DDX3X (DEAD-box helicase 3 X-linked) - Rat Genome Database

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Gene: DDX3X (DEAD-box helicase 3 X-linked) Sus scrofa
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Symbol: DDX3X
Name: DEAD-box helicase 3 X-linked
RGD ID: 13888800
Description: ENCODES a protein that exhibits primary miRNA binding (ortholog); INVOLVED IN negative regulation by host of viral genome replication; positive regulation of DNA-templated transcription; positive regulation of NLRP3 inflammasome complex assembly (ortholog); ASSOCIATED WITH autistic disorder (ortholog); breast cancer (ortholog); cerebellar hypoplasia (ortholog); FOUND IN cytoplasm; cytosolic small ribosomal subunit (ortholog); eukaryotic translation initiation factor 3 complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-dependent RNA helicase DDX3X; DEAD box protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX36,988,031 - 37,018,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X36,988,031 - 37,005,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X41,162,232 - 41,177,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IBA,IEA)
cellular response to arsenic-containing substance  (IEA)
cellular response to osmotic stress  (IEA)
cellular response to virus  (IEA)
chromosome segregation  (IEA)
cytosolic ribosome assembly  (IEA)
DNA duplex unwinding  (IEA)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
gamete generation  (IBA,IEA)
innate immune response  (IEA)
intracellular signal transduction  (IEA)
intrinsic apoptotic signaling pathway  (IEA)
lipid homeostasis  (IEA)
negative regulation by host of viral genome replication  (IMP)
negative regulation of apoptotic process  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
negative regulation of gene expression  (IBA)
negative regulation of intrinsic apoptotic signaling pathway  (IEA)
negative regulation of non-canonical NF-kappaB signal transduction  (IEA)
negative regulation of protein-containing complex assembly  (IEA)
negative regulation of translation  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of G1/S transition of mitotic cell cycle  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of interferon-alpha production  (IEA)
positive regulation of interferon-beta production  (IEA)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of protein acetylation  (IEA)
positive regulation of protein autophosphorylation  (IEA)
positive regulation of protein K63-linked ubiquitination  (IEA)
positive regulation of toll-like receptor 7 signaling pathway  (IEA)
positive regulation of toll-like receptor 8 signaling pathway  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of translation  (IEA)
positive regulation of translation in response to endoplasmic reticulum stress  (IEA)
positive regulation of translational initiation  (IEA)
positive regulation of type I interferon production  (IEA)
positive regulation of viral genome replication  (IEA)
primary miRNA processing  (ISO)
protein localization to cytoplasmic stress granule  (IEA)
response to virus  (IEA)
RNA secondary structure unwinding  (IEA)
stress granule assembly  (IEA)
translational initiation  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DDX3X
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX36,988,031 - 37,018,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X36,988,031 - 37,005,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X41,162,232 - 41,177,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDX3X
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X41,333,308 - 41,364,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX41,333,348 - 41,364,472 (+)EnsemblGRCh38hg38GRCh38
GRCh37X41,192,561 - 41,223,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X41,077,595 - 41,094,471 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X40,948,904 - 40,979,978NCBI
CeleraX45,333,407 - 45,350,283 (+)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX38,924,970 - 38,941,587 (+)NCBIHuRef
CHM1_1X41,225,367 - 41,242,242 (+)NCBICHM1_1
T2T-CHM13v2.0X40,735,393 - 40,766,556 (+)NCBIT2T-CHM13v2.0
Ddx3x
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X13,147,261 - 13,160,222 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX13,147,209 - 13,160,291 (+)EnsemblGRCm39 Ensembl
GRCm38X13,280,496 - 13,293,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX13,280,970 - 13,294,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X12,858,148 - 12,871,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X12,437,997 - 12,449,573 (+)NCBIMGSCv36mm8
CeleraX10,940,806 - 10,968,272 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX8.17NCBI
Ddx3x
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X12,152,346 - 12,165,983 (-)NCBIGRCr8
mRatBN7.2X9,479,532 - 9,493,169 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX9,479,532 - 9,493,168 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX9,663,528 - 9,677,065 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X13,160,667 - 13,174,198 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X9,425,314 - 9,438,972 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X10,400,363 - 10,414,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX10,400,366 - 10,413,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X11,198,745 - 11,212,383 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X21,495,072 - 21,508,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX10,011,280 - 10,024,898 (-)NCBICelera
Cytogenetic MapXq12NCBI
Ddx3x
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555651,386,973 - 1,404,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555651,387,043 - 1,403,624 (-)NCBIChiLan1.0ChiLan1.0
DDX3X
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X42,976,148 - 42,995,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X42,981,694 - 42,998,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X33,780,381 - 33,796,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X41,474,515 - 41,491,479 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX41,475,116 - 41,505,837 (+)Ensemblpanpan1.1panPan2
