FBXW7 (F-box and WD repeat domain containing 7) - Rat Genome Database
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Gene: FBXW7 (F-box and WD repeat domain containing 7) Homo sapiens
Analyze
Symbol: FBXW7
Name: F-box and WD repeat domain containing 7
RGD ID: 1347453
HGNC Page HGNC
Description: Exhibits several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular protein metabolic process; positive regulation of cellular protein metabolic process; and positive regulation of intracellular signal transduction. Localizes to several cellular components, including Parkin-FBXW7-Cul1 ubiquitin ligase complex; SCF ubiquitin ligase complex; and nuclear lumen.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGO; archipelago; archipelago homolog; archipelago, Drosophila, homolog of; CDC4; DKFZp686F23254; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; F-box/WD repeat-containing protein 7; FBW6; FBW7; FBX30; FBXO30; FBXW6; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL-10; SEL10
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4152,320,544 - 152,536,092 (-)EnsemblGRCh38hg38GRCh38
GRCh384152,320,544 - 152,536,873 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374153,241,696 - 153,457,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364153,461,860 - 153,675,622 (-)NCBINCBI36hg18NCBI36
Build 344153,601,099 - 153,690,635NCBI
Celera4150,566,189 - 150,779,958 (-)NCBI
Cytogenetic Map4q31.3NCBI
HuRef4148,968,491 - 149,182,492 (-)NCBIHuRef
CHM1_14153,220,162 - 153,434,185 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to DNA damage stimulus  (IDA)
cellular response to UV  (IDA)
lipid homeostasis  (ISS)
lung development  (IEA,ISO)
negative regulation of gene expression  (IGI,IMP)
negative regulation of hepatocyte proliferation  (ISS)
negative regulation of Notch signaling pathway  (ISS)
negative regulation of osteoclast development  (IMP,ISO)
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA,ISO)
negative regulation of SREBP signaling pathway  (ISS)
negative regulation of triglyceride biosynthetic process  (ISS)
Notch signaling pathway  (IEA,ISO)
positive regulation of epidermal growth factor-activated receptor activity  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IDA,ISO)
positive regulation of proteasomal protein catabolic process  (IDA,ISO)
positive regulation of protein targeting to mitochondrion  (IMP)
positive regulation of protein ubiquitination  (IDA)
positive regulation of ubiquitin-dependent protein catabolic process  (IDA,IMP,ISO)
positive regulation of ubiquitin-protein transferase activity  (IDA)
post-translational protein modification  (TAS)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IBA,IMP)
protein destabilization  (IEA,ISO)
protein polyubiquitination  (TAS)
protein stabilization  (IDA)
protein ubiquitination  (IDA)
regulation of autophagy of mitochondrion  (IMP)
regulation of cell cycle G1/S phase transition  (TAS)
regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
regulation of circadian rhythm  (IMP,ISO)
regulation of lipid storage  (ISS)
regulation of protein localization  (ISS)
rhythmic process  (IEA)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  (IDA,IMP,ISO)
sister chromatid cohesion  (IMP)
ubiquitin recycling  (IBA)
vasculature development  (TAS)
vasculogenesis  (IEA,ISO)
viral process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7829101   PMID:8125298   PMID:10531037   PMID:11425854   PMID:11461910   PMID:11533444   PMID:11565033   PMID:11565034   PMID:11585921   PMID:12183400   PMID:12354302   PMID:12477932  
PMID:12628165   PMID:12904573   PMID:14507635   PMID:14536078   PMID:14603323   PMID:14648662   PMID:14702039   PMID:14739463   PMID:14743216   PMID:14744259   PMID:14871801   PMID:14999283  
PMID:15070733   PMID:15103331   PMID:15150404   PMID:15364936   PMID:15467469   PMID:15489334   PMID:15498494   PMID:15520277   PMID:15611062   PMID:15917200   PMID:15980150   PMID:16023596  
PMID:16054087   PMID:16169070   PMID:16210249   PMID:16338364   PMID:16344560   PMID:16818231   PMID:16863506   PMID:16938571   PMID:17157259   PMID:17189384   PMID:17274947   PMID:17298674  
PMID:17314511   PMID:17320938   PMID:17434132   PMID:17526737   PMID:17558397   PMID:17588203   PMID:17646408   PMID:17646409   PMID:17873522   PMID:17909001   PMID:17909182   PMID:17992009  
PMID:18094723   PMID:18198341   PMID:18354482   PMID:18391985   PMID:18414042   PMID:18428053   PMID:18485478   PMID:18541364   PMID:18559665   PMID:18625840   PMID:18660489   PMID:18676680  
PMID:18765672   PMID:18784078   PMID:18787170   PMID:18931460   PMID:18938137   PMID:19028597   PMID:19084516   PMID:19109228   PMID:19111882   PMID:19124506   PMID:19126544   PMID:19170196  
PMID:19193609   PMID:19245433   PMID:19340001   PMID:19351817   PMID:19366810   PMID:19412162   PMID:19420964   PMID:19423708   PMID:19490893   PMID:19587092   PMID:19625176   PMID:19635999  
PMID:19679664   PMID:19692168   PMID:19739118   PMID:19794083   PMID:19847202   PMID:19956254   PMID:20208556   PMID:20332316   PMID:20338046   PMID:20388706   PMID:20448329   PMID:20484041  
PMID:20534483   PMID:20558726   PMID:20571051   PMID:20596027   PMID:20622901   PMID:20638938   PMID:20683149   PMID:20815813   PMID:20823234   PMID:20826802   PMID:20848231   PMID:20852628  
PMID:20861909   PMID:20861920   PMID:20890303   PMID:20944675   PMID:20970423   PMID:21070969   PMID:21092141   PMID:21122106   PMID:21123947   PMID:21134077   PMID:21145461   PMID:21147854  
PMID:21205095   PMID:21220517   PMID:21254166   PMID:21368833   PMID:21597324   PMID:21620836   PMID:21798897   PMID:21820430   PMID:21835957   PMID:21860413   PMID:21873635   PMID:21953459  
PMID:21964756   PMID:22017876   PMID:22108521   PMID:22144179   PMID:22270966   PMID:22285861   PMID:22307056   PMID:22388891   PMID:22399798   PMID:22405651   PMID:22426484   PMID:22513362  
PMID:22524983   PMID:22576686   PMID:22608923   PMID:22658674   PMID:22708077   PMID:22710716   PMID:22797700   PMID:22814294   PMID:22848434   PMID:22864569   PMID:22923510   PMID:22939624  
PMID:22975506   PMID:23022380   PMID:23040356   PMID:23082202   PMID:23095493   PMID:23108047   PMID:23166673   PMID:23219661   PMID:23228967   PMID:23232523   PMID:23322298   PMID:23324394  
