| 2561 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding; protein tyrosine kinase activity; protein-containing complex binding; INVOLVED IN axon regeneration; cellular response to mechanical stimulus; ERBB2-ERBB4 signaling pathway; PARTICIPATES IN mitogen activated protein kinase signaling pathway; Ras mediated signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH increased metastatic potential; ASSOCIATED WITH amblyopia; congestive heart failure; Diabetic Cardiomyopathies; FOUND IN apical plasma membrane; basal plasma membrane; basolateral plasma membrane; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene | 10 | 83907491 | 83931365 | Rat | 730 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10533 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | Enables coreceptor activity and protein tyrosine kinase activity. Involved in several processes, including ERBB2 signaling pathway; nervous system development; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of o r within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Part of semaphorin receptor complex. Is active in neuromuscular junction and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 98303310 | 98328542 | Mouse | 888 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 619563 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heter odimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] | 17 | 39688094 | 39728658 | Human | 969 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8789629 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits coreceptor activity (ortholog); ErbB-3 class receptor binding (ortholog); growth factor binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell population proliferation (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN cell projection; apical plasma membrane (ortholog); basal plasma membrane (ortholog) | NW_004955451 | 14442816 | 14456009 | Chinchilla | 299 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11911529 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein tyrosine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to mechanical stimulus (orthol og); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | 17 | 17560337 | 17600808 | Bonobo | 321 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12416215 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein tyrosine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to epidermal growth factor sti mulus (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | 9 | 22760373 | 22785367 | Dog | 335 | symbol , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12551677 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein tyrosine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to mechanical stimulus (orthol og); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | NW_004936490 | 14887062 | 14910038 | Squirrel | 321 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14209161 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein tyrosine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to mechanical stimulus (orthol og); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 319 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18624887 | ERBB2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits Hsp90 protein binding (ortholog); protein tyrosine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to mechanical stimulus (orthol og); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Green Monkey | 320 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914099 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits coreceptor activity (ortholog); ErbB-3 class receptor binding (ortholog); growth factor binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell population proliferation (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Naked Mole-Rat | 320 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284055348 | erbb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626118204 | Erbb2 | erb-b2 receptor tyrosine kinase 2 | ENCODES a protein that exhibits coreceptor activity (ortholog); ErbB-3 class receptor binding (ortholog); growth factor binding (ortholog); INVOLVED IN axon regeneration (ortholog); cell population proliferation (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; endometrial cancer pathway; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); amblyopia (ortholog); Animal Disease Models (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Black Rat | 296 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285739690 | erbb2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288057137 | erbb2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1321970 | Pds5b | PDS5 cohesin associated factor B | Predicted to enable DNA binding activity. Acts upstream of or within lens development in camera-type eye. Predicted to be located in nucleoplasm. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid syste m; nervous system; and sensory organ. Orthologous to human PDS5B (PDS5 cohesin associated factor B). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 150597178 | 150734174 | Mouse | 205 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1352967 | TOB1 | transducer of ERBB2, 1 | This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple tran script variants. [provided by RefSeq, Aug 2011] | 17 | 50862223 | 50867978 | Human | 165 | name | gene, protein-coding, REVIEWED [RefSeq] |
| 8954174 | Tob1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (ortholog); SMAD binding (ortholog); transcription corepressor activity (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of cell population proliferation (ortholog); negative regulati on of nuclear-transcribed mRNA poly(A) tail shortening (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog) | NW_004955451 | 10950270 | 10963183 | Chinchilla | 27 | name | gene, protein-coding, MODEL [RefSeq] |
