Picalm (phosphatidylinositol binding clathrin assembly protein) - Rat Genome Database

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Gene: Picalm (phosphatidylinositol binding clathrin assembly protein) Ictidomys tridecemlineatus
Analyze
Symbol: Picalm
Name: phosphatidylinositol binding clathrin assembly protein
RGD ID: 12580196
Description: ENCODES a protein that exhibits 1-phosphatidylinositol binding (ortholog); clathrin binding (ortholog); clathrin heavy chain binding (ortholog); INVOLVED IN amyloid-beta clearance by transcytosis (ortholog); axonogenesis (ortholog); clathrin coat assembly (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); Cognitive Dysfunction (ortholog); FOUND IN AP-2 adaptor complex (ortholog); cell surface (ortholog); clathrin coat of coated pit (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494772,186,022 - 72,286,358 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance by transcytosis  (ISO)
axonogenesis  (ISO)
clathrin coat assembly  (ISO)
clathrin-coated pit assembly  (ISO)
clathrin-dependent endocytosis  (ISO)
dendrite morphogenesis  (ISO)
endocytosis  (ISO)
endosomal transport  (ISO)
hemopoiesis  (ISO)
iron ion homeostasis  (ISO)
learning or memory  (ISO)
membrane bending  (ISO)
modulation of age-related behavioral decline  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process  (ISO)
negative regulation of protein localization to cell surface  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
negative regulation of receptor-mediated endocytosis  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of dendrite extension  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of synaptic vesicle clustering  (ISO)
positive regulation of synaptic vesicle endocytosis  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
receptor internalization  (ISO)
receptor-mediated endocytosis  (ISO)
regulation of amyloid-beta formation  (ISO)
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  (ISO)
regulation of endocytosis  (ISO)
regulation of protein localization  (ISO)
regulation of protein transport  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle transport  (ISO)
regulation of terminal button organization  (ISO)
regulation of vesicle size  (ISO)
synaptic vesicle endocytosis  (ISO)
synaptic vesicle maturation  (ISO)
vesicle budding from membrane  (ISO)
vesicle cargo loading  (ISO)
vesicle-mediated transport  (ISO)

