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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid precursor protein catabolic process
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Accession:GO:0042987 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP catabolic process;   APP catabolism;   amyloid precursor protein breakdown;   amyloid precursor protein catabolism;   amyloid precursor protein degradation

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amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:1,620,763...1,678,561
Ensembl chrNW_004936500:1,620,641...1,678,607 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:5,864,851...5,904,005
Ensembl chrNW_004936532:5,864,867...5,904,003 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 involved_in ISO (PMID:17112471) ARUK-UCL PMID:17112471 NCBI chrNW_004936515:5,603,095...5,683,347 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 involved_in ISO (PMID:12054541) ARUK-UCL PMID:12054541 NCBI chrNW_004936710:2,301,470...2,388,533
Ensembl chrNW_004936710:2,301,730...2,387,695 		JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:552,362...556,027
Ensembl chrNW_004936580:552,362...556,027 		JBrowse link
G Aph1b aph-1 homolog B, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:23,839,962...23,869,788
Ensembl chrNW_004936471:23,839,907...23,869,935 		JBrowse link
G Bace1 beta-secretase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:2,514,297...2,539,088
Ensembl chrNW_004936542:2,514,300...2,539,135 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,955,334...11,967,338
Ensembl chrNW_004936501:11,955,184...11,967,436 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16407971) Ensembl
MGI		 PMID:16407971 GO_REF:0000107 NCBI chrNW_004936522:6,423,561...6,447,363
Ensembl chrNW_004936522:6,423,561...6,444,814 		JBrowse link
G Ncstn nicastrin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936740:285,789...301,918
Ensembl chrNW_004936740:285,657...302,111 		JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10206645), (PMID:15452145)
(PMID:11567612)		 InterPro
MGI
Ensembl		 PMID:10206645 PMID:11567612 PMID:15452145 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936488:2,464,623...2,528,807
Ensembl chrNW_004936488:2,464,527...2,530,065 		JBrowse link
G Psen2 presenilin 2 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936526:3,584,194...3,611,719
Ensembl chrNW_004936526:3,584,188...3,614,074 		JBrowse link
G Psenen presenilin enhancer, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:576,722...578,022
Ensembl chrNW_004936570:576,722...578,010 		JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in ISO PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chrNW_004936471:19,760,709...19,911,759
Ensembl chrNW_004936471:19,758,118...19,911,759 		JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:552,362...556,027
Ensembl chrNW_004936580:552,362...556,027 		JBrowse link
G Aph1b aph-1 homolog B, gamma-secretase subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16371134) Ensembl
MGI		 PMID:16371134 GO_REF:0000107 NCBI chrNW_004936471:23,839,962...23,869,788
Ensembl chrNW_004936471:23,839,907...23,869,935 		JBrowse link
G Bace1 beta-secretase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:2,514,297...2,539,088
Ensembl chrNW_004936542:2,514,300...2,539,135 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:5,317,109...5,423,593
Ensembl chrNW_004936500:5,316,164...5,404,353 		JBrowse link
G Ncstn nicastrin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16371134) Ensembl
MGI		 PMID:16371134 GO_REF:0000107 NCBI chrNW_004936740:285,789...301,918
Ensembl chrNW_004936740:285,657...302,111 		JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20130175)
(PMID:16371134)		 Ensembl
MGI		 PMID:16371134 PMID:20130175 GO_REF:0000107 NCBI chrNW_004936488:2,464,623...2,528,807
Ensembl chrNW_004936488:2,464,527...2,530,065 		JBrowse link
G Psen2 presenilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936526:3,584,194...3,611,719
Ensembl chrNW_004936526:3,584,188...3,614,074 		JBrowse link
G Psenen presenilin enhancer, gamma-secretase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:576,722...578,022
Ensembl chrNW_004936570:576,722...578,010 		JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:5,071,546...5,090,287
Ensembl chrNW_004936538:5,071,546...5,090,313 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:6,192,407...6,352,835
Ensembl chrNW_004936542:6,192,407...6,352,424 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5553242|PMID:18429932)
(MGI:5487687|PMID:23467355), (MGI:5774886|PMID:27030769)		 Alzheimers_University_of_Toronto
ARUK-UCL		 PMID:18429932 PMID:23467355 PMID:27030769 MGI:5487687 MGI:5553242 MGI:5774886 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Bin1 bridging integrator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:44,128,308...44,185,739
Ensembl chrNW_004936469:44,127,970...44,185,246 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:531,844...548,487
Ensembl chrNW_004936594:532,342...548,440 		JBrowse link
G Hap1 huntingtin associated protein 1 involved_in ISO PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chrNW_004936490:16,645,116...16,652,310
Ensembl chrNW_004936490:16,643,520...16,652,479 		JBrowse link
G Igf1 insulin like growth factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:26094765) ARUK-UCL
Ensembl		 PMID:26094765 GO_REF:0000107 NCBI chrNW_004936680:267,850...621,467
