ONTOLOGY REPORT - ANNOTATIONS
Term: amyloid precursor protein catabolic process
Accession: GO:0042987
browse the term
Definition: The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms: exact_synonym: APP catabolic process; APP catabolism; amyloid precursor protein breakdown; amyloid precursor protein catabolism; amyloid precursor protein degradation
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Abcg1
ATP binding cassette subfamily G member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936500:1,620,763...1,678,561
Ensembl chrNW_004936500:1,620,641...1,678,607
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Adam10
ADAM metallopeptidase domain 10
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759
G
Adam17
ADAM metallopeptidase domain 17
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936532:5,864,851...5,904,005
Ensembl chrNW_004936532:5,864,867...5,904,003
G
Adam19
ADAM metallopeptidase domain 19
involved_in
ISO
(PMID:17112471)
ARUK-UCL
PMID:17112471
NCBI chrNW_004936515:5,603,095...5,683,347
G
Adam9
ADAM metallopeptidase domain 9
involved_in
ISO
(PMID:12054541)
ARUK-UCL
PMID:12054541
NCBI chrNW_004936710:2,301,470...2,388,533
Ensembl chrNW_004936710:2,301,730...2,387,695
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Aph1a
aph-1 homolog A, gamma-secretase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936580:552,362...556,027
Ensembl chrNW_004936580:552,362...556,027
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Aph1b
aph-1 homolog B, gamma-secretase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936471:23,839,962...23,869,788
Ensembl chrNW_004936471:23,839,907...23,869,935
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Bace1
beta-secretase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936542:2,514,297...2,539,088
Ensembl chrNW_004936542:2,514,300...2,539,135
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Cln3
CLN3 lysosomal/endosomal transmembrane protein, battenin
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936501:11,955,334...11,967,338
Ensembl chrNW_004936501:11,955,184...11,967,436
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Dhcr24
24-dehydrocholesterol reductase
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:16407971)
MGI Ensembl
PMID:16407971
GO_REF:0000107
NCBI chrNW_004936522:6,423,561...6,447,363
Ensembl chrNW_004936522:6,423,561...6,444,814
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Ncstn
nicastrin
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936740:285,789...301,918
Ensembl chrNW_004936740:285,657...302,111
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Psen1
presenilin 1
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:11567612) (PMID:10206645), (PMID:15452145)
MGI Ensembl InterPro
PMID:10206645 PMID:11567612 PMID:15452145
GO_REF:0000002 GO_REF:0000107
NCBI chrNW_004936488:2,464,623...2,528,807
Ensembl chrNW_004936488:2,464,527...2,530,065
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Psen2
presenilin 2
involved_in
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chrNW_004936526:3,584,194...3,611,719
Ensembl chrNW_004936526:3,584,188...3,614,074
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Psenen
presenilin enhancer, gamma-secretase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936570:576,722...578,022
Ensembl chrNW_004936570:576,722...578,010
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Abca7
ATP binding cassette subfamily A member 7
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229
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Adam10
ADAM metallopeptidase domain 10
involved_in
ISO
PMID:17301176
SynGO-UCL
PMID:17301176
RGD:12907557
NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759
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Aph1a
aph-1 homolog A, gamma-secretase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936580:552,362...556,027
Ensembl chrNW_004936580:552,362...556,027
G
Aph1b
aph-1 homolog B, gamma-secretase subunit
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16371134)
Ensembl MGI
PMID:16371134
GO_REF:0000107
NCBI chrNW_004936471:23,839,962...23,869,788
Ensembl chrNW_004936471:23,839,907...23,869,935
