BTK (Bruton tyrosine kinase) - Rat Genome Database

Name: BTK
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: BTK (Bruton tyrosine kinase) Sus scrofa

Analyze

Symbol:

BTK

Name:

Bruton tyrosine kinase

RGD ID:

14174315

Description:

ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN B cell affinity maturation (ortholog); cell maturation (ortholog); cellular response to interleukin-7 (ortholog); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Adenoviridae Infections (ortholog); agammaglobulinemia (ortholog); agammaglobulinemia 1 (ortholog); FOUND IN cytoplasm (ortholog); perinuclear region of cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BTK (Bruton tyrosine kinase)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Treefam
Mus musculus (house mouse):	Btk (Bruton agammaglobulinemia tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	82,981,512 - 83,014,475 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adenoviridae Infections (ISO)

agammaglobulinemia (ISO)

agammaglobulinemia 1 (ISO)

Anaphylaxis (ISO)

arthus reaction (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

B-cell lymphoma (ISO)

Breast Neoplasms (ISO)

Burkitt lymphoma (ISO)

central nervous system lymphoma (ISO)

colitis (ISO)

colon adenocarcinoma (ISO)

colorectal cancer (ISO)

common variable immunodeficiency (ISO)

COVID-19 (ISO)

cryptococcosis (ISO)

deafness-dystonia-optic neuronopathy syndrome (ISO)

developmental and epileptic encephalopathy 9 (ISO)

diffuse large B-cell lymphoma (ISO)

endometriosis of uterus (ISO)

Enterovirus Infections (ISO)

Experimental Arthritis (ISO)

Fabry disease (ISO)

factor VIII deficiency (ISO)

genetic disease (ISO)

Hypothermia (ISO)

influenza A (ISO)

isolated growth hormone deficiency type III (ISO)

leishmaniasis (ISO)

listeriosis (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

mantle cell lymphoma (ISO)

nasopharynx carcinoma (ISO)

oral squamous cell carcinoma (ISO)

Pneumococcal Pneumonia (ISO)

primary immunodeficiency disease (ISO)

ROLANDIC EPILEPSY, INTELLECTUAL DISABILITY, AND SPEECH DYSPRAXIA, X-LINKED (ISO)

Streptococcus pneumonia (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked agammaglobulinemia (ISO)

X-Linked Hypogammaglobulinemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IBA)

B cell affinity maturation (IEA,ISO)

B cell receptor signaling pathway (IBA,IEA)

cell maturation (IEA,ISO)

cellular response to interleukin-7 (IEA,ISO)

cellular response to molecule of fungal origin (ISO)

cellular response to reactive oxygen species (ISO)

eosinophil homeostasis (ISO)

histamine secretion by mast cell (ISO)

intracellular signal transduction (IEA)

monocyte proliferation (ISO)

negative regulation of B cell activation (ISO)

negative regulation of B cell proliferation (IEA,ISO)

negative regulation of cytokine production (IEA)

negative regulation of interleukin-10 production (ISO)

negative regulation of leukocyte proliferation (ISO)

neutrophil homeostasis (ISO)

peptidyl-tyrosine autophosphorylation (ISO)

peptidyl-tyrosine phosphorylation (ISO)

positive regulation of B cell proliferation (ISO)

positive regulation of cGAS/STING signaling pathway (ISO)

positive regulation of immunoglobulin production (ISO)

positive regulation of interleukin-17A production (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of NLRP3 inflammasome complex assembly (IEA)

positive regulation of phagocytosis (ISO)

positive regulation of synoviocyte proliferation (ISO)

positive regulation of tumor necrosis factor production (ISO)

positive regulation of type I hypersensitivity (ISO)

positive regulation of type III hypersensitivity (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

proteoglycan catabolic process (ISO)

response to lipopolysaccharide (ISO)

T cell receptor signaling pathway (IBA)

Cellular Component

cytoplasm (IEA,ISO)

cytoplasmic vesicle (IEA)

cytosol (IEA)

membrane raft (IEA)

nucleus (IEA)

perinuclear region of cytoplasm (ISO)

plasma membrane (IBA,IEA)

