120,873,192 - 20,890,536 (-)Ensembl
GRCm38.p6 Ensembl120,802,968 - 20,820,312 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185296
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl120,873,197 - 20,890,484 (-)Ensembl
GRCm38.p6 Ensembl120,802,973 - 20,820,260 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188112
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl120,873,230 - 20,873,945 (-)Ensembl
GRCm38.p6 Ensembl120,803,006 - 20,803,721 (-)Ensembl
RefSeq Acc Id: ENSMUST00000190421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl120,874,910 - 20,876,164 (-)Ensembl
GRCm38.p6 Ensembl120,804,686 - 20,805,940 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl120,873,389 - 20,875,157 (-)Ensembl
GRCm38.p6 Ensembl120,803,165 - 20,804,933 (-)Ensembl
RefSeq Acc Id: NM_008563   ⟹   NP_032589
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39120,873,192 - 20,890,536 (-)NCBI
GRCm38120,802,968 - 20,820,312 (-)NCBI
MGSCv37120,793,095 - 20,810,294 (-)RGD
Celera120,676,980 - 20,695,949 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030251926   ⟹   XP_030107786
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39120,873,188 - 20,890,407 (-)NCBI
GRCm38120,802,966 - 20,820,183 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032589   ⟸   NM_008563
- UniProtKB: Q61492 (UniProtKB/Swiss-Prot),   P25206 (UniProtKB/Swiss-Prot),   Q3UI57 (UniProtKB/TrEMBL),   Q3ULD6 (UniProtKB/TrEMBL),   Q3UZH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030107786   ⟸   XM_030251926
- Peptide Label: isoform X1
- UniProtKB: Q3UZH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000059192   ⟸   ENSMUST00000053266
Protein Domains
MCM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25206-F1-model_v2 AlphaFold P25206 1-812 view protein structure

Promoters
RGD ID:6818061
Promoter ID:MM_KWN:232
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Spleen
Transcripts:ENSMUST00000053266
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36120,810,094 - 20,810,594 (-)MPROMDB
RGD ID:6873270
Promoter ID:EPDNEW_M86
Type:initiation region
Name:Mcm3_1
Description:Mus musculus minichromosome maintenance complex component 3 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38120,820,260 - 20,820,320EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101845 AgrOrtholog
Ensembl Genes ENSMUSG00000041859 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053266 ENTREZGENE
  ENSMUST00000053266.11 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.28.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mini-chromosome maintenance (MCM) complex, chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mcm3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_OB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17215 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:101845 ENTREZGENE
NCBI Gene 17215 ENTREZGENE
PANTHER DNA REPLICATION LICENSING FACTOR MCM3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_OB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcm3 PhenoGen
PRINTS MCMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCMPROTEIN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MCM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MCM3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UI57 ENTREZGENE, UniProtKB/TrEMBL
  Q3ULD6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UZH2 ENTREZGENE, UniProtKB/TrEMBL
  Q61492 ENTREZGENE
UniProt Secondary Q61492 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Mcm3  minichromosome maintenance complex component 3    minichromosome maintenance deficient 3 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED