Pdk1 (pyruvate dehydrogenase kinase 1) - Rat Genome Database

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Gene: Pdk1 (pyruvate dehydrogenase kinase 1) Rattus norvegicus
Analyze
Symbol: Pdk1
Name: pyruvate dehydrogenase kinase 1
RGD ID: 69427
Description: Enables ATP binding activity; identical protein binding activity; and protein kinase activity. Involved in cell surface receptor signaling pathway and peptidyl-serine phosphorylation. Part of pyruvate dehydrogenase complex. Orthologous to human PDK1 (pyruvate dehydrogenase kinase 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; Fc epsilon receptor mediated signaling pathway; pyruvate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; MGC108625; PDH kinase 1; PDK p48; pyruvate dehydrogenase kinase isoenzyme 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8377,113,464 - 77,144,145 (+)NCBIGRCr8
mRatBN7.2356,705,824 - 56,733,040 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,705,871 - 56,733,038 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx360,101,009 - 60,128,030 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,684,633 - 68,711,654 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0366,449,705 - 66,476,726 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0358,530,870 - 58,561,494 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,530,870 - 58,558,027 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0365,019,116 - 65,049,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4354,292,076 - 54,319,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1354,188,447 - 54,215,612 (+)NCBI
Celera356,248,990 - 56,275,768 (+)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
EHT 1864  (ISO)
endosulfan  (EXP)
Erionite  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fipronil  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fructose  (EXP)
Fusaric acid  (ISO)
galactose  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (EXP)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
meldonium  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
minocycline  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
morphine  (EXP)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phosphane  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tubastatin A  (ISO)
Tungsten carbide  (ISO)
ubiquinone-0  (ISO)
undecane  (EXP)
urethane  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase. Boulatnikov I and Popov KM, Biochim Biophys Acta. 2003 Feb 21;1645(2):183-92.
2. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Bowker-Kinley MM, etal., Biochem J 1998 Jan 1;329 ( Pt 1):191-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. Korotchkina LG and Patel MS, J Biol Chem. 2001 Oct 5;276(40):37223-9. Epub 2001 Aug 2.
6. Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. McConkey M, etal., J Biol Chem. 2004 May 14;279(20):20882-8. Epub 2004 Mar 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases. Popov KM, etal., J Biol Chem 1993 Dec 15;268(35):26602-6.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE and Hiromasa Y, Cell Mol Life Sci. 2007 Apr;64(7-8):830-49.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7499431   PMID:11485553   PMID:12477932   PMID:14651853   PMID:17683942   PMID:18541534   PMID:18614015   PMID:21763680   PMID:22195962   PMID:22575885   PMID:24466133   PMID:25436986  
PMID:27748901   PMID:27988334   PMID:30053369   PMID:32216531   PMID:34133802   PMID:34800366   PMID:39080182  


Genomics

Comparative Map Data
Pdk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8377,113,464 - 77,144,145 (+)NCBIGRCr8
mRatBN7.2356,705,824 - 56,733,040 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,705,871 - 56,733,038 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx360,101,009 - 60,128,030 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,684,633 - 68,711,654 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0366,449,705 - 66,476,726 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0358,530,870 - 58,561,494 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,530,870 - 58,558,027 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0365,019,116 - 65,049,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4354,292,076 - 54,319,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1354,188,447 - 54,215,612 (+)NCBI
Celera356,248,990 - 56,275,768 (+)NCBICelera
Cytogenetic Map3q23NCBI
PDK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382172,555,373 - 172,724,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2172,555,373 - 172,608,669 (+)EnsemblGRCh38hg38GRCh38
GRCh372173,420,101 - 173,490,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,129,025 - 173,172,108 (+)NCBINCBI36Build 36hg18NCBI36
Build 342173,246,285 - 173,289,369NCBI
Celera2167,033,973 - 167,077,058 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2165,298,299 - 165,368,581 (+)NCBIHuRef
CHM1_12173,427,271 - 173,497,479 (+)NCBICHM1_1
T2T-CHM13v2.02173,041,625 - 173,210,788 (+)NCBIT2T-CHM13v2.0
Pdk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39271,703,398 - 71,734,202 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl271,703,568 - 71,734,202 (+)EnsemblGRCm39 Ensembl
GRCm38271,873,215 - 71,903,858 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl271,873,224 - 71,903,858 (+)EnsemblGRCm38mm10GRCm38
MGSCv37271,711,329 - 71,741,915 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36271,674,063 - 71,702,840 (+)NCBIMGSCv36mm8
Celera273,545,537 - 73,582,860 (+)NCBICelera
Cytogenetic Map2C3NCBI
cM Map242.84NCBI
Pdk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554492,549,139 - 2,582,243 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554492,546,790 - 2,582,402 (-)NCBIChiLan1.0ChiLan1.0
PDK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21375,229,457 - 75,391,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B75,244,422 - 75,361,852 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B59,841,840 - 59,958,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B177,297,840 - 177,412,691 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B177,297,840 - 177,341,113 (+)Ensemblpanpan1.1panPan2
PDK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13616,918,329 - 16,944,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3616,918,058 - 16,944,620 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3616,924,778 - 16,954,215 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03617,044,728 - 17,074,152 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3617,044,626 - 17,074,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13617,126,078 - 17,155,436 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03617,126,377 - 17,155,712 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03617,229,734 - 17,259,496 (+)NCBIUU_Cfam_GSD_1.0
Pdk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303134,043,765 - 134,079,877 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365092,597,452 - 2,633,780 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365092,597,593 - 2,633,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1578,608,432 - 78,652,962 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11578,608,394 - 78,650,958 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21587,917,870 - 87,949,472 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11058,055,508 - 58,168,505 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1058,055,511 - 58,096,774 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040141,395,556 - 141,502,606 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247879,917,309 - 9,959,875 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247879,917,366 - 9,956,393 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdk1
192 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir375rno-miR-375-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18591395

