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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69427
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdk1
Name: pyruvate dehydrogenase kinase 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:15527386480464CTDDoxorubicin results in decreased expression of PDK1 mRNA

PMID:26873546
decreases expressionISORGD:694806480464CTDDoxorubicin results in decreased expression of PDK1 mRNA

PMID:29803840
increases expressionISORGD:694806480464CTDDoxorubicin results in increased expression of PDK1 mRNA

PMID:28940058
multiple interactionsISORGD:15527386480464CTD[Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDK1 mRNA

PMID:26873546
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.