Stx2 (syntaxin 2) - Rat Genome Database

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Gene: Stx2 (syntaxin 2) Rattus norvegicus
Analyze
Symbol: Stx2
Name: syntaxin 2
RGD ID: 2558
Description: Enables SNARE binding activity. Involved in several processes, including digestive tract morphogenesis; microvillus assembly; and midbody abscission. Located in midbody. Is active in synapse. Orthologous to human STX2 (syntaxin 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Epim; epimorphin; syntaxin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Stx2_v1   Stx2_v4   Stx2_v3   Stx2_v2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81233,315,447 - 33,350,788 (+)NCBIGRCr8
mRatBN7.21227,678,744 - 27,714,751 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,689,819 - 27,714,751 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1228,829,065 - 28,850,843 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01229,439,629 - 29,461,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01228,498,608 - 28,520,373 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01231,324,203 - 31,360,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1231,335,372 - 31,360,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,250,624 - 33,286,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,751,591 - 28,773,351 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,614,978 - 28,636,739 (+)NCBI
Celera1229,385,007 - 29,406,766 (+)NCBICelera
RH 3.4 Map12461.4RGD
Cytogenetic Map12q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The syntaxin family of vesicular transport receptors. Bennett MK, etal., Cell 1993 Sep 10;74(5):863-73.
2. Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis. Fritsch C, etal., J Clin Invest 2002 Dec;110(11):1629-41.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, etal., Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.
7. Intracellular accumulation of pIgA-R and regulators of transcytotic trafficking in cholestatic rat hepatocytes. Larkin JM, etal., Hepatology 2003 Nov;38(5):1199-209.
8. Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Low SH, etal., Dev Cell 2003 May;4(5):753-9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Epimorphin is involved in differentiation of rat hepatic stem-like cells through cell-cell contact. Miura K, etal., Biochem Biophys Res Commun 2003 Nov 14;311(2):415-23.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties and subcellular localizations. Quinones B, etal., J Cell Sci 1999 Dec;112 ( Pt 23):4291-304.
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Thomas DM, etal., Mol Biol Cell. 1999 Jul;10(7):2285-95.
17. The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12. Zha H, etal., Genomics 1996 Nov 1;37(3):386-9.
Additional References at PubMed
PMID:7768895   PMID:8996080   PMID:11702001   PMID:11784086   PMID:15685636   PMID:15774481   PMID:16339081   PMID:16891298   PMID:17935821   PMID:18321981   PMID:20305811   PMID:21720706  
PMID:21810271   PMID:21935930   PMID:22226963   PMID:23376485   PMID:24971829   PMID:25119302   PMID:28560580  


Genomics

Comparative Map Data
Stx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81233,315,447 - 33,350,788 (+)NCBIGRCr8
mRatBN7.21227,678,744 - 27,714,751 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,689,819 - 27,714,751 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1228,829,065 - 28,850,843 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01229,439,629 - 29,461,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01228,498,608 - 28,520,373 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01231,324,203 - 31,360,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1231,335,372 - 31,360,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,250,624 - 33,286,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,751,591 - 28,773,351 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,614,978 - 28,636,739 (+)NCBI
Celera1229,385,007 - 29,406,766 (+)NCBICelera
RH 3.4 Map12461.4RGD
Cytogenetic Map12q13NCBI
STX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812130,789,600 - 130,839,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12130,789,600 - 130,839,254 (-)EnsemblGRCh38hg38GRCh38
GRCh3712131,274,145 - 131,323,795 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612129,840,098 - 129,889,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412129,799,028 - 129,848,691NCBI
Celera12130,887,358 - 130,937,200 (-)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12128,256,936 - 128,306,689 (-)NCBIHuRef
CHM1_112131,094,820 - 131,144,677 (-)NCBICHM1_1
T2T-CHM13v2.012130,828,749 - 130,878,417 (-)NCBIT2T-CHM13v2.0
Stx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,061,621 - 129,085,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,061,621 - 129,085,638 (-)EnsemblGRCm39 Ensembl