PMID:23381582   PMID:23453757   PMID:23507969   PMID:23514585   PMID:23558291   PMID:23575666   PMID:23623971   PMID:23670162   PMID:23676439   PMID:23750012   PMID:23776410   PMID:23791182  
PMID:23820376   PMID:23823476   PMID:23857984   PMID:23858059   PMID:23954152   PMID:23955342   PMID:24000165   PMID:24053468   PMID:24085301   PMID:24091628   PMID:24113472   PMID:24165483  
PMID:24166518   PMID:24298052   PMID:24344117   PMID:24362026   PMID:24377525   PMID:24398687   PMID:24412244   PMID:24424791   PMID:24586741   PMID:24686546   PMID:24727676   PMID:24731221  
PMID:24752894   PMID:24793136   PMID:24811168   PMID:24820417   PMID:24838835   PMID:24853181   PMID:24884509   PMID:24912190   PMID:24912918   PMID:25143387   PMID:25159729   PMID:25204433  
PMID:25269767   PMID:25314076   PMID:25344755   PMID:25437563   PMID:25445601   PMID:25450649   PMID:25493453   PMID:25515538   PMID:25555218   PMID:25586348   PMID:25622249   PMID:25623537  
PMID:25640309   PMID:25669969   PMID:25670854   PMID:25716680   PMID:25720964   PMID:25749036   PMID:25753158   PMID:25775507   PMID:25855785   PMID:25860929   PMID:25885523   PMID:25888377  
PMID:25893295   PMID:25897075   PMID:25918246   PMID:25944166   PMID:25955618   PMID:26033182   PMID:26087183   PMID:26091241   PMID:26097998   PMID:26108681   PMID:26163148   PMID:26173098  
PMID:26206584   PMID:26269414   PMID:26306035   PMID:26323375   PMID:26324296   PMID:26341754   PMID:26354767   PMID:26458995   PMID:26461473   PMID:26464659   PMID:26474281   PMID:26482194  
PMID:26540345   PMID:26602384   PMID:26759235   PMID:26774286   PMID:26774344   PMID:26898828   PMID:26912724   PMID:26954701   PMID:26976582   PMID:26983463   PMID:27152455   PMID:27229929  
PMID:27232758   PMID:27238018   PMID:27244218   PMID:27247421   PMID:27306418   PMID:27350307   PMID:27409838   PMID:27423313   PMID:27458189   PMID:27470268   PMID:27485116   PMID:27486687  
PMID:27566146   PMID:27579997   PMID:27593557   PMID:27625374   PMID:27704356   PMID:27751849   PMID:27764699   PMID:27773673   PMID:27795300   PMID:27806347   PMID:27837025   PMID:27852700  
PMID:27880917   PMID:28000896   PMID:28000899   PMID:28007894   PMID:28036276   PMID:28069035   PMID:28069547   PMID:28184929   PMID:28202514   PMID:28209614   PMID:28242758   PMID:28287082  
PMID:28407575   PMID:28422719   PMID:28423622   PMID:28424412   PMID:28459460   PMID:28464881   PMID:28498285   PMID:28514442   PMID:28522751   PMID:28581525   PMID:28614300   PMID:28619760  
PMID:28656290   PMID:28699179   PMID:28716020   PMID:28722108   PMID:28727686   PMID:28760857   PMID:28763841   PMID:28765935   PMID:28772241   PMID:28806398   PMID:28829765   PMID:28850619  
PMID:28903484   PMID:28920929   PMID:29048664   PMID:29072128   PMID:29074464   PMID:29097832   PMID:29103612   PMID:29135520   PMID:29149593   PMID:29150959   PMID:29198712   PMID:29200162  
PMID:29225075   PMID:29324317   PMID:29346117   PMID:29355657   PMID:29384474   PMID:29408378   PMID:29427543   PMID:29475832   PMID:29499133   PMID:29507755   PMID:29534580   PMID:29633504  
PMID:29638162   PMID:29665239   PMID:29695787   PMID:29701752   PMID:29720189   PMID:29735700   PMID:29891922   PMID:29964355   PMID:30044990   PMID:30086763   PMID:30094882   PMID:30098297  
PMID:30177679   PMID:30250038   PMID:30284149   PMID:30302867   PMID:30343112   PMID:30365154   PMID:30510140   PMID:30535501   PMID:30601691   PMID:30606768   PMID:30722038   PMID:30728155  
PMID:30742097   PMID:30783083   PMID:30783098   PMID:30789902   PMID:30830867   PMID:30854564   PMID:30854619   PMID:30865892   PMID:30883339   PMID:30898011   PMID:30922330   PMID:30981757  
PMID:31064356   PMID:31119177   PMID:31152129   PMID:31161818   PMID:31186535   PMID:31202256   PMID:31210753   PMID:31244938   PMID:31281471   PMID:31289136   PMID:31337255   PMID:31346036  
PMID:31351478   PMID:31371703   PMID:31409638   PMID:31450901   PMID:31519156   PMID:31534970   PMID:31569395   PMID:31612394   PMID:31679460   PMID:31740732   PMID:31741433   PMID:31772025  
PMID:31843895   PMID:31868589   PMID:31940492   PMID:32021252   PMID:32024555   PMID:32047362   PMID:32051583   PMID:32081857   PMID:32086376   PMID:32094308   PMID:32124957   PMID:32284542  
PMID:32345600   PMID:32350066   PMID:32353058   PMID:32380038   PMID:32396860   PMID:32433022   PMID:32694731   PMID:33147048  


Genomics

Comparative Map Data
FBXW7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4152,320,544 - 152,536,092 (-)EnsemblGRCh38hg38GRCh38
GRCh384152,320,544 - 152,536,873 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374153,241,696 - 153,457,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364153,461,860 - 153,675,622 (-)NCBINCBI36hg18NCBI36
Build 344153,601,099 - 153,690,635NCBI
Celera4150,566,189 - 150,779,958 (-)NCBI
Cytogenetic Map4q31.3NCBI
HuRef4148,968,491 - 149,182,492 (-)NCBIHuRef
CHM1_14153,220,162 - 153,434,185 (-)NCBICHM1_1
Fbxw7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39384,721,901 - 84,886,505 (+)NCBIGRCm39mm39
GRCm39 Ensembl384,722,575 - 84,886,505 (+)Ensembl
GRCm38384,814,990 - 84,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl384,815,268 - 84,979,198 (+)EnsemblGRCm38mm10GRCm38
MGSCv37384,619,499 - 84,783,120 (+)NCBIGRCm37mm9NCBIm37
MGSCv36385,038,138 - 85,063,561 (+)NCBImm8
Celera384,827,347 - 84,997,996 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map337.7NCBI
Fbxw7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22170,150,552 - 170,310,698 (+)NCBI
Rnor_6.0 Ensembl2184,231,260 - 184,309,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02184,230,191 - 184,309,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02203,633,724 - 203,708,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42176,675,226 - 176,750,737 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2164,144,641 - 164,303,043 (+)NCBICelera
Cytogenetic Map2q34NCBI
Fbxw7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554716,848,101 - 6,955,881 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554716,852,459 - 7,026,590 (-)NCBIChiLan1.0ChiLan1.0
FBXW7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14156,312,274 - 156,527,649 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4156,312,274 - 156,402,351 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04144,660,676 - 144,874,404 (-)NCBIMhudiblu_PPA_v0panPan3
