LIF (LIF interleukin 6 family cytokine) - Rat Genome Database

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Pathways
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Gene: LIF (LIF interleukin 6 family cytokine) Canis lupus familiaris
Analyze
Symbol: LIF
Name: LIF interleukin 6 family cytokine
RGD ID: 12430719
Description: ENCODES a protein that exhibits leukemia inhibitory factor receptor binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); astrocyte differentiation (ortholog); blood vessel remodeling (ortholog); ASSOCIATED WITH brain ischemia (ortholog); Cardiomegaly (ortholog); colon cancer (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF, interleukin 6 family cytokine
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,400,226 - 23,418,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,784,274 - 23,790,798 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
astrocyte differentiation  (ISO)
blood vessel remodeling  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell surface receptor signaling pathway via STAT  (IEA)
decidualization  (IEA,ISO)
embryo implantation  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
gene expression  (IEA,ISO)
immune response  (IEA)
leukemia inhibitory factor signaling pathway  (IEA)
lung alveolus development  (IEA,ISO)
lung development  (IEA,ISO)
lung lobe morphogenesis  (IEA,ISO)
lung vasculature development  (IEA,ISO)
maternal process involved in female pregnancy  (IEA,ISO)
meiotic nuclear division  (IEA,ISO)
muscle organ morphogenesis  (IEA,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of hormone secretion  (IEA,ISO)
negative regulation of meiotic nuclear division  (IEA,ISO)
neuron development  (IEA,ISO)
positive regulation of astrocyte differentiation  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of corticotropin secretion  (ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
regulation of cell communication  (IEA)
regulation of cell differentiation  (IEA,ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (IEA)
regulation of signaling  (IEA)
response to hypoxia  (IEA,ISO)
retina development in camera-type eye  (ISO)
somatic stem cell population maintenance  (IEA,ISO)
spongiotrophoblast differentiation  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
transdifferentiation  (ISO)
trophoblast giant cell differentiation  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:12644003   PMID:19754547   PMID:20036483   PMID:22301074   PMID:23016947   PMID:30032202  


