PDK1 (pyruvate dehydrogenase kinase 1)

Gene: PDK1 (pyruvate dehydrogenase kinase 1) Canis lupus familiaris

Analyze

Symbol:

PDK1

Name:

pyruvate dehydrogenase kinase 1

RGD ID:

12144102

Description:

ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); protein phosphorylation (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; Fc epsilon receptor mediated signaling pathway; pyruvate metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); split hand-foot malformation 5 (ortholog); FOUND IN pyruvate dehydrogenase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	16,918,329 - 16,944,532 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	16,918,058 - 16,944,620 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	16,924,778 - 16,954,215 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	17,044,728 - 17,074,152 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	17,044,626 - 17,074,144 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	17,126,078 - 17,155,436 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	17,126,377 - 17,155,712 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	17,229,734 - 17,259,496 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

split hand-foot malformation 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell population proliferation (IEA)

cell surface receptor signaling pathway (ISO)

hypoxia-inducible factor-1alpha signaling pathway (IEA)

intrinsic apoptotic signaling pathway in response to oxidative stress (IEA)

protein phosphorylation (ISO)

regulation of acetyl-CoA biosynthetic process from pyruvate (IEA)

regulation of glucose metabolic process (IEA)

Cellular Component

mitochondrial matrix (IEA)

mitochondrion (IEA)

pyruvate dehydrogenase complex (ISO)

Molecular Function

ATP binding (IEA,ISO)

identical protein binding (ISO)

kinase activity (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine/threonine kinase activity (ISO)

protein-containing complex binding (ISO)

pyruvate dehydrogenase (acetyl-transferring) kinase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

epidermal growth factor/neuregulin signaling pathway (ISO)

Fc epsilon receptor mediated signaling pathway (ISO)

pyruvate metabolic pathway (ISO)

References

Additional References at PubMed

PMID:25492927	PMID:30032202

Genomics

Comparative Map Data

PDK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	16,918,329 - 16,944,532 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	16,918,058 - 16,944,620 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	16,924,778 - 16,954,215 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	17,044,728 - 17,074,152 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	17,044,626 - 17,074,144 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	17,126,078 - 17,155,436 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	17,126,377 - 17,155,712 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	17,229,734 - 17,259,496 (+)	NCBI		UU_Cfam_GSD_1.0

PDK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	172,555,373 - 172,724,312 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	172,555,373 - 172,608,669 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	173,420,101 - 173,490,351 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	173,129,025 - 173,172,108 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	173,246,285 - 173,289,369	NCBI
Celera	2	167,033,973 - 167,077,058 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	165,298,299 - 165,368,581 (+)	NCBI		HuRef
CHM1_1	2	173,427,271 - 173,497,479 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	173,041,625 - 173,210,788 (+)	NCBI		T2T-CHM13v2.0

Pdk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	71,703,398 - 71,734,202 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	71,703,568 - 71,734,202 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	71,873,215 - 71,903,858 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	71,873,224 - 71,903,858 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	71,711,329 - 71,741,915 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	71,674,063 - 71,702,840 (+)	NCBI		MGSCv36	mm8
Celera	2	73,545,537 - 73,582,860 (+)	NCBI		Celera
Cytogenetic Map	2	C3	NCBI
cM Map	2	42.84	NCBI

Pdk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	77,113,464 - 77,144,145 (+)	NCBI		GRCr8
mRatBN7.2	3	56,705,824 - 56,733,040 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	56,705,871 - 56,733,038 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	60,101,009 - 60,128,030 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	68,684,633 - 68,711,654 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	66,449,705 - 66,476,726 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	58,530,870 - 58,561,494 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	58,530,870 - 58,558,027 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	65,019,116 - 65,049,739 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	54,292,076 - 54,319,242 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	54,188,447 - 54,215,612 (+)	NCBI
Celera	3	56,248,990 - 56,275,768 (+)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI

Pdk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	2,549,139 - 2,582,243 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	2,546,790 - 2,582,402 (-)	NCBI	ChiLan1.0	ChiLan1.0

PDK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	75,229,457 - 75,391,205 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	75,244,422 - 75,361,852 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	59,841,840 - 59,958,504 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	177,297,840 - 177,412,691 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	177,297,840 - 177,341,113 (+)	Ensembl	panpan1.1		panPan2

Pdk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	134,043,765 - 134,079,877 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	2,597,452 - 2,633,780 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	2,597,593 - 2,633,780 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	78,608,432 - 78,652,962 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	78,608,394 - 78,650,958 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	87,917,870 - 87,949,472 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	58,055,508 - 58,168,505 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	58,055,511 - 58,096,774 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	141,395,556 - 141,502,606 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	9,917,309 - 9,959,875 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	9,917,366 - 9,956,393 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PDK1
232 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5	5	22	6	6	6	6	6	12	8	10	6
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038447082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038463308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038463309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038521163	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038584862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038584863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038584864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038649279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038649280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038649281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_534032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000020752 ⟹ ENSCAFP00000019265

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	36	16,918,058 - 16,944,620 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845050888 ⟹ ENSCAFP00845039893