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:32
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000002072
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002072   ⟹   ENSRNOP00000002072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl356,705,871 - 56,733,038 (+)Ensembl
Rnor_6.0 Ensembl358,530,870 - 58,558,027 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115755   ⟹   ENSRNOP00000097986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl356,705,871 - 56,733,038 (+)Ensembl
RefSeq Acc Id: NM_053826   ⟹   NP_446278
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,113,514 - 77,140,680 (+)NCBI
mRatBN7.2356,705,871 - 56,733,040 (+)NCBI
Rnor_6.0358,530,870 - 58,558,029 (+)NCBI
Rnor_5.0365,019,116 - 65,049,739 (+)NCBI
RGSC_v3.4354,292,076 - 54,319,242 (+)RGD
Celera356,248,990 - 56,275,768 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234352   ⟹   XP_006234414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,113,778 - 77,144,145 (+)NCBI
mRatBN7.2356,706,137 - 56,733,027 (+)NCBI
Rnor_6.0358,531,192 - 58,561,494 (+)NCBI
Rnor_5.0365,019,116 - 65,049,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104113   ⟹   XP_038960041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,123,541 - 77,144,145 (+)NCBI
mRatBN7.2356,715,960 - 56,733,027 (+)NCBI
RefSeq Acc Id: XR_010064554
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8377,113,464 - 77,137,934 (+)NCBI
RefSeq Acc Id: NP_446278   ⟸   NM_053826
- Peptide Label: precursor
- UniProtKB: Q5FVT5 (UniProtKB/TrEMBL),   F1MA54 (UniProtKB/TrEMBL),   A0A8I6GMB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234414   ⟸   XM_006234352
- Peptide Label: isoform X1
- UniProtKB: A6HM61 (UniProtKB/TrEMBL),   A6HM58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002072   ⟸   ENSRNOT00000002072
RefSeq Acc Id: XP_038960041   ⟸   XM_039104113
- Peptide Label: isoform X2
- UniProtKB: A6HM65 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097986   ⟸   ENSRNOT00000115755
Protein Domains
Branched-chain alpha-ketoacid dehydrogenase   Histidine kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63065-F1-model_v2 AlphaFold Q63065 1-434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692139
Promoter ID:EPDNEW_R2663
Type:initiation region
Name:Pdk1_1
Description:pyruvate dehydrogenase kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0358,530,922 - 58,530,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69427 AgrOrtholog
BioCyc Gene G2FUF-49445 BioCyc
Ensembl Genes ENSRNOG00000001517 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002072.7 UniProtKB/TrEMBL
  ENSRNOT00000115755.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7321326 IMAGE-MGC_LOAD
InterPro AK/P_DHK_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCDHK/PDK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCKD/PDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116551 UniProtKB/TrEMBL
MGC_CLONE MGC:108625 IMAGE-MGC_LOAD
NCBI Gene 116551 ENTREZGENE
PANTHER [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11947 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BCDHK_Adom3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PDK1 RGD
PhenoGen Pdk1 PhenoGen
PROSITE HIS_KIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001517 RatGTEx
SMART HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69012 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206538
UniProt A0A8I6GMB0 ENTREZGENE, UniProtKB/TrEMBL
  A6HM58 ENTREZGENE, UniProtKB/TrEMBL
  A6HM59_RAT UniProtKB/TrEMBL
  A6HM60_RAT UniProtKB/TrEMBL
  A6HM61 ENTREZGENE, UniProtKB/TrEMBL
  A6HM62_RAT UniProtKB/TrEMBL
  A6HM63_RAT UniProtKB/TrEMBL
  A6HM64_RAT UniProtKB/TrEMBL
  A6HM65 ENTREZGENE, UniProtKB/TrEMBL
  A6HM67_RAT UniProtKB/TrEMBL
  F1MA54 ENTREZGENE
  PDK1_RAT UniProtKB/Swiss-Prot
  Q5FVT5 ENTREZGENE, UniProtKB/TrEMBL
  Q63065 ENTREZGENE
UniProt Secondary F1MA54 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Pdk1  pyruvate dehydrogenase kinase 1  Pdk1  pyruvate dehydrogenase kinase, isozyme 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Pdk1  pyruvate dehydrogenase kinase, isozyme 1  Pdk1  pyruvate dehydrogenase kinase, isoenzyme 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pdk1  pyruvate dehydrogenase kinase, isoenzyme 1    pyruvate dehydrogenase kinase 1  Name updated 1299863 APPROVED
2002-06-10 Pdk1  pyruvate dehydrogenase kinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product related to prokaryotic family of protein kinases 68684
gene_protein predicted 434 amino acid protein 68684