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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of Notch signaling pathway
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Accession:GO:0045746 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
Synonyms:exact_synonym: down regulation of Notch signaling pathway;   downregulation of Notch signaling pathway;   negative regulation of N signaling pathway;   negative regulation of N signalling pathway;   negative regulation of Notch signalling pathway
 narrow_synonym: inhibition of Notch signaling pathway


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negative regulation of Notch signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in TAS Reactome Reactome:R-HSA-9604328 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ARRB1 arrestin beta 1 involved_in IMP
IBA
IEA		 (PMID:23886940) UniProt
GO_Central
TreeGrafter		 PMID:23886940 GO_REF:0000033 GO_REF:0000118 NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705 		JBrowse link
G ARRDC1 arrestin domain containing 1 involved_in IMP (PMID:23886940) UniProt PMID:23886940 NCBI chr 9:137,605,686...137,615,360
Ensembl chr 9:137,605,685...137,615,360 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23160044) Ensembl
MGI		 PMID:23160044 GO_REF:0000107 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G BEND6 BEN domain containing 6 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:23571214) Ensembl
MGI
TreeGrafter
GO_Central
InterPro		 PMID:23571214 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:56,955,107...57,027,346
Ensembl chr 6:56,955,107...57,027,346 		JBrowse link
G BMP7 bone morphogenetic protein 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16324690) Ensembl
MGI		 PMID:16324690 GO_REF:0000107 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641 		JBrowse link
G CBFA2T2 CBFA2/RUNX1 partner transcriptional co-repressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:33,490,096...33,650,030
Ensembl chr20:33,490,075...33,650,036 		JBrowse link
G CCNC cyclin C involved_in IDA (PMID:25344755) ComplexPortal PMID:25344755 NCBI chr 6:99,542,387...99,568,814
Ensembl chr 6:99,542,387...99,568,825 		JBrowse link
G CDK3 cyclin dependent kinase 3 involved_in IDA (PMID:25344755) ComplexPortal PMID:25344755 NCBI chr17:76,000,855...76,005,998
Ensembl chr17:76,000,855...76,005,999 		JBrowse link
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 involved_in IMP (PMID:22445366) UniProt PMID:22445366 NCBI chr15:40,953,471...40,956,512
Ensembl chr15:40,952,962...40,956,512 		JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 involved_in
acts_upstream_of_or_within		 IDA
ISO
IEA
IBA		 (PMID:25093684)
(PMID:21419176)		 HGNC
MGI
TreeGrafter
GO_Central		 PMID:21419176 PMID:25093684 GO_REF:0000033 GO_REF:0000118 NCBI chr14:100,726,892...100,738,224
Ensembl chr14:100,725,705...100,738,224 		JBrowse link
G DLK2 delta like non-canonical Notch ligand 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IDA		 (PMID:21419176)
(PMID:25093684)		 Ensembl
MGI
HGNC		 PMID:21419176 PMID:25093684 GO_REF:0000107 NCBI chr 6:43,450,352...43,456,632
Ensembl chr 6:43,450,352...43,456,632 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:170,282,206...170,291,078
Ensembl chr 6:170,282,206...170,306,565 		JBrowse link
G DLL3 delta like canonical Notch ligand 3 involved_in ISO
IBA		 RGD
GO_Central		 PMID:16144902 GO_REF:0000033 RGD:1599776 NCBI chr19:39,498,947...39,508,469
Ensembl chr19:39,498,895...39,508,481 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 involved_in IEA
IBA
ISS		 Ensembl
GO_Central
TreeGrafter
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073 		JBrowse link
G DLX1 distal-less homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23042297) Ensembl
MGI		 PMID:23042297 GO_REF:0000107 NCBI chr 2:172,085,507...172,089,674
Ensembl chr 2:172,084,740...172,089,677 		JBrowse link
G DLX2 distal-less homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23042297) Ensembl
MGI		 PMID:23042297 GO_REF:0000107 NCBI chr 2:172,099,438...172,102,900
Ensembl chr 2:172,099,438...172,102,900 		JBrowse link
G EGFL7 EGF like domain multiple 7 acts_upstream_of_or_within IMP (PMID:20947685) MGI PMID:20947685 NCBI chr 9:136,658,856...136,672,678
Ensembl chr 9:136,658,856...136,672,678 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 4:152,320,544...152,536,092
Ensembl chr 4:152,320,544...152,536,092 		JBrowse link
G GATA2 GATA binding protein 2 acts_upstream_of_or_within IDA (PMID:16672344) MGI PMID:16672344 NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201 		JBrowse link
G GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 involved_in
acts_upstream_of_or_within		 ISO (MGI:5299268|PMID:21943603)
(PMID:21943603), (PMID:22951639)		 CACAO
MGI		 PMID:21943603 PMID:22951639 MGI:5299268 NCBI chr11:75,434,640...75,525,941
Ensembl chr11:75,434,640...75,525,941 		JBrowse link
G HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 acts_upstream_of_or_within ISO (PMID:26355680) MGI PMID:26355680 NCBI chr15:28,111,040...28,322,179
Ensembl chr15:28,111,040...28,322,179 		JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 involved_in IDA (PMID:18239137) BHF-UCL PMID:18239137 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269 		JBrowse link
G HIF1AN hypoxia inducible factor 1 subunit alpha inhibitor involved_in IDA
IBA
IEA		 (PMID:18299578) UniProt
GO_Central