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Apoa1
apolipoprotein A1
involved_in
ISO
(PMID:27992182)
DisProt
PMID:27992182
NCBI chrNW_004936542:2,111,055...2,112,626
Ensembl chrNW_004936542:2,111,052...2,112,854
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Bace1
beta-secretase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936542:2,514,297...2,539,088
Ensembl chrNW_004936542:2,514,300...2,539,135
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Dyrk1a
dual specificity tyrosine phosphorylation regulated kinase 1A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936500:5,317,109...5,423,593
Ensembl chrNW_004936500:5,316,164...5,404,353
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Ncstn
nicastrin
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16371134)
Ensembl MGI
PMID:16371134
GO_REF:0000107
NCBI chrNW_004936740:285,789...301,918
Ensembl chrNW_004936740:285,657...302,111
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Psen1
presenilin 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:20130175) (PMID:16371134)
Ensembl MGI TreeGrafter
PMID:16371134 PMID:20130175
GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936488:2,464,623...2,528,807
Ensembl chrNW_004936488:2,464,527...2,530,065
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Psen2
presenilin 2
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936526:3,584,194...3,611,719
Ensembl chrNW_004936526:3,584,188...3,614,074
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Psenen
presenilin enhancer, gamma-secretase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936570:576,722...578,022
Ensembl chrNW_004936570:576,722...578,010
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Flot2
flotillin 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936538:5,071,546...5,090,287
Ensembl chrNW_004936538:5,071,546...5,090,313
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Prnp
prion protein (Kanno blood group)
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629
G
Rock1
Rho associated coiled-coil containing protein kinase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601
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Sorl1
sortilin related receptor 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936542:6,192,407...6,352,835
Ensembl chrNW_004936542:6,192,407...6,352,424
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Abca7
ATP binding cassette subfamily A member 7
involved_in
ISO
(PMID:18429932) (PMID:23467355), (PMID:27030769)
Alzheimers_University_of_Toronto
PMID:18429932 PMID:23467355 PMID:27030769
NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229
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Apoe
apolipoprotein E
involved_in
ISO
(PMID:24154541), (PMID:24259049)
Alzheimers_University_of_Toronto
PMID:24154541 PMID:24259049
NCBI chrNW_004936706:1,512,438...1,516,805
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Bin1
bridging integrator 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936469:44,128,308...44,185,739
Ensembl chrNW_004936469:44,127,970...44,185,246
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
involved_in
ISO
(PMID:20708605)
ARUK-UCL
PMID:20708605
NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246
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Clu
clusterin
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836
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Gga3
golgi associated, gamma adaptin ear containing, ARF binding protein 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936594:531,844...548,487
Ensembl chrNW_004936594:532,342...548,440
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Hap1
huntingtin associated protein 1
involved_in
ISO
PMID:22731248
UniProt
PMID:22731248
RGD:10047200
NCBI chrNW_004936490:16,645,116...16,652,310
Ensembl chrNW_004936490:16,643,520...16,652,479
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Igf1
insulin like growth factor 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351
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Ntrk2
neurotrophic receptor tyrosine kinase 2
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:26094765)
ARUK-UCL Ensembl
PMID:26094765
