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ONTOLOGY REPORT - ANNOTATIONS

Term:protein lysine deacetylase activity
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Accession:GO:0033558 term browser browse the term
Definition:Catalysis of the reaction: Removal of an acetyl group from a lysine residue in a protein.
Synonyms:exact_synonym: protein deacetylase activity
 xref: RHEA:58108;   Reactome:R-HSA-9701565 "HDACs deacetylate p-STAT3 dimers";   Reactome:R-HSA-9825772 "SIRT1 deacetylates HINT1 dimer";   Reactome:R-HSA-9841847 "SIRT3 deacetylates Ac-K272,K290-FOXO3";   reactome:R-HSA-5693092 "Unknown deacetylase deacetylates 7K-BACE1(46-501)";   reactome:R-HSA-8952069 "HDAC4 deacetylates RUNX3";   reactome:R-HSA-9626962 "SIRT1 deacetylates FOXO1"


show annotations for term's descendants           Sort by:
protein lysine deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables ISO (PMID:16285960), (PMID:17172643), (PMID:19182791), (PMID:23629966) RGD PMID:16285960 PMID:17172643 PMID:19182791 PMID:23629966 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac10 histone deacetylase 10 NOT|enables ISS
ISO		 GO_REF:0000024
(PMID:17172643), (PMID:26221039)
(PMID:28516954)		 UniProt
RGD		 PMID:17172643 PMID:26221039 PMID:28516954 GO_REF:0000024 NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228 		JBrowse link
G Hdac2 histone deacetylase 2 enables ISO (PMID:19041327)
(PMID:18754010)		 RGD PMID:18754010 PMID:19041327 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 enables ISO (PMID:15653507), (PMID:17172643), (PMID:25301942)
(PMID:17158926), (PMID:24565863), (PMID:27798112)		 RGD PMID:15653507 PMID:17158926 PMID:17172643 PMID:24565863 PMID:25301942 More... NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables ISO (PMID:18614528)
(PMID:18250163)		 RGD PMID:18250163 PMID:18614528 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables ISO (PMID:23867755) RGD PMID:23867755 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac6 histone deacetylase 6 enables ISO (PMID:28516954), (PMID:31857589) RGD PMID:28516954 PMID:31857589 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Hdac7 histone deacetylase 7 enables ISS
ISO		 GO_REF:0000024
(PMID:30538141), (PMID:37369679)		 UniProt
RGD		 PMID:30538141 PMID:37369679 GO_REF:0000024 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables ISO (PMID:22885700) RGD PMID:22885700 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 enables ISO (PMID:11535832) RGD PMID:11535832 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Sirt1 sirtuin 1 enables ISO (PMID:19934257), (PMID:20027304), (PMID:20203304), (PMID:20424141), (PMID:20670893), (PMID:21807113), (PMID:23056314)
(PMID:17521387), (PMID:19578370), (PMID:20167603), (PMID:24089055)		 RGD PMID:17521387 PMID:19578370 PMID:19934257 PMID:20027304 PMID:20167603 More... NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables ISS
ISO		 GO_REF:0000024
(PMID:17521387), (PMID:17681146), (PMID:19037106), (PMID:23908241)
(PMID:17172643), (PMID:20543840), (PMID:23908241)		 UniProt
RGD		 PMID:17172643 PMID:17521387 PMID:17681146 PMID:19037106 PMID:20543840 More... GO_REF:0000024 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt3 sirtuin 3 enables ISO (PMID:21858060) RGD PMID:21858060 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Sirt6 sirtuin 6 IDA RGD PMID:22335191 RGD:9586060 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
histone deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 contributes_to IDA RGD PMID:17079677 RGD:5688291 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G ENSRNOG00000069033 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 7:78,933,181...78,934,754 JBrowse link
G Hdac1 histone deacetylase 1 enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:10615135), (PMID:21960634), (PMID:30279482)
GO_REF:0000033
(PMID:12590135), (PMID:16762839), (PMID:17996965), (PMID:19182791), (PMID:28497810)
GO_REF:0000002		 UniProt
RGD
GO_Central
InterPro		 PMID:10615135 PMID:12590135 PMID:16762839 PMID:17996965 PMID:19182791 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac10 histone deacetylase 10 enables ISO
IEA		 (PMID:11861901)
GO_REF:0000107
(PMID:11739383)		 RGD
Ensembl		 PMID:11739383 PMID:11861901 GO_REF:0000107 NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228 		JBrowse link
G Hdac11 histone deacetylase 11 enables ISO
IBA		 (PMID:11948178)
GO_REF:0000033		 RGD
GO_Central		 PMID:11948178 GO_REF:0000033 NCBI chr 4:123,645,873...123,667,407
Ensembl chr 4:123,650,157...123,667,405 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables ISO
IBA		 (PMID:16642021), (PMID:28497810)
MGI:1916782 (PMID:12975471), (PMID:15226430), (PMID:18754010), (PMID:30279482)
GO_REF:0000033		 RGD
GO_Central		 PMID:12975471 PMID:15226430 PMID:16642021 PMID:18754010 PMID:28497810 More... GO_REF:0000033 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 contributes_to
enables		 IDA
ISO