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	36	17,044,626 - 17,074,144 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845050937 ⟹ ENSCAFP00845039933

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	36	17,044,709 - 17,074,142 (+)	Ensembl

RefSeq Acc Id:

XM_038447082 ⟹ XP_038303010

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	36	17,044,728 - 17,074,152 (+)	NCBI

RefSeq Acc Id:

XM_038447083 ⟹ XP_038303011

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	36	17,045,574 - 17,071,829 (+)	NCBI

RefSeq Acc Id:

XM_038447084 ⟹ XP_038303012

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	36	17,044,728 - 17,074,152 (+)	NCBI

RefSeq Acc Id:

XM_038463308 ⟹ XP_038319236

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	36	16,924,778 - 16,954,215 (+)	NCBI

RefSeq Acc Id:

XM_038463309 ⟹ XP_038319237

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	36	16,924,778 - 16,954,215 (+)	NCBI

RefSeq Acc Id:

XM_038521163 ⟹ XP_038377091

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	36	17,126,078 - 17,155,436 (+)	NCBI

RefSeq Acc Id:

XM_038584862 ⟹ XP_038440790

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	36	17,229,734 - 17,259,496 (+)	NCBI

RefSeq Acc Id:

XM_038584863 ⟹ XP_038440791

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	36	17,230,723 - 17,257,174 (+)	NCBI

RefSeq Acc Id:

XM_038584864 ⟹ XP_038440792

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	36	17,229,734 - 17,259,496 (+)	NCBI

RefSeq Acc Id:

XM_038649279 ⟹ XP_038505207

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	36	17,126,377 - 17,155,712 (+)	NCBI

RefSeq Acc Id:

XM_038649280 ⟹ XP_038505208

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	36	17,127,154 - 17,153,389 (+)	NCBI

RefSeq Acc Id:

XM_038649281 ⟹ XP_038505209

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	36	17,126,377 - 17,155,712 (+)	NCBI

RefSeq Acc Id:

XM_534032 ⟹ XP_534032

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	36	16,918,329 - 16,944,532 (+)	NCBI
Dog10K_Boxer_Tasha	36	16,925,632 - 16,951,892 (+)	NCBI

Sequence:

show sequence

GACTGATGATAAACGATTGCGTAAAACCTCCGTGATGAGACGGGAGGCAGGTTATAACTGGCCC
GAGCGTTTCACAGAATGTTTGCCTTGCCACTTGCTTAATAGTGTTTCCATCCGCGGCACATTCG
TTTCATCATCAGCAAGATCTATGAACGCTTGTGAAAAGACCTCATTTATGTTTCTGCGACAAGA
GCTACCTGTTAGATTGGCAAATATAATGAAAGAAATAAGTCTTCTTCCAGATAATCTTCTCAGG
ACTCCATCAGTTCAATTGGTACAAAGCTGGTATATCCAGAGTCTTCAGGAACTTCTTGAATTTA
AAGACAAAAGTGCTGAAGAGGCTAAAACTATTTATGACTTTACAGATACTGTGATTCGGATCAG
GAATCGACACAACGATGTTATTCCCACGATGGCGCAGGGTGTGATTGAATACAAGGAGAGCTTC
GGGGTGGATCCTGTCACCAGCCAGAATGTTCAGTACTTTTTGGATCGCTTCTACATGAGTCGCA
TTTCAATTAGAATGTTACTCAATCAGCACTCTTTATTGTTTGGTGGAAAAGGCAAAGGAAGCCC
AGCTCATCGAAAACACATTGGAAGCATAAATCCAAACTGCGATGTAGTTGAAGTTATTAAAGAT
GGCTATGAAAATGCTAGGCGTCTGTGTGATTTGTATTATATTAACTCTCCTGAACTAGAACTTG
AAGAATTAAATGCAAAATCACCAGGACAGCCAATACAAGTGGTTTATGTACCATCCCATCTCTA
TCACATGGTGTTTGAACTTTTCAAGAATGCGATGAGAGCAACGATGGAACACCATGCTGACAAA
GGCGTTTACCCTCCTATTCAAGTCCACATCACACTGGGTAATGAGGATTTGACTGTGAAGATGA
GTGACCGAGGAGGTGGTGTTCCTTTGAGGAAAATTGACAGACTCTTCAACTACATGTACTCAAC
GGCACCCCGGCCTCGTGTTGAGACGTCCAGAGCTGTGCCCCTGGCTGGTTTTGGTTATGGATTG
CCCATCTCACGTCTTTATGCCCAATACTTCCAAGGAGACCTAAAGCTATATTCTCTAGAGGGTT
ATGGGACAGATGCAGTCATCTACATTAAGGCTCTGTCAACAGAATCAATAGAGAGACTGCCAGT
GTATAACAAGGCTGCCTGGAAGCATTACAATACCAACCATGAGGCTGACGACTGGTGTGTCCCC
AGCAGAGAACCAAAAGACATGACAACATTTCGCAGTGCCTAGATACACTTGGGACACCGTGAAC
ATCCAAATGTGGCTTTTGTATTAAATTTGGAAGGGATGACGTTCAGAACTACATTATACCAAAT
ACTTCACGTGTTATTTTCAAAATTAACTATTTGGGTAGAATAAATGGGAAGTGAATTCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038303010	(Get FASTA)	NCBI Sequence Viewer
	XP_038303011	(Get FASTA)	NCBI Sequence Viewer
	XP_038303012	(Get FASTA)	NCBI Sequence Viewer
	XP_038319236	(Get FASTA)	NCBI Sequence Viewer
	XP_038319237	(Get FASTA)	NCBI Sequence Viewer
	XP_038377091	(Get FASTA)	NCBI Sequence Viewer
	XP_038440790	(Get FASTA)	NCBI Sequence Viewer
	XP_038440791	(Get FASTA)	NCBI Sequence Viewer
	XP_038440792	(Get FASTA)	NCBI Sequence Viewer
	XP_038505207	(Get FASTA)	NCBI Sequence Viewer
	XP_038505208	(Get FASTA)	NCBI Sequence Viewer
	XP_038505209	(Get FASTA)	NCBI Sequence Viewer
	XP_534032	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000019265.5
	ENSCAFP00000069764.1
	ENSCAFP00030023572.1
	ENSCAFP00030023646.1
	ENSCAFP00040018048.1
	ENSCAFP00845039893
	ENSCAFP00845039893.1
	ENSCAFP00845039933.1

