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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid precursor protein catabolic process
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Accession:GO:0042987 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP catabolic process;   APP catabolism;   amyloid precursor protein breakdown;   amyloid precursor protein catabolism;   amyloid precursor protein degradation


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amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:1,620,763...1,678,561
Ensembl chrNW_004936500:1,620,641...1,678,607
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:5,864,851...5,904,005
Ensembl chrNW_004936532:5,864,867...5,904,003
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 involved_in ISO (PMID:17112471) ARUK-UCL PMID:17112471 NCBI chrNW_004936515:5,603,095...5,683,347 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 involved_in ISO (PMID:12054541) ARUK-UCL PMID:12054541 NCBI chrNW_004936710:2,301,470...2,388,533
Ensembl chrNW_004936710:2,301,730...2,387,695
JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:552,362...556,027
Ensembl chrNW_004936580:552,362...556,027
JBrowse link
G Aph1b aph-1 homolog B, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:23,839,962...23,869,788
Ensembl chrNW_004936471:23,839,907...23,869,935
JBrowse link
G Bace1 beta-secretase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:2,514,297...2,539,088
Ensembl chrNW_004936542:2,514,300...2,539,135
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,955,334...11,967,338
Ensembl chrNW_004936501:11,955,184...11,967,436
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:16407971) MGI
Ensembl
PMID:16407971 GO_REF:0000107 NCBI chrNW_004936522:6,423,561...6,447,363
Ensembl chrNW_004936522:6,423,561...6,444,814
JBrowse link
G Ncstn nicastrin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936740:285,789...301,918
Ensembl chrNW_004936740:285,657...302,111
JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:11567612)
(PMID:10206645), (PMID:15452145)
MGI
Ensembl
InterPro
PMID:10206645 PMID:11567612 PMID:15452145 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936488:2,464,623...2,528,807
Ensembl chrNW_004936488:2,464,527...2,530,065
JBrowse link
G Psen2 presenilin 2 involved_in IEA Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936526:3,584,194...3,611,719
Ensembl chrNW_004936526:3,584,188...3,614,074
JBrowse link
G Psenen presenilin enhancer, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:576,722...578,022
Ensembl chrNW_004936570:576,722...578,010
JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in ISO PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759
JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:552,362...556,027
Ensembl chrNW_004936580:552,362...556,027
JBrowse link
G Aph1b aph-1 homolog B, gamma-secretase subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16371134) Ensembl
MGI
PMID:16371134 GO_REF:0000107 NCBI chrNW_004936471:23,839,962...23,869,788
Ensembl chrNW_004936471:23,839,907...23,869,935
JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO (PMID:27992182) DisProt PMID:27992182 NCBI chrNW_004936542:2,111,055...2,112,626
Ensembl chrNW_004936542:2,111,052...2,112,854
JBrowse link
G Bace1 beta-secretase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:2,514,297...2,539,088
Ensembl chrNW_004936542:2,514,300...2,539,135
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:5,317,109...5,423,593
Ensembl chrNW_004936500:5,316,164...5,404,353
JBrowse link
G Ncstn nicastrin involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16371134) Ensembl
MGI
PMID:16371134 GO_REF:0000107 NCBI chrNW_004936740:285,789...301,918
Ensembl chrNW_004936740:285,657...302,111
JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:20130175)
(PMID:16371134)
Ensembl
MGI
TreeGrafter
PMID:16371134 PMID:20130175 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936488:2,464,623...2,528,807
Ensembl chrNW_004936488:2,464,527...2,530,065
JBrowse link
G Psen2 presenilin 2 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936526:3,584,194...3,611,719
Ensembl chrNW_004936526:3,584,188...3,614,074
JBrowse link
G Psenen presenilin enhancer, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:576,722...578,022
Ensembl chrNW_004936570:576,722...578,010
JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:5,071,546...5,090,287
Ensembl chrNW_004936538:5,071,546...5,090,313
JBrowse link
G Prnp prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629
JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:6,192,407...6,352,835
Ensembl chrNW_004936542:6,192,407...6,352,424
JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:18429932)
(PMID:23467355), (PMID:27030769)
Alzheimers_University_of_Toronto PMID:18429932 PMID:23467355 PMID:27030769 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Bin1 bridging integrator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:44,128,308...44,185,739
Ensembl chrNW_004936469:44,127,970...44,185,246
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246
JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:531,844...548,487
Ensembl chrNW_004936594:532,342...548,440
JBrowse link
G Hap1 huntingtin associated protein 1 involved_in ISO PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chrNW_004936490:16,645,116...16,652,310
Ensembl chrNW_004936490:16,643,520...16,652,479
JBrowse link
G Igf1 insulin like growth factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:26094765) ARUK-UCL
Ensembl
PMID:26094765 GO_REF:0000107 NCBI chrNW_004936680:267,850...621,467
Ensembl chrNW_004936680:267,596...615,928
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:309,530...321,294
Ensembl chrNW_004936659:309,506...321,334
JBrowse link
G Prnp prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629
JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601
JBrowse link
G Rtn1 reticulon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:3,933,652...4,158,269