GRCm385128,984,557 - 129,008,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5128,984,557 - 129,008,574 (-)EnsemblGRCm38mm10GRCm38
MGSCv375129,490,436 - 129,514,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365129,299,275 - 129,323,282 (-)NCBIMGSCv36mm8
MGSCv365127,256,039 - 127,280,159 (-)NCBIMGSCv36mm8
Celera5126,018,075 - 126,042,529 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map567.99NCBI
Stx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554821,252,600 - 1,270,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554821,249,972 - 1,273,250 (+)NCBIChiLan1.0ChiLan1.0
STX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210138,861,215 - 138,910,708 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112138,857,716 - 138,907,215 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012128,416,793 - 128,464,452 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112132,612,870 - 132,650,554 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12132,614,793 - 132,650,559 (-)Ensemblpanpan1.1panPan2
STX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1261,459,110 - 1,494,801 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl261,454,189 - 1,494,823 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,649,625 - 1,694,969 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,695,058 - 1,740,740 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,695,026 - 1,726,222 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1261,631,450 - 1,676,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0261,728,343 - 1,773,741 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0261,635,560 - 1,681,133 (+)NCBIUU_Cfam_GSD_1.0
Stx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118123,068,259 - 123,104,309 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366601,616,771 - 1,649,207 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366601,616,774 - 1,652,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1424,341,549 - 24,380,626 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11424,341,473 - 24,380,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21425,870,829 - 25,927,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111126,174,446 - 126,225,342 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11126,178,803 - 126,224,277 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037118,795,646 - 118,846,782 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,249,608 - 27,272,728 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474727,247,947 - 27,272,698 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stx2
198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:187
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000001242, ENSRNOT00000037296, ENSRNOT00000037306
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)122423477731894213Rat

Markers in Region
RH94687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21227,699,166 - 27,699,285 (+)MAPPERmRatBN7.2
Rnor_6.01231,344,669 - 31,344,787NCBIRnor6.0
Rnor_5.01233,271,103 - 33,271,221UniSTSRnor5.0
RGSC_v3.41228,760,835 - 28,760,953UniSTSRGSC3.4
Celera1229,394,250 - 29,394,368UniSTS
RH 3.4 Map12461.4UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 32 44 41 13 41 66 32 39 11
Low 1 11 13 6 8 11 8 3 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC118310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY302700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000001242   ⟹   ENSRNOP00000001242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,689,827 - 27,714,751 (+)Ensembl
Rnor_6.0 Ensembl1231,335,372 - 31,360,254 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000037296   ⟹   ENSRNOP00000036115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,699,149 - 27,709,290 (+)Ensembl
Rnor_6.0 Ensembl1231,335,425 - 31,355,445 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094953   ⟹   ENSRNOP00000091323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,699,149 - 27,714,751 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099417   ⟹   ENSRNOP00000085955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,689,842 - 27,714,739 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099729   ⟹   ENSRNOP00000092669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,689,819 - 27,709,943 (+)Ensembl
RefSeq Acc Id: NM_001415751   ⟹   NP_001402680
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,325,869 - 33,350,788 (+)NCBI
mRatBN7.21227,689,830 - 27,714,751 (+)NCBI
RefSeq Acc Id: NM_012748   ⟹   NP_036880
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,325,869 - 33,350,788 (+)NCBI
mRatBN7.21227,689,830 - 27,714,751 (+)NCBI
Rnor_6.01231,335,425 - 31,357,185 (+)NCBI
Rnor_5.01233,250,624 - 33,286,683 (+)NCBI
RGSC_v3.41228,751,591 - 28,773,351 (+)RGD