TreeGrafter		 PMID:18299578 GO_REF:0000033 GO_REF:0000118 NCBI chr10:100,535,943...100,559,998
Ensembl chr10:100,529,072...100,559,998 		JBrowse link
G KCTD10 potassium channel tetramerization domain containing 10 acts_upstream_of_or_within ISO (PMID:25401743) MGI PMID:25401743 NCBI chr12:109,448,655...109,477,300
Ensembl chr12:109,448,655...109,477,359 		JBrowse link
G LRRK2 leucine rich repeat kinase 2 acts_upstream_of_or_within ISO (PMID:26355680) MGI PMID:26355680 NCBI chr12:40,224,997...40,369,285
Ensembl chr12:40,196,744...40,369,285 		JBrowse link
G MAGEA1 MAGE family member A1 involved_in IDA (PMID:15316101) UniProt PMID:15316101 NCBI chr  X:153,179,284...153,183,880
Ensembl chr  X:153,179,284...153,183,880 		JBrowse link
G MEG8 maternally expressed 8, small nucleolar RNA host gene acts_upstream_of_or_within ISO (PMID:29636669), (PMID:31711641) MGI PMID:29636669 PMID:31711641 NCBI chr14:100,889,649...100,999,113
Ensembl chr14:100,894,770...101,038,859 		JBrowse link
G METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in ISS UniProt GO_REF:0000024 NCBI chr14:21,498,138...21,511,340
Ensembl chr14:21,498,133...21,511,342 		JBrowse link
G MIR1224 microRNA 1224 involved_in IDA (PMID:28717225) BHF-UCL PMID:28717225 NCBI chr 3:184,241,405...184,241,489
Ensembl chr 3:184,241,405...184,241,489 		JBrowse link
G MMP14 matrix metallopeptidase 14 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041 		JBrowse link
G NEURL1 neuralized E3 ubiquitin protein ligase 1 involved_in IDA
IEA
IBA		 (PMID:20847082) UniProt
TreeGrafter
GO_Central		 PMID:20847082 GO_REF:0000033 GO_REF:0000118 NCBI chr10:103,493,705...103,592,546
Ensembl chr10:103,493,705...103,592,546 		JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15845452) Ensembl
MGI		 PMID:15845452 GO_REF:0000107 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NIBAN2 niban apoptosis regulator 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:127,505,343...127,579,031
Ensembl chr 9:127,505,339...127,578,989 		JBrowse link
G NOTCH4 notch receptor 4 acts_upstream_of_or_within ISO (PMID:24667410) MGI PMID:24667410 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067 		JBrowse link
G NRARP NOTCH regulated ankyrin repeat protein involved_in
acts_upstream_of_or_within		 IEA
IBA
IMP		 (PMID:19154719) Ensembl
GO_Central
MGI		 PMID:19154719 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:137,299,631...137,302,271
Ensembl chr 9:137,299,631...137,302,271 		JBrowse link
G NUMB NUMB endocytic adaptor protein acts_upstream_of_or_within ISO (PMID:21385765) MGI PMID:21385765 NCBI chr14:73,275,216...73,458,546
Ensembl chr14:73,275,107...73,458,617 		JBrowse link
G OVOL2 ovo like zinc finger 2 involved_in IDA (PMID:19700410) BHF-UCL PMID:19700410 NCBI chr20:18,024,152...18,059,188
Ensembl chr20:17,956,979...18,059,188 		JBrowse link
G RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO RGD PMID:11165380 RGD:633801 NCBI chr17:82,047,902...82,051,811
Ensembl chr17:82,047,902...82,051,831 		JBrowse link
G RITA1 RBPJ interacting and tubulin associated 1 involved_in IDA
IBA		 (PMID:21102556) UniProt
GO_Central		 PMID:21102556 GO_REF:0000033 NCBI chr12:113,185,721...113,192,368
Ensembl chr12:113,185,526...113,192,368 		JBrowse link
G SLC35C1 solute carrier family 35 member C1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20837470) Ensembl
MGI		 PMID:20837470 GO_REF:0000107 NCBI chr11:45,804,072...45,813,016
Ensembl chr11:45,804,072...45,813,016 		JBrowse link
G TCIM transcriptional and immune response regulator involved_in IDA
IBA		 (PMID:25985737) UniProt
GO_Central		 PMID:25985737 GO_REF:0000033 NCBI chr 8:40,153,482...40,155,310
Ensembl chr 8:40,153,482...40,155,310 		JBrowse link
G TSPAN15 tetraspanin 15 involved_in IDA (PMID:30463011) UniProt PMID:30463011 NCBI chr10:69,451,465...69,549,508
Ensembl chr10:69,451,465...69,507,666 		JBrowse link
G WWP2 WW domain containing E3 ubiquitin protein ligase 2 involved_in TAS Reactome Reactome:R-HSA-9021523 NCBI chr16:69,762,332...69,941,739
Ensembl chr16:69,762,328...69,941,741 		JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein F2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:28,736,624...28,769,775
Ensembl chr 1:28,736,621...28,769,775 		JBrowse link
G ZBTB7A zinc finger and BTB domain containing 7A involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:4,043,303...4,066,899
Ensembl chr19:4,043,303...4,066,899 		JBrowse link
negative regulation of Notch signaling pathway involved in somitogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:2,512,529...2,529,177
Ensembl chr 7:2,512,529...2,529,177 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    response to stimulus 10179
      negative regulation of response to stimulus 2025
        negative regulation of signal transduction 1585
          negative regulation of Notch signaling pathway 48
            negative regulation of Notch signaling pathway involved in somitogenesis 1
Path 2
Term Annotations click to browse term
  biological_process 19669
    biological regulation 13404
      regulation of biological process 13020
        signaling 7179
          signal transduction 6575
            cell surface receptor signaling pathway 3202
              Notch signaling pathway 209
                regulation of Notch signaling pathway 112
                  negative regulation of Notch signaling pathway 48
                    negative regulation of Notch signaling pathway involved in somitogenesis 1
paths to the root