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Gene: TOB1 (transducer of ERBB2, 1) Chlorocebus sabaeus

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Symbol:

TOB1

Name:

transducer of ERBB2, 1

RGD ID:

18651519

Description:

ENCODES a protein that exhibits receptor tyrosine kinase binding (inferred); SMAD binding (inferred); transcription corepressor activity (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); regulation of SMAD protein signal transduction (ortholog); ASSOCIATED WITH Chloracne (ortholog); endometriosis (ortholog); Experimental Neoplasms (ortholog); FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protein Tob1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TOB1 (transducer of ERBB2, 1)	NCBI	Ortholog
Mus musculus (house mouse):	Tob1 (transducer of ErbB-2.1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tob1 (transducer of ErbB-2.1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tob1 (transducer of ERBB2, 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TOB1 (transducer of ERBB2, 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TOB1 (transducer of ERBB2, 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tob1 (transducer of ERBB2, 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TOB1 (transducer of ERBB2, 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tob1 (transducer of ERBB2, 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	42,479,823 - 42,483,964 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	42,482,161 - 42,483,198 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	13,193,189 - 13,197,338 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chloracne (ISO)

endometriosis (ISO)

Experimental Neoplasms (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of BMP signaling pathway (IEA,ISO)

negative regulation of cell population proliferation (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of nuclear-transcribed mRNA poly(A) tail shortening (IEA)

negative regulation of osteoblast differentiation (IEA,ISO)

negative regulation of translation (IEA)

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (IEA)

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (IEA)

regulation of gene expression (IEA)

regulation of SMAD protein signal transduction (IEA,ISO)

Cellular Component

CCR4-NOT complex (IEA)

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

protein binding (ISO)

receptor tyrosine kinase binding (IEA)

SMAD binding (IEA)

transcription corepressor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

TOB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	42,479,823 - 42,483,964 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	42,482,161 - 42,483,198 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	13,193,189 - 13,197,338 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TOB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	50,862,223 - 50,867,978 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	50,862,223 - 50,867,978 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	48,939,584 - 48,945,339 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	46,294,583 - 46,296,412 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	46,294,587 - 46,296,412	NCBI
Celera	17	45,400,917 - 45,402,746 (-)	NCBI		Celera
Cytogenetic Map	17	q21.33	NCBI
HuRef	17	44,306,934 - 44,312,696 (-)	NCBI		HuRef
CHM1_1	17	49,003,687 - 49,009,428 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	51,729,361 - 51,735,122 (-)	NCBI		T2T-CHM13v2.0

Tob1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	94,100,668 - 94,106,321 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	94,102,280 - 94,106,321 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	94,209,842 - 94,215,495 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	94,211,454 - 94,215,495 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	94,072,768 - 94,076,809 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	94,027,544 - 94,031,585 (+)	NCBI		MGSCv36	mm8
Celera	11	103,828,614 - 103,832,645 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	58.9	NCBI

Tob1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	79,659,993 - 79,662,031 (+)	NCBI		GRCr8
mRatBN7.2	10	79,163,093 - 79,165,131 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	79,160,154 - 79,165,215 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	83,768,159 - 83,770,193 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	83,266,284 - 83,268,318 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	78,780,630 - 78,782,672 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	81,913,689 - 81,915,727 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	81,913,689 - 81,915,716 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	81,746,516 - 81,748,554 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	82,852,405 - 82,854,443 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	82,866,780 - 82,868,808 (+)	NCBI
Celera	10	77,952,276 - 77,954,314 (+)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

Tob1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955451	10,950,270 - 10,963,183 (+)	NCBI	ChiLan1.0	ChiLan1.0

TOB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	67,050,939 - 67,055,128 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	71,857,996 - 71,862,123 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	44,953,343 - 44,957,465 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	49,824,888 - 49,829,036 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	49,825,646 - 49,826,683 (-)	Ensembl	panpan1.1		panPan2

TOB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	26,736,805 - 26,741,119 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	26,736,675 - 26,740,177 (-)	NCBI	CanFam3.1		canFam3	CanFam3.1
CanFam3.1 Ensembl	9	26,736,675 - 26,740,177 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	9	27,530,721 - 27,535,333 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	27,530,072 - 27,534,149 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	26,297,583 - 26,302,193 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	26,556,087 - 26,561,276 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	26,686,955 - 26,691,484 (-)	NCBI		UU_Cfam_GSD_1.0

Tob1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	26,195,594 - 26,199,037 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	10,876,113 - 10,880,256 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	10,876,113 - 10,880,267 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	27,116,584 - 27,117,614 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	27,116,579 - 27,119,906 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	27,309,991 - 27,311,177 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tob1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	6,689,005 - 6,693,582 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	6,689,005 - 6,693,580 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008011460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000017993 ⟹ ENSCSAP00000017463

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	42,482,161 - 42,483,198 (+)	Ensembl

RefSeq Acc Id:

XM_008011460 ⟹ XP_008009651

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	42,479,823 - 42,483,964 (+)	NCBI
Vero_WHO_p1.0	NW_023666077	13,193,189 - 13,197,338 (+)	NCBI