GO_REF:0000107
NCBI chrNW_004936680:267,850...621,467
Ensembl chrNW_004936680:267,596...615,928
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Pin1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936659:309,530...321,294
Ensembl chrNW_004936659:309,506...321,334
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Prnp
prion protein (Kanno blood group)
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629
G
Rock1
Rho associated coiled-coil containing protein kinase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601
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Rtn1
reticulon 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936495:3,933,652...4,158,269
Ensembl chrNW_004936495:3,933,605...4,158,571
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Rtn2
reticulon 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936706:1,913,852...1,922,982
Ensembl chrNW_004936706:1,913,842...1,922,772
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Rtn3
reticulon 3
involved_in
ISO
(PMID:15286784)
UniProt
PMID:15286784
NCBI chrNW_004936599:5,364,406...5,430,076
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Rtn4
reticulon 4
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936491:1,407,414...1,474,031
Ensembl chrNW_004936491:1,407,414...1,474,360
G
Sorl1
sortilin related receptor 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936542:6,192,407...6,352,835
Ensembl chrNW_004936542:6,192,407...6,352,424
G
Spon1
spondin 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16227578)
Ensembl MGI
PMID:16227578
GO_REF:0000107
NCBI chrNW_004936528:4,436,217...4,701,835
Ensembl chrNW_004936528:4,436,688...4,702,431
G
Bin1
bridging integrator 1
involved_in
ISO
(PMID:27179792)
ARUK-UCL
PMID:27179792
NCBI chrNW_004936469:44,128,308...44,185,739
Ensembl chrNW_004936469:44,127,970...44,185,246
G
Tmed10
transmembrane p24 trafficking protein 10
acts_upstream_of_or_within
ISO
(PMID:16641999)
MGI
PMID:16641999
NCBI chrNW_004936488:4,265,731...4,303,895
Ensembl chrNW_004936488:4,265,731...4,303,948
G
Abca2
ATP binding cassette subfamily A member 2
acts_upstream_of involved_in
ISO IEA
(PMID:22086926) (PMID:20704561)
ARUK-UCL Ensembl
PMID:20704561 PMID:22086926
GO_REF:0000107
NCBI chrNW_004936669:922,978...941,996
Ensembl chrNW_004936669:926,622...942,167
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Ager
advanced glycosylation end-product specific receptor
involved_in
ISO
(PMID:22406537)
ARUK-UCL
PMID:22406537
NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147
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App
amyloid beta precursor protein
involved_in
ISO
(PMID:22406537)
ARUK-UCL
PMID:22406537
NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286
G
Efna1
ephrin A1
involved_in
ISO
(PMID:24217950)
ARUK-UCL
PMID:24217950
NCBI chrNW_004936580:4,654,503...4,660,950
Ensembl chrNW_004936580:4,654,503...4,660,966
G
Efna3
ephrin A3
involved_in
ISO
(PMID:24217950)
ARUK-UCL
PMID:24217950
NCBI chrNW_004936580:4,613,847...4,622,834
Ensembl chrNW_004936580:4,613,847...4,621,208
G
Epha4
EPH receptor A4
involved_in
ISO
(PMID:24217950)
ARUK-UCL
PMID:24217950
NCBI chrNW_004936569:3,539,269...3,670,322
Ensembl chrNW_004936569:3,540,053...3,670,348
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Lyn
LYN proto-oncogene, Src family tyrosine kinase
involved_in
ISO
(PMID:24217950)
ARUK-UCL
PMID:24217950
NCBI chrNW_004936496:2,578,598...2,698,165
Ensembl chrNW_004936496:2,637,958...2,700,055
G
Picalm
phosphatidylinositol binding clathrin assembly protein
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
G
Ranbp9
RAN binding protein 9
acts_upstream_of
ISO
PMID:24592211
ARUK-UCL
PMID:24592211
RGD:38501074
NCBI chrNW_004936552:221,458...305,625
Ensembl chrNW_004936552:222,320...291,925
G
Rock2
Rho associated coiled-coil containing protein kinase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936532:7,142,580...7,284,722
Ensembl chrNW_004936532:7,145,882...7,286,244
G
Spon1
spondin 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16227578)
Ensembl MGI
PMID:16227578
GO_REF:0000107
NCBI chrNW_004936528:4,436,217...4,701,835
Ensembl chrNW_004936528:4,436,688...4,702,431
G
Abca2
ATP binding cassette subfamily A member 2