IEA		 (PMID:15832170), (PMID:17464331), (PMID:30279482)
GO_REF:0000002
(PMID:16924111), (PMID:18326024), (PMID:28497810)		 RGD
InterPro		 PMID:15832170 PMID:16924111 PMID:17464331 PMID:18326024 PMID:28497810 More... GO_REF:0000002, RGD:5688291 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA
ISO		 GO_REF:0000104
(PMID:10220385), (PMID:10869435), (PMID:12590135)		 UniProt
RGD		 PMID:10220385 PMID:10869435 PMID:12590135 GO_REF:0000104 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables ISO (PMID:10869435)
(PMID:10640276)		 RGD PMID:10640276 PMID:10869435 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac6 histone deacetylase 6 enables ISO (PMID:10220385), (PMID:23322205)
(PMID:11689694), (PMID:24882211), (PMID:9891014)		 RGD PMID:9891014 PMID:10220385 PMID:11689694 PMID:23322205 PMID:24882211 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Hdac7 histone deacetylase 7 enables TAS
ISO
ISS
IEA		 PMID:12711221
(PMID:10640276)
GO_REF:0000024
GO_REF:0000104		 RGD
UniProt		 PMID:10640276 PMID:12711221 GO_REF:0000024 GO_REF:0000104, RGD:8553516 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
(PMID:28497810)		 UniProt
GO_Central
Ensembl
InterPro
RGD		 PMID:28497810 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 NOT|enables ISO (PMID:10655483)
(PMID:11535832), (PMID:12590135)		 RGD PMID:10655483 PMID:11535832 PMID:12590135 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Mier1 MIER1 transcriptional regulator contributes_to ISO (PMID:28046085) RGD PMID:28046085 NCBI chr 5:117,876,012...117,927,592
Ensembl chr 5:117,870,382...117,927,589 		JBrowse link
G Mier2 MIER family member 2 contributes_to ISO (PMID:28046085) RGD PMID:28046085 NCBI chr 7:10,153,501...10,169,381
Ensembl chr 7:10,153,649...10,169,378 		JBrowse link
G Mier3 MIER family member 3 NOT|contributes_to ISO (PMID:28046085) RGD PMID:28046085 NCBI chr 2:43,287,546...43,316,422
Ensembl chr 2:43,287,916...43,316,136 		JBrowse link
G Mta2 metastasis associated 1 family, member 2 enables ISO (PMID:10444591) RGD PMID:10444591 NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946 		JBrowse link
G Sirt1 sirtuin 1 enables ISO
IEA		 (PMID:18485871)
GO_REF:0000117		 RGD
UniProt		 PMID:18485871 GO_REF:0000117 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables ISS
ISO		 GO_REF:0000024
(PMID:24334550)
(PMID:17488717)		 UniProt
RGD		 PMID:17488717 PMID:24334550 GO_REF:0000024 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt4 sirtuin 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439 		JBrowse link
G Suds3 SDS3 homolog, SIN3A corepressor complex component contributes_to ISO (PMID:21239494) RGD PMID:21239494 NCBI chr12:39,477,181...39,499,633
Ensembl chr12:39,477,568...39,499,628 		JBrowse link
histone deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables IDA
ISO
IBA		 (PMID:10693811)
GO_REF:0000033
(PMID:12006491), (PMID:15469825), (PMID:16079181), (PMID:16959573), (PMID:28497810)		 RGD
GO_Central		 PMID:10693811 PMID:12006491 PMID:15469825 PMID:16079181 PMID:16959573 More... GO_REF:0000033, RGD:2316170 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 NOT|enables ISO
IBA
IEA		 (PMID:24177535)
GO_REF:0000033
GO_REF:0000002
(PMID:11427894), (PMID:12697818)		 RGD
GO_Central
InterPro		 PMID:11427894 PMID:12697818 PMID:24177535 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt3 sirtuin 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Sirt6 sirtuin 6 enables ISO (PMID:24043303), (PMID:27912097) RGD PMID:24043303 PMID:27912097 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
histone H3K deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO (PMID:20027304) RGD PMID:20027304 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
histone H3K14 deacetylase activity, hydrolytic mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac7 histone deacetylase 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 enables ISO (PMID:21708950) RGD PMID:21708950 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
histone H3K14 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO
IEA		 (PMID:15469825)
GO_REF:0000107		 RGD
Ensembl		 PMID:15469825 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt7 sirtuin 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
histone H3K18 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt6 sirtuin 6 enables ISO (PMID:27043296)
(PMID:31002797)		 RGD PMID:27043296 PMID:31002797 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Sirt7 sirtuin 7 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:27225932), (PMID:31226208), (PMID:31256246)
GO_REF:0000033
(PMID:22722849), (PMID:26907567), (PMID:28655758), (PMID:30420520), (PMID:30653310), (PMID:35939806)		 UniProt
RGD
GO_Central		 PMID:22722849 PMID:26907567 PMID:27225932 PMID:28655758 PMID:30420520 More... GO_REF:0000024 GO_REF:0000033 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
histone H3K4 deacetylase activity, hydrolytic mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac7 histone deacetylase 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
