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ONTOLOGY REPORT - ANNOTATIONS

Term:histone deacetylase activity
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Accession:GO:0004407 term browser browse the term
Definition:Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
Synonyms:xref: EC:3.5.1.98;   MetaCyc:3.5.1.98-RXN;   RHEA:58196;   Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones";   reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin";   reactome:R-HSA-2545253 "Deacetylation of cohesin";   reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone";   reactome:R-HSA-3782637 "HDAC8 deacetylates histones";   reactome:R-HSA-3782655 "HDAC10 deacetylates histone";   reactome:R-HSA-427514 "eNoSC deacetylates histone H3";   reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3";   reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53"


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histone deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 contributes_to ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr12:101,885,160...101,928,139
Ensembl chr12:101,885,160...101,924,505 		JBrowse link
G Hdac1 histone deacetylase 1 enables TAS
IBA
ISO
IDA		 (MGI:3687778|PMID:10615135), (MGI:5288521|PMID:21960634), (MGI:6867113|PMID:30279482) Reactome
GO_Central
MGI
UniProt		 PMID:10615135 PMID:21960634 PMID:30279482 GO_REF:0000033 GO_REF:0000119 MGI:3687778 MGI:4834177 MGI:5288521 MGI:6867113 Reactome:R-MMU-573376 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hdac10 histone deacetylase 10 enables ISO (PMID:11677242) MGI PMID:11677242 GO_REF:0000119 MGI:4834177 NCBI chr15:89,007,506...89,012,903
Ensembl chr15:89,007,510...89,012,903 		JBrowse link
G Hdac11 histone deacetylase 11 enables TAS
IBA
ISO		 (MGI:3687879|PMID:12711221) UniProt
GO_Central
MGI		 PMID:12711221 GO_REF:0000033 GO_REF:0000119 MGI:3687879 MGI:4834177 NCBI chr 6:91,133,652...91,151,674
Ensembl chr 6:91,133,647...91,151,674 		JBrowse link
G Hdac2 histone deacetylase 2 enables TAS
IGI
IDA
IBA
ISO		 (MGI:3687879|PMID:12711221)
(PMID:12975471)
(MGI:3811960|PMID:18754010), (MGI:5567917|PMID:15226430), (MGI:6867113|PMID:30279482), (PMID:12975471)		 UniProt
MGI
GO_Central		 PMID:12711221 PMID:12975471 PMID:15226430 PMID:18754010 PMID:30279482 GO_REF:0000033 GO_REF:0000119 MGI:3687879 MGI:3811960 MGI:4834177 MGI:5567917 MGI:6867113 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Hdac3 histone deacetylase 3 contributes_to
enables		 ISO
TAS
IBA
IDA
IMP		 (MGI:3687879|PMID:12711221)
(MGI:6867113|PMID:30279482), (PMID:17464331)
(PMID:15832170)		 MGI
UniProt
GO_Central		 PMID:12711221 PMID:15832170 PMID:17464331 PMID:30279482 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:3687879 MGI:4417868 MGI:4834177 MGI:6867113 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069 		JBrowse link
G Hdac4 histone deacetylase 4 enables ISO MGI GO_REF:0000008 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421 		JBrowse link
G Hdac5 histone deacetylase 5 enables TAS
ISO
IDA		 (MGI:3687879|PMID:12711221)
(MGI:1889866|PMID:10640276)		 UniProt
MGI		 PMID:10640276 PMID:12711221 GO_REF:0000119 MGI:1889866 MGI:3687879 MGI:4834177 NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992 		JBrowse link
G Hdac6 histone deacetylase 6 enables IMP
IDA
ISO
IBA		 (MGI:5605128|PMID:24882211)
(PMID:11689694), (PMID:9891014)		 CACAO
MGI
GO_Central		 PMID:9891014 PMID:11689694 PMID:24882211 GO_REF:0000008 GO_REF:0000033 MGI:5605128 NCBI chr  X:7,796,355...7,814,284
Ensembl chr  X:7,796,359...7,814,128 		JBrowse link
G Hdac7 histone deacetylase 7 enables TAS
IDA		 (MGI:3687879|PMID:12711221)
(MGI:1889866|PMID:10640276)		 UniProt PMID:10640276 PMID:12711221 MGI:1889866 MGI:3687879 NCBI chr15:97,690,542...97,742,383
Ensembl chr15:97,690,545...97,742,383 		JBrowse link
G Hdac8 histone deacetylase 8 enables TAS
IBA
ISO		 (MGI:3687879|PMID:12711221) UniProt
GO_Central
MGI		 PMID:12711221 GO_REF:0000033 GO_REF:0000119 MGI:3687879 MGI:4834177 NCBI chr  X:101,328,244...101,549,005
Ensembl chr  X:101,328,245...101,548,965 		JBrowse link
G Hdac9 histone deacetylase 9 enables
NOT|enables		 TAS (MGI:3687879|PMID:12711221)
(PMID:11390982)		 UniProt
MGI		 PMID:11390982 PMID:12711221 MGI:3687879 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094 		JBrowse link
G Mier1 MEIR1 treanscription regulator contributes_to ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:102,971,521...103,022,951
Ensembl chr 4:102,971,587...103,022,951 		JBrowse link
G Mier2 MIER family member 2 contributes_to ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:79,376,079...79,395,229
Ensembl chr10:79,376,079...79,391,033 		JBrowse link
G Mier3 MIER family member 3 NOT|contributes_to ISO (PMID:28046085) UniProt PMID:28046085 NCBI chr13:111,822,607...111,855,130
Ensembl chr13:111,817,513...111,855,130 		JBrowse link
G Mta2 metastasis-associated gene family, member 2 enables IDA (PMID:10444591) MGI PMID:10444591 NCBI chr19:8,919,239...8,929,659
Ensembl chr19:8,919,239...8,929,667 		JBrowse link
G Sirt1 sirtuin 1 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt2 sirtuin 2 enables IMP
