Psen1 (presenilin 1) - Rat Genome Database

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Gene: Psen1 (presenilin 1) Ictidomys tridecemlineatus
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Symbol: Psen1
Name: presenilin 1
RGD ID: 12557796
Description: ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (ortholog); aspartic-type endopeptidase activity (ortholog); ATPase binding (ortholog); INVOLVED IN activation of MAPKK activity (ortholog); amyloid precursor protein catabolic process (ortholog); amyloid precursor protein metabolic process (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 3 (ortholog); Alzheimer's disease 4 (ortholog); FOUND IN aggresome (ortholog); axon (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: presenilin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864029,540,161 - 29,604,355 (-)NCBI
SpeTri2.0NW_0049364882,464,623 - 2,528,807 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (ISO)
amyloid precursor protein catabolic process  (ISO)
amyloid precursor protein metabolic process  (ISO)
amyloid-beta formation  (ISO)
amyloid-beta metabolic process  (ISO)
astrocyte activation  (ISO)
astrocyte activation involved in immune response  (ISO)
autophagosome assembly  (ISO)
autophagy  (ISO)
blood vessel development  (ISO)
brain development  (ISO)
brain morphogenesis  (ISO)
Cajal-Retzius cell differentiation  (ISO)
cell fate specification  (ISO)
cell-cell adhesion  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular protein metabolic process  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to DNA damage stimulus  (ISO)
cerebellum development  (ISO)
cerebral cortex cell migration  (ISO)
cerebral cortex development  (ISO)
choline transport  (ISO)
dorsal/ventral neural tube patterning  (ISO)
embryonic limb morphogenesis  (ISO)
endoplasmic reticulum calcium ion homeostasis  (ISO)
epithelial cell proliferation  (ISO)
forebrain development  (ISO)
gene expression  (ISO)
heart development  (ISO)
heart looping  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
L-glutamate import across plasma membrane  (ISO)
learning or memory  (ISO)
locomotion  (ISO)
membrane protein ectodomain proteolysis  (ISO)
memory  (ISO)
mitochondrial transport  (ISO)
modulation of age-related behavioral decline  (ISO)
myeloid dendritic cell differentiation  (ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of core promoter binding  (ISO)
negative regulation of epidermal growth factor-activated receptor activity  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (ISO)
negative regulation of ubiquitin-protein transferase activity  (ISO)
neural retina development  (ISO)
neurogenesis  (ISO)
neuron apoptotic process  (ISO)
neuron development  (ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
neuron projection maintenance  (ISO)
Notch receptor processing  (ISO)
Notch signaling pathway  (ISO)
positive regulation of amyloid fibril formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of coagulation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of L-glutamate import across plasma membrane  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor recycling  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
post-embryonic development  (ISO)
protein glycosylation  (ISO)
protein maturation  (ISO)
protein processing  (ISO)
protein transport  (ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of epidermal growth factor-activated receptor activity  (ISO)
regulation of gene expression  (ISO)
regulation of neuron projection development  (ISO)
regulation of phosphorylation  (ISO)
regulation of protein binding  (ISO)
regulation of resting membrane potential  (ISO)
regulation of synaptic plasticity  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
response to oxidative stress  (ISO)
segmentation  (ISO)
sequestering of calcium ion  (ISO)
skeletal system morphogenesis  (ISO)
skin morphogenesis  (ISO)
smooth endoplasmic reticulum calcium ion homeostasis  (ISO)
somitogenesis  (ISO)
synapse organization  (ISO)
synaptic vesicle targeting  (ISO)
T cell activation involved in immune response  (ISO)
T cell receptor signaling pathway  (ISO)
thymus development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Psen1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864029,540,161 - 29,604,355 (-)NCBI
SpeTri2.0NW_0049364882,464,623 - 2,528,807 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSEN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1473,136,418 - 73,223,691 (+)EnsemblGRCh38hg38GRCh38
