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Channel regulation of glucose sensing in the pancreatic beta-cell.

Authors: Hiriart, M  Aguilar-Bryan, L 
Citation: Hiriart M and Aguilar-Bryan L, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21.
Pubmed: (View Article at PubMed) PMID:18940941
DOI: Full-text: DOI:10.1152/ajpendo.90493.2008

Mammalian beta-cells are acutely and chronically regulated by sensing surrounding glucose levels that determine the rate at which insulin is secreted, to maintain euglycemia. Experimental research in vitro and in vivo has shown that, when these cells are exposed to adverse conditions like long periods of hypoglycemia or hyperglycemia, their capability to sense glucose is decreased. Understanding the normal physiology and identifying the main players along this route becomes paramount. In this review, we have taken on the task of looking at the role that ion channels play in the regulation of this process, delineating the different families, and describing the signaling that parallels the glucose sensing process that results in insulin release.


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RGD Object Information
RGD ID: 2311063
Created: 2009-06-23
Species: All species
Last Modified: 2009-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.