ISO		 (MGI:5567889|PMID:24334550) UniProt
MGI		 PMID:24334550 GO_REF:0000119 MGI:4834177 MGI:5567889 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086 		JBrowse link
G Sirt4 sirtuin 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 5:115,616,065...115,628,322
Ensembl chr 5:115,616,069...115,622,784 		JBrowse link
G Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) contributes_to ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:117,229,743...117,257,980
Ensembl chr 5:117,229,745...117,254,178 		JBrowse link
histone H3K deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
histone H3K14 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac9 histone deacetylase 9 enables IMP (MGI:5287924|PMID:21708950) ARUK-UCL PMID:21708950 MGI:5287924 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094 		JBrowse link
histone H3K9 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac9 histone deacetylase 9 enables IMP (MGI:5287924|PMID:21708950) ARUK-UCL PMID:21708950 MGI:5287924 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094 		JBrowse link
histone H4K12 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
histone H4K16 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac2 histone deacetylase 2 enables IMP (MGI:5619732|PMID:23516383) CACAO PMID:23516383 MGI:5619732 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Hdac9 histone deacetylase 9 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094 		JBrowse link
NAD-dependent histone deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO
IDA
IBA		 (PMID:16959573)
(PMID:10693811)		 MGI
GO_Central
RGD		 PMID:10693811 PMID:16959573 PMID:19356683 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:2316170 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt2 sirtuin 2 NOT|enables ISO
IBA		 (PMID:24177535) UniProt
GO_Central
MGI		 PMID:24177535 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086 		JBrowse link
G Sirt3 sirtuin 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Sirt6 sirtuin 6 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
NAD-dependent histone H3K14 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
NAD-dependent histone H3K18 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt6 sirtuin 6 enables IDA
ISO		 (MGI:7258357|PMID:31002797) UniProt
MGI		 PMID:31002797 GO_REF:0000119 MGI:4834177 MGI:7258357 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
G Sirt7 sirtuin 7 enables IMP
IBA
ISO		 (MGI:5789069|PMID:27225932), (MGI:6377981|PMID:31226208), (MGI:6378020|PMID:31256246) UniProt
GO_Central
MGI		 PMID:27225932 PMID:31226208 PMID:31256246 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5789069 MGI:6377981 MGI:6378020 NCBI chr11:120,509,197...120,515,840
Ensembl chr11:120,509,198...120,516,066 		JBrowse link
NAD-dependent histone H3K56 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt6 sirtuin 6 enables ISO
IDA		 (MGI:4867348|PMID:21098266), (MGI:6103696|PMID:28355567), (MGI:6757299|PMID:25915124), (MGI:7258357|PMID:31002797), (PMID:31399344) MGI
UniProt		 PMID:21098266 PMID:25915124 PMID:28355567 PMID:31002797 PMID:31399344 GO_REF:0000119 MGI:4834177 MGI:4867348 MGI:6103696 MGI:6757299 MGI:7258357 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
NAD-dependent histone H3K9 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables IDA
ISO		 (MGI:4887284|PMID:20972425) UniProt
MGI		 PMID:20972425 GO_REF:0000119 MGI:4834177 MGI:4887284 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt6 sirtuin 6 enables TAS
IDA
IBA
ISO
IMP		 (MGI:7258357|PMID:31002797), (PMID:31399344)
(MGI:4867348|PMID:21098266), (MGI:4881401|PMID:20141841), (MGI:6103696|PMID:28355567), (MGI:6284084|PMID:29555651), (MGI:6357632|PMID:31399344), (MGI:6757299|PMID:25915124)		 Reactome
UniProt
GO_Central
MGI		 PMID:20141841 PMID:21098266 PMID:25915124 PMID:28355567 PMID:29555651 More... GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:4867348 MGI:4881401 MGI:6103696 MGI:6284084 MGI:6357632 MGI:6757299 MGI:7258357 Reactome:R-MMU-9604841 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
NAD-dependent histone H4K16 deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt2 sirtuin 2 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5721
      catalytic activity, acting on a protein 2360
        protein lysine deacetylase activity 23
          histone deacetylase activity 23
            NAD-dependent histone deacetylase activity + 5
            NAD-independent histone deacetylase activity 0
            histone H3K deacetylase activity + 4
            histone H4K deacetylase activity + 4
Path 2
Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5721
      hydrolase activity 2454
        hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 144
          hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 87
            histone deacetylase activity 23
              NAD-dependent histone deacetylase activity + 5
              NAD-independent histone deacetylase activity 0
              histone H3K deacetylase activity + 4
              histone H4K deacetylase activity + 4
paths to the root