Dennd10 (DENN domain containing 10) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dennd10 (DENN domain containing 10) Rattus norvegicus
Analyze
Symbol: Dennd10
Name: DENN domain containing 10
RGD ID: 1308326
Description: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Predicted to be active in late endosome. Orthologous to several human genes including DENND10 (DENN domain containing 10); INTERACTS WITH bisphenol A; clozapine; flutamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DENN domain-containing protein 10; Fam45a; family with sequence similarity 45, member A; hypothetical protein LOC308009; LOC308009; RGD1308326; similar to RIKEN cDNA 1810055E12; uncharacterized protein LOC308009
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,937,023 - 269,960,506 (+)NCBIGRCr8
mRatBN7.21259,950,955 - 259,974,459 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,950,866 - 259,974,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1268,157,895 - 268,181,155 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,863,921 - 274,887,181 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,518,241 - 267,541,489 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,188,080 - 282,211,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,188,110 - 282,210,580 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,526,625 - 289,550,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,417,683 - 267,441,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,628,755 - 267,652,267 (+)NCBI
Celera1255,592,048 - 255,615,542 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
late endosome  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:30771381  


Genomics

Comparative Map Data
Dennd10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,937,023 - 269,960,506 (+)NCBIGRCr8
mRatBN7.21259,950,955 - 259,974,459 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,950,866 - 259,974,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1268,157,895 - 268,181,155 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,863,921 - 274,887,181 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,518,241 - 267,541,489 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,188,080 - 282,211,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,188,110 - 282,210,580 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,526,625 - 289,550,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,417,683 - 267,441,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,628,755 - 267,652,267 (+)NCBI
Celera1255,592,048 - 255,615,542 (+)NCBICelera
Cytogenetic Map1q55NCBI
DENND10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,104,113 - 119,137,984 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,104,086 - 119,137,984 (+)EnsemblGRCh38hg38GRCh38
GRCh3710120,863,625 - 120,897,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,853,601 - 120,887,213 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410120,853,600 - 120,887,212NCBI
Celera10114,594,076 - 114,626,795 (+)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10114,500,242 - 114,526,453 (+)NCBIHuRef
CHM1_110121,148,027 - 121,181,603 (+)NCBICHM1_1
T2T-CHM13v2.010119,999,563 - 120,033,391 (+)NCBIT2T-CHM13v2.0
Dennd10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,800,029 - 60,824,673 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,800,023 - 60,824,665 (+)EnsemblGRCm39 Ensembl
GRCm381960,811,555 - 60,836,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,811,585 - 60,836,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371960,887,473 - 60,912,135 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361960,866,274 - 60,890,890 (+)NCBIMGSCv36mm8
Celera1963,021,151 - 63,045,424 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
Dennd10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543123,600,589 - 23,624,292 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543123,601,338 - 23,623,852 (+)NCBIChiLan1.0ChiLan1.0
DENND10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28130,965,817 - 130,996,749 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110130,971,182 - 131,002,103 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010115,677,737 - 115,708,548 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110119,112,394 - 119,132,778 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,101,448 - 119,131,446 (+)Ensemblpanpan1.1panPan2
DENND10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,325,721 - 29,369,218 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,326,014 - 29,367,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,469,452 - 29,511,222 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02829,858,116 - 29,899,872 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,858,080 - 29,900,284 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,412,004 - 29,454,285 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,431,880 - 29,473,803 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,626,164 - 29,668,069 (+)NCBIUU_Cfam_GSD_1.0
Dennd10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721316,985,646 - 17,004,348 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,557,017 - 8,578,856 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,556,954 - 8,575,113 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,007,239 - 129,056,763 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114129,007,209 - 129,048,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,538,041 - 140,572,707 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DENND10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,900,679 - 111,929,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604873,168,280 - 73,199,750 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dennd10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473727,647,121 - 27,668,858 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473727,634,338 - 27,668,829 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dennd10
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:752
Count of miRNA genes:281
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000013845
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
737975Bw122Body weight QTL 1229.110.005body mass (VT:0001259)body weight (CMO:0000012)1258843780260122809Rat
71112Bw115Body weight QTL 11560.0001body mass (VT:0001259)body weight (CMO:0000012)1259647732260522016Rat