| 11812560 | TOB1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (inferred); SMAD binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); regulation of SMAD p rotein signal transduction (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | 17 | 44953343 | 44957465 | Bonobo | 33 | name | gene, protein-coding, MODEL [RefSeq] |
| 12692519 | Tob1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (inferred); SMAD binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); regulation of SMAD p rotein signal transduction (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | NW_004936490 | 10876113 | 10880267 | Squirrel | 32 | name | gene, protein-coding, MODEL [RefSeq] |
| 13982306 | TOB1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (ortholog); SMAD binding (ortholog); transcription corepressor activity (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of cell population proliferation (ortholog); negative regulati on of nuclear-transcribed mRNA poly(A) tail shortening (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 28 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18651519 | TOB1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (inferred); SMAD binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); regulation of SMAD p rotein signal transduction (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 33 | name | gene, protein-coding, MODEL [RefSeq] |
| 18929403 | Tob1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (inferred); SMAD binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); regulation of SMAD p rotein signal transduction (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 32 | name | gene, protein-coding, MODEL [RefSeq] |
| 39131546 | TOB1 | transducer of ERBB2, 1 | | | | | Chinchilla | | name | gene, protein-coding |
| 40910703 | TOB1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (inferred); SMAD binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); regulation of SMAD p rotein signal transduction (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred) | 9 | 26736805 | 26741119 | Dog | 32 | name | gene, protein-coding, MODEL [RefSeq] |
| 625896288 | Tob1 | transducer of ERBB2, 1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (ortholog); SMAD binding (ortholog); transcription corepressor activity (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of cell population proliferation (ortholog); negative regulati on of nuclear-transcribed mRNA poly(A) tail shortening (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog) | | | | Black Rat | 27 | name | gene, protein-coding, MODEL [RefSeq] |
| 1342508 | TOB2 | transducer of ERBB2, 2 | TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004] | 22 | 41433494 | 41446801 | Human | 123 | name | gene, protein-coding, VALIDATED [RefSeq] |
| 1359722 | Tob2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (ortholog); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); PARTICIPATES IN RNA degradation pathway; ASSOCIATED WITH vitiligo (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 7 | 115242843 | 115251563 | Rat | 111 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550938 | Tob2 | transducer of ERBB2, 2 | Enables nuclear vitamin D receptor binding activity. Acts upstream of or within negative regulation of osteoclast differentiation; positive regulation of ossification; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Meckel's cartilage; cerebral cortex; genitourinary system; lens; and orbito-sphenoid. Orthologous to human TOB2 (transducer of ERBB2, 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 81732471 | 81744742 | Mouse | 127 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9050621 | Tob2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (ortholog); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog) | NW_004955413 | 26999955 | 27010091 | Chinchilla | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 11824507 | TOB2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (ortholog); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog) | 22 | 22329783 | 22344795 | Bonobo | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 12081408 | TOB2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (inferred); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog) | 10 | 23817778 | 23830330 | Dog | 15 | name | gene, protein-coding, MODEL [RefSeq] |
| 12655807 | Tob2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (ortholog); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog); FOUND IN cytoplasm ( inferred); nucleus (inferred) | NW_004936492 | 467221 | 477838 | Squirrel | 15 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13961483 | TOB2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (inferred); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog) | | | | Pig | 15 | name | gene, protein-coding, MODEL [RefSeq] |
| 18559565 | TOB2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 18933547 | Tob2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 15 | name | gene, protein-coding, MODEL [RefSeq] |