Molecular Function

ATP binding (IEA)

identical protein binding (IEA)

metal ion binding (IEA)

non-membrane spanning protein tyrosine kinase activity (IBA,IEA)

phosphatidylinositol-3,4,5-trisphosphate binding (IEA)

phospholipase activator activity (IEA)

phospholipase binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein tyrosine kinase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

erythropoietin signaling pathway (ISO)

FasL mediated signaling pathway (ISO)

Fc epsilon receptor mediated signaling pathway (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

protein kinase C (PKC) signaling pathway (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

BTK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	82,981,512 - 83,014,475 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

BTK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	101,349,450 - 101,390,796 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	101,349,338 - 101,390,796 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	100,604,438 - 100,645,784 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	100,491,098 - 100,527,838 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	100,410,586 - 100,447,327	NCBI
Celera	X	101,123,894 - 101,160,669 (-)	NCBI		Celera
Cytogenetic Map	X	q22.1	NCBI
HuRef	X	90,410,583 - 90,447,505 (-)	NCBI		HuRef
CHM1_1	X	100,497,918 - 100,534,692 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	99,793,571 - 99,834,908 (-)	NCBI		T2T-CHM13v2.0

Btk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	133,443,083 - 133,484,366 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	133,443,085 - 133,484,319 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	134,542,334 - 134,583,628 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	134,542,336 - 134,583,570 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	131,076,880 - 131,117,679 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	129,888,761 - 129,929,466 (-)	NCBI		MGSCv36	mm8
Celera	X	117,421,885 - 117,462,725 (-)	NCBI		Celera
Cytogenetic Map	X	E3	NCBI
cM Map	X	56.18	NCBI

Btk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	102,016,070 - 102,055,448 (-)	NCBI		GRCr8
mRatBN7.2	X	97,722,796 - 97,762,315 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	97,722,802 - 97,761,853 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	99,397,016 - 99,436,088 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	102,907,749 - 102,946,794 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	100,410,180 - 100,449,237 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	105,360,922 - 105,390,580 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	105,360,922 - 105,390,580 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	105,250,666 - 105,279,934 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	121,998,935 - 122,030,289 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	122,072,367 - 122,103,722 (-)	NCBI
Celera	X	98,764,036 - 98,794,122 (-)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

Btk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955503	7,482,793 - 7,515,120 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955503	7,483,819 - 7,515,085 (-)	NCBI	ChiLan1.0	ChiLan1.0

BTK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	100,948,666 - 100,985,544 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	100,952,265 - 100,989,149 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	90,551,874 - 90,588,786 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	100,684,017 - 100,720,868 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	100,684,017 - 100,725,187 (-)	Ensembl	panpan1.1		panPan2

BTK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	75,270,952 - 75,302,663 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	75,270,979 - 75,302,562 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	76,691,359 - 76,723,087 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	76,691,367 - 76,723,042 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	74,255,464 - 74,287,205 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	75,915,885 - 75,947,610 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	75,678,325 - 75,710,045 (-)	NCBI		UU_Cfam_GSD_1.0

Btk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	63,007,672 - 63,045,710 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936813	429,224 - 463,441 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936813	429,400 - 467,481 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BTK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	89,690,569 - 89,727,420 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	14,609,796 - 14,647,019 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Btk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624902	1,182,682 - 1,216,171 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624902	1,173,101 - 1,216,662 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in BTK
421 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	6	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001243576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK230598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK231012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK236988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK236989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK391468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP015816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01003245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000013662 ⟹ ENSSSCP00000013290

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000025835 ⟹ ENSSSCP00000025530

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000097469 ⟹ ENSSSCP00000077524

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	X	82,981,518 - 83,014,463 (-)	Ensembl

RefSeq Acc Id:

NM_001243576 ⟹ NP_001230505

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	X	82,981,512 - 83,014,475 (-)	NCBI

