Psenen (presenilin enhancer, gamma-secretase subunit) - Rat Genome Database

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Gene: Psenen (presenilin enhancer, gamma-secretase subunit) Ictidomys tridecemlineatus
Analyze
Symbol: Psenen
Name: presenilin enhancer, gamma-secretase subunit
RGD ID: 12618531
Description: ENCODES a protein that exhibits endopeptidase activator activity (inferred); enzyme binding (inferred); INVOLVED IN Notch receptor processing (ortholog); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH Brugada syndrome 5 (ortholog); dystonia (ortholog); Familial Acne Inversa 2 (ortholog); FOUND IN gamma-secretase complex (ortholog); integral component of presynaptic membrane (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gamma-secretase subunit PEN-2; presenilin enhancer 2 homolog; presenilin enhancer gamma-secretase subunit; presenilin enhancer gamma-secretase subunit, transcript variant X1; presenilin enhancer gamma-secretase subunit, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,067,846 - 11,069,160 (+)NCBI
SpeTri2.0NW_004936570576,722 - 578,022 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Psenen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,067,846 - 11,069,160 (+)NCBI
SpeTri2.0NW_004936570576,722 - 578,022 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSENEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,745,651 - 35,747,519 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1935,745,600 - 35,747,519 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,236,552 - 36,238,420 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,928,334 - 40,929,743 (+)NCBINCBI36hg18NCBI36
Build 341940,928,333 - 40,929,743NCBI
Celera1932,949,971 - 32,951,380 (+)NCBI
Cytogenetic Map19q13.12NCBI
HuRef1932,741,466 - 32,743,044 (+)NCBIHuRef
CHM1_11936,237,788 - 36,239,366 (+)NCBICHM1_1
T2T-CHM13v2.01938,290,961 - 38,292,828 (+)NCBI
Psenen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,261,290 - 30,263,052 (-)NCBIGRCm39mm39
GRCm39 Ensembl730,261,288 - 30,263,052 (-)Ensembl
GRCm38730,561,865 - 30,563,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,561,863 - 30,563,627 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,346,884 - 31,348,203 (-)NCBIGRCm37mm9NCBIm37
MGSCv36730,270,625 - 30,271,944 (-)NCBImm8
Celera725,153,627 - 25,154,945 (-)NCBICelera
Cytogenetic Map7B1NCBI
Psenen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2185,814,905 - 85,816,654 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl185,814,905 - 85,816,192 (-)Ensembl
Rnor_6.0189,016,093 - 89,017,449 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,016,096 - 89,017,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,170,908 - 90,172,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,607,051 - 85,608,248 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1185,685,281 - 85,686,137 (-)NCBI
Celera180,186,425 - 80,187,622 (-)NCBICelera
Cytogenetic Map1q21NCBI
Psenen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,805,153 - 2,806,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,805,153 - 2,806,573 (-)NCBIChiLan1.0ChiLan1.0
PSENEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11941,409,662 - 41,411,089 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,409,662 - 41,411,089 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01932,675,331 - 32,677,285 (+)NCBIMhudiblu_PPA_v0panPan3
PSENEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,887,155 - 116,888,444 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,886,972 - 116,888,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,292,416 - 116,293,705 (-)NCBI
ROS_Cfam_1.01117,490,131 - 117,491,420 (-)NCBI
ROS_Cfam_1.0 Ensembl1117,489,948 - 117,491,434 (-)Ensembl
UMICH_Zoey_3.11117,053,507 - 117,054,796 (-)NCBI
UNSW_CanFamBas_1.01116,677,128 - 116,678,417 (-)NCBI
UU_Cfam_GSD_1.01117,732,508 - 117,733,796 (-)NCBI
PSENEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,171,825 - 45,174,102 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,171,825 - 45,174,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,627,906 - 40,629,565 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSENEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,655,162 - 30,656,587 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl630,655,243 - 30,656,584 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660738,446,437 - 8,447,968 (+)NCBIVero_WHO_p1.0
Psenen
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,053,114 - 10,054,411 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462479410,053,085 - 10,054,411 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005330581   ⟹   XP_005330638
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934911,067,846 - 11,069,160 (+)NCBI
SpeTri2.0NW_004936570576,722 - 578,022 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005330582   ⟹   XP_005330639
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934911,067,875 - 11,069,160 (+)NCBI
SpeTri2.0NW_004936570576,722 - 578,022 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005330638 (Get FASTA)   NCBI Sequence Viewer  
  XP_005330639 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3255870 (Get FASTA)   NCBI Sequence Viewer  
  KAG3255871 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005330638   ⟸   XM_005330581
- UniProtKB: A0A287CY61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005330639   ⟸   XM_005330582
- UniProtKB: A0A287CY61 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000024185 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000018355.2 UniProtKB/TrEMBL
  ENSSTOP00000026270 ENTREZGENE
  ENSSTOP00000026270.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000026952.2 UniProtKB/TrEMBL
  ENSSTOT00000039829.1 UniProtKB/TrEMBL
InterPro Gamma_Secretase_Asp_P_PEN2 UniProtKB/TrEMBL
NCBI Gene Psenen ENTREZGENE
PANTHER PTHR16318 UniProtKB/TrEMBL
Pfam PEN-2 UniProtKB/TrEMBL
UniProt A0A287CY61 ENTREZGENE, UniProtKB/TrEMBL
  I3N1V9_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Psenen  presenilin enhancer, gamma-secretase subunit    presenilin enhancer gamma-secretase subunit  Symbol and/or name change 5135510 APPROVED