Ensembl chrNW_004936495:3,933,605...4,158,571
JBrowse link
G Rtn2 reticulon 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,913,852...1,922,982
Ensembl chrNW_004936706:1,913,842...1,922,772
JBrowse link
G Rtn3 reticulon 3 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004936599:5,364,406...5,430,076 JBrowse link
G Rtn4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:1,407,414...1,474,031
Ensembl chrNW_004936491:1,407,414...1,474,360
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:6,192,407...6,352,835
Ensembl chrNW_004936542:6,192,407...6,352,424
JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16227578) Ensembl
MGI
PMID:16227578 GO_REF:0000107 NCBI chrNW_004936528:4,436,217...4,701,835
Ensembl chrNW_004936528:4,436,688...4,702,431
JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chrNW_004936469:44,128,308...44,185,739
Ensembl chrNW_004936469:44,127,970...44,185,246
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) MGI PMID:16641999 NCBI chrNW_004936488:4,265,731...4,303,895
Ensembl chrNW_004936488:4,265,731...4,303,948
JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
ISO
IEA
(PMID:22086926)
(PMID:20704561)
ARUK-UCL
Ensembl
PMID:20704561 PMID:22086926 GO_REF:0000107 NCBI chrNW_004936669:922,978...941,996
Ensembl chrNW_004936669:926,622...942,167
JBrowse link
G Ager advanced glycosylation end-product specific receptor involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147
JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286
JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004936580:4,654,503...4,660,950
Ensembl chrNW_004936580:4,654,503...4,660,966
JBrowse link
G Efna3 ephrin A3 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004936580:4,613,847...4,622,834
Ensembl chrNW_004936580:4,613,847...4,621,208
JBrowse link
G Epha4 EPH receptor A4 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004936569:3,539,269...3,670,322
Ensembl chrNW_004936569:3,540,053...3,670,348
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004936496:2,578,598...2,698,165
Ensembl chrNW_004936496:2,637,958...2,700,055
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chrNW_004936552:221,458...305,625
Ensembl chrNW_004936552:222,320...291,925
JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:7,142,580...7,284,722
Ensembl chrNW_004936532:7,145,882...7,286,244
JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16227578) Ensembl
MGI
PMID:16227578 GO_REF:0000107 NCBI chrNW_004936528:4,436,217...4,701,835
Ensembl chrNW_004936528:4,436,688...4,702,431
JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
ISO
IEA
(PMID:22086926) ARUK-UCL
Ensembl
PMID:22086926 GO_REF:0000107 NCBI chrNW_004936669:922,978...941,996
Ensembl chrNW_004936669:926,622...942,167
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:1,620,763...1,678,561
Ensembl chrNW_004936500:1,620,641...1,678,607
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Casp3 caspase 3 involved_in ISO (PMID:17553422) UniProt PMID:17553422 RGD:13825190 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246
JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836
JBrowse link
G Efna1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,654,503...4,660,950
Ensembl chrNW_004936580:4,654,503...4,660,966
JBrowse link
G Epha4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:3,539,269...3,670,322
Ensembl chrNW_004936569:3,540,053...3,670,348
JBrowse link
G Gsap gamma-secretase activating protein involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936479:20,705,596...20,800,026
Ensembl chrNW_004936479:20,705,585...20,800,020
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:266,462...277,256
Ensembl chrNW_004936706:269,126...277,256
JBrowse link
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452
JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004936560:4,519,858...4,545,763
Ensembl chrNW_004936560:4,519,474...4,545,796
JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17098871) MGI
Ensembl
PMID:17098871 GO_REF:0000107 NCBI chrNW_004936925:330,424...492,052
Ensembl chrNW_004936925:330,399...493,632
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of
involved_in
ISO
IEA
(PMID:21329555) ARUK-UCL
Ensembl
PMID:21329555 GO_REF:0000107 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813
JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:7,142,580...7,284,722
Ensembl chrNW_004936532:7,145,882...7,286,244
JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936607:909,691...1,185,550
Ensembl chrNW_004936607:909,677...1,186,922
JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of
involved_in
ISO
IEA
(PMID:14701757) ARUK-UCL
Ensembl
PMID:14701757 GO_REF:0000107 NCBI chrNW_004936512:10,655,116...10,693,025
Ensembl chrNW_004936512:10,655,349...10,693,042
JBrowse link
G Tnf tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
JBrowse link
regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) UniProt PMID:28164773 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (PMID:23070049) ParkinsonsUK-UCL PMID:23070049 NCBI chrNW_004936596:3,311,358...3,370,833
Ensembl chrNW_004936596:3,312,788...3,368,916
JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO (PMID:16641999) UniProt PMID:16641999 NCBI chrNW_004936488:4,265,731...4,303,895
Ensembl chrNW_004936488:4,265,731...4,303,948
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 17429
    cellular process 17029
      metabolic process 11322
        primary metabolic process 10062
          protein metabolic process 4193
            amyloid precursor protein metabolic process 74
              amyloid precursor protein catabolic process 58
                amyloid-beta formation + 45
                negative regulation of amyloid precursor protein catabolic process + 20
                positive regulation of amyloid precursor protein catabolic process + 25
                regulation of amyloid precursor protein catabolic process + 43
paths to the root