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ONTOLOGY REPORT - ANNOTATIONS

Term:macrophage differentiation
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Accession:GO:0030225 term browser browse the term
Definition:The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
Synonyms:exact_synonym: macrophage cell differentiation


show annotations for term's descendants           Sort by:
macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASXL2 ASXL transcriptional regulator 2 acts_upstream_of ISO (PMID:21490954) MGI PMID:21490954 NCBI chr17:19,914,026...20,065,141
Ensembl chr17:19,895,568...20,044,691 		JBrowse link
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557 		JBrowse link
G CASP8 caspase 8 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:15322156) GO_Central
MGI		 PMID:15322156 GO_REF:0000033 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G CD4 CD4 molecule involved_in ISO (PMID:24942581) ARUK-UCL PMID:24942581 NCBI chr27:38,204,003...38,250,771
Ensembl chr27:38,204,003...38,250,771 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha acts_upstream_of_or_within ISO (PMID:15073037) MGI PMID:15073037 NCBI chr 1:118,846,252...118,851,045 JBrowse link
G CEBPE CCAAT enhancer binding protein epsilon involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11861297) Ensembl
MGI		 PMID:11861297 GO_REF:0000107 NCBI chr 8:3,423,046...3,425,595
Ensembl chr 8:3,423,040...3,425,217 		JBrowse link
G CSF1 colony stimulating factor 1 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:9215625) RGD
MGI
Ensembl		 PMID:9215625 PMID:12379742 PMID:20628067 GO_REF:0000107 RGD:5131511 RGD:628338 NCBI chr 6:42,028,454...42,047,028
Ensembl chr 6:42,034,149...42,049,371 		JBrowse link
G CSF2 colony stimulating factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959 		JBrowse link
G DIAPH3 diaphanous related formin 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26471482) Ensembl
MGI		 PMID:26471482 GO_REF:0000107 NCBI chr22:15,573,485...16,078,580
Ensembl chr22:15,573,629...16,079,031 		JBrowse link
G EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17932563) Ensembl
MGI		 PMID:17932563 GO_REF:0000107 NCBI chr 6:11,447,225...11,478,611
Ensembl chr 6:11,447,081...11,478,658 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:23717624) MGI PMID:23717624 NCBI chr 1:251,985...322,081
Ensembl chr 1:252,103...322,718 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30181393)
(PMID:31135379)		 Ensembl
MGI		 PMID:30181393 PMID:31135379 GO_REF:0000107 NCBI chr17:22,340,469...22,364,994
Ensembl chr17:22,341,322...22,361,772 		JBrowse link
G GAB3 GRB2 associated binding protein 3 acts_upstream_of_or_within ISO (PMID:11739737) MGI PMID:11739737 NCBI chr  X:122,741,199...122,822,446
Ensembl chr  X:122,741,197...122,779,143 		JBrowse link
G GATA3 GATA binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760 		JBrowse link
G HLA-DRB1 MHC class II DLA DRB1 beta chain involved_in ISO (PMID:24942581) ARUK-UCL PMID:24942581 NCBI chr12:2,151,409...2,164,564 JBrowse link
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL15 interleukin 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 involved_in ISO (MGI:6856556|PMID:34644537) UniProt PMID:34644537 MGI:6856556 NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357 		JBrowse link
G IL33 interleukin 33 involved_in ISS UniProt GO_REF:0000024 NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721 		JBrowse link
G L3MBTL3 L3MBTL histone methyl-lysine binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15889154) Ensembl
MGI		 PMID:15889154 GO_REF:0000107 NCBI chr 1:68,538,014...68,655,173
Ensembl chr 1:68,540,051...68,654,414 		JBrowse link
G LARGE1 LARGE xylosyl- and glucuronyltransferase 1 acts_upstream_of_or_within ISO (PMID:25661440) MGI PMID:25661440 NCBI chr10:29,875,381...30,396,934
Ensembl chr10:29,919,521...30,395,787 		JBrowse link
G MYBPC2 myosin binding protein C2 acts_upstream_of_or_within ISO (PMID:11980719) MGI PMID:11980719 NCBI chr 1:106,294,360...106,301,700
Ensembl chr 1:106,266,817...106,301,686 		JBrowse link
G NFIX nuclear factor I X acts_upstream_of_or_within ISO (PMID:32183151) MGI PMID:32183151 NCBI chr20:49,117,087...49,187,023
Ensembl chr20:49,117,943...49,214,788 		JBrowse link
G NKX2-3 NK2 homeobox 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10926756) Ensembl
MGI		 PMID:10926756 GO_REF:0000107 NCBI chr28:12,466,319...12,469,467