FBXW7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1550,189,240 - 50,417,195 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11550,187,579 - 50,417,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Fbxw7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366892,261,163 - 2,449,951 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl876,482,022 - 76,699,351 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1876,482,027 - 76,699,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FBXW7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1798,894,261 - 99,105,955 (-)NCBI
ChlSab1.1 Ensembl798,892,504 - 99,106,084 (-)Ensembl
Fbxw7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248583,778,842 - 3,974,351 (-)NCBI

Position Markers
RH16593  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374153,432,327 - 153,432,500UniSTSGRCh37
Build 364153,651,777 - 153,651,950RGDNCBI36
Celera4150,756,111 - 150,756,284RGD
Cytogenetic Map4q31.3UniSTS
HuRef4149,158,425 - 149,158,599UniSTS
GeneMap99-GB4 RH Map4637.41UniSTS
NCBI RH Map41568.4UniSTS
SHGC-34878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374153,421,518 - 153,421,642UniSTSGRCh37
Build 364153,640,968 - 153,641,092RGDNCBI36
Celera4150,745,302 - 150,745,426RGD
Cytogenetic Map4q31.3UniSTS
HuRef4149,147,616 - 149,147,740UniSTS
TNG Radiation Hybrid Map492110.0UniSTS
GeneMap99-G3 RH Map48354.0UniSTS
SHGC-67303  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374153,242,464 - 153,242,677UniSTSGRCh37
Build 364153,461,914 - 153,462,127RGDNCBI36
Celera4150,566,243 - 150,566,456RGD
Cytogenetic Map4q31.3UniSTS
HuRef4148,968,545 - 148,968,758UniSTS
TNG Radiation Hybrid Map494638.0UniSTS
GeneMap99-GB4 RH Map4633.23UniSTS
SHGC-82456  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374153,394,969 - 153,395,258UniSTSGRCh37
Build 364153,614,419 - 153,614,708RGDNCBI36
Celera4150,718,753 - 150,719,042RGD
Cytogenetic Map4q31.3UniSTS
HuRef4149,121,067 - 149,121,356UniSTS
TNG Radiation Hybrid Map492124.0UniSTS
SHGC-33385  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371327,655,191 - 27,655,342UniSTSGRCh37
GRCh374153,358,805 - 153,359,303UniSTSGRCh37
Build 364153,578,255 - 153,578,753RGDNCBI36
Celera4150,682,589 - 150,683,087RGD
Celera138,724,095 - 8,724,246UniSTS
HuRef4149,084,889 - 149,085,387UniSTS
HuRef138,477,430 - 8,477,581UniSTS
TNG Radiation Hybrid Map134598.0UniSTS
DKFZP434I0714  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374153,457,589 - 153,457,843UniSTSGRCh37
Build 364153,677,039 - 153,677,293RGDNCBI36
Celera4150,781,375 - 150,781,629RGD
HuRef4149,183,688 - 149,183,942UniSTS
D4S957  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374153,418,019 - 153,418,194UniSTSGRCh37
Build 364153,637,469 - 153,637,644RGDNCBI36
Celera4150,741,803 - 150,741,978RGD
Cytogenetic Map4q31.3UniSTS
HuRef4149,144,117 - 149,144,292UniSTS
TNG Radiation Hybrid Map492110.0UniSTS
SHGC-59612  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374153,432,369 - 153,432,506UniSTSGRCh37
Build 364153,651,819 - 153,651,956RGDNCBI36
Celera4150,756,153 - 150,756,290RGD
Cytogenetic Map4q31.3UniSTS
HuRef4149,158,467 - 149,158,605UniSTS
GeneMap99-GB4 RH Map4633.79UniSTS
NCBI RH Map41599.0UniSTS
GDB:313807  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373182,388,191 - 182,388,553UniSTSGRCh37
GRCh374153,386,877 - 153,388,337UniSTSGRCh37
Build 363183,870,885 - 183,871,247RGDNCBI36
Celera4150,710,661 - 150,712,121UniSTS
Celera3180,822,840 - 180,823,181RGD
Cytogenetic Map4q31.3UniSTS
HuRef3179,792,940 - 179,793,286UniSTS
HuRef4149,112,975 - 149,114,435UniSTS
Fbxw7  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374153,273,672 - 153,274,049UniSTSGRCh37
Celera4150,597,448 - 150,597,825UniSTS
HuRef4148,999,751 - 149,000,128UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR128-1hsa-miR-128-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI20042474
MIR128-1hsa-miR-128-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
MIR107hsa-miR-107Mirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI20042474
MIR27Ahsa-miR-27a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21460851
MIR27Ahsa-miR-27a-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
MIR27Ahsa-miR-27a-3pOncomiRDBexternal_infoNANA22628407
MIR27Ahsa-miR-27a-3pOncomiRDBexternal_infoNANA21460851
MIR223hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22270966
MIR223hsa-miR-223-3pOncomiRDBexternal_infoNANA22270966
MIR223hsa-miR-223-3pOncomiRDBexternal_infoNANA22108521

Predicted Target Of
Summary Value
Count of predictions:2785
Count of miRNA genes:843
Interacting mature miRNAs:969
Transcripts:ENST00000263981, ENST00000281708, ENST00000296555, ENST00000393956, ENST00000603548, ENST00000603821, ENST00000603841, ENST00000604069, ENST00000604095, ENST00000604316, ENST00000604822, ENST00000604872, ENST00000605042
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 433 568 437 82 1049 17 2811 677 2274 29 788 810 68 478 1826 1
Low 1999 2410 1288 540 891 447 1544 1516 1449 389 662 799 105 1 726 962 3
Below cutoff 1 9 9 8 6 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001013415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001257069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001349798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB333777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC023424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC080078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF383178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI598129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW965611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX722143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY008274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY033553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY049984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF514288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI496455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX498391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX502790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA425646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA321362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ873864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ873865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ873866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ873867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ873868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ873869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ873870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ410470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ410471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W39194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000281708   ⟹   ENSP00000281708
