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Gene: HEY1 (hes related family bHLH transcription factor with YRPW motif 1) Homo sapiens
Symbol: HEY1
Name: hes related family bHLH transcription factor with YRPW motif 1
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; and negative regulation of transcription regulatory region DNA binding activity. Predicted to localize to the cytoplasm and nuclear chromatin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic helix-loop-helix protein OAF1; BHLHb31; cardiovascular helix-loop-helix factor 2; CHF2; class B basic helix-loop-helix protein 31; hairy and enhancer of split-related protein 1; hairy-related transcription factor 1; hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; HERP2; hes-related family bHLH transcription factor with YRPW motif 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR1; hHRT1; HRT-1; MGC1274; NERP2; OAF1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl879,764,010 - 79,767,857 (-)Ensembl
GRCh38879,764,010 - 79,767,863 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37880,676,245 - 80,680,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36880,838,800 - 80,842,653 (-)NCBINCBI36hg18NCBI36
Build 34880,838,800 - 80,842,559NCBI
Celera876,680,512 - 76,684,366 (-)NCBI
Cytogenetic Map8q21.13NCBI
HuRef876,165,779 - 76,169,632 (-)NCBIHuRef
CHM1_1880,728,484 - 80,732,338 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HEY1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735762
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.