histone H3K4 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt7 sirtuin 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
histone H3K56 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt6 sirtuin 6 enables ISO (PMID:23911928), (PMID:26456828), (PMID:26898756), (PMID:27912097), (PMID:30374165)
(PMID:21098266), (PMID:25915124), (PMID:28355567), (PMID:31002797), (PMID:31399344)		 RGD PMID:21098266 PMID:23911928 PMID:25915124 PMID:26456828 PMID:26898756 More... NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Sirt7 sirtuin 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
histone H3K9 deacetylase activity, hydrolytic mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac7 histone deacetylase 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 enables ISO (PMID:21708950) RGD PMID:21708950 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Sirt6 sirtuin 6 enables ISO (PMID:33067423) RGD PMID:33067423 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
histone H3K9 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables IEA
ISO		 GO_REF:0000107
(PMID:20972425)
(PMID:15469825)		 Ensembl
RGD		 PMID:15469825 PMID:20972425 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt6 sirtuin 6 enables ISO
IBA		 (PMID:18337721), (PMID:23892288), (PMID:26456828), (PMID:29555651), (PMID:30374165), (PMID:33067423)
(PMID:20141841), (PMID:21098266), (PMID:25915124), (PMID:28355567), (PMID:29555651), (PMID:31002797), (PMID:31399344)
GO_REF:0000033		 RGD
GO_Central		 PMID:18337721 PMID:20141841 PMID:21098266 PMID:23892288 PMID:25915124 More... GO_REF:0000033 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Sirt7 sirtuin 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
histone H4K12 deacetylase activity, hydrolytic mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac7 histone deacetylase 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Sirt1 sirtuin 1 enables ISO
IEA		 (PMID:15469825)
GO_REF:0000107		 RGD
Ensembl		 PMID:15469825 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
histone H4K16 deacetylase activity, hydrolytic mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables ISO (PMID:23516383) RGD PMID:23516383 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac7 histone deacetylase 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 enables ISO (PMID:28855441) RGD PMID:28855441 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
histone H4K16 deacetylase activity, NAD-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 enables ISO
IEA		 (PMID:15469825)
GO_REF:0000107		 RGD
Ensembl		 PMID:15469825 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 enables ISO
IEA
ISS		 (PMID:16648462)
GO_REF:0000003
GO_REF:0000107
GO_REF:0000024		 RGD
UniProt
Ensembl		 PMID:16648462 GO_REF:0000003 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt7 sirtuin 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
histone H4K5 deacetylase activity, hydrolytic mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac7 histone deacetylase 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
histone H4K8 deacetylase activity, hydrolytic mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac7 histone deacetylase 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Hdac9 histone deacetylase 9 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
tubulin deacetylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac1 histone deacetylase 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac3 histone deacetylase 3 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac6 histone deacetylase 6 enables ISO (PMID:12024216), (PMID:12620231), (PMID:19228685), (PMID:19457097), (PMID:20308065)
UniProtKB:Q5EG47|UniProtKB:Q8BRK8 (PMID:12606581), (PMID:19457097), (PMID:19893491), (PMID:27430620)		 RGD PMID:12024216 PMID:12606581 PMID:12620231 PMID:19228685 PMID:19457097 More... NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Hdac7 histone deacetylase 7 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hdac8 histone deacetylase 8 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Sirt2 sirtuin 2 enables
NOT|enables		 IDA
ISO
IEA		 PMID:17344398
(PMID:24334550)
GO_REF:0000107
(PMID:24177535)
(PMID:12620231), (PMID:18722353), (PMID:23886946)		 RGD
Ensembl		 PMID:12620231 PMID:18722353 PMID:23886946 PMID:24177535 PMID:24334550 More... GO_REF:0000107, RGD:8553877 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      catalytic activity, acting on a protein 2509
        protein lysine deacetylase activity 25
          histone deacetylase activity + 25
          tubulin deacetylase activity 7
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      deacylase activity 71
        deacetylase activity 38
          protein lysine deacetylase activity 25
            histone deacetylase activity + 25
            tubulin deacetylase activity 7
paths to the root