acts_upstream_of involved_in
ISO IEA
(PMID:22086926)
ARUK-UCL Ensembl
PMID:22086926
GO_REF:0000107
NCBI chrNW_004936669:922,978...941,996
Ensembl chrNW_004936669:926,622...942,167
G
Abcg1
ATP binding cassette subfamily G member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936500:1,620,763...1,678,561
Ensembl chrNW_004936500:1,620,641...1,678,607
G
Apoe
apolipoprotein E
involved_in
ISO
(PMID:24154541), (PMID:24259049)
Alzheimers_University_of_Toronto
PMID:24154541 PMID:24259049
NCBI chrNW_004936706:1,512,438...1,516,805
G
Casp3
caspase 3
involved_in
ISO
(PMID:17553422)
UniProt
PMID:17553422
RGD:13825190
NCBI chrNW_004936554:4,571,072...4,593,765
G
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246
G
Clu
clusterin
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836
G
Efna1
ephrin A1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936580:4,654,503...4,660,950
Ensembl chrNW_004936580:4,654,503...4,660,966
G
Epha4
EPH receptor A4
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936569:3,539,269...3,670,322
Ensembl chrNW_004936569:3,540,053...3,670,348
G
Gsap
gamma-secretase activating protein
involved_in
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004936479:20,705,596...20,800,026
Ensembl chrNW_004936479:20,705,585...20,800,020
G
Gsk3a
glycogen synthase kinase 3 alpha
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936706:266,462...277,256
Ensembl chrNW_004936706:269,126...277,256
G
Ifng
interferon gamma
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452
G
Ifngr1
interferon gamma receptor 1
involved_in
ISO
(PMID:17255335)
ARUK-UCL
PMID:17255335
NCBI chrNW_004936560:4,519,858...4,545,763
Ensembl chrNW_004936560:4,519,474...4,545,796
G
Lrrtm3
leucine rich repeat transmembrane neuronal 3
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:17098871)
MGI Ensembl
PMID:17098871
GO_REF:0000107
NCBI chrNW_004936925:330,424...492,052
Ensembl chrNW_004936925:330,399...493,632
G
Picalm
phosphatidylinositol binding clathrin assembly protein
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
G
Rela
RELA proto-oncogene, NF-kB subunit
acts_upstream_of involved_in
ISO IEA
(PMID:21329555)
ARUK-UCL Ensembl
PMID:21329555
GO_REF:0000107
NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813
G
Rock2
Rho associated coiled-coil containing protein kinase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936532:7,142,580...7,284,722
Ensembl chrNW_004936532:7,145,882...7,286,244
G
Slc2a13
solute carrier family 2 member 13
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936607:909,691...1,185,550
Ensembl chrNW_004936607:909,677...1,186,922
G
Sp1
Sp1 transcription factor
acts_upstream_of involved_in
ISO IEA
(PMID:14701757)
ARUK-UCL Ensembl
PMID:14701757
GO_REF:0000107
NCBI chrNW_004936512:10,655,116...10,693,025
Ensembl chrNW_004936512:10,655,349...10,693,042
G
Tnf
tumor necrosis factor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
G
Abca7
ATP binding cassette subfamily A member 7
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229
G
Apoe
apolipoprotein E
involved_in
ISO
(PMID:28164773)
UniProt
PMID:28164773
NCBI chrNW_004936706:1,512,438...1,516,805
G
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
involved_in
ISO
(PMID:20708605)
ARUK-UCL
PMID:20708605
NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246
G
Fkbp1a
FKBP prolyl isomerase 1A
involved_in
ISO
(PMID:24499793)
ParkinsonsUK-UCL
PMID:24499793
NCBI chrNW_004936485:17,305,376...17,311,797
G
Picalm
phosphatidylinositol binding clathrin assembly protein
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
G
Unc13a
unc-13 homolog A
involved_in
ISO
(PMID:23070049)
ParkinsonsUK-UCL
PMID:23070049
NCBI chrNW_004936596:3,311,358...3,370,833
Ensembl chrNW_004936596:3,312,788...3,368,916
G
Picalm
phosphatidylinositol binding clathrin assembly protein
NOT|involved_in
ISO
(PMID:26005850)
ARUK-UCL
PMID:26005850
NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167
G
Tmed10
transmembrane p24 trafficking protein 10
involved_in
ISO
(PMID:16641999)
UniProt
PMID:16641999
NCBI chrNW_004936488:4,265,731...4,303,895
Ensembl chrNW_004936488:4,265,731...4,303,948
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all