Celera1229,385,007 - 29,406,766 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249253   ⟹   XP_006249315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,315,447 - 33,346,760 (+)NCBI
mRatBN7.21227,678,744 - 27,713,274 (+)NCBI
Rnor_6.01231,324,203 - 31,358,725 (+)NCBI
Rnor_5.01233,250,624 - 33,286,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598270   ⟹   XP_017453759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,315,447 - 33,346,760 (+)NCBI
mRatBN7.21227,678,744 - 27,713,274 (+)NCBI
Rnor_6.01231,324,203 - 31,358,725 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598271   ⟹   XP_017453760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,325,795 - 33,346,552 (+)NCBI
mRatBN7.21227,689,755 - 27,710,515 (+)NCBI
Rnor_6.01231,335,266 - 31,356,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089101   ⟹   XP_038945029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,325,796 - 33,350,788 (+)NCBI
mRatBN7.21227,689,755 - 27,714,751 (+)NCBI
RefSeq Acc Id: XM_039089103   ⟹   XP_038945031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,344,345 - 33,349,198 (+)NCBI
mRatBN7.21227,708,313 - 27,713,274 (+)NCBI
RefSeq Acc Id: XM_063271077   ⟹   XP_063127147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,325,795 - 33,346,760 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036880   ⟸   NM_012748
- Peptide Label: isoform 1
- UniProtKB: G3V632 (UniProtKB/TrEMBL),   A6J0S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249315   ⟸   XM_006249253
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017453759   ⟸   XM_017598270
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017453760   ⟸   XM_017598271
- Peptide Label: isoform X4
- UniProtKB: Q7TS57 (UniProtKB/TrEMBL),   A0A0H2UHU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036115   ⟸   ENSRNOT00000037296
RefSeq Acc Id: ENSRNOP00000001242   ⟸   ENSRNOT00000001242
RefSeq Acc Id: XP_038945029   ⟸   XM_039089101
- Peptide Label: isoform X2
- UniProtKB: Q08848 (UniProtKB/Swiss-Prot),   Q08847 (UniProtKB/Swiss-Prot),   Q08846 (UniProtKB/Swiss-Prot),   P50279 (UniProtKB/Swiss-Prot),   A6J0S5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945031   ⟸   XM_039089103
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000091323   ⟸   ENSRNOT00000094953
RefSeq Acc Id: ENSRNOP00000092669   ⟸   ENSRNOT00000099729
RefSeq Acc Id: ENSRNOP00000085955   ⟸   ENSRNOT00000099417
RefSeq Acc Id: NP_001402680   ⟸   NM_001415751
- Peptide Label: isoform 2
- UniProtKB: A6J0S6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127147   ⟸   XM_063271077
- Peptide Label: isoform X1
Protein Domains
t-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50279-F1-model_v2 AlphaFold P50279 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698594
Promoter ID:EPDNEW_R9119
Type:initiation region
Name:Stx2_1
Description:syntaxin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01231,335,346 - 31,335,406EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2558 AgrOrtholog
BioCyc Gene G2FUF-19468 BioCyc
Ensembl Genes ENSRNOG00000000936 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001242 ENTREZGENE
  ENSRNOT00000001242.4 UniProtKB/TrEMBL
  ENSRNOT00000037296.4 UniProtKB/TrEMBL
  ENSRNOT00000094953.1 UniProtKB/TrEMBL
  ENSRNOT00000099417 ENTREZGENE
  ENSRNOT00000099417.1 UniProtKB/Swiss-Prot
  ENSRNOT00000099729.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin/epimorphin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25130 UniProtKB/Swiss-Prot
NCBI Gene 25130 ENTREZGENE
PANTHER PTHR19957 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19957:SF36 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Syntaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stx2 PhenoGen
PROSITE SYNTAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000936 RatGTEx
SMART SynN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  t_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232292
UniProt A0A0H2UHU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF84_RAT UniProtKB/TrEMBL
  A6J0S5 ENTREZGENE, UniProtKB/TrEMBL
  A6J0S6 ENTREZGENE, UniProtKB/TrEMBL
  A6J0S7 ENTREZGENE, UniProtKB/TrEMBL
  A6J0S9_RAT UniProtKB/TrEMBL
  G3V632 ENTREZGENE, UniProtKB/TrEMBL
  P50279 ENTREZGENE
  Q08846 ENTREZGENE
  Q08847 ENTREZGENE
  Q08848 ENTREZGENE
  Q7TS57 ENTREZGENE, UniProtKB/TrEMBL
  STX2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q08846 UniProtKB/Swiss-Prot
  Q08847 UniProtKB/Swiss-Prot
  Q08848 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Stx2  syntaxin 2  Epim  epimorphin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Epim  Epimorphin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript four splice variants have nearly identical N-terminal cytoplasmic domains; syntaxins 2A and 2B have hydrophobic C-terminal domains while syntaxins 2C and 2D have hydrophillic C-terminal domains 1298910