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,320,544 - 152,536,092 (-)Ensembl
RefSeq Acc Id: ENST00000296555   ⟹   ENSP00000296555
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,320,544 - 152,382,529 (-)Ensembl
RefSeq Acc Id: ENST00000393956   ⟹   ENSP00000377528
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,320,544 - 152,352,826 (-)Ensembl
RefSeq Acc Id: ENST00000603548   ⟹   ENSP00000474725
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,320,544 - 152,536,063 (-)Ensembl
RefSeq Acc Id: ENST00000603821
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,322,819 - 152,329,073 (-)Ensembl
RefSeq Acc Id: ENST00000603841   ⟹   ENSP00000474971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,322,819 - 152,411,878 (-)Ensembl
RefSeq Acc Id: ENST00000604069
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,326,222 - 152,332,767 (-)Ensembl
RefSeq Acc Id: ENST00000604095
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,530,273 - 152,535,210 (-)Ensembl
RefSeq Acc Id: ENST00000604316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,322,875 - 152,324,436 (-)Ensembl
RefSeq Acc Id: ENST00000604822
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,346,812 - 152,352,696 (-)Ensembl
RefSeq Acc Id: ENST00000604872   ⟹   ENSP00000474751
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,411,160 - 152,535,191 (-)Ensembl
RefSeq Acc Id: ENST00000605042   ⟹   ENSP00000474538
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,411,329 - 152,412,606 (-)Ensembl
RefSeq Acc Id: ENST00000642901   ⟹   ENSP00000495905
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,411,593 - 152,535,241 (-)Ensembl
RefSeq Acc Id: ENST00000643834   ⟹   ENSP00000495702
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,411,593 - 152,535,241 (-)Ensembl
RefSeq Acc Id: ENST00000647166   ⟹   ENSP00000495753
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,411,593 - 152,535,241 (-)Ensembl
RefSeq Acc Id: ENST00000647183
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4152,322,819 - 152,348,806 (-)Ensembl
RefSeq Acc Id: NM_001013415   ⟹   NP_001013433
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,320,544 - 152,382,529 (-)NCBI
GRCh374153,242,410 - 153,456,393 (-)NCBI
Build 364153,461,860 - 153,523,114 (-)NCBI Archive
HuRef4148,968,491 - 149,182,492 (-)NCBI
CHM1_14153,220,162 - 153,281,430 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001257069   ⟹   NP_001243998
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,411,160 - 152,535,241 (-)NCBI
GRCh374153,242,410 - 153,456,393 (-)NCBI
HuRef4148,968,491 - 149,182,492 (-)NCBI
CHM1_14153,310,076 - 153,434,185 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001349798   ⟹   NP_001336727
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,320,544 - 152,536,092 (-)NCBI
Sequence:
RefSeq Acc Id: NM_018315   ⟹   NP_060785
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,320,544 - 152,352,826 (-)NCBI
GRCh374153,242,410 - 153,456,393 (-)NCBI
Build 364153,461,860 - 153,493,560 (-)NCBI Archive
HuRef4148,968,491 - 149,182,492 (-)NCBI
CHM1_14153,220,162 - 153,251,875 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033632   ⟹   NP_361014
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,535,033 (-)NCBI
GRCh374153,242,410 - 153,456,393 (-)NCBI
Build 364153,461,860 - 153,675,622 (-)NCBI Archive
HuRef4148,968,491 - 149,182,492 (-)NCBI
CHM1_14153,220,162 - 153,433,977 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011532084   ⟹   XP_011530386
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011532085   ⟹   XP_011530387
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011532086   ⟹   XP_011530388
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011532087   ⟹   XP_011530389
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011532088   ⟹   XP_011530390
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024454121   ⟹   XP_024309889
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024454122   ⟹   XP_024309890
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024454123   ⟹   XP_024309891
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024454124   ⟹   XP_024309892
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024454125   ⟹   XP_024309893
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024454126   ⟹   XP_024309894
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,321,258 - 152,536,873 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001013433 (Get FASTA)   NCBI Sequence Viewer  
  NP_001243998 (Get FASTA)   NCBI Sequence Viewer  
  NP_001336727 (Get FASTA)   NCBI Sequence Viewer  
  NP_060785 (Get FASTA)   NCBI Sequence Viewer  
  NP_361014 (Get FASTA)   NCBI Sequence Viewer  
  XP_011530386 (Get FASTA)   NCBI Sequence Viewer  
  XP_011530387 (Get FASTA)   NCBI Sequence Viewer  
  XP_011530388 (Get FASTA)   NCBI Sequence Viewer  
  XP_011530389 (Get FASTA)   NCBI Sequence Viewer  
  XP_011530390 (Get FASTA)   NCBI Sequence Viewer  
  XP_024309889 (Get FASTA)   NCBI Sequence Viewer  
  XP_024309890 (Get FASTA)   NCBI Sequence Viewer  
  XP_024309891 (Get FASTA)   NCBI Sequence Viewer  
  XP_024309892 (Get FASTA)   NCBI Sequence Viewer  
  XP_024309893 (Get FASTA)   NCBI Sequence Viewer  
  XP_024309894 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG16640 (Get FASTA)   NCBI Sequence Viewer  
  AAH37320 (Get FASTA)   NCBI Sequence Viewer  
  AAI17245 (Get FASTA)   NCBI Sequence Viewer  
  AAI17247 (Get FASTA)   NCBI Sequence Viewer  
  AAI43945 (Get FASTA)   NCBI Sequence Viewer  
  AAK57547 (Get FASTA)   NCBI Sequence Viewer  
  AAK60269 (Get FASTA)   NCBI Sequence Viewer  
  AAL06290 (Get FASTA)   NCBI Sequence Viewer  
  AAL06291 (Get FASTA)   NCBI Sequence Viewer  
  AAL07271 (Get FASTA)   NCBI Sequence Viewer  
  AEK48270 (Get FASTA)   NCBI Sequence Viewer  