Ensembl chr28:12,466,368...12,469,473 		JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (MGI:5319292|PMID:22315447) UniProt PMID:22315447 MGI:5319292 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 involved_in ISO (PMID:32634427) BHF-UCL PMID:32634427 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557 		JBrowse link
G SPI1 Spi-1 proto-oncogene acts_upstream_of_or_within ISO (PMID:11980719) MGI PMID:11980719 NCBI chr18:42,253,849...42,269,497
Ensembl chr18:42,253,811...42,269,727 		JBrowse link
G UCP2 uncoupling protein 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr21:24,304,410...24,311,392
Ensembl chr21:24,304,457...24,311,128 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:22615127) Ensembl
MGI		 PMID:22615127 GO_REF:0000107 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
microglia development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO RGD PMID:33450391 RGD:126781687 NCBI chr 4:58,980,699...59,010,683
Ensembl chr 4:58,980,788...59,010,510 		JBrowse link
G ITGAM integrin subunit alpha M acts_upstream_of_or_within ISO (PMID:20578039) MGI PMID:20578039 NCBI chr 6:16,944,062...16,996,525
Ensembl chr 6:16,808,971...16,996,286 		JBrowse link
G NRROS negative regulator of reactive oxygen species involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:29,682,182...29,699,469
Ensembl chr33:29,692,371...29,767,771 		JBrowse link
G TLR2 toll like receptor 2 involved_in ISO (MGI:5307186|PMID:22198949) ARUK-UCL PMID:22198949 MGI:5307186 NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241 		JBrowse link
G TSPAN2 tetraspanin 2 acts_upstream_of_or_within ISO (PMID:24038504) MGI PMID:24038504 NCBI chr17:52,692,744...52,749,048
Ensembl chr17:52,694,603...52,744,276 		JBrowse link
microglia differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:23717624) MGI PMID:23717624 NCBI chr 1:251,985...322,081
Ensembl chr 1:252,103...322,718 		JBrowse link
G GBA1 glucosylceramidase beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17954912) Ensembl
MGI		 PMID:17954912 GO_REF:0000107 NCBI chr 7:42,317,704...42,322,285
Ensembl chr 7:42,317,862...42,322,864 		JBrowse link
G MFSD8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO (PMID:27654426) MGI PMID:27654426 NCBI chr19:12,905,336...13,030,901
Ensembl chr19:12,982,394...13,020,083 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18509511) Ensembl
MGI		 PMID:18509511 GO_REF:0000107 NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18509511) Ensembl
MGI		 PMID:18509511 GO_REF:0000107 NCBI chr 9:20,407,296...20,414,094
Ensembl chr 9:20,407,281...20,414,056 		JBrowse link
G NDP norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO (PMID:29654250) MGI PMID:29654250 NCBI chr  X:37,949,560...37,975,573
Ensembl chr  X:37,950,489...37,975,346 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755 		JBrowse link
G QKI QKI, KH domain containing RNA binding involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:51,800,294...51,956,891
Ensembl chr 1:51,800,309...51,952,714 		JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18509511) Ensembl
MGI		 PMID:18509511 GO_REF:0000107 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
G VPS13A vacuolar protein sorting 13 homolog A acts_upstream_of_or_within ISO (PMID:37714309) MGI PMID:37714309 NCBI chr 1:81,191,125...81,426,337
Ensembl chr 1:81,192,349...81,426,322 		JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:63,598,373...63,676,753
Ensembl chr10:63,599,229...63,676,747 		JBrowse link
negative regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:76,660,039...76,664,602
Ensembl chr 2:76,660,035...76,664,577 		JBrowse link
G GATA2 GATA binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16254139) Ensembl
MGI		 PMID:16254139 GO_REF:0000107 NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991 		JBrowse link
G MIR486 microRNA mir-486 involved_in ISO (PMID:25857263) BHF-UCL PMID:25857263 NCBI chr16:23,958,963...23,959,026
Ensembl chr16:23,958,963...23,959,026 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G QKI QKI, KH domain containing RNA binding involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:51,800,294...51,956,891
Ensembl chr 1:51,800,309...51,952,714 		JBrowse link
G THOC5 THO complex subunit 5 acts_upstream_of_or_within ISO (PMID:10597251) MGI PMID:10597251 NCBI chr26:22,748,857...22,785,288
Ensembl chr26:22,748,895...22,784,143 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22615127) Ensembl
