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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin secretion pathway
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Accession:PW:0000674 term browser browse the term
Definition:Insulin secretion by pancreatic beta-cells is an important aspect of glucose homeostasis. A major component of glucose stimulated insulin secretion is represented by the route dependent on the ATP sensitive potassium channels. However, other contributions are also likely to promote insulin secretion.

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insulin secretion pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:2311063
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:2311105
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:2311105
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:2311105
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:2311087
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:2311061
G Kcnb1 potassium voltage-gated channel subfamily B member 1 JBrowse link 3 163,850,785 163,935,610 RGD:2311121
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 JBrowse link 1 102,103,093 102,107,134 RGD:2311063
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:2311087
G Rab3a RAB3A, member RAS oncogene family JBrowse link 16 20,435,098 20,439,206 RGD:2311087
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:2311061
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:2311121
G Stx1a syntaxin 1A JBrowse link 12 24,682,050 24,710,002 RGD:2311087
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:2311087
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:2311148
RGD:2311143
G Syt7_v1 synaptotagmin 7, variant 1 RGD:2311143
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:2311148
RGD:2311147
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:2311087
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:2311087
altered insulin secretion pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:2313628
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 JBrowse link 1 102,103,093 102,107,134 RGD:2313610
RGD:2313628

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  pathway 6015
    regulatory pathway 3818
      homeostasis pathway 1751
        glucose homeostasis pathway 342
          insulin secretion pathway 19
            altered insulin secretion pathway 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.