DDX3X
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X35,759,367 - 35,789,759 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX35,759,416 - 35,789,774 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX23,107,814 - 23,138,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X35,809,592 - 35,840,330 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX35,809,593 - 35,840,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X35,887,325 - 35,918,053 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X35,859,851 - 35,889,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X35,902,946 - 35,933,679 (+)NCBIUU_Cfam_GSD_1.0
Ddx3x
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X27,967,669 - 27,979,844 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365027,804,824 - 7,820,569 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365027,770,896 - 7,820,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDX3X
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X38,513,251 - 38,539,982 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblY689,380 - 706,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660763,696,930 - 3,714,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddx3x
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476214,290,267 - 14,305,633 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476214,290,267 - 14,305,437 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DDX3X
468 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000013398   ⟹   ENSSSCP00000013038
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX36,988,031 - 37,003,935 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000041730   ⟹   ENSSSCP00000048200
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX36,988,031 - 37,003,206 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076469   ⟹   ENSSSCP00000067771
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX36,988,031 - 37,002,934 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000078562   ⟹   ENSSSCP00000070577
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX36,988,031 - 37,002,934 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000080042   ⟹   ENSSSCP00000066858
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX36,988,031 - 37,018,202 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082601   ⟹   ENSSSCP00000065708
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX36,988,031 - 37,002,934 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000088110   ⟹   ENSSSCP00000059869
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX36,992,063 - 37,002,934 (+)Ensembl
RefSeq Acc Id: NM_001246203   ⟹   NP_001233132
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X36,990,081 - 37,002,934 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005673561   ⟹   XP_005673618
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X36,988,031 - 37,005,496 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005673618   ⟸   XM_005673561
- Peptide Label: isoform X1
- UniProtKB: F1RX16 (UniProtKB/TrEMBL),   A0A8D0ZIA5 (UniProtKB/TrEMBL),   A0A8D1BZQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001233132   ⟸   NM_001246203
- UniProtKB: F4ZS18 (UniProtKB/TrEMBL),   A0A8D1BZQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000070577   ⟸   ENSSSCT00000078562
RefSeq Acc Id: ENSSSCP00000059869   ⟸   ENSSSCT00000088110
RefSeq Acc Id: ENSSSCP00000048200   ⟸   ENSSSCT00000041730
RefSeq Acc Id: ENSSSCP00000066858   ⟸   ENSSSCT00000080042
RefSeq Acc Id: ENSSSCP00000067771   ⟸   ENSSSCT00000076469
RefSeq Acc Id: ENSSSCP00000013038   ⟸   ENSSSCT00000013398
RefSeq Acc Id: ENSSSCP00000065708   ⟸   ENSSSCT00000082601

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012252 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015071674 UniProtKB/TrEMBL
  ENSSSCG00025064999 UniProtKB/TrEMBL
  ENSSSCG00030011778 UniProtKB/TrEMBL
  ENSSSCG00035035008 UniProtKB/TrEMBL
  ENSSSCG00040028256 UniProtKB/TrEMBL
  ENSSSCG00045031857 UniProtKB/TrEMBL
  ENSSSCG00050040809 UniProtKB/TrEMBL
  ENSSSCG00055000630 UniProtKB/TrEMBL
  ENSSSCG00060069366 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013398 ENTREZGENE
  ENSSSCT00000013398.5 UniProtKB/TrEMBL
  ENSSSCT00000041730.3 UniProtKB/TrEMBL
  ENSSSCT00000076469.1 UniProtKB/TrEMBL
  ENSSSCT00000078562.1 UniProtKB/TrEMBL
  ENSSSCT00000080042.1 UniProtKB/TrEMBL
  ENSSSCT00000082601.1 UniProtKB/TrEMBL
  ENSSSCT00000088110 ENTREZGENE
  ENSSSCT00000088110.1 UniProtKB/TrEMBL
  ENSSSCT00015099487.1 UniProtKB/TrEMBL
  ENSSSCT00025090616.1 UniProtKB/TrEMBL
  ENSSSCT00025091660.1 UniProtKB/TrEMBL
  ENSSSCT00030016337.1 UniProtKB/TrEMBL
  ENSSSCT00030016374.1 UniProtKB/TrEMBL
  ENSSSCT00035046645.1 UniProtKB/TrEMBL
  ENSSSCT00035046719.1 UniProtKB/TrEMBL
  ENSSSCT00040038556.1 UniProtKB/TrEMBL
  ENSSSCT00040038646.1 UniProtKB/TrEMBL
  ENSSSCT00045055441.1 UniProtKB/TrEMBL
  ENSSSCT00050055353.1 UniProtKB/TrEMBL
  ENSSSCT00050055398.1 UniProtKB/TrEMBL
  ENSSSCT00055001324.1 UniProtKB/TrEMBL
  ENSSSCT00055001472.1 UniProtKB/TrEMBL
  ENSSSCT00060095951.1 UniProtKB/TrEMBL
  ENSSSCT00060096337.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/TrEMBL
KEGG Report ssc:100515940 UniProtKB/TrEMBL
NCBI Gene DDX3X ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE DBP3 UniProtKB/TrEMBL
  ATP-DEPENDENT RNA HELICASE DDX3X UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
PROSITE DEAD_ATP_HELICASE UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  Q_MOTIF UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A287AVQ1_PIG UniProtKB/TrEMBL
  A0A5G2QCV6_PIG UniProtKB/TrEMBL
  A0A5G2QM78_PIG UniProtKB/TrEMBL
  A0A5G2R0P1_PIG UniProtKB/TrEMBL
  A0A5G2R8C2_PIG UniProtKB/TrEMBL
  A0A8D0ZIA5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1BZQ1 ENTREZGENE, UniProtKB/TrEMBL
  D3UD05_PIG UniProtKB/TrEMBL
  F1RX16 ENTREZGENE, UniProtKB/TrEMBL
  F4ZS18 ENTREZGENE, UniProtKB/TrEMBL