MGI		 PMID:22615127 GO_REF:0000107 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
positive regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASXL2 ASXL transcriptional regulator 2 acts_upstream_of_or_within ISO (PMID:21490954) MGI PMID:21490954 NCBI chr17:19,914,026...20,065,141
Ensembl chr17:19,895,568...20,044,691 		JBrowse link
G CASP8 caspase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G CRSP-3 calcitonin receptor-stimulating peptide 3 involved_in ISO (PMID:10822112) UniProt PMID:10822112 NCBI chr21:37,676,841...37,680,643
Ensembl chr21:37,676,841...37,680,645 		JBrowse link
G CSF1 colony stimulating factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9215625) Ensembl
TreeGrafter
MGI		 PMID:9215625 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:42,028,454...42,047,028
Ensembl chr 6:42,034,149...42,049,371 		JBrowse link
G FADD Fas associated via death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:48,087,447...48,094,497 JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:24,901,023...24,925,710
Ensembl chr33:24,901,287...24,922,923 		JBrowse link
G HSF1 heat shock transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,724,741...37,745,259
Ensembl chr13:37,724,759...37,745,252 		JBrowse link
G IL34 interleukin 34 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:76,601,310...76,612,665
Ensembl chr 5:76,555,214...76,625,012 		JBrowse link
G LIF LIF interleukin 6 family cytokine acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7957045) MGI
Ensembl		 PMID:7957045 GO_REF:0000107 NCBI chr26:23,400,226...23,418,538
Ensembl chr26:23,403,364...23,406,851 		JBrowse link
G LOC102151783 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:15616565) MGI PMID:15616565 NCBI chr10:54,954,852...54,957,116 JBrowse link
G MIR145 microRNA mir-145 acts_upstream_of ISO (PMID:30634164) ARUK-UCL PMID:30634164 NCBI chr 4:59,533,128...59,533,210
Ensembl chr 4:59,533,128...59,533,210 		JBrowse link
G PRKCA protein kinase C alpha involved_in ISO (MGI:5306334|PMID:9508782) UniProt PMID:9508782 MGI:5306334 NCBI chr 9:13,638,106...13,879,571
Ensembl chr 9:13,644,010...13,967,630 		JBrowse link
G RB1 RB transcriptional corepressor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15616565) Ensembl
MGI		 PMID:15616565 GO_REF:0000107 NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:3,367,796...3,407,631
Ensembl chr35:3,263,226...3,405,883 		JBrowse link
G ROR2 receptor tyrosine kinase like orphan receptor 2 ISO RGD PMID:25749876 RGD:11537353 NCBI chr 1:95,209,122...95,280,956
Ensembl chr 1:95,088,745...95,280,151 		JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) CACAO PMID:23515163 MGI:5488531 NCBI chr13:23,337,788...23,346,304
Ensembl chr13:23,337,788...23,346,304 		JBrowse link
positive regulation of microglia differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 involved_in ISO (MGI:6192878|PMID:29909984) UniProt PMID:29909984 MGI:6192878 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G QKI QKI, KH domain containing RNA binding involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:51,800,294...51,956,891
Ensembl chr 1:51,800,309...51,952,714 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17919
    developmental process 6839
      cellular developmental process 4596
        cell differentiation 4595
          myeloid cell differentiation 497
            myeloid leukocyte differentiation 273
              macrophage differentiation 67
                microglia differentiation + 19
                negative regulation of macrophage differentiation + 8
                positive regulation of macrophage differentiation + 18
                regulation of macrophage differentiation + 26
Path 2
Term Annotations click to browse term
  biological_process 17919
    developmental process 6839
      cellular developmental process 4596
        cell differentiation 4595
          cell development 3259
            hemopoiesis 1054
              leukocyte differentiation 674
                myeloid leukocyte differentiation 273
                  macrophage differentiation 67
                    microglia differentiation + 19
                    negative regulation of macrophage differentiation + 8
                    positive regulation of macrophage differentiation + 18
                    regulation of macrophage differentiation + 26
paths to the root