Chrna7 (cholinergic receptor nicotinic alpha 7 subunit) - Rat Genome Database

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Gene: Chrna7 (cholinergic receptor nicotinic alpha 7 subunit) Ictidomys tridecemlineatus
Analyze
Symbol: Chrna7 (Ensembl: CHRFAM7A)
Name: cholinergic receptor nicotinic alpha 7 subunit (Ensembl:CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion)
RGD ID: 12493250
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); adenylate cyclase binding (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); associative learning (ortholog); B cell activation (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH Alzheimer's disease (ortholog); attention deficit hyperactivity disorder (ortholog); Auditory Perceptual Disorders (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); asymmetric synapse (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC101976251; neuronal acetylcholine receptor subunit alpha-7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640146,502,956 - 146,512,072 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493735134,921 - 47,246 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493735132,324 - 46,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (ISO)
associative learning  (IEA,ISO)
B cell activation  (IEA,ISO)
behavioral response to ethanol  (IEA,ISO)
behavioral response to nicotine  (IEA,ISO)
calcium ion transport  (ISO)
cognition  (ISO)
dendrite arborization  (IEA)
dendritic spine organization  (IEA)
dopamine biosynthetic process  (ISO)
endocytosis  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
excitatory postsynaptic potential  (IEA)
flagellated sperm motility  (IEA,ISO)
generation of ovulation cycle rhythm  (IEA,ISO)
intracellular calcium ion homeostasis  (ISO)
learning or memory  (IEA,ISO)
memory  (IEA,ISO)
modulation of chemical synaptic transmission  (IEA)
modulation of excitatory postsynaptic potential  (IEA)
monoatomic ion transmembrane transport  (IEA,ISO)
monoatomic ion transport  (IEA,ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-1 beta production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of protein phosphorylation  (IEA)
negative regulation of tumor necrosis factor production  (IEA,ISO)
nervous system process  (IEA)
neuronal action potential  (ISO)
ovulation cycle  (IEA,ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of CoA-transferase activity  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of excitatory postsynaptic potential  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IEA)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of protein metabolic process  (IEA)
positive regulation of protein phosphorylation  (IEA)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of amyloid fibril formation  (IEA)
regulation of amyloid precursor protein catabolic process  (ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of membrane potential  (IEA,ISO)
regulation of norepinephrine secretion  (IEA,ISO)
regulation of postsynaptic membrane potential  (IEA)
regulation of response to drug  (ISO)
regulation of synapse structural plasticity  (IEA)
regulation of synaptic transmission, dopaminergic  (IEA,ISO)
response to acetylcholine  (ISO)
response to amyloid-beta  (IEA)
response to carbamate  (ISO)
response to cold  (IEA)
response to ethanol  (IEA,ISO)
response to food  (IEA,ISO)
response to hypoxia  (ISO)
response to nicotine  (IEA,ISO)
sensory processing  (IEA)
signal transduction  (IEA)
synapse organization  (IEA)
synaptic transmission, cholinergic  (IEA,ISO)
T cell activation  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Chrna7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640146,502,956 - 146,512,072 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493735134,921 - 47,246 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493735132,324 - 46,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381532,030,483 - 32,173,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1531,923,438 - 32,173,018 (+)EnsemblGRCh38hg38GRCh38
GRCh371532,322,686 - 32,465,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,110,018 - 30,248,541 (+)NCBINCBI36Build 36hg18NCBI36
Build 341530,110,017 - 30,248,525NCBI
Celera158,162,865 - 8,292,202 (-)NCBICelera
Cytogenetic Map15q13.3NCBI
HuRef159,499,328 - 9,603,273 (+)NCBIHuRef
CHM1_11532,312,897 - 32,452,812 (+)NCBICHM1_1
T2T-CHM13v2.01529,824,630 - 29,967,342 (+)NCBIT2T-CHM13v2.0
Chrna7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39762,748,440 - 62,862,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl762,748,440 - 62,862,317 (-)EnsemblGRCm39 Ensembl
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl763,098,692 - 63,212,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBIMGSCv36mm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.47NCBI
Chrna7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81126,123,425 - 126,249,181 (-)NCBIGRCr8
mRatBN7.21116,711,559 - 116,837,269 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1116,714,711 - 116,837,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1124,676,761 - 124,793,917 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,859,276 - 131,976,435 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,684,982 - 124,802,138 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01123,897,341 - 124,039,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1123,899,657 - 124,039,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01125,029,451 - 125,158,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41117,587,580 - 117,716,267 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11117,665,347 - 117,794,621 (-)NCBI
Celera1108,976,664 - 109,097,764 (-)NCBICelera
Cytogenetic Map1q22NCBI
Chrna7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541630,687,478 - 30,798,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541630,687,518 - 30,798,700 (+)NCBIChiLan1.0ChiLan1.0
LOC100977072
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21620,841,679 - 20,981,068 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11525,565,746 - 25,705,121 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01510,525,535 - 10,667,227 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11529,565,885 - 29,705,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1529,565,885 - 29,705,194 (+)Ensemblpanpan1.1panPan2
CHRNA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,852,082 - 37,164,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,852,543 - 36,978,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha339,517,659 - 39,644,156 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0337,232,973 - 37,359,572 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,231,040 - 37,360,220 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1336,756,424 - 36,882,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,011,929 - 37,138,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,222,873 - 37,349,426 (-)NCBIUU_Cfam_GSD_1.0
CHRNA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,803,701 - 142,937,123 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11142,803,697 - 142,937,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21158,717,002 - 158,849,994 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,554,143 - 50,686,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2650,551,829 - 50,686,803 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604890,139,706 - 90,283,400 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624768909,099 - 1,024,902 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624768908,907 - 1,024,953 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021721557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000021371   ⟹   ENSSTOP00000022673
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493735134,921 - 47,246 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000033436   ⟹   ENSSTOP00000025876
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493735134,921 - 43,764 (-)Ensembl
RefSeq Acc Id: XM_021721557   ⟹   XP_021577232
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640146,502,956 - 146,512,072 (+)NCBI
SpeTri2.0NW_00493735132,324 - 46,871 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021577232 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000022673.2
  ENSSTOP00000025876.1
GenBank Protein KAG3262716 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021577232   ⟸   XM_021721557
- Sequence:
Ensembl Acc Id: ENSSTOP00000025876   ⟸   ENSSTOT00000033436
Ensembl Acc Id: ENSSTOP00000022673   ⟸   ENSSTOT00000021371

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000023213 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000021371.2 UniProtKB/TrEMBL
  ENSSTOT00000033436.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
NCBI Gene LOC101976251 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7 UniProtKB/TrEMBL
  PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
UniProt A0A287CX70_ICTTR UniProtKB/TrEMBL
  I3NE76_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Chrna7  cholinergic receptor nicotinic alpha 7 subunit  LOC101976251  CHRNA7-FAM7A fusion protein  Symbol and/or name change 5135510 APPROVED