  AEK48271 (Get FASTA)   NCBI Sequence Viewer  
  AEK48272 (Get FASTA)   NCBI Sequence Viewer  
  AEK48273 (Get FASTA)   NCBI Sequence Viewer  
  AEK48274 (Get FASTA)   NCBI Sequence Viewer  
  AEK48275 (Get FASTA)   NCBI Sequence Viewer  
  AEK48276 (Get FASTA)   NCBI Sequence Viewer  
  AFD64626 (Get FASTA)   NCBI Sequence Viewer  
  AFD64627 (Get FASTA)   NCBI Sequence Viewer  
  BAA91986 (Get FASTA)   NCBI Sequence Viewer  
  BAD92962 (Get FASTA)   NCBI Sequence Viewer  
  BAD97169 (Get FASTA)   NCBI Sequence Viewer  
  BAF73721 (Get FASTA)   NCBI Sequence Viewer  
  BAH11814 (Get FASTA)   NCBI Sequence Viewer  
  BAH13109 (Get FASTA)   NCBI Sequence Viewer  
  CAD90236 (Get FASTA)   NCBI Sequence Viewer  
  CAH18160 (Get FASTA)   NCBI Sequence Viewer  
  EAX04977 (Get FASTA)   NCBI Sequence Viewer  
  EAX04978 (Get FASTA)   NCBI Sequence Viewer  
  EAX04979 (Get FASTA)   NCBI Sequence Viewer  
  Q969H0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_361014   ⟸   NM_033632
- Peptide Label: isoform 1
- UniProtKB: Q969H0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001013433   ⟸   NM_001013415
- Peptide Label: isoform 3
- UniProtKB: Q969H0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_060785   ⟸   NM_018315
- Peptide Label: isoform 2
- UniProtKB: Q969H0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243998   ⟸   NM_001257069
- Peptide Label: isoform 4
- UniProtKB: G0Z2K0 (UniProtKB/TrEMBL),   S4R3U4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011530390   ⟸   XM_011532088
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011530387   ⟸   XM_011532085
- Peptide Label: isoform X1
- UniProtKB: Q969H0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011530386   ⟸   XM_011532084
- Peptide Label: isoform X1
- UniProtKB: Q969H0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011530389   ⟸   XM_011532087
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011530388   ⟸   XM_011532086
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024309891   ⟸   XM_024454123
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024309892   ⟸   XM_024454124
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024309890   ⟸   XM_024454122
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024309894   ⟸   XM_024454126
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024309889   ⟸   XM_024454121
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024309893   ⟸   XM_024454125
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001336727   ⟸   NM_001349798
- Peptide Label: isoform 1
- Sequence:
RefSeq Acc Id: ENSP00000281708   ⟸   ENST00000281708
RefSeq Acc Id: ENSP00000296555   ⟸   ENST00000296555
RefSeq Acc Id: ENSP00000474971   ⟸   ENST00000603841
RefSeq Acc Id: ENSP00000495905   ⟸   ENST00000642901
RefSeq Acc Id: ENSP00000474725   ⟸   ENST00000603548
RefSeq Acc Id: ENSP00000377528   ⟸   ENST00000393956
RefSeq Acc Id: ENSP00000495702   ⟸   ENST00000643834
RefSeq Acc Id: ENSP00000474751   ⟸   ENST00000604872
RefSeq Acc Id: ENSP00000474538   ⟸   ENST00000605042
RefSeq Acc Id: ENSP00000495753   ⟸   ENST00000647166
Protein Domains
F-box   WD_REPEATS_REGION

Promoters
RGD ID:6868668
Promoter ID:EPDNEW_H7499
Type:initiation region
Name:FBXW7_3
Description:F-box and WD repeat domain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7500  EPDNEW_H7501  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,352,971 - 152,353,031EPDNEW
RGD ID:6868670
Promoter ID:EPDNEW_H7500
Type:initiation region
Name:FBXW7_2
Description:F-box and WD repeat domain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7499  EPDNEW_H7501  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,382,529 - 152,382,589EPDNEW
RGD ID:6868672
Promoter ID:EPDNEW_H7501
Type:initiation region
Name:FBXW7_1
Description:F-box and WD repeat domain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7499  EPDNEW_H7500  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384152,536,063 - 152,536,123EPDNEW
RGD ID:6802310
Promoter ID:HG_KWN:49281
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:NM_018315
Position:
Human AssemblyChrPosition (strand)Source
Build 364153,493,039 - 153,493,539 (-)MPROMDB
RGD ID:6802309
Promoter ID:HG_KWN:49282
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_001013415
Position:
Human AssemblyChrPosition (strand)Source
Build 364153,522,721 - 153,523,221 (-)MPROMDB
RGD ID:6802195
Promoter ID:HG_KWN:49283
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000393956
Position:
Human AssemblyChrPosition (strand)Source
Build 364153,551,924 - 153,552,424 (-)MPROMDB
RGD ID:6802311
Promoter ID:HG_KWN:49284
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:UC003IMT.1,   UC003IMU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364153,675,356 - 153,676,792 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001349798.2(FBXW7):c.45_46insCCT (p.Gly16_Gly17insPro) insertion not specified [RCV000121055] Chr4:152411758..152411759 [GRCh38]
Chr4:153332910..153332911 [GRCh37]
Chr4:4q31.3
not provided
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
Chr4:4q26-35.2
pathogenic
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
Chr4:4q27-35.2
pathogenic
GRCh38/hg38 4q31.22-34.1(chr4:147317283-173675559)x3 copy number gain See cases [RCV000051788] Chr4:147317283..173675559 [GRCh38]
Chr4:148238435..174596710 [GRCh37]
Chr4:148457885..174833285 [NCBI36]
Chr4:4q31.22-34.1
pathogenic
GRCh38/hg38 4q31.23-35.2(chr4:148356485-189548183)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051789]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051789]|See cases [RCV000051789] Chr4:148356485..189548183 [GRCh38]
Chr4:149277637..190469337 [GRCh37]
Chr4:149497087..190706331 [NCBI36]
Chr4:4q31.23-35.2
pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
NM_033632.3(FBXW7):c.1053G>A (p.Trp351Ter) single nucleotide variant Malignant melanoma [RCV000066295] Chr4:152330801 [GRCh38]
Chr4:153251953 [GRCh37]
Chr4:153471403 [NCBI36]
Chr4:4q31.3
not provided
NM_033632.3(FBXW7):c.1778dupT (p.Leu594Serfs) duplication Malignant melanoma [RCV000060928] Chr4:152324261 [GRCh38]
Chr4:153245413 [GRCh37]
Chr4:153464863 [NCBI36]
Chr4:4q31.3
not provided