GRCh381473,136,436 - 73,223,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371473,603,215 - 73,690,399 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361472,672,932 - 72,756,862 (+)NCBINCBI36hg18NCBI36
Build 341472,684,480 - 72,755,750NCBI
Celera1453,666,429 - 53,753,632 (+)NCBI
Cytogenetic Map14q24.2NCBI
HuRef1453,768,824 - 53,855,913 (+)NCBIHuRef
CHM1_11473,542,049 - 73,629,540 (+)NCBICHM1_1
Psen1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391283,734,926 - 83,781,869 (+)NCBIGRCm39mm39
GRCm39 Ensembl1283,734,926 - 83,781,973 (+)Ensembl
GRCm381283,688,152 - 83,735,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1283,688,152 - 83,735,199 (+)EnsemblGRCm38mm10GRCm38
MGSCv371285,029,513 - 85,076,149 (+)NCBIGRCm37mm9NCBIm37
MGSCv361284,578,311 - 84,624,947 (+)NCBImm8
Celera1285,135,054 - 85,181,689 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1238.84NCBI
Psen1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26103,323,014 - 103,375,088 (+)NCBI
Rnor_6.0 Ensembl6107,169,528 - 107,216,798 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06107,169,514 - 107,221,000 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06118,324,910 - 118,373,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46107,737,543 - 107,776,357 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16107,729,188 - 107,781,021 (+)NCBI
Celera6101,163,513 - 101,199,486 (+)NCBICelera
Cytogenetic Map6q24NCBI
Psen1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555232,128,529 - 2,210,737 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555232,128,529 - 2,210,737 (-)NCBIChiLan1.0ChiLan1.0
PSEN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11472,579,024 - 72,663,876 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1472,579,024 - 72,663,876 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01453,718,299 - 53,802,684 (+)NCBIMhudiblu_PPA_v0panPan3
PSEN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1846,495,551 - 46,569,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl846,495,624 - 46,569,532 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha846,188,004 - 46,253,311 (+)NCBI
ROS_Cfam_1.0846,719,986 - 46,800,157 (+)NCBI
UMICH_Zoey_3.1846,399,068 - 46,464,638 (+)NCBI
UNSW_CanFamBas_1.0846,414,872 - 46,480,438 (+)NCBI
UU_Cfam_GSD_1.0846,805,794 - 46,871,397 (+)NCBI
PSEN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl796,478,181 - 96,569,132 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1796,478,179 - 96,567,884 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27102,265,830 - 102,360,301 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q12-q26NCBI
PSEN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12450,394,310 - 50,476,521 (+)NCBI
ChlSab1.1 Ensembl2450,405,590 - 50,472,132 (+)Ensembl
Psen1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473428,200,358 - 28,272,684 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005321204   ⟹   XP_005321261
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,540,161 - 29,604,355 (-)NCBI
SpeTri2.0NW_0049364882,464,623 - 2,528,807 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013356867   ⟹   XP_013212321
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864029,540,161 - 29,604,355 (-)NCBI
SpeTri2.0NW_0049364882,464,623 - 2,528,807 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321261 (Get FASTA)   NCBI Sequence Viewer  
  XP_013212321 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005321261   ⟸   XM_005321204
- Peptide Label: isoform X1
- UniProtKB: A0A287CTD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013212321   ⟸   XM_013356867
- Peptide Label: isoform X2
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003845 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000003444 UniProtKB/TrEMBL
  ENSSTOP00000024539 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000025290 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003841 UniProtKB/TrEMBL
  ENSSTOT00000034098 UniProtKB/TrEMBL
  ENSSTOT00000037772 UniProtKB/TrEMBL
Gene3D-CATH 1.10.472.100 UniProtKB/TrEMBL
InterPro Pept_A22A_PS1 UniProtKB/TrEMBL
  Peptidase_A22A UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/TrEMBL
  Presenilin_C UniProtKB/TrEMBL
NCBI Gene Psen1 ENTREZGENE
PANTHER PTHR10202 UniProtKB/TrEMBL
Pfam Presenilin UniProtKB/TrEMBL
PRINTS PRESENILIN UniProtKB/TrEMBL
  PRESENILIN1 UniProtKB/TrEMBL
SMART PSN UniProtKB/TrEMBL
UniProt A0A287CTD7 ENTREZGENE, UniProtKB/TrEMBL
  I3M339_ICTTR UniProtKB/TrEMBL