MIR1224 (microRNA 1224) - Rat Genome Database

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Gene: MIR1224 (microRNA 1224) Homo sapiens
Analyze
Symbol: MIR1224
Name: microRNA 1224
RGD ID: 2312874
HGNC Page HGNC
Description: Predicted to act upstream of or within cellular response to amino acid stimulus; cellular response to forskolin; and cellular response to inorganic substance.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-1224; MIRN1224
RGD Orthologs
Mouse
Rat
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3184,241,405 - 184,241,489 (+)EnsemblGRCh38hg38GRCh38
GRCh383184,241,405 - 184,241,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373183,959,193 - 183,959,277 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera3182,399,957 - 182,400,041 (+)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3181,366,162 - 181,366,246 (+)NCBIHuRef
CHM1_13183,923,615 - 183,923,699 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

Additional References at PubMed
PMID:16381832   PMID:16954537   PMID:17964270   PMID:21037258   PMID:22472876   PMID:25648114   PMID:28645739   PMID:28717225   PMID:29050938   PMID:29474539   PMID:29908542   PMID:30964106  
PMID:31419446   PMID:31646570   PMID:32002629   PMID:32319715   PMID:32534700   PMID:33083473  


Genomics

Comparative Map Data
MIR1224
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3184,241,405 - 184,241,489 (+)EnsemblGRCh38hg38GRCh38
GRCh383184,241,405 - 184,241,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373183,959,193 - 183,959,277 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera3182,399,957 - 182,400,041 (+)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3181,366,162 - 181,366,246 (+)NCBIHuRef
CHM1_13183,923,615 - 183,923,699 (+)NCBICHM1_1
Mir1224
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,423,202 - 20,423,286 (+)NCBIGRCm39mm39
GRCm39 Ensembl1620,423,202 - 20,423,286 (+)Ensembl
GRCm381620,604,452 - 20,604,536 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,604,452 - 20,604,536 (+)EnsemblGRCm38mm10GRCm38
Celera1621,168,528 - 21,168,612 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.48NCBI
Mir1224
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,306,902 - 80,306,986 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1180,306,902 - 80,306,986 (-)Ensembl
Rnor_6.01183,992,628 - 83,992,712 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,992,628 - 83,992,712 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,064,950 - 87,065,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1179,146,571 - 79,146,655 (-)NCBICelera
Cytogenetic Map11q23NCBI
MIR1224
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,141,042 - 122,141,149 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,141,042 - 122,141,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,580,811 - 131,580,918 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
NUP62hsa-miR-1224-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
KMT2Dhsa-miR-1224-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:45229
Count of gene targets:14772
Count of transcripts:33689
Interacting mature miRNAs:hsa-miR-1224-3p, hsa-miR-1224-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1 1
Low 202 115 367 6 25 6 222 113 1150 10 217 109 1 55 173
Below cutoff 212 108 117 17 43 12 212 202 640 6 97 48 5 44 170