| 625992936 | Tob2 | transducer of ERBB2, 2 | ENCODES a protein that exhibits nuclear vitamin D receptor binding (ortholog); INVOLVED IN negative regulation of osteoclast differentiation (ortholog); positive regulation of ossification (ortholog); regulation of gene expression (ortholog); ASSOCIATED WITH vitiligo (ortholog) | | | | Black Rat | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 1321667 | ERBIN | erbb2 interacting protein | This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 span> function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] | 5 | 65926575 | 66082546 | Human | 132 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1558339 | Erbin | Erbb2 interacting protein | Predicted to enable signaling receptor binding activity. Involved in negative regulation of monocyte chemotactic protein-1 production; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and regulation of postsynaptic membrane neurotransmitter re ceptor levels. Acts upstream of or within protein targeting. Located in basolateral plasma membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in cerebral cortex and retina nuclear layer. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 103955294 | 104057094 | Mouse | 143 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1562952 | Erbin | erbb2 interacting protein | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN cellular response to tumor necrosis factor (ortholog); negative regulation of monocyte chemotactic protein-1 production (ortholog); negative regulation of nucleotide-binding oligomerization domain containing 2 signali ng pathway (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN glutamatergic synapse; neuromuscular junction; postsynaptic specialization; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 2 | 36660399 | 36762584 | Rat | 149 | old_gene_name , name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 9049882 | Erbin | erbb2 interacting protein | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN cellular response to tumor necrosis factor (ortholog); negative regulation of monocyte chemotactic protein-1 production (ortholog); negative regulation of nucleotide-binding oligomerization domain containing 2 signali ng pathway (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell junction (ortholog); cytoplasm (ortholog) | NW_004955446 | 3046268 | 3151796 | Chinchilla | 35 | name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11747533 | ERBIN | erbb2 interacting protein | ENCODES a protein that exhibits protein kinase binding (inferred); signaling receptor binding (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic specialization (ortholog) | 5 | 47929305 | 48081381 | Bonobo | 51 | name | gene, protein-coding, MODEL [RefSeq] |
| 12220588 | ERBIN | erbb2 interacting protein | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic specialization (ortholog) | 2 | 51613344 | 51730868 | Dog | 41 | name | gene, protein-coding, MODEL [RefSeq] |
| 12445767 | Erbin | erbb2 interacting protein | ENCODES a protein that exhibits protein kinase binding (inferred); signaling receptor binding (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic specialization (ortholog) | NW_004936480 | 3155934 | 3293224 | Squirrel | 51 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13970760 | ERBIN | erbb2 interacting protein | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic specialization (ortholog) | | | | Pig | 48 | name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18716575 | ERBIN | erbb2 interacting protein | ENCODES a protein that exhibits protein kinase binding (inferred); signaling receptor binding (inferred); INVOLVED IN protein targeting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic specialization (ortholog) | | | | Green Monkey | 51 | name | gene, protein-coding, MODEL [RefSeq] |
| 18928498 | Erbin | erbb2 interacting protein | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN cellular response to tumor necrosis factor (ortholog); negative regulation of monocyte chemotactic protein-1 production (ortholog); protein targeting (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); pr ostate cancer (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); neuromuscular junction (ortholog) | | | | Naked Mole-Rat | 48 | name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 625999656 | Erbin | erbb2 interacting protein | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN cellular response to tumor necrosis factor (ortholog); negative regulation of monocyte chemotactic protein-1 production (ortholog); negative regulation of nucleotide-binding oligomerization domain containing 2 signali ng pathway (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); prostate cancer (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell junction (ortholog); cytoplasm (ortholog) | | | | Black Rat | 34 | name | gene, protein-coding, MODEL [RefSeq] |
| 1347878 | TOB2P1 | transducer of ERBB2, 2 pseudogene 1 | INTERACTS WITH 2-hydroxypropanoic acid; aflatoxin B1; all-trans-retinoic acid | 6 | 28215338 | 28218929 | Human | 13 | name | gene, pseudo, VALIDATED [RefSeq] |
| 1586288 | Tob2-ps1 | transducer of ERBB2, 2, pseudogene 1 | | 1 | 219845703 | 219846849 | Rat | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 731920 | Tob1 | transducer of ErbB-2.1 | Enables SMAD binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of SMAD protein signal transduction. Located in cytoplasm. Is expressed in several structur es, including 1st branchial arch; back skin; genitourinary system; limb; and sensory organ. Orthologous to human TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 94100668 | 94106321 | Mouse | 177 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 621126 | Tob1 | transducer of ErbB-2.1 | ENCODES a protein that exhibits receptor tyrosine kinase binding (ortholog); SMAD binding (ortholog); transcription corepressor activity (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of cell population proliferation (ortholog); negative regulati on of nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN