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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of NLRP3 inflammasome complex assembly
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Accession:GO:1900225 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly.
Synonyms:exact_synonym: regulation of NALP3 inflammasome complex assembly
 related_synonym: regulation of NLRP3 inflammasome activation


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regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:103,041,029...103,096,741
Ensembl chr 3:103,041,221...103,096,738 		JBrowse link
G KCNK13 potassium two pore domain channel subfamily K member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:111,866,471...111,981,304
Ensembl chr 7:111,867,546...111,980,663 		JBrowse link
negative regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD17A abhydrolase domain containing 17A, depalmitoylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:76,658,073...76,666,561
Ensembl chr 2:76,658,068...76,666,552 		JBrowse link
G CPTP ceramide-1-phosphate transfer protein involved_in ISO (PMID:29164996) UniProt PMID:29164996 NCBI chr 6:63,607,991...63,612,325 JBrowse link
G CSNK1A1 casein kinase 1 alpha 1 involved_in ISO (PMID:34615873) UniProt PMID:34615873 NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284 		JBrowse link
G FBXL2 F-box and leucine rich repeat protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:19,128,145...19,206,458
Ensembl chr13:19,128,237...19,221,201 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:49,982,278...49,986,760
Ensembl chr 9:49,982,284...49,990,508 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 involved_in ISO (PMID:36586411) UniProt PMID:36586411 NCBI chr  X:98,586,718...98,623,939
Ensembl chr  X:98,581,992...98,623,940 		JBrowse link
G MEFV MEFV innate immunity regulator, pyrin involved_in ISO (PMID:26347139) UniProt PMID:26347139 NCBI chr 3:38,934,573...38,948,609 JBrowse link
G NLRC3 NLR family CARD domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,673,590...38,719,188
Ensembl chr 3:38,687,967...38,710,938 		JBrowse link
G SIRT2 sirtuin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chr 6:47,682,427...47,703,408
Ensembl chr 6:47,682,429...47,703,384 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138)
(PMID:29887864)		 ARUK-UCL
Ensembl		 PMID:29887864 PMID:32514138 GO_REF:0000107 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
G TRIM31 tripartite motif containing 31 involved_in ISO (PMID:27929086) UniProt PMID:27929086 NCBI chr 7:22,665,150...22,681,616 JBrowse link
G ZDHHC12 zinc finger DHHC-type palmitoyltransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:269,081,274...269,084,853
Ensembl chr 1:269,081,272...269,084,840 		JBrowse link
G ZER1 zyg-11 related cell cycle regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:269,088,696...269,121,895
Ensembl chr 1:269,090,159...269,108,256 		JBrowse link
positive regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAT1 alpha tubulin acetyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chr 7:23,173,138...23,185,463
Ensembl chr 7:23,173,438...23,185,451 		JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:125,383,392...125,439,082
Ensembl chr  X:125,383,414...125,439,082 		JBrowse link
G BTK Bruton tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G CD36 CD36 molecule involved_in ISO (PMID:23812099) UniProt PMID:23812099 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:31511697) UniProt PMID:31511697 NCBI chr  X:36,988,031...37,005,496
Ensembl chr  X:36,988,031...37,018,202 		JBrowse link
G DHX33 DEAH-box helicase 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:51,527,071...51,547,334
Ensembl chr12:51,527,083...51,546,448 		JBrowse link
G KCNK6 potassium two pore domain channel subfamily K member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,237,665...47,249,178
Ensembl chr 6:47,238,685...47,249,136 		JBrowse link
G LATS1 large tumor suppressor kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:16,274,955...16,320,980
Ensembl chr 1:16,274,970...16,320,604 		JBrowse link
G LATS2 large tumor suppressor kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:1,225,523...1,265,970
Ensembl chr11:1,225,527...1,265,946 		JBrowse link
G LOC100522887 caspase-13 involved_in ISO (PMID:26173909) UniProt PMID:26173909 NCBI chr 9:35,167,567...35,185,791 JBrowse link
G LOC100523492 guanylate-binding protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:127,289,938...127,303,065
Ensembl chr 4:127,289,956...127,303,011 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G MARK4 microtubule affinity regulating kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,665,923...51,700,553
Ensembl chr 6:51,665,918...51,700,552 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:31,850,646...31,869,273
Ensembl chr17:31,850,900...31,869,188 		JBrowse link
G MIR21 microRNA mir-21 ISO RGD PMID:29084974 RGD:41404715 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NEK7 NIMA related kinase 7 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr10:20,966,660...21,124,283
Ensembl chr10:20,966,651...21,124,271 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472 		JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chr 6:6,433,146...6,603,092
Ensembl chr 6:6,433,153...6,603,060 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:136,497,780...136,522,630
Ensembl chr 2:136,494,541...136,522,646 		JBrowse link
G PRKD1 protein kinase D1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:69,527,743...69,872,374
Ensembl chr 7:69,527,811...69,872,863 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099 		JBrowse link
G STMP1 short transmembrane mitochondrial protein 1 involved_in ISO (PMID:31836654) UniProt PMID:31836654 NCBI chr13:138,779,975...138,781,436 JBrowse link
G STMP1 short transmembrane mitochondrial protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr18:13,641,541...13,665,565 JBrowse link
G TLR4 toll like receptor 4 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (PMID:23812099) UniProt PMID:23812099 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
G USP50 ubiquitin specific peptidase 50 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:28094437) MGI
Ensembl		 PMID:28094437 GO_REF:0000107 NCBI chr 1:121,272,977...121,307,029
Ensembl chr 1:121,273,043...121,307,075 		JBrowse link
G ZDHHC1 zinc finger DHHC-type containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:28,046,099...28,071,535
Ensembl chr 6:28,049,949...28,071,540 		JBrowse link
G ZDHHC5 zinc finger DHHC-type palmitoyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:13,250,967...13,276,517
Ensembl chr 2:13,250,970...13,276,114 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18954
    cellular process 18495
      regulation of cellular process 12302
        regulation of cellular component biogenesis 1139
          regulation of protein-containing complex assembly 446
            regulation of NLRP3 inflammasome complex assembly 44
              negative regulation of NLRP3 inflammasome complex assembly 13
              positive regulation of NLRP3 inflammasome complex assembly 29
Path 2
Term Annotations click to browse term
  biological_process 18954
    response to stimulus 10124
      response to biotic stimulus 1761
        response to external biotic stimulus 1715
          response to other organism 1711
            defense response to other organism 1183
              defense response to symbiont 984
                innate immune response 907
                  regulation of innate immune response 449
                    positive regulation of innate immune response 366
                      activation of innate immune response 302
                        innate immune response-activating signaling pathway 280
                          pattern recognition receptor signaling pathway 274
                            cytoplasmic pattern recognition receptor signaling pathway 182
                              inflammasome-mediated signaling pathway 54
                                canonical inflammasome complex assembly 50
                                  NLRP3 inflammasome complex assembly 48
                                    regulation of NLRP3 inflammasome complex assembly 44
                                      negative regulation of NLRP3 inflammasome complex assembly 13
                                      positive regulation of NLRP3 inflammasome complex assembly 29
paths to the root