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000408193
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3184,241,405 - 184,241,489 (+)Ensembl
RefSeq Acc Id: NR_030410
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383184,241,405 - 184,241,489 (+)NCBI
GRCh373183,959,193 - 183,959,277 (+)RGD
Celera3182,399,957 - 182,400,041 (+)RGD
HuRef3181,366,162 - 181,366,246 (+)ENTREZGENE
CHM1_13183,923,615 - 183,923,699 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q26.33-28(chr3:182678453-188418928)x1 copy number loss See cases [RCV000051607] Chr3:182678453..188418928 [GRCh38]
Chr3:182396241..188136716 [GRCh37]
Chr3:183878935..189619410 [NCBI36]
Chr3:3q26.33-28
pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29
pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:157293378-198134727)x3 copy number gain See cases [RCV000051726] Chr3:157293378..198134727 [GRCh38]
Chr3:157011167..197861598 [GRCh37]
Chr3:158493861..199345995 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q26.32-29(chr3:178411707-198110319)x3 copy number gain See cases [RCV000051736] Chr3:178411707..198110319 [GRCh38]
Chr3:178129495..197837190 [GRCh37]
Chr3:179612189..199321587 [NCBI36]
Chr3:3q26.32-29
pathogenic
GRCh38/hg38 3q27.1(chr3:184200139-184656801)x3 copy number gain See cases [RCV000051737] Chr3:184200139..184656801 [GRCh38]
Chr3:183917927..184374589 [GRCh37]
Chr3:185400621..185857283 [NCBI36]
Chr3:3q27.1
pathogenic
GRCh38/hg38 3q27.1(chr3:184239109-184391437)x1 copy number loss See cases [RCV000054002] Chr3:184239109..184391437 [GRCh38]
Chr3:183956897..184109225 [GRCh37]
Chr3:185439591..185591919 [NCBI36]
Chr3:3q27.1
uncertain significance
NM_138345.1(VWA5B2):c.2865G>A (p.Gln955=) single nucleotide variant Malignant melanoma [RCV000065951] Chr3:184240915 [GRCh38]
Chr3:183958703 [GRCh37]
Chr3:185441397 [NCBI36]
Chr3:3q27.1
not provided
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q26.2-29(chr3:168167568-198110178)x3 copy number gain See cases [RCV000137106] Chr3:168167568..198110178 [GRCh38]
Chr3:167885356..197837049 [GRCh37]
Chr3:169368050..199321446 [NCBI36]
Chr3:3q26.2-29
pathogenic
GRCh38/hg38 3q26.32-29(chr3:176439911-198118383)x3 copy number gain See cases [RCV000138009] Chr3:176439911..198118383 [GRCh38]
Chr3:176157699..197845254 [GRCh37]
Chr3:177640393..199329651 [NCBI36]
Chr3:3q26.32-29
pathogenic|likely benign
GRCh38/hg38 3q27.1(chr3:183816693-184365094)x3 copy number gain See cases [RCV000137910] Chr3:183816693..184365094 [GRCh38]
Chr3:183534481..184082882 [GRCh37]
Chr3:185017175..185565576 [NCBI36]
Chr3:3q27.1
uncertain significance
GRCh38/hg38 3q26.32-29(chr3:176168525-198118383)x3 copy number gain See cases [RCV000138662] Chr3:176168525..198118383 [GRCh38]
Chr3:175886313..197845254 [GRCh37]
Chr3:177369007..199329651 [NCBI36]
Chr3:3q26.32-29
pathogenic
GRCh38/hg38 3q25.1-29(chr3:152100512-198118383)x3 copy number gain See cases [RCV000139435] Chr3:152100512..198118383 [GRCh38]
Chr3:151818301..197845254 [GRCh37]
Chr3:153300991..199329651 [NCBI36]
Chr3:3q25.1-29
pathogenic
GRCh38/hg38 3q27.1-27.2(chr3:184010704-186288926)x1 copy number loss See cases [RCV000139917] Chr3:184010704..186288926 [GRCh38]
Chr3:183728492..186006715 [GRCh37]
Chr3:185211186..187489409 [NCBI36]
Chr3:3q27.1-27.2
likely pathogenic
GRCh38/hg38 3q25.31-29(chr3:156321878-198113452)x3 copy number gain See cases [RCV000140849] Chr3:156321878..198113452 [GRCh38]
Chr3:156039667..197840323 [GRCh37]
Chr3:157522361..199324720 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156118441-198125115)x3 copy number gain See cases [RCV000142310] Chr3:156118441..198125115 [GRCh38]
Chr3:155836230..197851986 [GRCh37]
