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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | RGD:2558 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of STX2 mRNA] | CTD | PMID:31150632 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:10530 | 6480464 | Ethinyl Estradiol results in increased expression of STX2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of STX2 mRNA | CTD | PMID:30165855 | 17beta-hydroxy-5alpha-androstan-3-one | decreases expression | ISO | RGD:10530 | 6480464 | Dihydrotestosterone results in decreased expression of STX2 mRNA | CTD | PMID:17023530 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | RGD:10530 | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STX2 mRNA] | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of STX2 mRNA | CTD | PMID:11007951, PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10530 | 6480464 | Tetrachlorodibenzodioxin affects the expression of STX2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:2558 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of STX2 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:2558 | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of STX2 mRNA] | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:10530 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of STX2 mRNA | CTD | PMID:17942748 | 2-ethoxyethanol | increases expression | ISO | RGD:2558 | 6480464 | 2-ethoxyethanol results in increased expression of STX2 mRNA | CTD | PMID:19643169 | 2-methoxyethanol | increases expression | ISO | RGD:2558 | 6480464 | methyl cellosolve results in increased expression of STX2 mRNA | CTD | PMID:19643169 | 4-hydroxyphenyl retinamide | decreases expression | ISO | RGD:10530 | 6480464 | Fenretinide results in decreased expression of STX2 mRNA | CTD | PMID:28973697 | 8-Br-cAMP | increases expression | EXP | | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STX2 mRNA | CTD | PMID:22079614 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of STX2 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | RGD:10530 | 6480464 | Tretinoin results in increased expression of STX2 mRNA | CTD | PMID:16604517 | ammonium chloride | affects expression | ISO | RGD:2558 | 6480464 | Ammonium Chloride affects the expression of STX2 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzoapyrene results in increased methylation of STX2 promoter | CTD | PMID:27901495 | bisphenol A | decreases expression | ISO | RGD:10530 | 6480464 | bisphenol A results in decreased expression of STX2 mRNA | CTD | PMID:26063408 | bisphenol A | increases expression | ISO | RGD:2558 | 6480464 | bisphenol A results in increased expression of STX2 mRNA | CTD | PMID:30816183 | bisphenol A | decreases expression | ISO | RGD:2558 | 6480464 | bisphenol A results in decreased expression of STX2 mRNA | CTD | PMID:25181051 | cadmium atom | increases expression | EXP | | 6480464 | Cadmium results in increased expression of STX2 mRNA | CTD | PMID:24376830 | carboplatin | increases response to substance | EXP | | 6480464 | STX2 protein results in increased susceptibility to Carboplatin | CTD | PMID:24039787 | ciguatoxin CTX1B | affects expression | ISO | RGD:10530 | 6480464 | Ciguatoxins affects the expression of STX2 mRNA | CTD | PMID:18353800 | copper(II) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of STX2 mRNA | CTD | PMID:19549813 | cycloheximide | multiple interactions | EXP | | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STX2 mRNA] | CTD | PMID:11007951 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of STX2 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | ISO | RGD:2558 | 6480464 | Endosulfan results in decreased expression of STX2 mRNA | CTD | PMID:29391264 | fipronil | increases expression | ISO | RGD:2558 | 6480464 | fipronil results in increased expression of STX2 mRNA | CTD | PMID:31881178 | flavonoids | increases expression | ISO | RGD:2558 | 6480464 | Flavonoids results in increased expression of STX2 mRNA | CTD | PMID:18035473 | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of STX2 mRNA | CTD | PMID:28001369 | methylseleninic acid | increases expression | EXP | | 6480464 | methylselenic acid results in increased expression of STX2 mRNA | CTD | PMID:18548127 | monosodium L-glutamate | increases expression | ISO | RGD:10530 | 6480464 | Sodium Glutamate results in increased expression of STX2 mRNA | CTD | PMID:22078008 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:10530 | 6480464 | Ethylnitrosourea results in increased mutagenesis of STX2 gene | CTD | PMID:18277055 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:2558 | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of STX2 mRNA | CTD | PMID:20360939 | oxaliplatin | decreases expression | ISO | RGD:2558 | 6480464 | oxaliplatin results in decreased expression of STX2 mRNA | CTD | PMID:25729387 | oxaliplatin | multiple interactions | ISO | RGD:2558 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of STX2 mRNA | CTD | PMID:25729387 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of STX2 mRNA | CTD | PMID:22230336 | phenethyl caffeate | multiple interactions | ISO | RGD:2558 | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of STX2 mRNA | CTD | PMID:20360939 | pirinixic acid | increases expression | ISO | RGD:10530 | 6480464 | pirinixic acid results in increased expression of STX2 mRNA | CTD | PMID:18301758, PMID:23811191 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | RGD:10530 | 6480464 | Pregnenolone Carbonitrile results in decreased expression of STX2 mRNA | CTD | PMID:28903501 | tetrachloromethane | affects expression | ISO | RGD:10530 | 6480464 | Carbon Tetrachloride affects the expression of STX2 mRNA, Carbon Tetrachloride affects the expression of STX2 protein | CTD | PMID:16480920 | tetrachloromethane | decreases expression | ISO | RGD:2558 | 6480464 | Carbon Tetrachloride results in decreased expression of STX2 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | ISO | RGD:2558 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of STX2 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | RGD:10530 | 6480464 | Carbon Tetrachloride results in increased expression of STX2 protein | CTD | PMID:16246199 | thimerosal | decreases expression | EXP | | 6480464 | Thimerosal results in decreased expression of STX2 mRNA | CTD | PMID:27188386 | topotecan | decreases expression | ISO | RGD:2558 | 6480464 | Topotecan results in decreased expression of STX2 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | ISO | RGD:2558 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of STX2 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | RGD:2558 | 6480464 | trichostatin A results in increased expression of STX2 mRNA | CTD | PMID:23558232 | triptonide | decreases expression | ISO | RGD:10530 | 6480464 | triptonide results in decreased expression of STX2 mRNA | CTD | PMID:33045310 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of STX2 mRNA | CTD | PMID:25979313 | vinclozolin | increases expression | ISO | RGD:2558 | 6480464 | vinclozolin results in increased expression of STX2 mRNA | CTD | PMID:23034163 | vorinostat | decreases expression | EXP | | 6480464 | vorinostat results in decreased expression of STX2 mRNA | CTD | PMID:27188386 | zinc atom | decreases expression | ISO | RGD:2558 | 6480464 | Zinc deficiency results in decreased expression of STX2 mRNA | CTD | PMID:12672911 | zinc(0) | decreases expression | ISO | RGD:2558 | 6480464 | Zinc deficiency results in decreased expression of STX2 mRNA | CTD | PMID:12672911 | |