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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation

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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) UniProt PMID:28164773 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (PMID:23070049) ParkinsonsUK-UCL PMID:23070049 NCBI chrNW_004936596:3,311,358...3,370,833
Ensembl chrNW_004936596:3,312,788...3,368,916 		JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:5,071,546...5,090,287
Ensembl chrNW_004936538:5,071,546...5,090,313 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:6,192,407...6,352,835
Ensembl chrNW_004936542:6,192,407...6,352,424 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:18429932)
(PMID:23467355), (PMID:27030769) 		Alzheimers_University_of_Toronto PMID:18429932 PMID:23467355 PMID:27030769 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Bin1 bridging integrator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:44,128,308...44,185,739
Ensembl chrNW_004936469:44,127,970...44,185,246 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:531,844...548,487
Ensembl chrNW_004936594:532,342...548,440 		JBrowse link
G Hap1 huntingtin associated protein 1 involved_in ISO PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chrNW_004936490:16,645,116...16,652,310
Ensembl chrNW_004936490:16,643,520...16,652,479 		JBrowse link
G Igf1 insulin like growth factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936680:267,850...621,467
Ensembl chrNW_004936680:267,596...615,928 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:309,530...321,294
Ensembl chrNW_004936659:309,506...321,334 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601 		JBrowse link
G Rtn1 reticulon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:3,933,652...4,158,269
Ensembl chrNW_004936495:3,933,605...4,158,571 		JBrowse link
G Rtn2 reticulon 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,913,852...1,922,982
Ensembl chrNW_004936706:1,913,842...1,922,772 		JBrowse link
G Rtn3 reticulon 3 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004936599:5,364,406...5,430,076 JBrowse link
G Rtn4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:1,407,414...1,474,031
Ensembl chrNW_004936491:1,407,414...1,474,360 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:6,192,407...6,352,835
Ensembl chrNW_004936542:6,192,407...6,352,424 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:4,436,217...4,701,835
Ensembl chrNW_004936528:4,436,688...4,702,431 		JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chrNW_004936469:44,128,308...44,185,739
Ensembl chrNW_004936469:44,127,970...44,185,246 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) MGI PMID:16641999 NCBI chrNW_004936488:4,265,731...4,303,895
Ensembl chrNW_004936488:4,265,731...4,303,948 		JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:922,978...941,996
Ensembl chrNW_004936669:926,622...942,167 		JBrowse link
G Ager advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286 		JBrowse link
G Efna1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,654,503...4,660,950
Ensembl chrNW_004936580:4,654,503...4,660,966 		JBrowse link
G Efna3 ephrin A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,613,847...4,622,834
Ensembl chrNW_004936580:4,613,847...4,621,208 		JBrowse link
G Epha4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:3,539,269...3,670,322
Ensembl chrNW_004936569:3,540,053...3,670,348 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:2,578,598...2,698,165
Ensembl chrNW_004936496:2,637,958...2,700,055 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chrNW_004936552:221,458...305,625
Ensembl chrNW_004936552:222,320...291,925 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:7,142,580...7,284,722
Ensembl chrNW_004936532:7,145,882...7,286,244 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:4,436,217...4,701,835
Ensembl chrNW_004936528:4,436,688...4,702,431 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in 		IEA
ISO 		PMID:22086926 Ensembl
ARUK-UCL		 PMID:22086926 GO_REF:0000107 RGD:14697726 NCBI chrNW_004936669:922,978...941,996
Ensembl chrNW_004936669:926,622...942,167 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:1,620,763...1,678,561
Ensembl chrNW_004936500:1,620,641...1,678,607 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Casp3 caspase 3 involved_in ISO (PMID:17553422) UniProt PMID:17553422 RGD:13825190 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004937351:32,324...46,871
Ensembl chrNW_004937351:34,921...47,246 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Efna1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,654,503...4,660,950
Ensembl chrNW_004936580:4,654,503...4,660,966 		JBrowse link
G Epha4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:3,539,269...3,670,322
Ensembl chrNW_004936569:3,540,053...3,670,348 		JBrowse link
G Gsap gamma-secretase activating protein involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936479:20,705,596...20,800,026
Ensembl chrNW_004936479:20,705,585...20,800,020 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:266,462...277,256
Ensembl chrNW_004936706:269,126...277,256 		JBrowse link
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004936560:4,519,858...4,545,763
Ensembl chrNW_004936560:4,519,474...4,545,796 		JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936925:330,424...492,052
Ensembl chrNW_004936925:330,399...493,632 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:7,142,580...7,284,722
Ensembl chrNW_004936532:7,145,882...7,286,244 		JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936607:909,691...1,185,550
Ensembl chrNW_004936607:909,677...1,186,922 		JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:10,655,116...10,693,025
Ensembl chrNW_004936512:10,655,349...10,693,042 		JBrowse link
G Tnf tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:5,317,109...5,423,593
Ensembl chrNW_004936500:5,316,164...5,404,353 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO (PMID:16641999) UniProt PMID:16641999 NCBI chrNW_004936488:4,265,731...4,303,895
Ensembl chrNW_004936488:4,265,731...4,303,948 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17413
    regulation of biological process 11034
      regulation of cellular process 10709
        regulation of metabolic process 5854
          regulation of macromolecule metabolic process 5333
            regulation of protein metabolic process 1732
              regulation of amyloid precursor protein catabolic process 44
                negative regulation of amyloid precursor protein catabolic process + 20
                positive regulation of amyloid precursor protein catabolic process + 25
                regulation of amyloid-beta formation + 36
Path 2
Term Annotations click to browse term
  biological_process 17413
    biological regulation 11398
      regulation of biological process 11034
        regulation of cellular process 10709
          regulation of metabolic process 5854
            regulation of primary metabolic process 4771
              regulation of protein metabolic process 1732
                regulation of amyloid precursor protein catabolic process 44
                  negative regulation of amyloid precursor protein catabolic process + 20
                  positive regulation of amyloid precursor protein catabolic process + 25
                  regulation of amyloid-beta formation + 36
paths to the root