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ONTOLOGY REPORT - ANNOTATIONS


Term:multivesicular body sorting pathway
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Accession:GO:0071985 term browser browse the term
Definition:A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.



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multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp5 charged multivesicular body protein 5 involved_in ISO (PMID:15644320) RGD PMID:15644320 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529
JBrowse link
G Exph5 exophilin 5 involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:19966785)
UniProt
RGD
PMID:19966785 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:53,698,825...53,775,371
Ensembl chr 8:53,698,852...53,773,169
JBrowse link
G Mitd1 microtubule interacting and trafficking domain containing 1 NOT|involved_in ISO (PMID:23015756), (PMID:23045692) RGD PMID:23015756 PMID:23045692 NCBI chr 9:40,113,943...40,125,280
Ensembl chr 9:40,113,946...40,125,289
JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:19966785) RGD PMID:19966785 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G Rab27b RAB27B, member RAS oncogene family involved_in ISO (PMID:19966785) RGD PMID:19966785 NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180
JBrowse link
G Sytl4 synaptotagmin-like 4 involved_in ISO
IEA
(PMID:19966785)
GO_REF:0000107
RGD
Ensembl
PMID:19966785 GO_REF:0000107 NCBI chr  X:97,135,500...97,185,867
Ensembl chr  X:97,135,500...97,185,854
JBrowse link
G Vta1 vesicle trafficking 1 involved_in ISO (PMID:15644320) RGD PMID:15644320 NCBI chr 1:9,031,226...9,080,654
Ensembl chr 1:9,032,335...9,080,635
JBrowse link
endosome to lysosome transport via multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07028902.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Lyst lysosomal trafficking regulator involved_in ISO (PMID:9606205) RGD PMID:9606205 NCBI chr17:86,241,384...86,443,501 JBrowse link
G Mvb12a multivesicular body subunit 12A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:18,252,227...18,257,111
Ensembl chr16:18,252,222...18,257,539
JBrowse link
G Ubxn6 UBX domain protein 6 involved_in ISO (PMID:21822278) RGD PMID:21822278 NCBI chr 9:900,883...906,047
Ensembl chr 9:900,884...906,124
JBrowse link
G Vcp valosin-containing protein involved_in ISS
ISO
GO_REF:0000024
(PMID:21822278)
UniProt
RGD
PMID:21822278 GO_REF:0000024 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:15024011) RGD PMID:15024011 NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229
JBrowse link
endosome transport via multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp1a charged multivesicular body protein 1A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436
JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452
JBrowse link
G Chmp2b charged multivesicular body protein 2B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:3,338,007...3,364,357
Ensembl chr11:3,337,494...3,385,181
JBrowse link
G Chmp3 charged multivesicular body protein 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959
JBrowse link
G Dennd10 DENN domain containing 10 involved_in ISO (PMID:30771381) RGD PMID:30771381 NCBI chr 1:259,950,928...259,974,456
Ensembl chr 1:259,950,866...259,974,455
JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta involved_in ISO
ISS
(PMID:25588945)
GO_REF:0000024
RGD
UniProt
PMID:25588945 GO_REF:0000024 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383
JBrowse link
G RGD1566265 similar to RIKEN cDNA 2610002M06 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,860,409...72,901,232
Ensembl chr  X:72,860,409...72,901,246
JBrowse link
G Rilp Rab interacting lysosomal protein involved_in ISO (PMID:17010938) RGD PMID:17010938 NCBI chr10:60,355,276...60,358,434
Ensembl chr10:60,355,278...60,358,781
JBrowse link
G Sort1 sortilin 1 involved_in ISO (PMID:11331584) RGD PMID:11331584 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
JBrowse link
late endosome to vacuole transport via multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp4b charged multivesicular body protein 4B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844
JBrowse link
G Chmp4bl1 chromatin modifying protein 4B-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:68,049,742...68,050,791
Ensembl chr 4:68,049,705...68,050,676
JBrowse link
G Chmp4c charged multivesicular body protein 4C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668
JBrowse link
G Chmp5 charged multivesicular body protein 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529
JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640
JBrowse link
G Chmp7 charged multivesicular body protein 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:44,790,983...44,806,216
Ensembl chr15:44,790,996...44,806,216
JBrowse link
G Leprot leptin receptor overlapping transcript involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:116,289,843...116,301,951
Ensembl chr 5:116,289,822...116,301,988
JBrowse link
G Leprotl1 leptin receptor overlapping transcript-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:58,040,934...58,053,600
Ensembl chr16:58,040,960...58,053,593
JBrowse link
G Tmem50a transmembrane protein 50A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:147,123,670...147,138,859
Ensembl chr 5:147,123,688...147,138,849
JBrowse link
G Tmem50b transmembrane protein 50B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:30,804,835...30,837,675
Ensembl chr11:30,804,837...30,837,661
JBrowse link
G Vta1 vesicle trafficking 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:9,031,226...9,080,654
Ensembl chr 1:9,032,335...9,080,635
JBrowse link
multivesicular body-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959
JBrowse link
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snf8 SNF8 subunit of ESCRT-II involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:80,984,337...80,996,724
Ensembl chr10:80,984,363...80,996,734
JBrowse link
G Stam signal transducing adaptor molecule involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467
JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,196,062...86,201,606 JBrowse link
G Vps28 VPS28 subunit of ESCRT-I involved_in IBA
IEA
PMID:21873635
GO_REF:0000104
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 7:108,341,989...108,345,837
Ensembl chr 7:108,341,989...108,345,837
JBrowse link
G Vps36 vacuolar protein sorting 36 homolog involved_in IEA
IBA
GO_REF:0000104
PMID:21873635
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr16:69,810,404...69,834,789
Ensembl chr16:69,808,193...69,834,810
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    cellular process 18252
      vesicle-mediated transport 1667
        multivesicular body sorting pathway 36
          endosome transport via multivesicular body sorting pathway + 31
Path 2
Term Annotations click to browse term
  biological_process 19390
    localization 6437
      establishment of localization 4853
        transport 4689
          vesicle-mediated transport 1667
            multivesicular body sorting pathway 36
              endosome transport via multivesicular body sorting pathway + 31
paths to the root