Sequence:

show sequence

CTTCCTCTCTGGACTGTAAGAATATGTCTCCAGGGCCAGTGTCTTCTGACATCGAGTCCCACCT
TCAAAGTCCTGGCATCTCAATGCATCCAGGAAGCTACCTGCATTAAAGTCAGGACTGAGCATAC
AGTGAGCTCCAGAAAGAAGAAGCTATGGCTGCGGTGATACTGGAGAGCATCTTTCTGAAACGAT
CTCAGCAGGAAAAGAAAACATCACCTTTGAACTTCAAGAAGCGCCTCTTTCTCTTGACCGTGCA
AAAACTTTCCTACTATGAGTATGACTTTGAACGTGGGAGAAGAGGCAGTAAGAAGGGTTCAATA
GATGTTGAGAAGATCACCTGCGTTGAAACAGTTGTTCCTGAGAAAAATCCTCCCCCTGAAAGAC
AGATTCCGAGAAGGGGTGAAGAGTCCAGTGAAATGGAGCAGATTTCAATTATTGAAAGGTTCCC
TTACCCCTTCCAGGTTGTATATGATGAAGGGCCTCTCTACGTCTTCTCCCCAACTGAAGAACTG
AGAAAGCGTTGGATTCACCAGCTCAAAAGTGTAATCCGGTACAACAGTGATCTGGTACAGAAAT
ACCACCCTTGCTTCTGGATTGATGGGCAGTATCTCTGCTGCTCTCAGACAGCCAAAAATGCTAT
GGGCTGCCAAATTTTGGAGAACAGAAATGGAAGCTTAAAACCTGGGAGTTCACACCGAAAGACG
AAAAAGCCTCTTCCTCCCACACCTGAGGAGGACCAGATCTTAAAAAAGCCACTGCCCCCTGAGC
CAACAGCAGCACCGGTCTCGACAAGTGAGCTGAAAAAGGTTGTAGCCCTTTATGATTACATGCC
AATGAATGCAAATGATCTACAGCTGCGGAAGGGCGACGAGTATTTTATCCTGGAGGAGAGCAAC
TTACCCTGGTGGCGAGCCCGGGACAAAAATGGGCAGGAAGGCTACATCCCTAGTAACTATGTAA
CCGAAGCAGAAGACTCCATAGAAATGTATGAGTGGTATTCCAAACACATGACTCGGAGTCAAGC
TGAGCAACTGCTAAAGCAAGAGGGCAAAGAAGGAGGCTTCATTGTCAGAGACTCCAGCAAAGCT
GGAAAATATACTGTGTCTGTGTTTGCTAAAGCCACAGGGGAACCTCAAGGGGTGATACGTCATT
ATGTTGTGTGTTCCACACCTCAGAGCCAGTATTATCTGGCTGAGAAGCACCTTTTCAGCACCAT
CCCTGAGCTCATTAACTACCACCAGCATAATTCTGCAGGACTCATATCTAGGCTCAAATATCCA
GTGTCTCAACAAAACAAGAATGCGCCGTCCACTGCAGGCCTGGGCTACGGATCATGGGAAATTG
ATCCAAAAGACCTGACCTTCTTGAAGGAGCTGGGGACTGGACAATTTGGAGTAGTGAAGTATGG
GAAATGGAGGGGCCAGTATGATGTGGCCATCAAGATGATCAAAGAAGGCTCCATGTCTGAGGAT
GAGTTCATTGAAGAAGCCAAAGTCATGATGAATCTTTCCCACGAGAAGCTGGTGCAGCTGTATG
GTGTCTGCACCAAACAGCGCCCCATCTTCATCATCACTGAGTACATGGCCAATGGCTGCCTCCT
GAACTACCTGAGGGAGATGCGCCACCGCTTCCAGACTCAGCAGCTGCTGGAGATGTGCAAGGAT
