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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:insulin secretion pathway
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Accession:PW:0000674 term browser browse the term
Definition:Insulin secretion by pancreatic beta-cells is an important aspect of glucose homeostasis. A major component of glucose-stimulated insulin secretion is represented by the route dependent on the ATP-sensitive potassium channels. However, other contributions are also likely to promote insulin secretion.
Synonyms:related_synonym: Regulation of insulin secretion;   insulin secretion
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insulin secretion pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 TAS RGD PMID:18940941 RGD:2311063 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A TAS RGD PMID:16868246 RGD:2311105 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C TAS RGD PMID:16868246 RGD:2311105 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D TAS RGD PMID:16868246 RGD:2311105 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,233,690...5,674,692 		JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:19295123 RGD:2311087 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627 		JBrowse link
G Gck glucokinase TAS RGD PMID:18774732 RGD:2311061 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 TAS RGD PMID:12830383 RGD:2311121 NCBI chr 3:176,239,285...176,332,408
Ensembl chr 3:176,242,589...176,332,408 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 TAS RGD PMID:18940941 RGD:2311063 NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:105,727,570...105,731,169 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family ISO RGD PMID:19295123 RGD:2311087 NCBI chr 8:82,663,373...82,717,267
Ensembl chr 8:82,663,276...82,717,262 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family ISO RGD PMID:19295123 RGD:2311087 NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 TAS RGD PMID:18774732 RGD:2311061 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467 		JBrowse link
G Snap25 synaptosome associated protein 25 TAS RGD PMID:12830383 RGD:2311121 NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448 		JBrowse link
G Stx1a syntaxin 1A ISO RGD PMID:19295123 RGD:2311087 NCBI chr12:27,278,517...27,306,547
Ensembl chr12:27,278,517...27,306,471 		JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO RGD PMID:19295123 RGD:2311087 NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058 		JBrowse link
G Syt7 synaptotagmin 7 TAS
IMP 		RGD PMID:18713958 PMID:17709608 RGD:2311148, RGD:2311143 NCBI chr 1:216,456,148...216,518,718
Ensembl chr 1:216,456,259...216,518,718 		JBrowse link
G Syt7_v1 synaptotagmin 7, variant 1 IMP RGD PMID:17709608 RGD:2311143
G Syt9 synaptotagmin 9 TAS
IMP 		RGD PMID:18713958 PMID:16165130 RGD:2311148, RGD:2311147 NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:170,687,606...170,881,375 		JBrowse link
G Unc13a unc-13 homolog A ISO RGD PMID:19295123 RGD:2311087 NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,367,919...18,415,899 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 ISO RGD PMID:19295123 RGD:2311087 NCBI chr10:54,292,423...54,296,657
Ensembl chr10:54,292,806...54,296,654 		JBrowse link
altered insulin secretion pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO DNA:missense mutation::A1369S (human) RGD PMID:17259403 RGD:2313628 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 ISO polymorphisms in the human gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
DNA:missense mutation::p.E23K (human) 		RGD PMID:15565284 PMID:17259403 RGD:2313610, RGD:2313628 NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:105,727,570...105,731,169 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      homeostasis pathway 1772
        organic chemical homeostasis pathway 767
          glucose homeostasis pathway 344
            insulin secretion pathway 19
              altered insulin secretion pathway 2
paths to the root