NM_001349798.2(FBXW7):c.1513C>T (p.Arg505Cys) single nucleotide variant Adenocarcinoma of stomach [RCV000433395]|Carcinoma of esophagus [RCV000437170]|Chronic lymphocytic leukemia [RCV000444088]|Malignant melanoma of skin [RCV000443061]|Malignant neoplasm of body of uterus [RCV000422076]|Neoplasm of the large intestine [RCV000438775]|Neoplasm of uterine cervix [RCV000444218]|Ovarian Serous Cystadenocarcinoma [RCV000422275]|Squamous cell carcinoma of the head and neck [RCV000432318]|Squamous cell lung carcinoma [RCV000426925]|Transitional cell carcinoma of the bladder [RCV000427176]|Uterine Carcinosarcoma [RCV000428536] Chr4:152326137 [GRCh38]
Chr4:153247289 [GRCh37]
Chr4:153466739 [NCBI36]
Chr4:4q31.3
likely pathogenic|not provided
NM_001349798.2(FBXW7):c.501+29101T>G single nucleotide variant not specified [RCV000121053] Chr4:152382202 [GRCh38]
Chr4:153303354 [GRCh37]
Chr4:4q31.3
not provided
NM_001349798.2(FBXW7):c.502-2437G>A single nucleotide variant not specified [RCV000121054] Chr4:152352561 [GRCh38]
Chr4:153273713 [GRCh37]
Chr4:4q31.3
not provided
NM_001349798.2(FBXW7):c.397A>G (p.Arg133Gly) single nucleotide variant not specified [RCV000121056] Chr4:152411407 [GRCh38]
Chr4:153332559 [GRCh37]
Chr4:4q31.3
not provided
NM_001349798.2(FBXW7):c.58A>G (p.Arg20Gly) single nucleotide variant not specified [RCV000121057] Chr4:152411746 [GRCh38]
Chr4:153332898 [GRCh37]
Chr4:4q31.3
not provided
NM_001349798.2(FBXW7):c.458C>G (p.Pro153Arg) single nucleotide variant not specified [RCV000121058] Chr4:152411346 [GRCh38]
Chr4:153332498 [GRCh37]
Chr4:4q31.3
not provided
NM_001349798.2(FBXW7):c.479C>T (p.Pro160Leu) single nucleotide variant not specified [RCV000121059] Chr4:152411325 [GRCh38]
Chr4:153332477 [GRCh37]
Chr4:4q31.3
not provided
GRCh38/hg38 4q31.21-35.2(chr4:145042668-189975519)x3 copy number gain See cases [RCV000135845] Chr4:145042668..189975519 [GRCh38]
Chr4:145963820..190828225 [GRCh37]
Chr4:146183270..191133668 [NCBI36]
Chr4:4q31.21-35.2
pathogenic
GRCh38/hg38 4q31.3-32.1(chr4:151299810-160314050)x1 copy number loss See cases [RCV000135696] Chr4:151299810..160314050 [GRCh38]
Chr4:152220962..161235202 [GRCh37]
Chr4:152440412..161454652 [NCBI36]
Chr4:4q31.3-32.1
likely pathogenic
GRCh38/hg38 4q31.1-35.2(chr4:138510532-189963195)x3 copy number gain See cases [RCV000136810] Chr4:138510532..189963195 [GRCh38]
Chr4:139431686..190828225 [GRCh37]
Chr4:139651136..191121344 [NCBI36]
Chr4:4q31.1-35.2
pathogenic
GRCh38/hg38 4q28.3-35.2(chr4:131985253-190095391)x3 copy number gain See cases [RCV000137721] Chr4:131985253..190095391 [GRCh38]
Chr4:132906408..190828225 [GRCh37]
Chr4:133125858..191250527 [NCBI36]
Chr4:4q28.3-35.2
pathogenic|likely benign
GRCh38/hg38 4q28.1-35.1(chr4:125432943-185761887)x3 copy number gain See cases [RCV000138578] Chr4:125432943..185761887 [GRCh38]
Chr4:126354098..186683041 [GRCh37]
Chr4:126573548..186920035 [NCBI36]
Chr4:4q28.1-35.1
pathogenic|likely benign
GRCh38/hg38 4q31.3(chr4:151956656-152519401)x1 copy number loss See cases [RCV000140236] Chr4:151956656..152519401 [GRCh38]
Chr4:152877808..153440553 [GRCh37]
Chr4:153097258..153660003 [NCBI36]
Chr4:4q31.3
uncertain significance
GRCh38/hg38 4q31.3(chr4:152519348-153381536)x1 copy number loss See cases [RCV000139726] Chr4:152519348..153381536 [GRCh38]
Chr4:153440500..154302688 [GRCh37]
Chr4:153659950..154522138 [NCBI36]
Chr4:4q31.3
uncertain significance
GRCh38/hg38 4q28.3-35.2(chr4:134935616-190036318)x3 copy number gain See cases [RCV000143559] Chr4:134935616..190036318 [GRCh38]
Chr4:135856771..190957473 [GRCh37]
Chr4:136076221..191194467 [NCBI36]
Chr4:4q28.3-35.2
pathogenic
GRCh38/hg38 4q31.3-32.1(chr4:152500649-155788803)x3 copy number gain See cases [RCV000143617] Chr4:152500649..155788803 [GRCh38]
Chr4:153421801..156709955 [GRCh37]
Chr4:153641251..156929405 [NCBI36]
Chr4:4q31.3-32.1
likely pathogenic
GRCh37/hg19 4q28.3-35.1(chr4:136912336-184253252)x3 copy number gain See cases [RCV000240245] Chr4:136912336..184253252 [GRCh37]
Chr4:4q28.3-35.1
pathogenic
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
Chr4:4q26-35.2
pathogenic
NM_001349798.2(FBXW7):c.1436G>C (p.Arg479Pro) single nucleotide variant Adenocarcinoma of stomach [RCV000428805]|Breast neoplasm [RCV000435084]|Glioblastoma [RCV000434336]|Malignant melanoma of skin [RCV000422262]|Malignant neoplasm of body of uterus [RCV000433275]|Neoplasm of the large intestine [RCV000438793]|Neoplasm of uterine cervix [RCV000439933]|Papillary renal cell carcinoma, sporadic [RCV000417415]|Squamous cell carcinoma of the head and neck [RCV000418562]|Squamous cell lung carcinoma [RCV000423233]|Transitional cell carcinoma of the bladder [RCV000440893]|Uterine Carcinosarcoma [RCV000428552] Chr4:152326214 [GRCh38]
Chr4:153247366 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1394G>C (p.Arg465Pro) single nucleotide variant Adenocarcinoma of stomach [RCV000435527]|Adenoid cystic carcinoma [RCV000434066]|Breast neoplasm [RCV000422698]|Carcinoma of esophagus [RCV000443932]|Chronic lymphocytic leukemia [RCV000427741]|Lung adenocarcinoma [RCV000428799]|Malignant neoplasm of body of uterus [RCV000436201]|Medulloblastoma [RCV000433446]|Neoplasm of the large intestine [RCV000424801]|Neoplasm of uterine cervix [RCV000440831]|Ovarian Serous Cystadenocarcinoma [RCV000418970]|Squamous cell carcinoma of the head and neck [RCV000442912]|Squamous cell lung carcinoma [RCV000424610]|Uterine Carcinosarcoma [RCV000417428] Chr4:152328232 [GRCh38]
Chr4:153249384 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1394G>A (p.Arg465His) single nucleotide variant Adenocarcinoma of stomach [RCV000426392]|Adenoid cystic carcinoma [RCV000420844]|Breast neoplasm [RCV000437827]|Carcinoma of esophagus [RCV000437932]|Chronic lymphocytic leukemia [RCV000417975]|Lung adenocarcinoma [RCV000417744]|Malignant neoplasm of body of uterus [RCV000443195]|Medulloblastoma [RCV000428675]|Neoplasm of the large intestine [RCV000422069]|Neoplasm of uterine cervix [RCV000427168]|Ovarian Serous Cystadenocarcinoma [RCV000439989]|Squamous cell carcinoma of the head and neck [RCV000438452]|Squamous cell lung carcinoma [RCV000433642]|Uterine Carcinosarcoma [RCV000429314] Chr4:152328232 [GRCh38]
