CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) Chlorocebus sabaeus
Analyze
Symbol: CHRNA7
Name: cholinergic receptor nicotinic alpha 7 subunit
RGD ID: 18769691
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); adenylate cyclase binding (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); associative learning (ortholog); B cell activation (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH Alzheimer's disease (ortholog); attention deficit hyperactivity disorder (ortholog); Auditory Perceptual Disorders (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); apical plasma membrane (ortholog); asymmetric synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuronal acetylcholine receptor subunit alpha-7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,554,143 - 50,686,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2650,551,829 - 50,686,803 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604890,139,706 - 90,283,400 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (ISO)
associative learning  (ISO)
B cell activation  (ISO)
behavioral response to ethanol  (ISO)
behavioral response to nicotine  (ISO)
calcium ion transport  (ISO)
cognition  (ISO)
dendrite arborization  (ISO)
dendritic spine organization  (ISO)
dopamine biosynthetic process  (ISO)
endocytosis  (ISO)
establishment of localization in cell  (ISO)
excitatory postsynaptic potential  (IEA)
flagellated sperm motility  (ISO)
generation of ovulation cycle rhythm  (ISO)
intracellular calcium ion homeostasis  (ISO)
learning or memory  (ISO)
memory  (ISO)
modulation of chemical synaptic transmission  (ISO)
modulation of excitatory postsynaptic potential  (ISO)
monoatomic ion transmembrane transport  (IEA,ISO)
monoatomic ion transport  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
nervous system process  (IEA)
neuronal action potential  (ISO)
ovulation cycle  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of CoA-transferase activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid precursor protein catabolic process  (ISO)
regulation of inflammatory response  (ISO)
regulation of membrane potential  (IEA,ISO)
regulation of norepinephrine secretion  (ISO)
regulation of postsynaptic membrane potential  (IEA)
regulation of response to drug  (ISO)
regulation of synapse structural plasticity  (ISO)
regulation of synaptic transmission, dopaminergic  (ISO)
response to acetylcholine  (ISO)
response to amyloid-beta  (ISO)
response to carbamate  (ISO)
response to cold  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to hypoxia  (ISO)
response to nicotine  (ISO)
sensory processing  (ISO)
signal transduction  (IEA)
synapse organization  (ISO)
synaptic transmission, cholinergic  (IEA,ISO)
T cell activation  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHRNA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,554,143 - 50,686,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2650,551,829 - 50,686,803 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604890,139,706 - 90,283,400 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CHRNA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381532,030,483 - 32,173,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1531,923,438 - 32,173,018 (+)EnsemblGRCh38hg38GRCh38
GRCh371532,322,686 - 32,465,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,110,018 - 30,248,541 (+)NCBINCBI36Build 36hg18NCBI36
Build 341530,110,017 - 30,248,525NCBI
Celera158,162,865 - 8,292,202 (-)NCBICelera
Cytogenetic Map15q13.3NCBI
HuRef159,499,328 - 9,603,273 (+)NCBIHuRef
CHM1_11532,312,897 - 32,452,812 (+)NCBICHM1_1
T2T-CHM13v2.01529,824,630 - 29,967,342 (+)NCBIT2T-CHM13v2.0
Chrna7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39762,748,440 - 62,862,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl762,748,440 - 62,862,317 (-)EnsemblGRCm39 Ensembl
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl763,098,692 - 63,212,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBIMGSCv36mm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.47NCBI
Chrna7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81126,123,425 - 126,249,181 (-)NCBIGRCr8
mRatBN7.21116,711,559 - 116,837,269 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1116,714,711 - 116,837,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1124,676,761 - 124,793,917 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,859,276 - 131,976,435 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,684,982 - 124,802,138 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01123,897,341 - 124,039,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1123,899,657 - 124,039,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01125,029,451 - 125,158,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41117,587,580 - 117,716,267 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11117,665,347 - 117,794,621 (-)NCBI
Celera1108,976,664 - 109,097,764 (-)NCBICelera
Cytogenetic Map1q22NCBI
Chrna7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541630,687,478 - 30,798,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541630,687,518 - 30,798,700 (+)NCBIChiLan1.0ChiLan1.0
LOC100977072
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21620,841,679 - 20,981,068 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11525,565,746 - 25,705,121 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01510,525,535 - 10,667,227 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11529,565,885 - 29,705,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1529,565,885 - 29,705,194 (+)Ensemblpanpan1.1panPan2
CHRNA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,852,082 - 37,164,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,852,543 - 36,978,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha339,517,659 - 39,644,156 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0337,232,973 - 37,359,572 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,231,040 - 37,360,220 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1336,756,424 - 36,882,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,011,929 - 37,138,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,222,873 - 37,349,426 (-)NCBIUU_Cfam_GSD_1.0
Chrna7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640146,502,956 - 146,512,072 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493735134,921 - 47,246 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493735132,324 - 46,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,803,701 - 142,937,123 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11142,803,697 - 142,937,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21158,717,002 - 158,849,994 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Chrna7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624768909,099 - 1,024,902 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624768908,907 - 1,024,953 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSCSAT00000004909   ⟹   ENSCSAP00000003153
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2650,551,829 - 50,686,803 (-)Ensembl
RefSeq Acc Id: XM_008017180   ⟹   XP_008015371
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12650,554,143 - 50,686,847 (-)NCBI
Vero_WHO_p1.0NW_02366604890,139,706 - 90,283,400 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038009782   ⟹   XP_037865710
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604890,140,170 - 90,283,400 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008015371 (Get FASTA)   NCBI Sequence Viewer  
  XP_037865710 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000003153.1
RefSeq Acc Id: XP_008015371   ⟸   XM_008017180
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R3G4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000003153   ⟸   ENSCSAT00000004909
RefSeq Acc Id: XP_037865710   ⟸   XM_038009782
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006863 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004909.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
KEGG Report csab:103245932 UniProtKB/TrEMBL
NCBI Gene CHRNA7 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7 UniProtKB/TrEMBL
  PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
UniProt A0A0D9R3G4 ENTREZGENE, UniProtKB/TrEMBL