Genomics

Comparative Map Data
LIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,400,226 - 23,418,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,784,274 - 23,790,798 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBIUU_Cfam_GSD_1.0
LIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,240,453 - 30,246,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,240,453 - 30,246,759 (-)EnsemblGRCh38hg38GRCh38
GRCh372230,636,442 - 30,642,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,966,441 - 28,972,748 (-)NCBINCBI36Build 36hg18NCBI36
Build 342228,960,996 - 28,967,302NCBI
Celera2214,436,129 - 14,442,479 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBIHuRef
CHM1_12230,595,573 - 30,601,977 (-)NCBICHM1_1
T2T-CHM13v2.02230,703,775 - 30,710,077 (-)NCBIT2T-CHM13v2.0
Lif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,207,587 - 4,222,514 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,207,557 - 4,222,514 (+)EnsemblGRCm39 Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,257,557 - 4,272,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBIMGSCv36mm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
Lif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,354,602 - 83,364,053 (+)NCBIGRCr8
mRatBN7.21479,131,049 - 79,140,486 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,134,574 - 79,140,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,575,221 - 83,577,994 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,815,297 - 84,818,070 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,261,251 - 81,264,024 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,482,652 - 84,500,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,482,674 - 84,500,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,163,603 - 85,181,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,887,856 - 84,890,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,907,000 - 84,909,775 (+)NCBI
Celera1478,044,967 - 78,047,741 (+)NCBICelera
Cytogenetic Map14q21NCBI
Lif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,489,421 - 4,497,940 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,489,515 - 4,505,439 (-)NCBIChiLan1.0ChiLan1.0
LIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,207,582 - 40,213,909 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,906,197 - 42,912,484 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,276,576 - 11,282,972 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,078,862 - 29,095,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,078,862 - 29,095,608 (-)Ensemblpanpan1.1panPan2
Lif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,317,865 - 116,334,346 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936904410,043 - 413,257 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936904410,043 - 413,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,221,560 - 47,238,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,221,540 - 47,239,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,263,470 - 50,277,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,121,261 - 13,127,663 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,121,297 - 13,127,679 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045113,007,597 - 113,025,154 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,558,817 - 6,565,281 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,558,872 - 6,565,207 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LIF
206 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1
Low 5 13 6 5 6 6 2 9 4
Below cutoff 5 9 1 6 10 8 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000046012   ⟹   ENSCAFP00000036140
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845054922   ⟹   ENSCAFP00845043191
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2623,784,274 - 23,790,798 (-)Ensembl
RefSeq Acc Id: NM_001197073   ⟹   NP_001184002
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12623,403,364 - 23,406,851 (-)NCBI
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBI
ROS_Cfam_1.02623,787,471 - 23,790,798 (-)NCBI
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBI
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBI
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038436066   ⟹   XP_038291994
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBI
RefSeq Acc Id: XM_038436067   ⟹   XP_038291995
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02623,784,273 - 23,794,583 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001184002   ⟸   NM_001197073
- Peptide Label: precursor
- UniProtKB: A0A8C0JKF9 (UniProtKB/TrEMBL),   A0A8C0RQT8 (UniProtKB/TrEMBL),   A0A8I3Q5S6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000036140   ⟸   ENSCAFT00000046012
RefSeq Acc Id: XP_038291994   ⟸   XM_038436066
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JKF9 (UniProtKB/TrEMBL),   A0A8C0RQT8 (UniProtKB/TrEMBL),   A0A8I3Q5S6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038291995   ⟸   XM_038436067
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JKF9 (UniProtKB/TrEMBL),   A0A8C0RQT8 (UniProtKB/TrEMBL),   A0A8I3Q5S6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845043191   ⟸   ENSCAFT00845054922

Promoters
RGD ID:13687971
Promoter ID:EPDNEW_C6040
Type:single initiation site
Name:LIF_1
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12623,406,759 - 23,406,819EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030931 Ensembl
  ENSCAFG00000057455 UniProtKB/TrEMBL
  ENSCAFG00030022058 UniProtKB/TrEMBL
  ENSCAFG00040022154 UniProtKB/TrEMBL
  ENSCAFG00845030902 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000094209.1 UniProtKB/TrEMBL
  ENSCAFT00030040498.1 UniProtKB/TrEMBL
  ENSCAFT00040041114.1 UniProtKB/TrEMBL
  ENSCAFT00040041128.1 UniProtKB/TrEMBL
  ENSCAFT00845054922 ENTREZGENE
  ENSCAFT00845054922.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Leukemia_IF UniProtKB/TrEMBL
  Leukemia_IF/oncostatin UniProtKB/TrEMBL
  Leukemia_IF/oncostatin_CS UniProtKB/TrEMBL
KEGG Report cfa:403449 UniProtKB/TrEMBL
NCBI Gene LIF ENTREZGENE
PANTHER LEUKEMIA INHIBITORY FACTOR UniProtKB/TrEMBL
  PTHR10633 UniProtKB/TrEMBL
Pfam LIF_OSM UniProtKB/TrEMBL
PRINTS LEUKAEMIAIF UniProtKB/TrEMBL
PROSITE LIF_OSM UniProtKB/TrEMBL
SMART LIF_OSM UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A8C0JKF9 ENTREZGENE
  A0A8C0RQT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TE68_CANLF UniProtKB/TrEMBL
  A0A8I3Q5S6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42671 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-30 LIF  LIF interleukin 6 family cytokine    LIF, interleukin 6 family cytokine  Symbol and/or name change 5135510 APPROVED
2017-03-21 LIF  LIF, interleukin 6 family cytokine    leukemia inhibitory factor  Symbol and/or name change 5135510 APPROVED