RNA degradation pathway; ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate | 10 | 79659993 | 79662031 | Rat | 165 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1352306 | PGAP3 | post-GPI attachment to proteins phospholipase 3 | This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of t he constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017] | 17 | 39671122 | 39688057 | Human | 168 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1309929 | Memo1 | mediator of cell motility 1 | INVOLVED IN regulation of microtubule-based process (ortholog); INTERACTS WITH sodium chloride; 4,4'-sulfonyldiphenol (ortholog); cadmium atom (ortholog) | 6 | 26895497 | 26986248 | Rat | 16 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320537 | MEMO1 | mediator of cell motility 1 | Involved in regulation of microtubule-based process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 31867823 | 32011008 | Human | 18 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1552554 | Memo1 | mediator of cell motility 1 | Predicted to enable peptide binding activity. Predicted to be involved in regulation of microtubule-based process. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MEMO1 (mediator of ce ll motility 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 74493759 | 74602677 | Mouse | 74 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 731515 | NRG1 | neuregulin 1 | The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016] | 8 | 31639245 | 32774046 | Human | 580 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 9059226 | Btc | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway ( ortholog); ERBB4-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular space (ortholog) | NW_004955474 | 895573 | 946152 | Chinchilla | 39 | description | gene, protein-coding, MODEL [RefSeq] |
| 12310144 | BTC | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB4-ERBB4 signaling path way (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | 15 | 64133051 | 64159155 | Dog | 43 | description | gene, protein-coding, MODEL [RefSeq] |
| 18903782 | Btc | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB4-ERBB4 signaling path way (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 1310178 | Cpne3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to growth factor stimulus (ortholog); ERBB2 style='font-weight:700;'>ERBB2 signaling pathway (ortholog); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 5 | 37811566 | 37860840 | Rat | 135 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8929914 | Cpne3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to growth factor stimulus (ortholog); ERBB2 style='font-weight:700;'>ERBB2 signaling pathway (ortholog); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955417 | 4115298 | 4146878 | Chinchilla | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 11669000 | CPNE3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (inferred); calcium-dependent protein binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to calcium ion (inferred); cellular response to growth factor stimulus (inferred); ERBB2 ;'>ERBB2 signaling pathway (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (inferred); cytoplasm (inferred); cytosol (inferred) | 8 | 83209949 | 83257088 | Bonobo | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12329637 | CPNE3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (inferred); calcium-dependent protein binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to calcium ion (inferred); cellular response to growth factor stimulus (inferred); ERBB2 ;'>ERBB2 signaling pathway (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (inferred); cytoplasm (inferred); cytosol (inferred) | 29 | 32682019 | 32736871 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12593931 | Cpne3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (inferred); calcium-dependent protein binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to calcium ion (inferred); cellular response to growth factor stimulus (inferred); ERBB2 ;'>ERBB2 signaling pathway (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936544 | 1094257 | 1147964 | Squirrel | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 14220408 | CPNE3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (inferred); calcium-dependent protein binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to calcium ion (inferred); cellular response to growth factor stimulus (inferred); ERBB2 ;'>ERBB2 signaling pathway (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN anchoring junction (inferred); cell junction (inferred); cytoplasm (inferred) | | | | Pig | 44 | description | gene, protein-coding, MODEL [RefSeq] |
| 18663392 | CPNE3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (inferred); calcium-dependent protein binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to calcium ion (inferred); cellular response to growth factor stimulus (inferred); ERBB2 ;'>ERBB2 signaling pathway (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 625878154 | Cpne3 | copine 3 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to growth factor stimulus (ortholog); ERBB2 style='font-weight:700;'>ERBB2 signaling pathway (ortholog); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN cell junction (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 1315195 | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3 | This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] | 16 | 4425868 | 4456775 | Human | 183 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11955338 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog) | 4 | 102410724 | 102509691 | Bonobo | 155 | description | gene, protein-coding, MODEL [RefSeq] |