Chr4:153249384 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1436G>T (p.Arg479Leu) single nucleotide variant Adenocarcinoma of stomach [RCV000424541]|Breast neoplasm [RCV000425643]|Glioblastoma [RCV000435934]|Malignant melanoma of skin [RCV000434540]|Malignant neoplasm of body of uterus [RCV000418015]|Neoplasm of the large intestine [RCV000443948]|Neoplasm of uterine cervix [RCV000427761]|Papillary renal cell carcinoma, sporadic [RCV000429417]|Squamous cell carcinoma of the head and neck [RCV000435692]|Squamous cell lung carcinoma [RCV000419083]|Transitional cell carcinoma of the bladder [RCV000440513]|Uterine Carcinosarcoma [RCV000442879] Chr4:152326214 [GRCh38]
Chr4:153247366 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1514G>T (p.Arg505Leu) single nucleotide variant Adenocarcinoma of stomach [RCV000421948]|Carcinoma of esophagus [RCV000418253]|Chronic lymphocytic leukemia [RCV000439833]|Malignant melanoma of skin [RCV000434990]|Malignant neoplasm of body of uterus [RCV000439579]|Neoplasm of the large intestine [RCV000438226]|Neoplasm of uterine cervix [RCV000423047]|Ovarian Serous Cystadenocarcinoma [RCV000428228]|Squamous cell carcinoma of the head and neck [RCV000420626]|Squamous cell lung carcinoma [RCV000429608]|Transitional cell carcinoma of the bladder [RCV000433338]|Uterine Carcinosarcoma [RCV000428507] Chr4:152326136 [GRCh38]
Chr4:153247288 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1514G>A (p.Arg505His) single nucleotide variant Adenocarcinoma of stomach [RCV000434393]|Carcinoma of esophagus [RCV000424983]|Chronic lymphocytic leukemia [RCV000435656]|Malignant melanoma of skin [RCV000427831]|Malignant neoplasm of body of uterus [RCV000442928]|Neoplasm of the large intestine [RCV000443929]|Neoplasm of uterine cervix [RCV000431557]|Ovarian Serous Cystadenocarcinoma [RCV000425614]|Squamous cell carcinoma of the head and neck [RCV000418430]|Squamous cell lung carcinoma [RCV000436317]|Transitional cell carcinoma of the bladder [RCV000423701]|Uterine Carcinosarcoma [RCV000440517]|not provided [RCV000660655] Chr4:152326136 [GRCh38]
Chr4:153247288 [GRCh37]
Chr4:4q31.3
likely pathogenic|uncertain significance
NM_001349798.2(FBXW7):c.1513C>A (p.Arg505Ser) single nucleotide variant Adenocarcinoma of stomach [RCV000420985]|Carcinoma of esophagus [RCV000431685]|Chronic lymphocytic leukemia [RCV000444420]|Malignant melanoma of skin [RCV000441048]|Malignant neoplasm of body of uterus [RCV000434480]|Neoplasm of the large intestine [RCV000441739]|Neoplasm of uterine cervix [RCV000440442]|Ovarian Serous Cystadenocarcinoma [RCV000423791]|Squamous cell carcinoma of the head and neck [RCV000430339]|Squamous cell lung carcinoma [RCV000429788]|Transitional cell carcinoma of the bladder [RCV000419073]|Uterine Carcinosarcoma [RCV000419711] Chr4:152326137 [GRCh38]
Chr4:153247289 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1435C>G (p.Arg479Gly) single nucleotide variant Adenocarcinoma of stomach [RCV000431962]|Breast neoplasm [RCV000441809]|Glioblastoma [RCV000424081]|Malignant melanoma of skin [RCV000434161]|Malignant neoplasm of body of uterus [RCV000419134]|Neoplasm of the large intestine [RCV000440536]|Neoplasm of uterine cervix [RCV000444444]|Papillary renal cell carcinoma, sporadic [RCV000444414]|Squamous cell carcinoma of the head and neck [RCV000430277]|Squamous cell lung carcinoma [RCV000423892]|Transitional cell carcinoma of the bladder [RCV000431768]|Uterine Carcinosarcoma [RCV000421698] Chr4:152326215 [GRCh38]
Chr4:153247367 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1393C>G (p.Arg465Gly) single nucleotide variant Adenocarcinoma of stomach [RCV000443495]|Adenoid cystic carcinoma [RCV000437252]|Breast neoplasm [RCV000428024]|Carcinoma of esophagus [RCV000419147]|Chronic lymphocytic leukemia [RCV000421262]|Lung adenocarcinoma [RCV000431326]|Malignant neoplasm of body of uterus [RCV000421492]|Medulloblastoma [RCV000420198]|Neoplasm of the large intestine [RCV000436581]|Neoplasm of uterine cervix [RCV000437918]|Ovarian Serous Cystadenocarcinoma [RCV000426581]|Squamous cell carcinoma of the head and neck [RCV000441574]|Squamous cell lung carcinoma [RCV000429882]|Uterine Carcinosarcoma [RCV000439102] Chr4:152328233 [GRCh38]
Chr4:153249385 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1973G>A (p.Arg658Gln) single nucleotide variant Glioblastoma [RCV000425775]|Malignant melanoma of skin [RCV000419184]|Malignant neoplasm of body of uterus [RCV000425117]|Neoplasm of the large intestine [RCV000437095]|Neoplasm of uterine cervix [RCV000444286]|Squamous cell carcinoma of the head and neck [RCV000436448]|Transitional cell carcinoma of the bladder [RCV000426437]|Uterine Carcinosarcoma [RCV000432336] Chr4:152323032 [GRCh38]
Chr4:153244184 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1513C>G (p.Arg505Gly) single nucleotide variant Adenocarcinoma of stomach [RCV000431005]|Carcinoma of esophagus [RCV000438652]|Chronic lymphocytic leukemia [RCV000437332]|Malignant melanoma of skin [RCV000426495]|Malignant neoplasm of body of uterus [RCV000443509]|Neoplasm of the large intestine [RCV000425337]|Neoplasm of uterine cervix [RCV000420774]|Ovarian Serous Cystadenocarcinoma [RCV000430756]|Squamous cell carcinoma of the head and neck [RCV000437528]|Squamous cell lung carcinoma [RCV000419644]|Transitional cell carcinoma of the bladder [RCV000436496]|Uterine Carcinosarcoma [RCV000420999] Chr4:152326137 [GRCh38]
Chr4:153247289 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1394G>T (p.Arg465Leu) single nucleotide variant Adenocarcinoma of stomach [RCV000419727]|Adenoid cystic carcinoma [RCV000422964]|Breast neoplasm [RCV000436100]|Carcinoma of esophagus [RCV000430408]|Chronic lymphocytic leukemia [RCV000434382]|Lung adenocarcinoma [RCV000443518]|Malignant neoplasm of body of uterus [RCV000425901]|Medulloblastoma [RCV000431539]|Neoplasm of the large intestine [RCV000440224]|Neoplasm of uterine cervix [RCV000443662]|Ovarian Serous Cystadenocarcinoma [RCV000441781]|Squamous cell carcinoma of the head and neck [RCV000431029]|Squamous cell lung carcinoma [RCV000421731]|Uterine Carcinosarcoma [RCV000423635] Chr4:152328232 [GRCh38]
Chr4:153249384 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1393C>T (p.Arg465Cys) single nucleotide variant Adenocarcinoma of stomach [RCV000431798]|Adenoid cystic carcinoma [RCV000420611]|Breast neoplasm [RCV000441161]|Carcinoma of esophagus [RCV000433796]|Chronic lymphocytic leukemia [RCV000439851]|Lung adenocarcinoma [RCV000443314]|Malignant neoplasm of body of uterus [RCV000428525]|Medulloblastoma [RCV000439190]|Neoplasm of the large intestine [RCV000432242]|Neoplasm of uterine cervix [RCV000426601]|Ovarian Serous Cystadenocarcinoma [RCV000420440]|Squamous cell carcinoma of the head and neck [RCV000422617]|Squamous cell lung carcinoma [RCV000421110]|Uterine Carcinosarcoma [RCV000431273] Chr4:152328233 [GRCh38]
