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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69427
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdk1
Name: pyruvate dehydrogenase kinase 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdk1increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of PDK1 protein modified formPMID:19931519
Pdk1multiple interactionsEXP 6480464CTDmorin inhibits the reaction [Diethylnitrosamine results in increased expression of PDK1 protein modified form]PMID:19931519
Pdk1increases phosphorylationISOPdk1 (Mus musculus)6480464CTDDiethylnitrosamine results in increased phosphorylation of PDK1 proteinPMID:20583210
Pdk1multiple interactionsISOPdk1 (Mus musculus)6480464CTDCTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of PDK1 protein]PMID:20583210
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