| 12168776 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog) | 32 | 30073541 | 30166904 | Dog | 156 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 13916117 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 158 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18687900 | EGF | epidermal growth factor | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PAR TICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 155 | description | gene, protein-coding, MODEL [RefSeq] |
| 10511 | Egfr | epidermal growth factor receptor | Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in ERBB2-EGFR signaling pathway; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferation. Acts upstream of or within se veral processes, including eyelid development in camera-type eye; protein modification process; and regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 16700153 | 16868158 | Mouse | 1900 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 736142 | Erbb3 | erb-b2 receptor tyrosine kinase 3 | Enables neuregulin receptor activity. Involved in ERBB2-ERBB3 signaling pathway; Schwann cell development; and myelination. Acts upstream of or within several processes, including negative regulation of motor neuron apoptotic process; nervous system development; and positive regulation of calcineurin-NFAT signaling cascade. Located in apical plasma membrane and lateral plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 128403392 | 128425504 | Mouse | 524 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11962137 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog) | 4 | 49806505 | 49827961 | Bonobo | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 12141175 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH bisphenol A | 13 | 62857325 | 62877831 | Dog | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 12504983 | Ereg | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog) | NW_004936598 | 1328803 | 1336141 | Squirrel | 75 | description | gene, protein-coding, MODEL [RefSeq] |
| 14027555 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 18571345 | EREG | epiregulin | ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB2-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH cholesteatoma (ortholog); erythropoietic protoporphyria (ortholog); Experimental Colitis (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 1552258 | Hbegf | heparin-binding EGF-like growth factor | Enables epidermal growth factor receptor binding activity; heparin binding activity; and signaling receptor activator activity. Involved in several processes, including ERBB2 signaling pathway; positive regulation of keratinocyte migration; and wound healing, sp reading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; heart; submandibular gland primordium; and telencephalon. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 36637980 | 36648858 | Mouse | 488 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 731429 | ITGA6 | integrin subunit alpha 6 | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] | 2 | 172427336 | 172506459 | Human | 348 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 8948702 | Map2k2 | mitogen-activated protein kinase kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); MAP-kinase scaffold activity (ortholog); INVOLVED IN epithelial cell proliferation involved in lung morphogenesis (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); breast cancer (ortholog); cardiofaciocutaneous syndrome (ortholog); FOUND IN cell cortex (ortholog); cell-cell junction (ortholog); cytoplasm (ortholog) | NW_004955495 | 4695239 | 4718380 | Chinchilla | 110 | description | gene, protein-coding, MODEL [RefSeq] |
| 11981791 | MAP2K2 | mitogen-activated protein kinase kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN epithelial cell proliferation involved in lung morphogenesis (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); E RK1 and ERK2 cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); breast cancer (ortholog); cardiofaciocutaneous syndrome (ortholog); FOUND IN cell cortex (ortholog); cytoplasm (ortholog) | 19 | 3114445 | 3148619 | Bonobo | 123 | description | gene, protein-coding, MODEL [RefSeq] |
| 12428789 | MAP2K2 | mitogen-activated protein kinase kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); MAP-kinase scaffold activity (ortholog); INVOLVED IN epithelial cell proliferation involved in lung morphogenesis (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); breast cancer (ortholog); cardiofaciocutaneous syndrome (ortholog); FOUND IN cell cortex (ortholog); cell-cell junction (ortholog); cytoplasmic side of plasma membrane (ortholog) | 20 | 55465460 | 55487629 | Dog | 133 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 14072870 | MAP2K2 | mitogen-activated protein kinase kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN epithelial cell proliferation involved in lung morphogenesis (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); E RK1 and ERK2 cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); breast cancer (ortholog); cardiofaciocutaneous syndrome (ortholog); FOUND IN cell cortex (ortholog); cytoplasm (ortholog); INTERACTS WITH Monobutylphthalate | | | | Pig | 115 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18900513 | Map2k2 | mitogen-activated protein kinase kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); MAP-kinase scaffold activity (ortholog); INVOLVED IN epithelial cell proliferation involved in lung morphogenesis (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); breast cancer (ortholog); cardiofaciocutaneous syndrome (ortholog); FOUND IN cell cortex (ortholog); cell-cell junction (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 127 | description | gene, protein-coding, MODEL [RefSeq] |