Chr3:157318924..199336383 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q26.33-27.3(chr3:182319764-186443121)x1 copy number loss See cases [RCV000142154] Chr3:182319764..186443121 [GRCh38]
Chr3:182037552..186160910 [GRCh37]
Chr3:183520246..187643604 [NCBI36]
Chr3:3q26.33-27.3
likely pathogenic
GRCh38/hg38 3q26.1-28(chr3:167717962-188365272)x3 copy number gain See cases [RCV000142107] Chr3:167717962..188365272 [GRCh38]
Chr3:167435750..188083060 [GRCh37]
Chr3:168918444..189565754 [NCBI36]
Chr3:3q26.1-28
likely pathogenic
GRCh38/hg38 3q26.33-28(chr3:181138664-192512023)x1 copy number loss See cases [RCV000142019] Chr3:181138664..192512023 [GRCh38]
Chr3:180856452..192229812 [GRCh37]
Chr3:182339146..193712506 [NCBI36]
Chr3:3q26.33-28
pathogenic
GRCh38/hg38 3q27.1(chr3:183521497-184472038)x1 copy number loss See cases [RCV000143297] Chr3:183521497..184472038 [GRCh38]
Chr3:183239285..184189826 [GRCh37]
Chr3:184721979..185672520 [NCBI36]
Chr3:3q27.1
likely pathogenic
GRCh38/hg38 3q26.1-29(chr3:166137209-198125115)x3 copy number gain See cases [RCV000143694] Chr3:166137209..198125115 [GRCh38]
Chr3:165854997..197851986 [GRCh37]
Chr3:167337691..199336383 [NCBI36]
Chr3:3q26.1-29
pathogenic
GRCh37/hg19 3q24-29(chr3:142995020-192997215)x4 copy number gain See cases [RCV000240256] Chr3:142995020..192997215 [GRCh37]
Chr3:3q24-29
pathogenic
GRCh37/hg19 3q25.32-29(chr3:158980631-197766890)x3 copy number gain See cases [RCV000447464] Chr3:158980631..197766890 [GRCh37]
Chr3:3q25.32-29
pathogenic
GRCh37/hg19 3q26.33-29(chr3:181911498-197851986)x4 copy number gain See cases [RCV000446732] Chr3:181911498..197851986 [GRCh37]
Chr3:3q26.33-29
pathogenic
Single allele duplication Currarino triad [RCV000417195] Chr3:177772523..185716872 [GRCh38]
Chr3:3q26.32-27.2
likely pathogenic
GRCh37/hg19 3q27.1-27.3(chr3:183178932-186838042)x1 copy number loss See cases [RCV000448937] Chr3:183178932..186838042 [GRCh37]
Chr3:3q27.1-27.3
pathogenic
GRCh37/hg19 3q25.2-29(chr3:152356847-197851986)x3 copy number gain See cases [RCV000448608] Chr3:152356847..197851986 [GRCh37]
Chr3:3q25.2-29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q26.33-29(chr3:182539234-197851986)x3 copy number gain not provided [RCV000682336] Chr3:182539234..197851986 [GRCh37]
Chr3:3q26.33-29
pathogenic
GRCh37/hg19 3q26.33-28(chr3:182650681-191275809)x1 copy number loss not provided [RCV000682337] Chr3:182650681..191275809 [GRCh37]
Chr3:3q26.33-28
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q26.31-29(chr3:173281266-197838262)x3 copy number gain not provided [RCV000742968] Chr3:173281266..197838262 [GRCh37]
Chr3:3q26.31-29
pathogenic
GRCh37/hg19 3q26.2-28(chr3:169617690-190593854)x3 copy number gain not provided [RCV001005487] Chr3:169617690..190593854 [GRCh37]
Chr3:3q26.2-28
pathogenic
GRCh37/hg19 3q27.1-27.3(chr3:183789584-186034649)x1 copy number loss not provided [RCV001005495] Chr3:183789584..186034649 [GRCh37]
Chr3:3q27.1-27.3
likely pathogenic
GRCh37/hg19 3q27.1-27.3(chr3:182877291-186830759)x1 copy number loss not provided [RCV001259730] Chr3:182877291..186830759 [GRCh37]
Chr3:3q27.1-27.3
pathogenic
GRCh37/hg19 3q26.33-27.2(chr3:181171210-184706091)x1 copy number loss Anophthalmia/microphthalmia-esophageal atresia syndrome [RCV001267847] Chr3:181171210..184706091 [GRCh37]
Chr3:3q26.33-27.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33923 AgrOrtholog
COSMIC MIR1224 COSMIC
Ensembl Genes ENSG00000221120 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000408193 ENTREZGENE
GTEx ENSG00000221120 GTEx
HGNC ID HGNC:33923 ENTREZGENE
Human Proteome Map MIR1224 Human Proteome Map
miRBase MI0003764 ENTREZGENE
NCBI Gene 100187716 ENTREZGENE
OMIM 611620 OMIM
PharmGKB PA164722367 PharmGKB
RNAcentral URS0000435A77 RNACentral
  URS00006378D3 RNACentral
  URS000075C165 RNACentral