Markers in Region
BE109682  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21259,973,238 - 259,973,434 (+)MAPPERmRatBN7.2
Rnor_6.01282,210,369 - 282,210,564NCBIRnor6.0
Rnor_5.01289,548,920 - 289,549,115UniSTSRnor5.0
RGSC_v3.41267,439,966 - 267,440,161UniSTSRGSC3.4
Celera1255,614,325 - 255,614,520UniSTS
RH 3.4 Map11704.6UniSTS
Cytogenetic Map1q55UniSTS
RH138686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21259,974,256 - 259,974,392 (+)MAPPERmRatBN7.2
Rnor_6.01282,211,387 - 282,211,522NCBIRnor6.0
Rnor_5.01289,549,938 - 289,550,073UniSTSRnor5.0
RGSC_v3.41267,440,984 - 267,441,119UniSTSRGSC3.4
Celera1255,615,343 - 255,615,478UniSTS
RH 3.4 Map11711.1UniSTS
Cytogenetic Map1q55UniSTS
RH138824  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21259,969,638 - 259,970,922 (+)MAPPERmRatBN7.2
Rnor_6.01282,206,769 - 282,208,052NCBIRnor6.0
Rnor_5.01289,545,320 - 289,546,603UniSTSRnor5.0
RGSC_v3.41267,436,366 - 267,437,649UniSTSRGSC3.4
Celera1255,610,725 - 255,612,008UniSTS
RH 3.4 Map11706.8UniSTS
Cytogenetic Map1q55UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 53 37 19 37 2 3 74 35 34 11 2
Low 17 4 4 4 6 8 7 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000013845   ⟹   ENSRNOP00000013845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1259,950,866 - 259,974,455 (+)Ensembl
Rnor_6.0 Ensembl1282,188,110 - 282,210,580 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108463   ⟹   ENSRNOP00000094983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1259,952,993 - 259,974,455 (+)Ensembl
RefSeq Acc Id: NM_001127681   ⟹   NP_001121153
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81269,937,023 - 269,960,506 (+)NCBI
mRatBN7.21259,950,976 - 259,974,459 (+)NCBI
Rnor_6.01282,188,086 - 282,211,586 (+)NCBI
Rnor_5.01289,526,625 - 289,550,139 (+)NCBI
RGSC_v3.41267,417,683 - 267,441,183 (+)RGD
Celera1255,592,048 - 255,615,542 (+)RGD
Sequence:
RefSeq Acc Id: NM_001398802   ⟹   NP_001385731
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81269,937,023 - 269,960,506 (+)NCBI
mRatBN7.21259,950,976 - 259,974,459 (+)NCBI
RefSeq Acc Id: XM_063288305   ⟹   XP_063144375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81269,939,785 - 269,960,502 (+)NCBI
RefSeq Acc Id: NP_001121153   ⟸   NM_001127681
- Peptide Label: isoform 2
- UniProtKB: A6JIA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013845   ⟸   ENSRNOT00000013845
RefSeq Acc Id: ENSRNOP00000094983   ⟸   ENSRNOT00000108463
RefSeq Acc Id: NP_001385731   ⟸   NM_001398802
- Peptide Label: isoform 1
- UniProtKB: A6JIA6 (UniProtKB/TrEMBL),   F1LNS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144375   ⟸   XM_063288305
- Peptide Label: isoform X1
Protein Domains
uDENN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LNS2-F1-model_v2 AlphaFold F1LNS2 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691022
Promoter ID:EPDNEW_R1547
Type:initiation region
Name:Fam45a_1
Description:family with sequence similarity 45, member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,188,107 - 282,188,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308326 AgrOrtholog
BioCyc Gene G2FUF-55222 BioCyc
Ensembl Genes ENSRNOG00000010230 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013845 ENTREZGENE
  ENSRNOT00000013845.8 UniProtKB/TrEMBL
  ENSRNOT00000108463.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7388963 IMAGE-MGC_LOAD
InterPro FAM45 UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
KEGG Report rno:308009 UniProtKB/TrEMBL
MGC_CLONE MGC:189440 IMAGE-MGC_LOAD
NCBI Gene 308009 ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 10-RELATED UniProtKB/TrEMBL
  PTHR28544 UniProtKB/TrEMBL
Pfam SPA UniProtKB/TrEMBL
PhenoGen Dennd10 PhenoGen
PROSITE DENN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010230 RatGTEx
UniProt A0A8I6AM52_RAT UniProtKB/TrEMBL
  A6JIA6 ENTREZGENE, UniProtKB/TrEMBL
  A6JIA9 ENTREZGENE, UniProtKB/TrEMBL
  F1LNS2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-02 Dennd10  DENN domain containing 10  Fam45a  family with sequence similarity 45, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam45a  family with sequence similarity 45, member A  RGD1308326_predicted  similar to RIKEN cDNA 1810055E12 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308326_predicted  similar to RIKEN cDNA 1810055E12 (predicted)  LOC308009_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC308009_predicted  similar to RIKEN cDNA 1810055E12 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL