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Gene: BTK (Bruton tyrosine kinase) Sus scrofa

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Symbol:

BTK

Name:

Bruton tyrosine kinase

RGD ID:

14174315

Description:

ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cellular response to molecule of fungal origin (ortholog); cellular response to reactive oxygen species (ortholog); eosinophil homeostasis (ortholog); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Adenoviridae Infections (ortholog); agammaglobulinemia (ortholog); agammaglobulinemia 1 (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BTK (Bruton tyrosine kinase)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Treefam
Mus musculus (house mouse):	Btk (Bruton agammaglobulinemia tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	82,981,512 - 83,014,475 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	Adenoviridae Infections	susceptibility	ISO	RGD:1551411	9068941		RGD	PMID:15140955\|REF_RGD_ID:124713567
BTK	Pig	agammaglobulinemia	susceptibility	ISO	RGD:1342660	9068941	DNA:insertions, point mutations	RGD	PMID:8162018\|REF_RGD_ID:1600526
BTK	Pig	Anaphylaxis	treatment	ISO	RGD:1359683	9068941		RGD	PMID:22228807\|REF_RGD_ID:11040701
BTK	Pig	arthus reaction	treatment	ISO	RGD:1359683	9068941		RGD	PMID:22228807\|REF_RGD_ID:11040701
BTK	Pig	B-Cell Chronic Lymphocytic Leukemia	treatment	ISO	RGD:1342660	9068941		RGD	PMID:23045577\|REF_RGD_ID:11040699
BTK	Pig	B-cell lymphoma	treatment	ISO	RGD:1551411	9068941		RGD	PMID:25662332\|REF_RGD_ID:11040764
BTK	Pig	B-cell lymphoma	treatment	ISO	RGD:1342660	9068941	human cell in a mouse model	RGD	PMID:28348046\|REF_RGD_ID:124713554
BTK	Pig	Burkitt lymphoma	ameliorates	ISO	RGD:1342660	9068941	Human cell line in a mouse model	RGD	PMID:30546948\|REF_RGD_ID:124715474
BTK	Pig	Burkitt lymphoma	treatment	ISO	RGD:1342660	9068941	mRNA:increased expression:multiple (human)	RGD	PMID:28474336\|REF_RGD_ID:124713565
BTK	Pig	central nervous system lymphoma	ameliorates	ISO	RGD:1342660	9068941		RGD	PMID:28552327\|REF_RGD_ID:124715478
BTK	Pig	colitis	ameliorates	ISO	RGD:1551411	9068941	Associated with candidiasis	RGD	PMID:25379804\|REF_RGD_ID:124713568
BTK	Pig	colon adenocarcinoma		ISO	RGD:1342660	9068941	mRNA:decreased expression:colon (human)	RGD	PMID:31402962\|REF_RGD_ID:151347853
BTK	Pig	colorectal cancer	exacerbates	ISO	RGD:1342660	9068941	protein:increased expression:colorectum (human)	RGD	PMID:31238520\|REF_RGD_ID:151347852
BTK	Pig	colorectal cancer	disease_progression	ISO	RGD:1342660	9068941	protein:increased expression:colorectum (human)	RGD	PMID:31518438\|REF_RGD_ID:151347850
BTK	Pig	COVID-19		ISO	RGD:1342660	9068941	protein:increased phosphorylation:blood, monocyte (human)	RGD	PMID:32503877\|REF_RGD_ID:124713553
BTK	Pig	cryptococcosis	exacerbates	ISO	RGD:1551411	9068941		RGD	PMID:23820392\|REF_RGD_ID:124715476
BTK	Pig	endometriosis of uterus	disease_progression	ISO	RGD:1551411	9068941		RGD	PMID:31247078\|REF_RGD_ID:124715471
BTK	Pig	Enterovirus Infections	treatment	ISO	RGD:1551411	9068941	Associated with X-linked agammaglobulinemia	RGD	PMID:10508272\|REF_RGD_ID:124715472
BTK	Pig	Experimental Arthritis	treatment	ISO	RGD:1551411	9068941		RGD	PMID:22228807\|REF_RGD_ID:11040701
BTK	Pig	Experimental Arthritis	treatment	ISO	RGD:1359683	9068941		RGD	PMID:22228807\|PMID:32083858\|REF_RGD_ID:11040701\|REF_RGD_ID:151665122
BTK	Pig	Hypothermia	exacerbates	ISO	RGD:1323170	9068941	Associated with Endotoxemia; with Itk knockout	RGD	PMID:26581914\|REF_RGD_ID:11533169
BTK	Pig	influenza A	ameliorates	ISO	RGD:1551411	9068941	Associated with Acute Lung Injury	RGD	PMID:29516781\|REF_RGD_ID:124713566
BTK	Pig	leishmaniasis	susceptibility	ISO	RGD:1551411	9068941		RGD	PMID:28783468\|REF_RGD_ID:124715477
BTK	Pig	listeriosis	ameliorates	ISO	RGD:1551411	9068941		RGD	PMID:23544144\|REF_RGD_ID:124713555
BTK	Pig	lung adenocarcinoma	exacerbates	ISO	RGD:1342660	9068941	mRNA:decreased expression:lung (human)	RGD	PMID:32351880\|REF_RGD_ID:151347848
BTK	Pig	lung adenocarcinoma	susceptibility	ISO	RGD:1342660	9068941	mRNA:decreased expression:lung (human)	RGD	PMID:31803536\|REF_RGD_ID:151347849
BTK	Pig	lung non-small cell carcinoma	ameliorates	ISO	RGD:1342660	9068941	mRNA:increased expression:lung (human)	RGD	PMID:32623229\|REF_RGD_ID:151347854
BTK	Pig	Lymphatic Metastasis	disease_progression	ISO	RGD:1342660	9068941	associated with lung adenocarcinoma;protein:increased expression:lung (human)	RGD	PMID:31200752\|REF_RGD_ID:151347847
BTK	Pig	mantle cell lymphoma	treatment	ISO	RGD:1342660	9068941		RGD	PMID:23045577\|REF_RGD_ID:11040699
BTK	Pig	nasopharynx carcinoma		ISO	RGD:1342660	9068941	mRNA:decreased expression:nasopharynx (human)	RGD	PMID:33096113\|REF_RGD_ID:151347855
BTK	Pig	oral squamous cell carcinoma	treatment	ISO	RGD:1342660	9068941	mRNA:increased expression:oral epithelium (human)	RGD	PMID:33640903\|REF_RGD_ID:151347851
BTK	Pig	Pneumococcal Pneumonia	ameliorates	ISO	RGD:1551411	9068941		RGD	PMID:30646846\|REF_RGD_ID:124715470
BTK	Pig	Streptococcus pneumonia		ISO	RGD:1551411	9068941		RGD	PMID:30873567\|REF_RGD_ID:124715473
BTK	Pig	X-linked agammaglobulinemia	ameliorates	ISO	RGD:1342660	9068941	human gene in a mouse model	RGD	PMID:15142874\|REF_RGD_ID:124713551
BTK	Pig	X-linked agammaglobulinemia	ameliorates	ISO	RGD:1342660	9068941	Human gene in mouse model	RGD	PMID:20574453\|REF_RGD_ID:124715475

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	agammaglobulinemia 1		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Autosomal recessive agammaglobulinemia 1	ClinVar	PMID:10092645\|PMID:11206059\|PMID:11410123\|PMID:11445810\|PMID:11472359\|PMID:11668622\|PMID:11742281\|PMID:12217331\|PMID:14974089\|PMID:15661032\|PMID:16862044\|PMID:16951917\|PMID:17327079\|PMID:17765309\|PMID:18518992\|PMID:19039656\|PMID:19419768\|PMID:19904586\|PMID:20529312\|PMID:23424595\|PMID:25741868\|PMID:27512878\|PMID:27980540\|PMID:28492532\|PMID:29424453\|PMID:29503650\|PMID:30072168\|PMID:30564228\|PMID:7678697\|PMID:7809124\|PMID:7849697\|PMID:7849721\|PMID:7880320\|PMID:8090769\|PMID:8162056\|PMID:8380905\|PMID:8594569\|PMID:8695804\|PMID:8939985\|PMID:9143921\|PMID:9188445\|PMID:9445504\|PMID:9524120\|PMID:9545398\|PMID:9880544
BTK	Pig	autistic disorder		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106\|PMID:30208311
BTK	Pig	autosomal hemophilia A		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA A	ClinVar	PMID:31690835
BTK	Pig	common variable immunodeficiency		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Common variable immunodeficiency	ClinVar	PMID:11472359\|PMID:18241230\|PMID:25741868\|PMID:28492532
BTK	Pig	deafness-dystonia-optic neuronopathy syndrome		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Deafness dystonia syndrome	ClinVar
BTK	Pig	developmental and epileptic encephalopathy 9		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Developmental and epileptic encephalopathy, 9	ClinVar	PMID:28492532
BTK	Pig	diffuse large B-cell lymphoma		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Diffuse large B cell lymphoma	ClinVar	PMID:24869598\|PMID:25082755\|PMID:25189416\|PMID:25741868\|PMID:27199251\|PMID:28049639\|PMID:28212557\|PMID:28418267\|PMID:28492532\|PMID:29496671\|PMID:29875397\|PMID:30018078\|PMID:32455989\|PMID:33154951\|PMID:36029036
BTK	Pig	Fabry disease		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Fabry disease	ClinVar	PMID:10666480\|PMID:12175777\|PMID:15661032\|PMID:16862044\|PMID:19419768\|PMID:28492532\|PMID:31795557
BTK	Pig	factor VIII deficiency		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Factor 8 deficiency, congenital	ClinVar	PMID:31690835
BTK	Pig	genetic disease		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:28492532\|PMID:33584693\|PMID:36790564
BTK	Pig	isolated growth hormone deficiency type III		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: BTK-related condition \| ClinVar Annotator: match by term: X-linked agammaglobulinemia more ...	ClinVar	PMID:10092645\|PMID:10373551\|PMID:10612838\|PMID:10666480\|PMID:10678660\|PMID:10737994\|PMID:10754312\|PMID:10844531\|PMID:10859027\|PMID:10887125\|PMID:11027452\|PMID:11102984\|PMID:11206059\|PMID:11410123\|PMID:11438999\|PMID:11445810\|PMID:11472359\|PMID:11527964\|PMID:11555397\|PMID:11564824\|PMID:11668622\|PMID:11742281\|PMID:11809909\|PMID:11892085\|PMID:11956200\|PMID:12175777\|PMID:12204007\|PMID:12217331\|PMID:1240516\|PMID:12405164\|PMID:12655572\|PMID:12768435\|PMID:14974089\|PMID:15024743\|PMID:15112668\|PMID:15358621\|PMID:15661032\|PMID:15821893\|PMID:16159644\|PMID:16160918\|PMID:16199547\|PMID:16297664\|PMID:16712653\|PMID:16729790\|PMID:16751014\|PMID:16862044\|PMID:16913189\|PMID:16943681\|PMID:16951917\|PMID:17045652\|PMID:17327079\|PMID:17576681\|PMID:17765309\|PMID:18241230\|PMID:18518992\|PMID:18677443\|PMID:19039656\|PMID:19302039\|PMID:19419768\|PMID:19763152\|PMID:19904586\|PMID:20307669\|PMID:20529312\|PMID:20721470\|PMID:20723125\|PMID:21039741\|PMID:21397315\|PMID:21520333\|PMID:21984432\|PMID:22378381\|PMID:22406018\|PMID:22736418\|PMID:23335184\|PMID:23424595\|PMID:24001798\|PMID:24033266\|PMID:24383975\|PMID:24477949\|PMID:24586880\|PMID:24658450\|PMID:24869597\|PMID:24869598\|PMID:24885015\|PMID:25082755\|PMID:25189416\|PMID:25270678\|PMID:25525159\|PMID:25640679\|PMID:25741868\|PMID:25777788\|PMID:26915675\|PMID:26931785\|PMID:26960951\|PMID:27199251\|PMID:27512878\|PMID:27535475\|PMID:27577878\|PMID:27593100\|PMID:27980540\|PMID:28049639\|PMID:28212557\|PMID:28359783\|PMID:28418267\|PMID:28492532\|PMID:2896233\|PMID:29202590\|PMID:29424453\|PMID:29496671\|PMID:29503650\|PMID:29658452\|PMID:29709555\|PMID:29875397\|PMID:29921932\|PMID:30018078\|PMID:30072168\|PMID:30240888\|PMID:30290665\|PMID:30311057\|PMID:30564228\|PMID:30697212\|PMID:30882382\|PMID:31795557\|PMID:32067425\|PMID:32117230\|PMID:32441320\|PMID:32455989\|PMID:32477911\|PMID:32492159\|PMID:32499645\|PMID:32552675\|PMID:32581362\|PMID:32888943\|PMID:33013854\|PMID:33042921\|PMID:33154951\|PMID:33224144\|PMID:33225392\|PMID:33226337\|PMID:33377626\|PMID:33584693\|PMID:33815962\|PMID:34029777\|PMID:34177947\|PMID:34182127\|PMID:34249912\|PMID:34262886\|PMID:3486747\|PMID:34975878\|PMID:35196427\|PMID:35382780\|PMID:35482138\|PMID:36029036\|PMID:36790564\|PMID:4697357\|PMID:7554467\|PMID:7627183\|PMID:7633420\|PMID:7633429\|PMID:7678697\|PMID:7711734\|PMID:7809124\|PMID:7849697\|PMID:7849721\|PMID:7880320\|PMID:7897635\|PMID:8013627\|PMID:8090769\|PMID:8162018\|PMID:8162056\|PMID:8164701\|PMID:8164707\|PMID:8332900\|PMID:8332901\|PMID:8380905\|PMID:8562928\|PMID:8594569\|PMID:8644706\|PMID:8695804\|PMID:8723128\|PMID:8834236\|PMID:8851194\|PMID:8938104\|PMID:8939985\|PMID:9106525\|PMID:9143921\|PMID:9188445\|PMID:9192269\|PMID:9260159\|PMID:9445504\|PMID:9524120\|PMID:9536098\|PMID:9545398\|PMID:9880544
BTK	Pig	primary immunodeficiency disease		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Inherited Immunodeficiency Diseases	ClinVar	PMID:11809909\|PMID:12405164\|PMID:15661032\|PMID:16862044\|PMID:17576681\|PMID:19419768\|PMID:25741868\|PMID:28492532\|PMID:32499645\|PMID:32581362\|PMID:7627183\|PMID:7849697\|PMID:9536098\|PMID:9545398
BTK	Pig	ROLANDIC EPILEPSY, INTELLECTUAL DISABILITY, AND SPEECH DYSPRAXIA, X-LINKED		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Rolandic epilepsy, intellectual disability, and speech dyspraxia, X-linked	ClinVar	PMID:28492532
BTK	Pig	syndromic X-linked intellectual disability Lubs type		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs type	ClinVar	PMID:25741868
BTK	Pig	X-linked agammaglobulinemia		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: X-linked agammaglobulinemia	ClinVar	PMID:10092645\|PMID:10373551\|PMID:10678660\|PMID:10737994\|PMID:10754312\|PMID:10844531\|PMID:10859027\|PMID:10887125\|PMID:11102984\|PMID:11206059\|PMID:11410123\|PMID:11445810\|PMID:11472359\|PMID:11527964\|PMID:11555397\|PMID:11564824\|PMID:11586956\|PMID:11668622\|PMID:11742281\|PMID:11809909\|PMID:12204007\|PMID:12217331\|PMID:12405164\|PMID:12655572\|PMID:12768435\|PMID:14974089\|PMID:15024743\|PMID:15112668\|PMID:15661032\|PMID:16053733\|PMID:16159644\|PMID:16160918\|PMID:16199547\|PMID:16712653\|PMID:16751014\|PMID:16862044\|PMID:16913189\|PMID:16951917\|PMID:17045652\|PMID:17164954\|PMID:17327079\|PMID:17576681\|PMID:17765309\|PMID:18241230\|PMID:18518992\|PMID:18677443\|PMID:19039656\|PMID:19419768\|PMID:19904586\|PMID:20529312\|PMID:21397315\|PMID:23335184\|PMID:23424595\|PMID:24001798\|PMID:24033266\|PMID:24383975\|PMID:24820629\|PMID:24885015\|PMID:25142992\|PMID:25525159\|PMID:25741868\|PMID:25777788\|PMID:26915675\|PMID:26981933\|PMID:27512878\|PMID:27577878\|PMID:27980540\|PMID:28492532\|PMID:2896233\|PMID:29424453\|PMID:29503650\|PMID:29921932\|PMID:30072168\|PMID:30240888\|PMID:30290665\|PMID:30311057\|PMID:30564228\|PMID:30627929\|PMID:30697212\|PMID:31803177\|PMID:32499645\|PMID:32581362\|PMID:32888943\|PMID:33042921\|PMID:33224144\|PMID:33377626\|PMID:34029777\|PMID:3486747\|PMID:34975878\|PMID:4697357\|PMID:7554467\|PMID:7627183\|PMID:7633420\|PMID:7633429\|PMID:7678697\|PMID:7711734\|PMID:7809124\|PMID:7849697\|PMID:7849721\|PMID:7880320\|PMID:8090769\|PMID:8162018\|PMID:8162056\|PMID:8164701\|PMID:8164707\|PMID:8332900\|PMID:8332901\|PMID:8380905\|PMID:8594569\|PMID:8644706\|PMID:8695804\|PMID:8938104\|PMID:8939985\|PMID:9106525\|PMID:9143921\|PMID:9188445\|PMID:9260159\|PMID:9445504\|PMID:9524120\|PMID:9536098\|PMID:9545398\|PMID:9880544
BTK	Pig	X-Linked Hypogammaglobulinemia		ISO	RGD:1342660	8554872	ClinVar Annotator: match by term: Hypogammaglobulinemia, X-linked	ClinVar	PMID:8758136

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	agammaglobulinemia		ISO	RGD:1342660	9068941	CTD Direct Evidence: therapeutic	CTD	PMID:15142874
BTK	Pig	COVID-19		ISO	RGD:1342660	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:32503877

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	isolated growth hormone deficiency type III		ISO	RGD:1342660	7240710		OMIM
BTK	Pig	X-linked agammaglobulinemia		ISO	RGD:1342660	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	adaptive immune response	involved_in	IBA	MGI:102960\|MGI:88216\|MGI:96621\|PANTHER:PTN000700360	150520179		GO_Central	GO_REF:0000033
BTK	Pig	B cell affinity maturation	acts_upstream_of_or_within	IEA	UniProtKB:P35991\|ensembl:ENSMUSP00000033617	150520179		Ensembl	GO_REF:0000107
BTK	Pig	B cell receptor signaling pathway	involved_in	IBA	PANTHER:PTN000700360\|UniProtKB:P42680\|UniProtKB:Q06187	150520179		GO_Central	GO_REF:0000033
BTK	Pig	B cell receptor signaling pathway	involved_in	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	cell maturation	acts_upstream_of_or_within	IEA	UniProtKB:P35991\|ensembl:ENSMUSP00000033617	150520179		Ensembl	GO_REF:0000107
BTK	Pig	cellular response to interleukin-7	acts_upstream_of_or_within	IEA	UniProtKB:P35991\|ensembl:ENSMUSP00000033617	150520179		Ensembl	GO_REF:0000107
BTK	Pig	cellular response to molecule of fungal origin		ISO	RGD:1359683	9068941		RGD	PMID:10744701\|REF_RGD_ID:1600536
BTK	Pig	cellular response to reactive oxygen species		ISO	RGD:1359683	9068941		RGD	PMID:10744701\|REF_RGD_ID:1600536
BTK	Pig	eosinophil homeostasis		ISO	RGD:12283322	9068941		RGD	PMID:32484067\|REF_RGD_ID:151665124
BTK	Pig	eosinophil homeostasis		ISO	RGD:1359683	9068941		RGD	PMID:32484067\|REF_RGD_ID:151665124
BTK	Pig	histamine secretion by mast cell		ISO	RGD:1359683	9068941		RGD	PMID:12220673\|REF_RGD_ID:1600535
BTK	Pig	intracellular signal transduction	involved_in	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	intracellular signal transduction	involved_in	IEA	InterPro:IPR001562	150520179		InterPro	GO_REF:0000002
BTK	Pig	monocyte proliferation		ISO	RGD:1359683	9068941		RGD	PMID:32484067\|REF_RGD_ID:151665124
BTK	Pig	monocyte proliferation		ISO	RGD:12283322	9068941		RGD	PMID:32484067\|REF_RGD_ID:151665124
BTK	Pig	negative regulation of B cell activation		ISO	RGD:1359683	9068941		RGD	PMID:25545336\|REF_RGD_ID:151665128
BTK	Pig	negative regulation of B cell proliferation	acts_upstream_of_or_within	IEA	UniProtKB:P35991\|ensembl:ENSMUSP00000033617	150520179		Ensembl	GO_REF:0000107
BTK	Pig	negative regulation of cytokine production	involved_in	IEA	UniProtKB:P35991\|ensembl:ENSMUSP00000033617	150520179		Ensembl	GO_REF:0000107
BTK	Pig	negative regulation of interleukin-10 production		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	negative regulation of leukocyte proliferation		ISO	RGD:12283322	9068941		RGD	PMID:32484067\|REF_RGD_ID:151665124
BTK	Pig	negative regulation of leukocyte proliferation		ISO	RGD:1359683	9068941		RGD	PMID:32484067\|REF_RGD_ID:151665124
BTK	Pig	neutrophil homeostasis		ISO	RGD:1359683	9068941		RGD	PMID:32484067\|REF_RGD_ID:151665124
BTK	Pig	neutrophil homeostasis		ISO	RGD:12283322	9068941		RGD	PMID:32484067\|REF_RGD_ID:151665124
BTK	Pig	peptidyl-tyrosine autophosphorylation		ISO	RGD:1359683	9068941		RGD	PMID:21521773\|REF_RGD_ID:151665123
BTK	Pig	peptidyl-tyrosine phosphorylation	involved_in	ISO	RGD:1342660	9068941	PMID:11606584	CACAO	PMID:11606584
BTK	Pig	peptidyl-tyrosine phosphorylation	acts_upstream_of_or_within	ISO	RGD:1551411	9068941	PMID:10872802	MGI	PMID:10872802
BTK	Pig	positive regulation of B cell proliferation		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	positive regulation of cGAS/STING signaling pathway	involved_in	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	positive regulation of immunoglobulin production		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	positive regulation of interleukin-17A production		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	positive regulation of interleukin-6 production		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	positive regulation of NLRP3 inflammasome complex assembly	involved_in	IEA	UniProtKB:P35991\|UniProtKB:Q06187\|ensembl:ENSMUSP00000033617\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	positive regulation of phagocytosis		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	positive regulation of synoviocyte proliferation		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	positive regulation of tumor necrosis factor production		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	positive regulation of type I hypersensitivity		ISO	RGD:1359683	9068941		RGD	PMID:22228807\|REF_RGD_ID:11040701
BTK	Pig	positive regulation of type III hypersensitivity		ISO	RGD:1359683	9068941		RGD	PMID:22228807\|REF_RGD_ID:11040701
BTK	Pig	protein autophosphorylation		ISO	RGD:1359683	9068941		RGD	PMID:7696342\|REF_RGD_ID:1600538
BTK	Pig	protein phosphorylation	acts_upstream_of_or_within	ISO	RGD:1551411	9068941	PMID:12235209	MGI	PMID:12235209
BTK	Pig	proteoglycan catabolic process		ISO	RGD:1359683	9068941		RGD	PMID:32083858\|REF_RGD_ID:151665122
BTK	Pig	response to lipopolysaccharide		ISO	RGD:1359683	9068941		RGD	PMID:28352114\|REF_RGD_ID:151665126
BTK	Pig	T cell receptor signaling pathway	involved_in	IBA	MGI:102960\|MGI:96621\|PANTHER:PTN000700360	150520179		GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	150520179		UniProt	GO_REF:0000043
BTK	Pig	cytoplasm	located_in	IEA	UniProtKB:P35991\|ensembl:ENSMUSP00000033617	150520179		Ensembl	GO_REF:0000107
BTK	Pig	cytoplasm	is_active_in	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	cytoplasmic vesicle	located_in	IEA	UniProtKB:P35991\|ensembl:ENSMUSP00000033617	150520179		Ensembl	GO_REF:0000107
BTK	Pig	cytosol	located_in	IEA	ARBA:ARBA00029243	150520179		UniProt	GO_REF:0000117
BTK	Pig	cytosol	located_in	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	membrane raft	located_in	IEA	UniProtKB:P35991\|UniProtKB:Q06187\|ensembl:ENSMUSP00000033617\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	nucleus	located_in	IEA	UniProtKB:P35991\|ensembl:ENSMUSP00000033617	150520179		Ensembl	GO_REF:0000107
BTK	Pig	perinuclear region of cytoplasm		ISO	RGD:1359683	9068941		RGD	PMID:12220673\|REF_RGD_ID:1600535
BTK	Pig	plasma membrane	located_in	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	plasma membrane	is_active_in	IBA	FB:FBgn0000017\|FB:FBgn0000723\|FB:FBgn0003502\|MGI:1858308\|MGI:87860\|MGI:95481\|MGI:95527\|MGI:95602\|MGI:96892\|MGI:98397\|MGI:99147\|MGI:99515\|MGI:99613\|PANTHER:PTN002521457\|RGD:3443\|RGD:620795\|RGD:621017\|RGD:628758\|UniProtKB:P00523\|UniProtKB:P06239\|UniProtKB:P06241\|UniProtKB:P07332\|UniProtKB:P07947\|UniProtKB:P07948\|UniProtKB:P08631\|UniProtKB:P09769\|UniProtKB:P12931\|UniProtKB:P16591\|UniProtKB:P41240\|UniProtKB:P42680\|UniProtKB:P42681\|UniProtKB:P43403\|UniProtKB:P43405\|UniProtKB:P51813\|UniProtKB:Q00944\|UniProtKB:Q06187\|UniProtKB:Q07912\|UniProtKB:Q13882\|UniProtKB:Q6J9G0\|WB:WBGene00000812\|WB:WBGene00001487\|WB:WBGene00004962\|WB:WBGene00005077	150520179		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	ATP binding	enables	IEA	UniRule:UR001503341	150520179		UniProt	GO_REF:0000104
BTK	Pig	ATP binding	enables	IEA	InterPro:IPR000719\|InterPro:IPR017441	150520179		InterPro	GO_REF:0000002
BTK	Pig	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	150520179		UniProt	GO_REF:0000043
BTK	Pig	identical protein binding	enables	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	150520179		UniProt	GO_REF:0000043
BTK	Pig	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
BTK	Pig	non-membrane spanning protein tyrosine kinase activity	enables	IBA	PANTHER:PTN001231474\|UniProtKB:P42680\|UniProtKB:P51813\|UniProtKB:Q06187\|UniProtKB:Q08881	150520179		GO_Central	GO_REF:0000033
BTK	Pig	non-membrane spanning protein tyrosine kinase activity	enables	IEA	EC:2.7.10.2	150520179		UniProt	GO_REF:0000003
BTK	Pig	non-membrane spanning protein tyrosine kinase activity	enables	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	150520179		UniProt	GO_REF:0000043
BTK	Pig	nucleotide binding	enables	IEA	UniRule:UR001503341	150520179		UniProt	GO_REF:0000104
BTK	Pig	phosphatidylinositol-3,4,5-trisphosphate binding	enables	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	phospholipase activator activity	enables	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	phospholipase binding	enables	IEA	UniProtKB:Q06187\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	protein binding	enables	ISO	PR:Q99LJ5	9068941	PMID:15196959	MGI	PMID:15196959
BTK	Pig	protein binding	enables	ISO	MGI:1927238	9068941	PMID:11007757	MGI	PMID:11007757
BTK	Pig	protein binding	enables	ISO	PR:Q62431	9068941	PMID:15456761	MGI	PMID:15456761
BTK	Pig	protein binding	enables	ISO	UniProtKB:P22366\|UniProtKB:P27512\|UniProtKB:Q80UF7	9068941	PMID:21441935	IntAct	PMID:21441935
BTK	Pig	protein binding	enables	ISO	UniProtKB:O35305,UniProtKB:P24604,UniProtKB:Q78T81,UniProtKB:Q8CIH5,UniProtKB:Q9Z1S8	9068941	PMID:23478294	UniProt	PMID:23478294
BTK	Pig	protein binding	enables	ISO	UniProtKB:P78347\|UniProtKB:Q99856	9068941	PMID:19214191	IntAct	PMID:19214191
BTK	Pig	protein binding	enables	ISO	UniProtKB:P78347	9068941	PMID:9012831	IntAct	PMID:9012831
BTK	Pig	protein binding	enables	ISO	UniProtKB:Q13882	9068941	PMID:15539407	UniProt	PMID:15539407
BTK	Pig	protein binding	enables	ISO	UniProtKB:P21145	9068941	PMID:22366891	IntAct	PMID:22366891
BTK	Pig	protein binding	enables	ISO	UniProtKB:Q9Y2I7	9068941	PMID:15046600	HGNC-UCL	PMID:15046600
BTK	Pig	protein binding	enables	ISO	UniProtKB:O60239	9068941	PMID:9571151	IntAct	PMID:9571151
BTK	Pig	protein binding	enables	ISO	UniProtKB:Q60631	9068941	PMID:15102471	IntAct	PMID:15102471
BTK	Pig	protein binding	enables	ISO	UniProtKB:Q9BVA0	9068941	PMID:28514442	IntAct	PMID:28514442
BTK	Pig	protein binding	enables	ISO	UniProtKB:P08238\|UniProtKB:Q9BVA0	9068941	PMID:33961781	IntAct	PMID:33961781
BTK	Pig	protein binding	enables	ISO	UniProtKB:P08238	9068941	PMID:22939624	IntAct	PMID:22939624
BTK	Pig	protein binding	enables	ISO	UniProtKB:P50222	9068941	PMID:25910212	IntAct	PMID:25910212
BTK	Pig	protein binding	enables	ISO	UniProtKB:P42768	9068941	PMID:8892607	BHF-UCL	PMID:8892607
BTK	Pig	protein binding	enables	ISO	UniProtKB:Q8WV28	9068941	PMID:16969585	IntAct	PMID:16969585
BTK	Pig	protein binding	enables	ISO	UniProtKB:Q13444	9068941	PMID:25825872	IntAct	PMID:25825872
BTK	Pig	protein binding	enables	ISO	UniProtKB:Q04759	9068941	PMID:11788586	IntAct	PMID:11788586
BTK	Pig	protein kinase activity	enables	IEA	InterPro:IPR000719\|InterPro:IPR001245\|InterPro:IPR008266	150520179		InterPro	GO_REF:0000002
BTK	Pig	protein tyrosine kinase activity		ISO	RGD:1359683	9068941		RGD	PMID:12193692\|PMID:7696342\|REF_RGD_ID:151665129\|REF_RGD_ID:1600538
BTK	Pig	protein tyrosine kinase activity	enables	IEA	UniProtKB:P35991\|UniProtKB:Q06187\|ensembl:ENSMUSP00000033617\|ensembl:ENSP00000308176	150520179		Ensembl	GO_REF:0000107
BTK	Pig	protein tyrosine kinase activity	enables	IEA	UniProtKB-KW:KW-0829	150520179		UniProt	GO_REF:0000043
BTK	Pig	protein tyrosine kinase activity	enables	IEA	InterPro:IPR020635	150520179		InterPro	GO_REF:0000002
BTK	Pig	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	150520179		UniProt	GO_REF:0000043
BTK	Pig	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	150520179		UniProt	GO_REF:0000043

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	protein kinase C (PKC) signaling pathway		ISO	RGD:1342660	9068941		RGD	PMID:15380937\|REF_RGD_ID:5131492

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	Fc epsilon receptor mediated signaling pathway		ISO	RGD:1342660	9068941		SMPDB	SMP:00358

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
BTK	Pig	erythropoietin signaling pathway		ISO	RGD:1342660	9068941		PID	PID:200183
BTK	Pig	FasL mediated signaling pathway		ISO	RGD:1342660	9068941		PID	PID:200080
BTK	Pig	phosphatidylinositol 3-kinase class I signaling pathway		ISO	RGD:1342660	9068941		PID	PID:200116

PMID:14681463	PMID:22301074	PMID:30032202

BTK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	82,981,512 - 83,014,475 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

BTK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	101,349,450 - 101,390,796 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	101,349,338 - 101,390,796 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	100,604,438 - 100,645,784 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	100,491,098 - 100,527,838 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	100,410,586 - 100,447,327	NCBI
Celera	X	101,123,894 - 101,160,669 (-)	NCBI		Celera
Cytogenetic Map	X	q22.1	NCBI
HuRef	X	90,410,583 - 90,447,505 (-)	NCBI		HuRef
CHM1_1	X	100,497,918 - 100,534,692 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	99,793,571 - 99,834,908 (-)	NCBI		T2T-CHM13v2.0

Btk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	133,443,083 - 133,484,366 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	133,443,085 - 133,484,319 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	134,542,334 - 134,583,628 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	134,542,336 - 134,583,570 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	131,076,880 - 131,117,679 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	129,888,761 - 129,929,466 (-)	NCBI		MGSCv36	mm8
Celera	X	117,421,885 - 117,462,725 (-)	NCBI		Celera
Cytogenetic Map	X	E3	NCBI
cM Map	X	56.18	NCBI

Btk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	102,016,070 - 102,055,448 (-)	NCBI		GRCr8
mRatBN7.2	X	97,722,796 - 97,762,315 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	97,722,802 - 97,761,853 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	99,397,016 - 99,436,088 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	102,907,749 - 102,946,794 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	100,410,180 - 100,449,237 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	105,360,922 - 105,390,580 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	105,360,922 - 105,390,580 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	105,250,666 - 105,279,934 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	121,998,935 - 122,030,289 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	122,072,367 - 122,103,722 (-)	NCBI
Celera	X	98,764,036 - 98,794,122 (-)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

Btk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955503	7,482,793 - 7,515,120 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955503	7,483,819 - 7,515,085 (-)	NCBI	ChiLan1.0	ChiLan1.0

BTK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	100,948,666 - 100,985,544 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	100,952,265 - 100,989,149 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	90,551,874 - 90,588,786 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	100,684,017 - 100,720,868 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	100,684,017 - 100,725,187 (-)	Ensembl	panpan1.1		panPan2

BTK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	75,270,952 - 75,302,663 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	75,270,979 - 75,302,562 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	76,691,359 - 76,723,087 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	76,691,367 - 76,723,042 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	74,255,464 - 74,287,205 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	75,915,885 - 75,947,610 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	75,678,325 - 75,710,045 (-)	NCBI		UU_Cfam_GSD_1.0

Btk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	63,007,672 - 63,045,710 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936813	429,224 - 463,441 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936813	429,400 - 467,481 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BTK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	89,690,569 - 89,727,420 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	14,609,796 - 14,647,019 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Btk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624902	1,182,682 - 1,216,171 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624902	1,173,101 - 1,216,662 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in BTK
445 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	6	3


RefSeq Transcripts	NM_001243576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK230598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK231012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK236988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK236989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK391468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP015816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01003245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000013662 ⟹ ENSSSCP00000013290

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000025835 ⟹ ENSSSCP00000025530

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000097469 ⟹ ENSSSCP00000077524

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	X	82,981,518 - 83,014,463 (-)	Ensembl

RefSeq Acc Id:

NM_001243576 ⟹ NP_001230505

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	X	82,981,512 - 83,014,475 (-)	NCBI

Sequence:

show sequence

CTTCCTCTCTGGACTGTAAGAATATGTCTCCAGGGCCAGTGTCTTCTGACATCGAGTCCCACCTTCAAAGTCCTGGCATCTCAATGCATCCAGGAAGCTACCTGCATTAAAGTCAGGACTGAGCATAC
AGTGAGCTCCAGAAAGAAGAAGCTATGGCTGCGGTGATACTGGAGAGCATCTTTCTGAAACGATCTCAGCAGGAAAAGAAAACATCACCTTTGAACTTCAAGAAGCGCCTCTTTCTCTTGACCGTGCA
AAAACTTTCCTACTATGAGTATGACTTTGAACGTGGGAGAAGAGGCAGTAAGAAGGGTTCAATAGATGTTGAGAAGATCACCTGCGTTGAAACAGTTGTTCCTGAGAAAAATCCTCCCCCTGAAAGAC
AGATTCCGAGAAGGGGTGAAGAGTCCAGTGAAATGGAGCAGATTTCAATTATTGAAAGGTTCCCTTACCCCTTCCAGGTTGTATATGATGAAGGGCCTCTCTACGTCTTCTCCCCAACTGAAGAACTG
AGAAAGCGTTGGATTCACCAGCTCAAAAGTGTAATCCGGTACAACAGTGATCTGGTACAGAAATACCACCCTTGCTTCTGGATTGATGGGCAGTATCTCTGCTGCTCTCAGACAGCCAAAAATGCTAT
GGGCTGCCAAATTTTGGAGAACAGAAATGGAAGCTTAAAACCTGGGAGTTCACACCGAAAGACGAAAAAGCCTCTTCCTCCCACACCTGAGGAGGACCAGATCTTAAAAAAGCCACTGCCCCCTGAGC
CAACAGCAGCACCGGTCTCGACAAGTGAGCTGAAAAAGGTTGTAGCCCTTTATGATTACATGCCAATGAATGCAAATGATCTACAGCTGCGGAAGGGCGACGAGTATTTTATCCTGGAGGAGAGCAAC
TTACCCTGGTGGCGAGCCCGGGACAAAAATGGGCAGGAAGGCTACATCCCTAGTAACTATGTAACCGAAGCAGAAGACTCCATAGAAATGTATGAGTGGTATTCCAAACACATGACTCGGAGTCAAGC
TGAGCAACTGCTAAAGCAAGAGGGCAAAGAAGGAGGCTTCATTGTCAGAGACTCCAGCAAAGCTGGAAAATATACTGTGTCTGTGTTTGCTAAAGCCACAGGGGAACCTCAAGGGGTGATACGTCATT
ATGTTGTGTGTTCCACACCTCAGAGCCAGTATTATCTGGCTGAGAAGCACCTTTTCAGCACCATCCCTGAGCTCATTAACTACCACCAGCATAATTCTGCAGGACTCATATCTAGGCTCAAATATCCA
GTGTCTCAACAAAACAAGAATGCGCCGTCCACTGCAGGCCTGGGCTACGGATCATGGGAAATTGATCCAAAAGACCTGACCTTCTTGAAGGAGCTGGGGACTGGACAATTTGGAGTAGTGAAGTATGG
GAAATGGAGGGGCCAGTATGATGTGGCCATCAAGATGATCAAAGAAGGCTCCATGTCTGAGGATGAGTTCATTGAAGAAGCCAAAGTCATGATGAATCTTTCCCACGAGAAGCTGGTGCAGCTGTATG
GTGTCTGCACCAAACAGCGCCCCATCTTCATCATCACTGAGTACATGGCCAATGGCTGCCTCCTGAACTACCTGAGGGAGATGCGCCACCGCTTCCAGACTCAGCAGCTGCTGGAGATGTGCAAGGAT
GTCTGTGAAGCTATGGAATACCTGGAGTCAAAGCAGTTCCTCCACCGAGACCTGGCGGCTCGGAACTGTTTGGTGAATGACCAAGGAGTTGTTAAAGTATCAGACTTTGGCCTATCCAGGTATGTTCT
GGATGATGAATACACAAGCTCAGTAGGCTCCAAATTTCCAGTCCGGTGGTCTCCACCAGAAGTCCTCATGTATAGCAAGTTCAGCAGCAAATCTGATATTTGGGCTTTTGGGGTGTTGATGTGGGAAA
TTTACTCTCTGGGGAAGATGCCATATGAGAGATTTACCAACAGCGAAACAGCTGAACACATTGCCCAAGGCCTACGTCTCTACAGGCCTCATCTAGCTTCAGAGAGGGTCTATACCATCATGTACAGC
TGCTGGCATGAGAAAGCAGATGAACGTCCCACTTTCAAAATTCTTCTGAGCAACATTCTAGATGTCATGGATGAAGAATCCTGAGCTCACCAATAAGTTTCTTGGTTCCACTCCTCGCCTCCGCAAGC
CCCAATTTCACTTTCTCTGAGGAAATCCCAGGCTTACAGGCCCTGGAGCCTTTGCACCCTCGCTGAATACACAAAGGCCCCTCTCTACATCTAGGAATGCCTCTCTTTTTCCTGGGATAGTACCTTCT
GAGGGCAAGGAATTATTGTGCCTGGTATTTTCCCCCAGAGAGGACATTTCCTAAGAGTATTAAGACAGACTGAATTGGGAATAGAAACGTTTTGGGGGGAGGGAGGGATGTAAATAGCCTCACAAGGG
GTCCAACCGCTCTCTAGGTAGGCAATAGAACTTGAGGGGAGGGAGGTAGAATTTGGCAGGAATGAAACGGTGTTATAAAAATGGGAGGGGAGGGTGTTTTGATAAAATAAAATTACTGGAAAGCAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence


Protein RefSeqs	NP_001230505	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000013290.4
	ENSSSCP00000025530
	ENSSSCP00000025530.1
	ENSSSCP00000077524.1
	ENSSSCP00015009423.1
	ENSSSCP00015009461.1
	ENSSSCP00015009515.1
	ENSSSCP00025028085.1
	ENSSSCP00025028229.1
	ENSSSCP00025028360.1
	ENSSSCP00030020984.1
	ENSSSCP00030021009.1
	ENSSSCP00030021037.1
	ENSSSCP00035033204.1
	ENSSSCP00035033207.1
	ENSSSCP00035033213.1
	ENSSSCP00040028921.1
	ENSSSCP00040028994.1
	ENSSSCP00040029080.1
	ENSSSCP00045017354.1
	ENSSSCP00045017419.1
	ENSSSCP00050022217.1
	ENSSSCP00050022219.1
	ENSSSCP00050022221.1
	ENSSSCP00055016029.1
	ENSSSCP00055016101.1
	ENSSSCP00060043221.1
	ENSSSCP00060043256.1
	ENSSSCP00060043272.1
	ENSSSCP00065010870.1
	ENSSSCP00070049109.1
	ENSSSCP00070049115.1

RefSeq Acc Id:

NP_001230505 ⟸ NM_001243576

- UniProtKB:

A0A8D1AME0 (UniProtKB/TrEMBL), A0A8W4FDY6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVILESIFLKRSQQEKKTSPLNFKKRLFLLTVQKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQL
KSVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD
KNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKATGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNA
PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL
ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADE
RPTFKILLSNILDVMDEES

hide sequence

Ensembl Acc Id:

ENSSSCP00000025530 ⟸ ENSSSCT00000025835

Ensembl Acc Id:

ENSSSCP00000013290 ⟸ ENSSSCT00000013662

Ensembl Acc Id:

ENSSSCP00000077524 ⟸ ENSSSCT00000097469

Protein Domains

PH Protein kinase SH2 SH3

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000026742	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015018253	UniProtKB/TrEMBL
	ENSSSCG00025048323	UniProtKB/TrEMBL
	ENSSSCG00030033633	UniProtKB/TrEMBL
	ENSSSCG00035060034	UniProtKB/TrEMBL
	ENSSSCG00040050338	UniProtKB/TrEMBL
	ENSSSCG00045014738	UniProtKB/TrEMBL
	ENSSSCG00050039216	UniProtKB/TrEMBL
	ENSSSCG00055010356	UniProtKB/TrEMBL
	ENSSSCG00060072862	UniProtKB/TrEMBL
	ENSSSCG00065019790	UniProtKB/TrEMBL
	ENSSSCG00070028800	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000013662.5	UniProtKB/TrEMBL
	ENSSSCT00000025835	ENTREZGENE
	ENSSSCT00000025835.3	UniProtKB/TrEMBL
	ENSSSCT00000097469.1	UniProtKB/TrEMBL
	ENSSSCT00015024195.1	UniProtKB/TrEMBL
	ENSSSCT00015024297.1	UniProtKB/TrEMBL
	ENSSSCT00015024428.1	UniProtKB/TrEMBL
	ENSSSCT00025065809.1	UniProtKB/TrEMBL
	ENSSSCT00025066094.1	UniProtKB/TrEMBL
	ENSSSCT00025066359.1	UniProtKB/TrEMBL
	ENSSSCT00030046587.1	UniProtKB/TrEMBL
	ENSSSCT00030046642.1	UniProtKB/TrEMBL
	ENSSSCT00030046708.1	UniProtKB/TrEMBL
	ENSSSCT00035080507.1	UniProtKB/TrEMBL
	ENSSSCT00035080512.1	UniProtKB/TrEMBL
	ENSSSCT00035080524.1	UniProtKB/TrEMBL
	ENSSSCT00040068039.1	UniProtKB/TrEMBL
	ENSSSCT00040068173.1	UniProtKB/TrEMBL
	ENSSSCT00040068339.1	UniProtKB/TrEMBL
	ENSSSCT00045025128.1	UniProtKB/TrEMBL
	ENSSSCT00045025235.1	UniProtKB/TrEMBL
	ENSSSCT00050052901.1	UniProtKB/TrEMBL
	ENSSSCT00050052908.1	UniProtKB/TrEMBL
	ENSSSCT00050052910.1	UniProtKB/TrEMBL
	ENSSSCT00055020293.1	UniProtKB/TrEMBL
	ENSSSCT00055020378.1	UniProtKB/TrEMBL
	ENSSSCT00060099623.1	UniProtKB/TrEMBL
	ENSSSCT00060099705.1	UniProtKB/TrEMBL
	ENSSSCT00060099761.1	UniProtKB/TrEMBL
	ENSSSCT00065026406.1	UniProtKB/TrEMBL
	ENSSSCT00070057778.1	UniProtKB/TrEMBL
	ENSSSCT00070057784.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	BTK_SH3	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Non-receptor_tyrosine_kinases	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Znf_Btk_motif	UniProtKB/TrEMBL
NCBI Gene	BTK	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	BTK	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TECBTKDOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	ZF_BTK	UniProtKB/TrEMBL
SMART	BTK	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF50044	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A4X1VZ31_PIG	UniProtKB/TrEMBL
	A0A8D0S7Y0_PIG	UniProtKB/TrEMBL
	A0A8D1AME0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1XTQ8_PIG	UniProtKB/TrEMBL
	A0A8W4FDY6	ENTREZGENE, UniProtKB/TrEMBL
	I3LN58_PIG	UniProtKB/TrEMBL
UniProt Secondary	A0A4X1W3S0	UniProtKB/TrEMBL
	F1S1L0	UniProtKB/TrEMBL
VGNC ID	VGNC:85914	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


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Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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