GTCTGTGAAGCTATGGAATACCTGGAGTCAAAGCAGTTCCTCCACCGAGACCTGGCGGCTCGGA
ACTGTTTGGTGAATGACCAAGGAGTTGTTAAAGTATCAGACTTTGGCCTATCCAGGTATGTTCT
GGATGATGAATACACAAGCTCAGTAGGCTCCAAATTTCCAGTCCGGTGGTCTCCACCAGAAGTC
CTCATGTATAGCAAGTTCAGCAGCAAATCTGATATTTGGGCTTTTGGGGTGTTGATGTGGGAAA
TTTACTCTCTGGGGAAGATGCCATATGAGAGATTTACCAACAGCGAAACAGCTGAACACATTGC
CCAAGGCCTACGTCTCTACAGGCCTCATCTAGCTTCAGAGAGGGTCTATACCATCATGTACAGC
TGCTGGCATGAGAAAGCAGATGAACGTCCCACTTTCAAAATTCTTCTGAGCAACATTCTAGATG
TCATGGATGAAGAATCCTGAGCTCACCAATAAGTTTCTTGGTTCCACTCCTCGCCTCCGCAAGC
CCCAATTTCACTTTCTCTGAGGAAATCCCAGGCTTACAGGCCCTGGAGCCTTTGCACCCTCGCT
GAATACACAAAGGCCCCTCTCTACATCTAGGAATGCCTCTCTTTTTCCTGGGATAGTACCTTCT
GAGGGCAAGGAATTATTGTGCCTGGTATTTTCCCCCAGAGAGGACATTTCCTAAGAGTATTAAG
ACAGACTGAATTGGGAATAGAAACGTTTTGGGGGGAGGGAGGGATGTAAATAGCCTCACAAGGG
GTCCAACCGCTCTCTAGGTAGGCAATAGAACTTGAGGGGAGGGAGGTAGAATTTGGCAGGAATG
AAACGGTGTTATAAAAATGGGAGGGGAGGGTGTTTTGATAAAATAAAATTACTGGAAAGCAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001230505	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000013290.4
	ENSSSCP00000025530
	ENSSSCP00000025530.1
	ENSSSCP00000077524.1
	ENSSSCP00005013629.1
	ENSSSCP00005013670.1
	ENSSSCP00015009423.1
	ENSSSCP00015009461.1
	ENSSSCP00015009515.1
	ENSSSCP00025028085.1
	ENSSSCP00025028229.1
	ENSSSCP00025028360.1
	ENSSSCP00030020984.1
	ENSSSCP00030021009.1
	ENSSSCP00030021037.1
	ENSSSCP00035033204.1
	ENSSSCP00035033207.1
	ENSSSCP00035033213.1
	ENSSSCP00040028921.1
	ENSSSCP00040028994.1
	ENSSSCP00040029080.1
	ENSSSCP00045017354.1
	ENSSSCP00045017419.1
	ENSSSCP00050022217.1
	ENSSSCP00050022219.1
	ENSSSCP00050022221.1
	ENSSSCP00055016029.1
	ENSSSCP00055016101.1
	ENSSSCP00060043221.1
	ENSSSCP00060043256.1
	ENSSSCP00060043272.1
	ENSSSCP00065010870.1
	ENSSSCP00070049109.1
	ENSSSCP00070049115.1

