NRG2 (neuregulin 2) - Rat Genome Database

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Gene: NRG2 (neuregulin 2) Chlorocebus sabaeus
Analyze
Symbol: NRG2
Name: neuregulin 2
RGD ID: 18516648
Description: ENCODES a protein that exhibits epidermal growth factor receptor activity (ortholog); epidermal growth factor receptor binding (ortholog); ErbB-3 class receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 31 (ortholog); familial adenomatous polyposis 1 (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pro-neuregulin-2, membrane-bound isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12342,498,367 - 42,694,330 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2342,499,503 - 42,692,968 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603435,126,483 - 35,386,932 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NRG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12342,498,367 - 42,694,330 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2342,499,503 - 42,692,968 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603435,126,483 - 35,386,932 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NRG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385139,846,781 - 140,043,299 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5139,846,779 - 140,043,299 (-)EnsemblGRCh38hg38GRCh38
GRCh375139,226,366 - 139,422,884 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,207,444 - 139,403,063 (-)NCBINCBI36Build 36hg18NCBI36
Celera5135,301,792 - 135,498,704 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5134,369,651 - 134,566,061 (-)NCBIHuRef
CHM1_15138,659,474 - 138,855,994 (-)NCBICHM1_1
T2T-CHM13v2.05140,371,883 - 140,568,402 (-)NCBIT2T-CHM13v2.0
Nrg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391836,147,634 - 36,332,754 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1836,150,705 - 36,330,433 (-)EnsemblGRCm39 Ensembl
GRCm381836,014,581 - 36,197,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,017,652 - 36,197,380 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,177,303 - 36,356,814 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361836,177,303 - 36,356,814 (-)NCBIMGSCv36mm8
Celera1836,474,450 - 36,653,084 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.38NCBI
Nrg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81827,890,578 - 28,072,538 (-)NCBIGRCr8
mRatBN7.21827,616,542 - 27,798,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1827,619,661 - 27,798,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1827,743,902 - 27,925,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01828,505,789 - 28,687,737 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01827,840,647 - 28,022,647 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01828,835,391 - 29,015,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1828,835,417 - 29,015,552 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01828,544,864 - 28,724,922 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41828,650,097 - 28,828,772 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11828,676,749 - 28,855,418 (-)NCBI
Celera1827,350,962 - 27,529,758 (-)NCBICelera
Cytogenetic Map18p11NCBI
Nrg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955418548,624 - 793,861 (+)NCBIChiLan1.0ChiLan1.0
NRG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24135,109,036 - 135,304,138 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15133,248,589 - 133,444,133 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05135,212,496 - 135,411,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15141,333,911 - 141,528,420 (-)NCBIpanpan1.1PanPan1.1panPan2
NRG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1235,085,192 - 35,264,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl235,085,361 - 35,264,378 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,188,379 - 32,434,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0235,540,482 - 35,786,931 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl235,540,758 - 35,596,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1232,592,831 - 32,839,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,459,495 - 33,706,597 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,211,046 - 34,457,510 (-)NCBIUU_Cfam_GSD_1.0
Nrg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213152,546,964 - 152,728,032 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365318,884,642 - 9,064,869 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365318,884,565 - 9,064,541 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2141,662,369 - 141,824,727 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12141,660,936 - 141,825,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22147,549,110 - 147,575,155 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nrg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474332,620,295 - 32,810,391 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474332,620,025 - 32,810,990 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 9
Low 36 14 51
Below cutoff 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011016   ⟹   ENSCSAP00000009099
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2342,499,503 - 42,692,968 (-)Ensembl
RefSeq Acc Id: XM_008014662   ⟹   XP_008012853
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12342,498,367 - 42,694,330 (-)NCBI
Vero_WHO_p1.0NW_02366603435,191,722 - 35,386,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008014663   ⟹   XP_008012854
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12342,498,367 - 42,694,330 (-)NCBI
Vero_WHO_p1.0NW_02366603435,191,723 - 35,386,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008014664   ⟹   XP_008012855
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12342,498,367 - 42,694,330 (-)NCBI
Vero_WHO_p1.0NW_02366603435,191,722 - 35,386,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038009461   ⟹   XP_037865389
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603435,126,483 - 35,386,087 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008012853 (Get FASTA)   NCBI Sequence Viewer  
  XP_008012854 (Get FASTA)   NCBI Sequence Viewer  
  XP_008012855 (Get FASTA)   NCBI Sequence Viewer  
  XP_037865389 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009099
  ENSCSAP00000009099.1
Reference Protein Sequences
RefSeq Acc Id: XP_008012855   ⟸   XM_008014664
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RKG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008012853   ⟸   XM_008014662
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RKG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008012854   ⟸   XM_008014663
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RKG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009099   ⟸   ENSCSAT00000011016
RefSeq Acc Id: XP_037865389   ⟸   XM_038009461
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RKG0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012979 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011016.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Neuregulin UniProtKB/TrEMBL
  Neuregulin_C UniProtKB/TrEMBL
NCBI Gene NRG2 ENTREZGENE
PANTHER PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM UniProtKB/TrEMBL
  PTHR11100 UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Neuregulin UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0D9RKG0 ENTREZGENE, UniProtKB/TrEMBL