Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:multivesicular body sorting pathway
go back to main search page
Accession:GO:0071985 term browser browse the term
Definition:A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.


show annotations for term's descendants           Sort by:
multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp1a charged multivesicular body protein 1A involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436 		JBrowse link
G Chmp1b charged multivesicular body protein 1B involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr18:60,740,349...60,742,879 JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Chmp2b charged multivesicular body protein 2B involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr11:3,337,478...3,364,015
Ensembl chr11:3,337,494...3,385,181 		JBrowse link
G Chmp3 charged multivesicular body protein 3 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Chmp4b charged multivesicular body protein 4B involved_in ISO (PMID:16554368), (PMID:21975012) RGD PMID:16554368 PMID:21975012 NCBI chr 3:143,170,859...143,211,376
Ensembl chr 3:143,170,902...143,210,844 		JBrowse link
G Chmp4c charged multivesicular body protein 4C involved_in ISO
IEA		 (PMID:16554368)
GO_REF:0000107		 RGD
Ensembl		 PMID:16554368 GO_REF:0000107 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668 		JBrowse link
G Chmp5 charged multivesicular body protein 5 involved_in ISO (PMID:15644320), (PMID:16554368) RGD PMID:15644320 PMID:16554368 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529 		JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Chmp7 charged multivesicular body protein 7 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr15:44,790,983...44,806,216
Ensembl chr15:44,790,996...44,806,216 		JBrowse link
G Exph5 exophilin 5 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:19966785)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:19966785 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:53,698,825...53,775,371
Ensembl chr 8:53,698,852...53,773,169 		JBrowse link
G Mitd1 microtubule interacting and trafficking domain containing 1 NOT|involved_in ISO (PMID:23015756), (PMID:23045692) RGD PMID:23015756 PMID:23045692 NCBI chr 9:40,113,943...40,125,280
Ensembl chr 9:40,113,946...40,125,289 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:110,360,804...110,383,271
Ensembl chr 8:110,360,804...110,383,271 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:19966785) RGD PMID:19966785 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Rab27b RAB27B, member RAS oncogene family involved_in ISO (PMID:19966785) RGD PMID:19966785 NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180 		JBrowse link
G Ramp2 receptor activity modifying protein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in IEA
ISS
ISO		 GO_REF:0000104
GO_REF:0000024
(PMID:38423010)		 UniProt
RGD		 PMID:38423010 GO_REF:0000024 GO_REF:0000104 NCBI chr10:80,984,337...80,996,724
Ensembl chr10:80,984,363...80,996,734 		JBrowse link
G Sytl4 synaptotagmin-like 4 involved_in ISO
IEA		 (PMID:19966785)
GO_REF:0000107		 RGD
Ensembl		 PMID:19966785 GO_REF:0000107 NCBI chr  X:97,135,496...97,185,867
Ensembl chr  X:97,135,500...97,185,854 		JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:86,196,062...86,201,606
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Vta1 vesicle trafficking 1 involved_in ISO (PMID:15644320) RGD PMID:15644320 NCBI chr 1:9,032,861...9,080,635
Ensembl chr 1:9,032,335...9,080,635 		JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:86,202,552...86,219,655
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
endosome to lysosome transport via multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lyst lysosomal trafficking regulator involved_in ISO (PMID:9606205) RGD PMID:9606205 NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480 		JBrowse link
G Mvb12a multivesicular body subunit 12A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:18,252,227...18,257,111
Ensembl chr16:18,252,222...18,257,539 		JBrowse link
G Ubxn6 UBX domain protein 6 involved_in ISO (PMID:21822278) RGD PMID:21822278 NCBI chr 9:900,883...906,047
Ensembl chr 9:900,884...906,124 		JBrowse link
G Vcp valosin-containing protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:21822278)		 UniProt
RGD		 PMID:21822278 GO_REF:0000024 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:15024011) RGD PMID:15024011 NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
endosome transport via multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp1a charged multivesicular body protein 1A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436 		JBrowse link