Ensembl chrNW_004936680:267,596...615,928 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:309,530...321,294
Ensembl chrNW_004936659:309,506...321,334 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601 		JBrowse link
G Rtn1 reticulon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:3,933,652...4,158,269
Ensembl chrNW_004936495:3,933,605...4,158,571 		JBrowse link
G Rtn2 reticulon 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,913,852...1,922,982
Ensembl chrNW_004936706:1,913,842...1,922,772 		JBrowse link
G Rtn3 reticulon 3 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004936599:5,364,406...5,430,076 JBrowse link
G Rtn4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:1,407,414...1,474,031
Ensembl chrNW_004936491:1,407,414...1,474,360 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:6,192,407...6,352,835
Ensembl chrNW_004936542:6,192,407...6,352,424 		JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16227578) Ensembl
MGI		 PMID:16227578 GO_REF:0000107 NCBI chrNW_004936528:4,436,217...4,701,835
Ensembl chrNW_004936528:4,436,688...4,702,431 		JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:22086926)
(PMID:20704561)		 ARUK-UCL
Ensembl		 PMID:20704561 PMID:22086926 GO_REF:0000107 NCBI chrNW_004936669:922,978...941,996
Ensembl chrNW_004936669:926,622...942,167 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chrNW_004936552:221,458...305,625
Ensembl chrNW_004936552:222,320...291,925 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:7,142,580...7,284,722
Ensembl chrNW_004936532:7,145,882...7,286,244 		JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16227578) Ensembl
MGI		 PMID:16227578 GO_REF:0000107 NCBI chrNW_004936528:4,436,217...4,701,835
Ensembl chrNW_004936528:4,436,688...4,702,431 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:22086926) ARUK-UCL
Ensembl		 PMID:22086926 GO_REF:0000107 NCBI chrNW_004936669:922,978...941,996
Ensembl chrNW_004936669:926,622...942,167 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:1,620,763...1,678,561
Ensembl chrNW_004936500:1,620,641...1,678,607 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Casp3 caspase 3 involved_in ISO (PMID:17553422) UniProt PMID:17553422 RGD:13825190 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Efna1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,654,503...4,660,950
Ensembl chrNW_004936580:4,654,503...4,660,966 		JBrowse link
G Epha4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:3,539,269...3,670,322
Ensembl chrNW_004936569:3,540,053...3,670,348 		JBrowse link
G Gsap gamma-secretase activating protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936479:20,705,596...20,800,026
Ensembl chrNW_004936479:20,705,585...20,800,020 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:266,462...277,256
Ensembl chrNW_004936706:269,126...277,256 		JBrowse link
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (MGI:3697769|PMID:17255335) ARUK-UCL PMID:17255335 MGI:3697769 NCBI chrNW_004936560:4,519,858...4,545,763
Ensembl chrNW_004936560:4,519,474...4,545,796 		JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17098871) MGI
Ensembl		 PMID:17098871 GO_REF:0000107 NCBI chrNW_004936925:330,424...492,052
Ensembl chrNW_004936925:330,399...493,632 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of
involved_in		 ISO
IEA		 (MGI:6414694|PMID:21329555) ARUK-UCL
Ensembl		 PMID:21329555 GO_REF:0000107 MGI:6414694 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:7,142,580...7,284,722
Ensembl chrNW_004936532:7,145,882...7,286,244 		JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936607:909,691...1,185,550
Ensembl chrNW_004936607:909,677...1,186,922 		JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of
involved_in		 ISO
IEA		 (PMID:14701757) ARUK-UCL
Ensembl		 PMID:14701757 GO_REF:0000107 NCBI chrNW_004936512:10,655,116...10,693,025
Ensembl chrNW_004936512:10,655,349...10,693,042 		JBrowse link
G Tnf tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) UniProt PMID:28164773 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (MGI:5795815|PMID:23070049) ParkinsonsUK-UCL PMID:23070049 MGI:5795815 NCBI chrNW_004936596:3,311,358...3,370,833
Ensembl chrNW_004936596:3,312,788...3,368,916 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (MGI:5637941|PMID:26005850) ARUK-UCL PMID:26005850 MGI:5637941 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:4,265,731...4,303,895 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      primary metabolic process 8425
        protein metabolic process 3729
          amyloid precursor protein metabolic process 70
            amyloid precursor protein catabolic process 54
              amyloid-beta formation + 44
              negative regulation of amyloid precursor protein catabolic process + 19
              positive regulation of amyloid precursor protein catabolic process + 22
              regulation of amyloid precursor protein catabolic process + 40
Path 2
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      organic substance metabolic process 9204
        macromolecule metabolic process 7677
          protein metabolic process 3729
            amyloid precursor protein metabolic process 70
              amyloid precursor protein catabolic process 54
                amyloid-beta formation + 44
                negative regulation of amyloid precursor protein catabolic process + 19
                positive regulation of amyloid precursor protein catabolic process + 22
                regulation of amyloid precursor protein catabolic process + 40
paths to the root