| 625936760 | Map2k2 | mitogen-activated protein kinase kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); MAP-kinase scaffold activity (ortholog); INVOLVED IN epithelial cell proliferation involved in lung morphogenesis (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); breast cancer (ortholog); cardiofaciocutaneous syndrome (ortholog); FOUND IN cell cortex (ortholog); cell-cell junction (ortholog); cytoplasm (ortholog) | | | | Black Rat | 106 | description | gene, protein-coding, MODEL [RefSeq] |
| 734341 | Myoc | myocilin | Enables receptor tyrosine kinase binding activity. Involved in several processes, including ERBB2-ERBB3 signaling pathway; neurogenesis; and skeletal muscle hypertrophy. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; an d node of Ranvier. Is expressed in several structures, including brain; eye; genitourinary system; lung; and meninges. Used to study open-angle glaucoma. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 162466719 | 162477263 | Mouse | 208 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1612360 | Nrg2 | neuregulin 2 | Enables receptor ligand activity. Involved in ERBB2-ERBB3 signaling pathway and ERBB4-ERBB4 signaling pathway. Is active in extracellular space. Is expressed in epidermis; heart; mammary gland primordium; nervous system; and surface ectoderm. Orthologous to huma n NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 36147634 | 36332754 | Mouse | 132 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8813137 | Nrg2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | NW_004955418 | 548624 | 793861 | Chinchilla | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 11891171 | NRG2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | 5 | 135212496 | 135411469 | Bonobo | 39 | description | gene, protein-coding, MODEL [RefSeq] |
| 12362760 | NRG2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | 2 | 35085192 | 35264509 | Dog | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 12670916 | Nrg2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | NW_004936531 | 8884565 | 9064541 | Squirrel | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 14250438 | NRG2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18516648 | NRG2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 39 | description | gene, protein-coding, MODEL [RefSeq] |
| 18918917 | Nrg2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 626115651 | Nrg2 | neuregulin 2 | ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ort holog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 29 | description | gene, protein-coding, MODEL [RefSeq] |
| 620780 | Ptprr | protein tyrosine phosphatase, receptor type, R | ENCODES a protein that exhibits protein kinase binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN nervous system development; neuron differentiation; ERBB2 signaling pathway (ortholog); PARTICIPATES IN mitogen activated protein kin ase signaling pathway; FOUND IN cell junction (ortholog); cytosol (ortholog); plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 7 | 53548611 | 53815632 | Rat | 135 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8854175 | Ptprr | protein tyrosine phosphatase receptor type R | ENCODES a protein that exhibits protein kinase binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN ERBB2 signaling pathway (ortholog); in utero embryonic development (ortholog); negative regulation of epithelial cell migration (orth olog); FOUND IN cell junction (ortholog); cytosol (ortholog); plasma membrane (ortholog) | NW_004955405 | 10767548 | 11133695 | Chinchilla | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 18904493 | Ptprr | protein tyrosine phosphatase receptor type R | ENCODES a protein that exhibits hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); protein kinase binding (inferred); INVOLVED IN ERBB2 signaling pathway (ortholog); in utero embryonic development (ortholog); negative regulation of ep ithelial cell migration (ortholog); FOUND IN cell junction (inferred); cytosol (inferred); endomembrane system (inferred) | | | | Naked Mole-Rat | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 626096173 | Ptprr | protein tyrosine phosphatase receptor type R | ENCODES a protein that exhibits protein kinase binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN ERBB2 signaling pathway (ortholog); in utero embryonic development (ortholog); negative regulation of epithelial cell migration (orth olog); FOUND IN cell junction (ortholog); cytosol (ortholog); plasma membrane (ortholog) | | | | Black Rat | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 11826938 | TGFA | transforming growth factor alpha | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PARTICIPATES IN altered epidermal gr owth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | 2A | 70510727 | 70617628 | Bonobo | 84 | description | gene, protein-coding, MODEL [RefSeq] |
| 12516463 | Tgfa | transforming growth factor alpha | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PARTICIPATES IN altered epidermal gr owth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | NW_004936491 | 14659089 | 14758614 | Squirrel | 85 | description | gene, protein-coding, MODEL [RefSeq] |
| 18533950 | TGFA | transforming growth factor alpha | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); PARTICIPATES IN altered epidermal gr owth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 84 | description | gene, protein-coding, MODEL [RefSeq] |