G Chmp1b2 charged multivesicular body protein 1B2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:72,860,409...72,901,232
Ensembl chr  X:72,860,409...72,901,246 		JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Chmp2b charged multivesicular body protein 2B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:3,337,478...3,364,015
Ensembl chr11:3,337,494...3,385,181 		JBrowse link
G Chmp3 charged multivesicular body protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Dennd10 DENN domain containing 10 involved_in ISO (PMID:30771381) RGD PMID:30771381 NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455 		JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta involved_in ISO
IEA
ISS		 (PMID:25588945)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:25588945 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:65,434,525...65,477,386
Ensembl chr 7:65,434,394...65,477,383 		JBrowse link
G Rilp Rab interacting lysosomal protein involved_in ISO (PMID:17010938) RGD PMID:17010938 NCBI chr10:60,355,276...60,358,434
Ensembl chr10:60,355,278...60,358,781 		JBrowse link
G Sort1 sortilin 1 involved_in ISO
IEA		 (PMID:11331584)
GO_REF:0000107		 RGD
Ensembl		 PMID:11331584 GO_REF:0000107 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354 		JBrowse link
G Vps28 VPS28 subunit of ESCRT-I involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:108,341,989...108,345,837
Ensembl chr 7:108,341,989...108,345,837 		JBrowse link
late endosome to vacuole transport via multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp4b charged multivesicular body protein 4B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:143,170,859...143,211,376
Ensembl chr 3:143,170,902...143,210,844 		JBrowse link
G Chmp4bl1 chromatin modifying protein 4B-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:68,049,742...68,050,791
Ensembl chr 4:68,049,705...68,050,676 		JBrowse link
G Chmp4c charged multivesicular body protein 4C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668 		JBrowse link
G Chmp5 charged multivesicular body protein 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529 		JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Chmp7 charged multivesicular body protein 7 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:44,790,983...44,806,216
Ensembl chr15:44,790,996...44,806,216 		JBrowse link
G Leprot leptin receptor overlapping transcript involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:116,289,843...116,301,951
Ensembl chr 5:116,289,822...116,301,988 		JBrowse link
G Leprotl1 leptin receptor overlapping transcript-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:58,040,934...58,053,602
Ensembl chr16:58,040,960...58,053,593 		JBrowse link
G Tmem50a transmembrane protein 50A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:147,123,670...147,138,859
Ensembl chr 5:147,123,688...147,138,849 		JBrowse link
G Tmem50b transmembrane protein 50B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:30,804,835...30,837,675
Ensembl chr11:30,804,837...30,837,661 		JBrowse link
G Vta1 vesicle trafficking 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:9,032,861...9,080,635
Ensembl chr 1:9,032,335...9,080,635 		JBrowse link
multivesicular body-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 involved_in ISO (PMID:16554368) RGD PMID:16554368 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:110,360,804...110,383,271
Ensembl chr 8:110,360,804...110,383,271 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:80,984,337...80,996,724
Ensembl chr10:80,984,363...80,996,734 		JBrowse link
G Stam signal transducing adaptor molecule involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467 		JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:86,196,062...86,201,606
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Vps28 VPS28 subunit of ESCRT-I involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,341,989...108,345,837
Ensembl chr 7:108,341,989...108,345,837 		JBrowse link
G Vps36 vacuolar protein sorting 36 homolog involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr16:69,810,404...69,834,789
Ensembl chr16:69,808,193...69,834,810 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19870
    cellular process 18312
      vesicle-mediated transport 1634
        multivesicular body sorting pathway 40
          endosome transport via multivesicular body sorting pathway + 31
Path 2
Term Annotations click to browse term
  biological_process 19870
    localization 5634
      establishment of localization 4940
        transport 4626
          vesicle-mediated transport 1634
            multivesicular body sorting pathway 40
              endosome transport via multivesicular body sorting pathway + 31
paths to the root