Chr4:153249385 [GRCh37]
Chr4:4q31.3
likely pathogenic
NM_001349798.2(FBXW7):c.1436G>A (p.Arg479Gln) single nucleotide variant Adenocarcinoma of stomach [RCV000443229]|Breast neoplasm [RCV000437563]|Glioblastoma [RCV000433841]|Malignant melanoma of skin [RCV000426198]|Malignant neoplasm of body of uterus [RCV000432590]|Neoplasm of the large intestine [RCV000427334]|Neoplasm of uterine cervix [RCV000432827]|Papillary renal cell carcinoma, sporadic [RCV000427513]|Squamous cell carcinoma of the head and neck [RCV000444094]|Squamous cell lung carcinoma [RCV000420785]|Transitional cell carcinoma of the bladder [RCV000422547]|Uterine Carcinosarcoma [RCV000444172] Chr4:152326214 [GRCh38]
Chr4:153247366 [GRCh37]
Chr4:4q31.3
likely pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q31.3-32.2(chr4:153203431-162912359)x1 copy number loss See cases [RCV000511404] Chr4:153203431..162912359 [GRCh37]
Chr4:4q31.3-32.2
pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q31.3(chr4:153023340-153657206)x3 copy number gain not provided [RCV000682471] Chr4:153023340..153657206 [GRCh37]
Chr4:4q31.3
likely benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q31.3(chr4:153184316-153334717)x3 copy number gain not provided [RCV000744055] Chr4:153184316..153334717 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4q31.3(chr4:153195089-153451356)x3 copy number gain not provided [RCV000744056] Chr4:153195089..153451356 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4q31.3(chr4:153242605-153315320)x3 copy number gain not provided [RCV000744057] Chr4:153242605..153315320 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4q31.3(chr4:153242605-153451356)x3 copy number gain not provided [RCV000744058] Chr4:153242605..153451356 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4q31.3(chr4:153242605-153452160)x3 copy number gain not provided [RCV000744059] Chr4:153242605..153452160 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4q31.3(chr4:153248578-153425502)x1 copy number loss not provided [RCV000744060] Chr4:153248578..153425502 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4q31.3(chr4:153390057-153519781)x3 copy number gain not provided [RCV000744061] Chr4:153390057..153519781 [GRCh37]
Chr4:4q31.3
benign
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_001349798.2(FBXW7):c.1444A>G (p.Thr482Ala) single nucleotide variant Esophageal atresia [RCV000984647] Chr4:152326206 [GRCh38]
Chr4:153247358 [GRCh37]
Chr4:4q31.3
uncertain significance
GRCh37/hg19 4q31.3-32.1(chr4:153061243-157994448)x1 copy number loss not provided [RCV001005606] Chr4:153061243..157994448 [GRCh37]
Chr4:4q31.3-32.1
likely pathogenic
GRCh37/hg19 4q31.3(chr4:153244033-153332955)x1 copy number loss not provided [RCV000998342] Chr4:153244033..153332955 [GRCh37]
Chr4:4q31.3
uncertain significance
GRCh37/hg19 4q31.3-35.2(chr4:151174061-190957473)x3 copy number gain not provided [RCV000849098] Chr4:151174061..190957473 [GRCh37]
Chr4:4q31.3-35.2
pathogenic
GRCh37/hg19 4q28.1-35.1(chr4:124873497-185278662)x3 copy number gain not provided [RCV000849686] Chr4:124873497..185278662 [GRCh37]
Chr4:4q28.1-35.1
pathogenic
GRCh37/hg19 4q31.3(chr4:153322965-153563968)x3 copy number gain not provided [RCV001005607] Chr4:153322965..153563968 [GRCh37]
Chr4:4q31.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16712 AgrOrtholog
COSMIC FBXW7 COSMIC
Ensembl Genes ENSG00000109670 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000281708 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000296555 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000377528 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000474538 UniProtKB/TrEMBL
  ENSP00000474725 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000474751 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000474971 UniProtKB/Swiss-Prot
  ENSP00000495702 UniProtKB/TrEMBL
  ENSP00000495753 UniProtKB/TrEMBL
  ENSP00000495905 UniProtKB/TrEMBL
Ensembl Transcript ENST00000281708 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000296555 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393956 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000603548 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000603841 UniProtKB/Swiss-Prot
  ENST00000604872 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000605042 UniProtKB/TrEMBL
  ENST00000642901 UniProtKB/TrEMBL
  ENST00000643834 UniProtKB/TrEMBL
  ENST00000647166 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000109670 GTEx
HGNC ID HGNC:16712 ENTREZGENE
Human Proteome Map FBXW7 Human Proteome Map
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot
  F-box_dom UniProtKB/Swiss-Prot
  G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:55294 UniProtKB/Swiss-Prot
NCBI Gene 55294 ENTREZGENE
OMIM 606278 OMIM
Pfam F-box-like UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28054 PharmGKB
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot
PROSITE FBOX UniProtKB/Swiss-Prot
  WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBOX UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81383 UniProtKB/Swiss-Prot
UniProt A7BJS8_HUMAN UniProtKB/TrEMBL
  FBXW7_HUMAN UniProtKB/Swiss-Prot
  G0Z2K0 ENTREZGENE, UniProtKB/TrEMBL
  H9CWI2_HUMAN UniProtKB/TrEMBL
  H9CWI3_HUMAN UniProtKB/TrEMBL
  Q969H0 ENTREZGENE
  S4R3N3_HUMAN UniProtKB/TrEMBL
  S4R3U4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B7ZLP9 UniProtKB/Swiss-Prot
  Q68DR0 UniProtKB/Swiss-Prot
  Q96A16 UniProtKB/Swiss-Prot
  Q96LE0 UniProtKB/Swiss-Prot
  Q96RI2 UniProtKB/Swiss-Prot
  Q9NUX6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 FBXW7  F-box and WD repeat domain containing 7    F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase  Symbol and/or name change 5135510 APPROVED
2012-03-01 FBXW7  F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase  FBXW7  F-box and WD repeat domain containing 7  Symbol and/or name change 5135510 APPROVED
2011-08-16 FBXW7  F-box and WD repeat domain containing 7  FBXW7  F-box and WD repeat domain containing 7  Symbol and/or name change 5135510 APPROVED