SIRT2 (sirtuin 2) - Rat Genome Database

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Gene: SIRT2 (sirtuin 2) Sus scrofa
Analyze
Symbol: SIRT2
Name: sirtuin 2
RGD ID: 14177130
Description: ENCODES a protein that exhibits histone deacetylase activity, NAD-dependent (ortholog); tubulin deacetylase activity (ortholog); INVOLVED IN chromatin organization (ortholog); lipid catabolic process (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); cocaine dependence (ortholog); high grade glioma (ortholog); FOUND IN glial cell projection (ortholog); glutamatergic synapse (ortholog); heterochromatin (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NAD-dependent protein deacetylase sirtuin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,682,429 - 47,703,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,682,427 - 47,703,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,218,298 - 43,228,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to caloric restriction  (IEA)
cellular response to epinephrine stimulus  (IEA)
cellular response to hypoxia  (IEA)
cellular response to oxidative stress  (IEA)
chromatin organization  (IEA,ISO)
epigenetic regulation of gene expression  (IEA)
lipid catabolic process  (ISO)
myelination in peripheral nervous system  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of fat cell differentiation  (IEA)
negative regulation of NLRP3 inflammasome complex assembly  (IEA,ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of oligodendrocyte progenitor proliferation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein catabolic process  (IEA)
negative regulation of reactive oxygen species metabolic process  (IEA)
negative regulation of striated muscle tissue development  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
NLRP3 inflammasome complex assembly  (IEA,ISO)
peptidyl-lysine deacetylation  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (IEA)
positive regulation of cell division  (IEA)
positive regulation of execution phase of apoptosis  (IEA)
positive regulation of fatty acid biosynthetic process  (IEA)
positive regulation of meiotic nuclear division  (IEA)
positive regulation of oocyte maturation  (IEA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
post-translational protein modification  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein deacetylation  (ISO)
rDNA heterochromatin formation  (IBA)
regulation of cell cycle  (IEA)
regulation of fat cell differentiation  (IEA,ISO)
regulation of myelination  (IEA)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
response to cocaine  (ISO)
substantia nigra development  (ISO)
tubulin deacetylation  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:19389481   PMID:19823955   PMID:22301074  


Genomics

Comparative Map Data
SIRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,682,429 - 47,703,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,682,427 - 47,703,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,218,298 - 43,228,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,878,555 - 38,899,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,878,555 - 38,899,862 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,369,195 - 39,390,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,061,040 - 44,082,201 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,061,039 - 44,082,193NCBI
Celera1936,171,632 - 36,192,939 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,815,856 - 35,837,294 (-)NCBIHuRef
CHM1_11939,369,665 - 39,390,970 (-)NCBICHM1_1
T2T-CHM13v2.01941,682,611 - 41,703,673 (-)NCBIT2T-CHM13v2.0
Sirt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,466,192 - 28,488,086 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,466,160 - 28,488,086 (+)EnsemblGRCm39 Ensembl
GRCm38728,766,752 - 28,788,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,766,735 - 28,788,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,551,771 - 29,573,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,475,543 - 28,497,420 (+)NCBIMGSCv36mm8
Celera723,327,529 - 23,349,457 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.92NCBI
Sirt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,181,472 - 93,204,499 (+)NCBIGRCr8
mRatBN7.2184,053,883 - 84,076,975 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,052,903 - 84,076,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,463,787 - 89,486,870 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,922,897 - 97,945,932 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,219,644 - 91,242,728 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,948,918 - 86,971,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
Sirt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBIChiLan1.0ChiLan1.0
SIRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,181,332 - 45,202,521 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,051,896 - 47,073,091 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,984,453 - 36,005,582 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,533,965 - 44,554,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,533,965 - 44,554,799 (-)Ensemblpanpan1.1panPan2
SIRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,224,922 - 114,235,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,224,900 - 114,234,583 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,618,889 - 113,636,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,817,111 - 114,834,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,817,428 - 114,834,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,375,328 - 114,392,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,008,029 - 114,025,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,003,788 - 115,021,492 (+)NCBIUU_Cfam_GSD_1.0
Sirt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,400,802 - 13,421,980 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,828,831 - 1,850,000 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,828,868 - 1,849,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,493,106 - 33,518,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,493,079 - 33,518,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,514,410 - 11,540,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,235,263 - 12,259,276 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,239,363 - 12,259,561 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SIRT2
426 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000022319   ⟹   ENSSSCP00000020261
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,682,430 - 47,703,384 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000046012   ⟹   ENSSSCP00000051299
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,682,430 - 47,703,384 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000087456   ⟹   ENSSSCP00000072455
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,683,294 - 47,703,384 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000089506   ⟹   ENSSSCP00000064320
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,682,429 - 47,698,914 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000094110   ⟹   ENSSSCP00000080059
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,682,429 - 47,702,651 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000097906   ⟹   ENSSSCP00000077584
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,683,451 - 47,698,154 (-)Ensembl
RefSeq Acc Id: NM_001114271   ⟹   NP_001107743
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1647,682,427 - 47,703,342 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093185   ⟹   XP_020948844
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1647,682,427 - 47,703,408 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020948844   ⟸   XM_021093185
- Peptide Label: isoform X1
- UniProtKB: A0A287B4T1 (UniProtKB/TrEMBL),   I3L8A1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001107743   ⟸   NM_001114271
- UniProtKB: B0FWP5 (UniProtKB/TrEMBL),   C3W332 (UniProtKB/TrEMBL),   I3L8A1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000064320   ⟸   ENSSSCT00000089506
Ensembl Acc Id: ENSSSCP00000051299   ⟸   ENSSSCT00000046012
Ensembl Acc Id: ENSSSCP00000020261   ⟸   ENSSSCT00000022319
Ensembl Acc Id: ENSSSCP00000072455   ⟸   ENSSSCT00000087456
Ensembl Acc Id: ENSSSCP00000080059   ⟸   ENSSSCT00000094110
Ensembl Acc Id: ENSSSCP00000077584   ⟸   ENSSSCT00000097906
Protein Domains
Deacetylase sirtuin-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026794 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000022319.4 UniProtKB/TrEMBL
  ENSSSCT00000046012 ENTREZGENE
  ENSSSCT00000046012.3 UniProtKB/TrEMBL
  ENSSSCT00000087456.2 UniProtKB/TrEMBL
  ENSSSCT00000089506.2 UniProtKB/TrEMBL
  ENSSSCT00000094110 ENTREZGENE
  ENSSSCT00000094110.1 UniProtKB/TrEMBL
  ENSSSCT00000097906.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD-dep_sirtuin_deacylases UniProtKB/TrEMBL
  Sirtuin UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/TrEMBL
  Sirtuin_class_I UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
KEGG Report ssc:100125964 UniProtKB/TrEMBL
NCBI Gene SIRT2 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PIRSF SIR2_euk UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A287B4T1 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QQH9_PIG UniProtKB/TrEMBL
  A0A5G2RK85_PIG UniProtKB/TrEMBL
  A0A8W4FE47_PIG UniProtKB/TrEMBL
  A0A8W4FL43_PIG UniProtKB/TrEMBL
  B0FWP5 ENTREZGENE, UniProtKB/TrEMBL
  C3W331_PIG UniProtKB/TrEMBL
  C3W332 ENTREZGENE, UniProtKB/TrEMBL
  I3L8A1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92885 ENTREZGENE