RefSeq Acc Id:

NP_001230505 ⟸ NM_001243576

- UniProtKB:

A0A8D1AME0 (UniProtKB/TrEMBL), A0A8W4FDY6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVILESIFLKRSQQEKKTSPLNFKKRLFLLTVQKLSYYEYDFERGRRGSKKGSIDVEKITCV
ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQL
KSVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTP
EEDQILKKPLPPEPTAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD
KNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVF
AKATGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNA
PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKV
MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL
ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSS
KSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADE
RPTFKILLSNILDVMDEES

hide sequence

Ensembl Acc Id:

ENSSSCP00000025530 ⟸ ENSSSCT00000025835

Ensembl Acc Id:

ENSSSCP00000013290 ⟸ ENSSSCT00000013662

Ensembl Acc Id:

ENSSSCP00000077524 ⟸ ENSSSCT00000097469

Protein Domains

PH Protein kinase SH2 SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000026742	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005014014	UniProtKB/TrEMBL
	ENSSSCG00015018253	UniProtKB/TrEMBL
	ENSSSCG00025048323	UniProtKB/TrEMBL
	ENSSSCG00030033633	UniProtKB/TrEMBL
	ENSSSCG00035060034	UniProtKB/TrEMBL
	ENSSSCG00040050338	UniProtKB/TrEMBL
	ENSSSCG00045014738	UniProtKB/TrEMBL
	ENSSSCG00050039216	UniProtKB/TrEMBL
	ENSSSCG00055010356	UniProtKB/TrEMBL
	ENSSSCG00060072862	UniProtKB/TrEMBL
	ENSSSCG00065019790	UniProtKB/TrEMBL
	ENSSSCG00070028800	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000013662.5	UniProtKB/TrEMBL
	ENSSSCT00000025835	ENTREZGENE
	ENSSSCT00000025835.3	UniProtKB/TrEMBL
	ENSSSCT00000097469.1	UniProtKB/TrEMBL
	ENSSSCT00005022743.1	UniProtKB/TrEMBL
	ENSSSCT00005022793.1	UniProtKB/TrEMBL
	ENSSSCT00015024195.1	UniProtKB/TrEMBL
	ENSSSCT00015024297.1	UniProtKB/TrEMBL
	ENSSSCT00015024428.1	UniProtKB/TrEMBL
	ENSSSCT00025065809.1	UniProtKB/TrEMBL
	ENSSSCT00025066094.1	UniProtKB/TrEMBL
	ENSSSCT00025066359.1	UniProtKB/TrEMBL
	ENSSSCT00030046587.1	UniProtKB/TrEMBL
	ENSSSCT00030046642.1	UniProtKB/TrEMBL
	ENSSSCT00030046708.1	UniProtKB/TrEMBL
	ENSSSCT00035080507.1	UniProtKB/TrEMBL
	ENSSSCT00035080512.1	UniProtKB/TrEMBL
	ENSSSCT00035080524.1	UniProtKB/TrEMBL
	ENSSSCT00040068039.1	UniProtKB/TrEMBL
	ENSSSCT00040068173.1	UniProtKB/TrEMBL
	ENSSSCT00040068339.1	UniProtKB/TrEMBL
	ENSSSCT00045025128.1	UniProtKB/TrEMBL
	ENSSSCT00045025235.1	UniProtKB/TrEMBL
	ENSSSCT00050052901.1	UniProtKB/TrEMBL
	ENSSSCT00050052908.1	UniProtKB/TrEMBL
	ENSSSCT00050052910.1	UniProtKB/TrEMBL
	ENSSSCT00055020293.1	UniProtKB/TrEMBL
	ENSSSCT00055020378.1	UniProtKB/TrEMBL
	ENSSSCT00060099623.1	UniProtKB/TrEMBL
	ENSSSCT00060099705.1	UniProtKB/TrEMBL
	ENSSSCT00060099761.1	UniProtKB/TrEMBL
	ENSSSCT00065026406.1	UniProtKB/TrEMBL
	ENSSSCT00070057778.1	UniProtKB/TrEMBL
	ENSSSCT00070057784.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	BTK_SH3	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Non-receptor_tyrosine_kinases	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Znf_Btk_motif	UniProtKB/TrEMBL
NCBI Gene	BTK	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE BTK	UniProtKB/TrEMBL
Pfam	BTK	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TECBTKDOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	ZF_BTK	UniProtKB/TrEMBL
SMART	BTK	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF50044	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A4X1VZ31_PIG	UniProtKB/TrEMBL
	A0A8D0S7Y0_PIG	UniProtKB/TrEMBL
	A0A8D1AME0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1XTQ8_PIG	UniProtKB/TrEMBL
	A0A8W4FDY6	ENTREZGENE, UniProtKB/TrEMBL
	I3LN58_PIG	UniProtKB/TrEMBL
UniProt Secondary	A0A4X1W3S0	UniProtKB/TrEMBL
	F1S1L0	UniProtKB/TrEMBL
VGNC ID	VGNC:85914	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)