LIF (LIF interleukin 6 family cytokine) - Rat Genome Database

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Gene: LIF (LIF interleukin 6 family cytokine) Canis lupus familiaris
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Symbol: LIF
Name: LIF interleukin 6 family cytokine
RGD ID: 12430719
Description: ENCODES a protein that exhibits leukemia inhibitory factor receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); astrocyte differentiation (ortholog); blood vessel remodeling (ortholog); ASSOCIATED WITH brain ischemia (ortholog); Cardiomegaly (ortholog); congestive heart failure (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF, interleukin 6 family cytokine
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,400,226 - 23,418,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBI
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBI
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBI
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBI
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
astrocyte differentiation  (ISO)
blood vessel remodeling  (IEA,ISO)
decidualization  (IEA,ISO)
embryo implantation  (IEA,ISO)
immune response  (IEA)
leukemia inhibitory factor signaling pathway  (IBA)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
lung lobe morphogenesis  (IEA,ISO)
lung vasculature development  (IEA,ISO)
maternal process involved in female pregnancy  (ISO)
muscle organ morphogenesis  (IEA,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of hormone secretion  (IEA,ISO)
negative regulation of meiotic nuclear division  (IEA,ISO)
neuron development  (IEA,ISO)
positive regulation of astrocyte differentiation  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of corticotropin secretion  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of histone H3-K27 acetylation  (IEA)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
regulation of cell differentiation  (IBA,ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (IEA)
regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA,ISO)
retina development in camera-type eye  (ISO)
spongiotrophoblast differentiation  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
stem cell population maintenance  (IEA,ISO)
transdifferentiation  (ISO)
trophoblast giant cell differentiation  (IEA,ISO)
tyrosine phosphorylation of STAT protein  (IEA,ISO)

Cellular Component
cytosol  (IEA)
extracellular space  (IBA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:12644003   PMID:19754547   PMID:20036483  


Genomics

Comparative Map Data
LIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,400,226 - 23,418,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBI
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBI
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBI
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBI
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBI
LIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,240,453 - 30,246,759 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,240,453 - 30,257,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,636,442 - 30,642,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,966,441 - 28,972,748 (-)NCBINCBI36hg18NCBI36
Build 342228,960,996 - 28,967,302NCBI
Celera2214,436,129 - 14,442,479 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBIHuRef
CHM1_12230,595,573 - 30,601,977 (-)NCBICHM1_1
Lif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,207,568 - 4,222,514 (+)NCBIGRCm39mm39
GRCm39 Ensembl114,207,557 - 4,222,514 (+)Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,257,557 - 4,272,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBImm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
Lif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21479,131,049 - 79,140,486 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1479,134,574 - 79,140,482 (+)Ensembl
Rnor_6.01484,482,652 - 84,500,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,482,674 - 84,500,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,163,603 - 85,181,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,887,856 - 84,890,630 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11484,907,000 - 84,909,775 (+)NCBI
Celera1478,044,967 - 78,047,741 (+)NCBICelera
Cytogenetic Map14q21NCBI
Lif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,489,421 - 4,497,940 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,489,515 - 4,505,439 (-)NCBIChiLan1.0ChiLan1.0
LIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12229,078,862 - 29,095,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,078,862 - 29,095,608 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02211,276,576 - 11,282,972 (-)NCBIMhudiblu_PPA_v0panPan3
Lif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,317,865 - 116,334,346 (-)NCBI
SpeTri2.0NW_004936904410,043 - 413,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,221,560 - 47,238,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,221,540 - 47,239,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,263,470 - 50,277,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,121,261 - 13,127,663 (-)NCBI
ChlSab1.1 Ensembl1913,121,297 - 13,127,679 (-)Ensembl
Vero_WHO_p1.0NW_023666045113,007,597 - 113,025,154 (+)NCBI
Lif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247476,558,872 - 6,565,207 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1
Low 5 13 6 5 6 6 2 9 4
Below cutoff 5 9 1 6 10 8 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000046012   ⟹   ENSCAFP00000036140
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)Ensembl
RefSeq Acc Id: NM_001197073   ⟹   NP_001184002
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12623,403,364 - 23,406,851 (-)NCBI
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBI
ROS_Cfam_1.02623,787,471 - 23,790,798 (-)NCBI
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBI
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBI
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005636000   ⟹   XP_005636057
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12623,400,226 - 23,411,209 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022410147   ⟹   XP_022265855
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12623,400,226 - 23,418,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038436066   ⟹   XP_038291994
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBI
RefSeq Acc Id: XM_038436067   ⟹   XP_038291995
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02623,784,273 - 23,794,583 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001184002 (Get FASTA)   NCBI Sequence Viewer  
  XP_038291994 (Get FASTA)   NCBI Sequence Viewer  
  XP_038291995 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL87132 (Get FASTA)   NCBI Sequence Viewer  
  AAM44067 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005636057   ⟸   XM_005636000
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001184002   ⟸   NM_001197073
- Peptide Label: precursor
- UniProtKB: J9NRL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022265855   ⟸   XM_022410147
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000036140   ⟸   ENSCAFT00000046012
RefSeq Acc Id: XP_038291994   ⟸   XM_038436066
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038291995   ⟸   XM_038436067
- Peptide Label: isoform X1

Promoters
RGD ID:13687971
Promoter ID:EPDNEW_C6040
Type:single initiation site
Name:LIF_1
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12623,406,759 - 23,406,819EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030931 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000036140 ENTREZGENE
Ensembl Transcript ENSCAFT00000046012 ENTREZGENE
NCBI Gene LIF ENTREZGENE
UniProt J9NRL6 ENTREZGENE
VGNC ID VGNC:42671 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-30 LIF  LIF interleukin 6 family cytokine    LIF, interleukin 6 family cytokine  Symbol and/or name change 5135510 APPROVED
2017-03-21 LIF  LIF, interleukin 6 family cytokine    leukemia inhibitory factor  Symbol and/or name change 5135510 APPROVED