References

Genomics

Comparative Map Data
Picalm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494772,186,022 - 72,286,358 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PICALM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1185,957,175 - 86,069,882 (-)EnsemblGRCh38hg38GRCh38
GRCh381185,957,175 - 86,069,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371185,668,218 - 85,780,902 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,346,133 - 85,457,756 (-)NCBINCBI36hg18NCBI36
Build 341185,346,133 - 85,457,756NCBI
Celera1182,977,768 - 83,089,435 (-)NCBI
Cytogenetic Map11q14.2NCBI
HuRef1181,965,384 - 82,078,030 (-)NCBIHuRef
CHM1_11185,553,010 - 85,665,742 (-)NCBICHM1_1
Picalm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,779,418 - 89,858,655 (+)NCBIGRCm39mm39
GRCm39 Ensembl789,779,421 - 89,862,673 (+)Ensembl
GRCm38790,130,192 - 90,209,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl790,130,213 - 90,213,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv37797,278,742 - 97,357,442 (+)NCBIGRCm37mm9NCBIm37
MGSCv36790,005,424 - 90,084,124 (+)NCBImm8
Celera787,455,394 - 87,534,538 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map750.47NCBI
Picalm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21144,056,415 - 144,138,045 (+)NCBI
Rnor_6.0 Ensembl1154,377,247 - 154,458,425 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01154,377,229 - 154,458,966 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01160,681,689 - 160,763,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,754,085 - 146,834,197 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11146,832,490 - 146,912,603 (+)NCBI
Celera1142,288,691 - 142,367,949 (+)NCBICelera
Cytogenetic Map1q32NCBI
Picalm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,871,520 - 6,969,208 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554146,871,220 - 6,970,569 (+)NCBIChiLan1.0ChiLan1.0
PICALM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11184,619,241 - 84,730,516 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,619,241 - 84,730,684 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01181,011,324 - 81,122,352 (-)NCBIMhudiblu_PPA_v0panPan3
PICALM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12113,437,819 - 13,540,167 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2113,437,925 - 13,539,616 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2113,303,451 - 13,405,757 (+)NCBI
ROS_Cfam_1.02113,619,410 - 13,719,561 (+)NCBI
UMICH_Zoey_3.12113,405,869 - 13,508,626 (+)NCBI
UNSW_CanFamBas_1.02113,478,428 - 13,581,047 (+)NCBI
UU_Cfam_GSD_1.02113,531,568 - 13,633,911 (+)NCBI
PICALM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl919,835,938 - 20,104,632 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1919,835,934 - 19,947,239 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2922,107,100 - 22,184,702 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PICALM
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1177,214,391 - 77,325,626 (-)NCBI
ChlSab1.1 Ensembl177,213,836 - 77,324,875 (-)Ensembl
Vero_WHO_p1.0NW_02366604348,400,453 - 48,511,604 (+)NCBI
Picalm
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248453,875,601 - 3,990,347 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005323282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005323284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005323285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005323286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013357669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021725156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021725157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021725158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021725159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005323282   ⟹   XP_005323339
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,353 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005323284   ⟹   XP_005323341
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,352 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005323285   ⟹   XP_005323342
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,350 (-)NCBI
SpeTri2.0NW_00493649813,785,639 - 13,885,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005323286   ⟹   XP_005323343
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,352 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357658   ⟹   XP_013213112
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,356 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357659   ⟹   XP_013213113
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,358 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357660   ⟹   XP_013213114
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,355 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357661   ⟹   XP_013213115
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,357 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357663   ⟹   XP_013213117
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,354 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357666   ⟹   XP_013213120
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,355 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357667   ⟹   XP_013213121
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,353 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357668   ⟹   XP_013213122
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,354 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013357669   ⟹   XP_013213123
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,349 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,929 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725156   ⟹   XP_021580831
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,357 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725157   ⟹   XP_021580832
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,356 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725158   ⟹   XP_021580833
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,358 (-)NCBI
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725159   ⟹   XP_021580834
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494772,186,022 - 72,286,353 (-)NCBI
SpeTri2.0NW_00493649813,785,643 - 13,885,915 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005323342   ⟸   XM_005323285
- Peptide Label: isoform X15
- UniProtKB: A0A287D211 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005323343   ⟸   XM_005323286
- Peptide Label: isoform X16
- Sequence:
RefSeq Acc Id: XP_005323341   ⟸   XM_005323284
- Peptide Label: isoform X9
- UniProtKB: I3MC44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005323339   ⟸   XM_005323282
- Peptide Label: isoform X8
- UniProtKB: A0A287CS00 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013213122   ⟸   XM_013357668
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_013213120   ⟸   XM_013357666
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_013213123   ⟸   XM_013357669
- Peptide Label: isoform X17
- Sequence:
RefSeq Acc Id: XP_013213121   ⟸   XM_013357667
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_013213117   ⟸   XM_013357663
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_013213115   ⟸   XM_013357661
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013213113   ⟸   XM_013357659
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013213114   ⟸   XM_013357660
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013213112   ⟸   XM_013357658
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021580833   ⟸   XM_021725158
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_021580832   ⟸   XM_021725157
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_021580831   ⟸   XM_021725156
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021580834   ⟸   XM_021725159
- Peptide Label: isoform X10
- Sequence:
Protein Domains
ENTH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008689 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000007792 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000024059 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000027621 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008695 UniProtKB/TrEMBL
  ENSSTOT00000036621 UniProtKB/TrEMBL
  ENSSTOT00000038906 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.150 UniProtKB/TrEMBL
  1.25.40.90 UniProtKB/TrEMBL
InterPro ANTH_dom UniProtKB/TrEMBL
  Clathrin_AP_dom2 UniProtKB/TrEMBL
  ENTH UniProtKB/TrEMBL
  ENTH_VHS UniProtKB/TrEMBL
  PICALM UniProtKB/TrEMBL
NCBI Gene Picalm ENTREZGENE
PANTHER PTHR22951:SF16 UniProtKB/TrEMBL
Pfam ANTH UniProtKB/TrEMBL
PROSITE ENTH UniProtKB/TrEMBL
SMART ENTH UniProtKB/TrEMBL
Superfamily-SCOP SSF48464 UniProtKB/TrEMBL
UniProt A0A287CS00 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D211 ENTREZGENE, UniProtKB/TrEMBL
  I3MC44 ENTREZGENE, UniProtKB/TrEMBL