Sequence:

show sequence

GAGTGAAGCTCTGGCCCGGCGTGGAGCGGGCGCACTACGGGGACGCTGGGCCGGGCACCGGGCT
GTGTGGAGAAGTGAGCGCGCTCGTCTGACCCCCGCGCCCGCCACCCCGAGCCACCATCGGCGAG
CTCCCAAGGCCCGCCCGAGGCCTCCGTCCTCTGCCCTCAGCCCCGCAGCGGCGACGTCTTGCAC
TCGGCGAGCTCGCCGCTCCCGACCCTCCCGCGCCCCCGCCCTGCCGCGCTGCTCCCCGCCCAGC
CGCGGGTCTGTGGTCCAAGCCGCCCCGAAGCAGCCCGAACAAGATCACTCAAGGTGAAGGATAA
TCTACTAATACCAGCACTTTGAATGAAAATTTGTTTCTCTGCCACAAACTGAACTTTTTTTTTT
TTTTTTTTTTTTGGTGGGGGAGTTGAAACCTAATTTTGTGGCGTAGCAGCTATGCAGCTTGAAA
TCCAAGTAGCACTAAATTTTATTATTTCATATTTGTACAATAAGCTTCCCAGGAGACGTGTCAA
CATTTTTGGTGAAGAACTTGAAAGACTTCTTAAGAAGAAATATGAAGGGCACTGGTATCCTGAA
AAGCCATACAAAGGATCGGGGTTTAGATGTATACACATAGGGGAGAAAGTGGACCCAGTGATTG
AACAAGCATCCAAAGAGAGTGGTTTGGACATTGATGATGTTCGTGGCAATCTGCCACAGGATCT
TAGTGTTTGGATCGACCCATTTGAGGTTTCTTACCAAATTGGTGAAAAGGGACCAGTGAAGGTG
CTTTACGTGGATGATAATAATGAAAATGGATGTGAGTTGGATAAGGAGATCAAAAACAGCTTTA
ACCCAGAGGCCCAGGTTTTTATGCCCATAAGTGACCCAGCCTCATCAGTGTCCAGCTCTCCATC
GCCTCCTTTTGGTCACTCTGCTGCTGTAAGCCCTACCTTCATGCCCCGGTCCACTCAGCCTTTA
ACCTTTACCACTGCCACTTTTGCTGCCACCAAGTTTGGCTCTACCAAAATGAAGAATAGCGGCC
GTAGCAACAAGGTTGCACGTACTTCTCCTATCAACCTCGGCTTGAATGTGAATGACCTCTTGAA
GCAGAAAGCCATCTCTTCCTCAATGCACTCTCTGTATGGGCTTGGCTTGGGTAGCCAGCAGCAG
CCACAGCAACAGCAGCAGCCAGCCCAGCCGCCACCGCCACCACCACCACCACAGCAGCAACAAC
AGCAGAAAACCTCTGCTCTTTCTCCTAATGCCAAGGAATTTATTTTTCCTAATATGCAGGGTCA
AGGTAGTAGTACCAATGGAATGTTCCCAGGTGACAGCCCCCTTAACCTCAGTCCTCTCCAGTAC
AGTAATGCCTTTGATGTGTTTGCGGCCTATGGAGGCCTCAATGAGAAGTCTTTTGTAGATGGCT
TGAATTTTAGCTTAAATAACATGCAGTATTCTAACCAGCAATTCCAGCCTGTTATGGCTAACTA
AAAAAAAGAAAATGTATCGTACAAGTTAAAATGCACGGGCCCAAGGGGGATTTTGTTGTTTTTT
TTTTTACCTCCTTGAGAAATTTTTTTTTAAGCTTATAGTAAGGATACATTCAAGCTTGGTTAAA
AAAATAATAAAACATGCATCATTTTTCATTTGCCAACCAAGCACAAAGTTATTTTATACTGACT
GTATATTTTAAAGTATACTCTCAGATATGGCCTCTTACAGTATTTAAGATATAGCAAGGACATG
GCTGATTTTTTTTTTTTATAAAAATTGGCACTAATAAGTGGGTTTATTGGTCTTTTCTAATTGT
ATAATTTAATTTAGTACAAAGTTTGTAAAATATCAGAGGATATATATATATTGTTTCTACGACA
TGGTATTGCATTTATATCTTTTTACTACAGTGATCTGTGACAGCAGCAGCTTCATGTTGTATTT
TTTTTACTGAAATTGTACAATATCCATCTTAAAGACATCAACTATTCTAAAAATTGTGTACAGG
ATATTCCTTTAGTGGTGGAATTAAAATGTACGAATATTTGCTTTTTTCAAAAAAATGTATTTTC
TGTTAAAAGTTTAAAGATTTTTGCTATATATTATGGAAGAAAAATGTAATCGTAAATATTAATT
TTGTACCTATATTGTGCAATACTTGAAAAAAAGGTATAAAAAAGTATTTTGAGTCAGTGTCTTA
CATGTTAAGAGGGACTGAAATAGTTTATATTAAGTTTGTATTAAAATTCTTTAAAATTAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008009651	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017463
	ENSCSAP00000017463.1

RefSeq Acc Id:	XP_008009651 ⟸ XM_008011460
- UniProtKB:	A0A0D9S9C4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000017463 ⟸ ENSCSAT00000017993

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000542	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017993.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.640.90	UniProtKB/TrEMBL
InterPro	Anti_prolifrtn	UniProtKB/TrEMBL
	BTG-like_sf	UniProtKB/TrEMBL
	Tob1/2	UniProtKB/TrEMBL
KEGG Report	csab:103242916	UniProtKB/TrEMBL
NCBI Gene	TOB1	ENTREZGENE
PANTHER	PTHR17537	UniProtKB/TrEMBL
	PTHR17537:SF6	UniProtKB/TrEMBL
Pfam	BTG	UniProtKB/TrEMBL
PRINTS	ANTIPRLFBTG1	UniProtKB/TrEMBL
PROSITE	BTG_1	UniProtKB/TrEMBL
	BTG_2	UniProtKB/TrEMBL
SMART	btg1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF160696	UniProtKB/TrEMBL
UniProt	A0A0D9S9C4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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