RefSeq Acc Id:	XP_534032 ⟸ XM_534032
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0NA53 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRREAGYNWPERFTECLPCHLLNSVSIRGTFVSSSARSMNACEKTSFMFLRQELPVRLANIMKE ISLLPDNLLRTPSVQLVQSWYIQSLQELLEFKDKSAEEAKTIYDFTDTVIRIRNRHNDVIPTMA QGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPAHRKHIGSINP NCDVVEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAM RATMEHHADKGVYPPIQVHITLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRA VPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYNT NHEADDWCVPSREPKDMTTFRSA hide sequence

RefSeq Acc Id:

ENSCAFP00000019265 ⟸ ENSCAFT00000020752

RefSeq Acc Id:	XP_038377091 ⟸ XM_038521163
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038505207 ⟸ XM_038649279
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038505209 ⟸ XM_038649281
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038505208 ⟸ XM_038649280
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038303010 ⟸ XM_038447082
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0JUS9 (UniProtKB/TrEMBL), A0A8C0N992 (UniProtKB/TrEMBL), A0A8I3S6V6 (UniProtKB/TrEMBL), A0A8C0SA42 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303012 ⟸ XM_038447084
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0SA42 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303011 ⟸ XM_038447083
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0NA53 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038319236 ⟸ XM_038463308
- Peptide Label:	isoform X1
- UniProtKB:	A0A8P0SHX6 (UniProtKB/TrEMBL), A0A8C0SA42 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038319237 ⟸ XM_038463309
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0SA42 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038440790 ⟸ XM_038584862
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0SA42 (UniProtKB/TrEMBL), A0A8P0SHX6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038440792 ⟸ XM_038584864
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0SA42 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038440791 ⟸ XM_038584863
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0NA53 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845039893 ⟸ ENSCAFT00845050888

RefSeq Acc Id:

ENSCAFP00845039933 ⟸ ENSCAFT00845050937

Protein Domains

Histidine kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000013060	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030014574	UniProtKB/TrEMBL
	ENSCAFG00040011199	UniProtKB/TrEMBL
	ENSCAFG00845028798	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000020752.5	UniProtKB/TrEMBL
	ENSCAFT00000094478.1	UniProtKB/TrEMBL
	ENSCAFT00030027008.1	UniProtKB/TrEMBL
	ENSCAFT00030027092.1	UniProtKB/TrEMBL
	ENSCAFT00040020793.1	UniProtKB/TrEMBL
	ENSCAFT00845050888	ENTREZGENE
	ENSCAFT00845050888.1	UniProtKB/TrEMBL
	ENSCAFT00845050937.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.140.20	UniProtKB/TrEMBL
	3.30.565.10	UniProtKB/TrEMBL
InterPro	AK/P_DHK_N_sf	UniProtKB/TrEMBL
	BCDHK/PDK_N	UniProtKB/TrEMBL
	BCKD/PDK	UniProtKB/TrEMBL
	HATPase_C	UniProtKB/TrEMBL
	HATPase_C_sf	UniProtKB/TrEMBL
	His_kinase_dom	UniProtKB/TrEMBL
NCBI Gene	PDK1	ENTREZGENE
PANTHER	[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR11947	UniProtKB/TrEMBL
Pfam	BCDHK_Adom3	UniProtKB/TrEMBL
	HATPase_c	UniProtKB/TrEMBL
PROSITE	HIS_KIN	UniProtKB/TrEMBL
SMART	HATPase_c	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55874	UniProtKB/TrEMBL
	SSF69012	UniProtKB/TrEMBL
UniProt	A0A8C0JUS9	ENTREZGENE
	A0A8C0N992	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0NA53	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0SA42	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3Q1S1_CANLF	UniProtKB/TrEMBL
	A0A8I3S6V6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SHX6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TM90_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:97211	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB