BTK (Bruton tyrosine kinase) - Rat Genome Database

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Gene: BTK (Bruton tyrosine kinase) Pan paniscus
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Symbol: BTK
Name: Bruton tyrosine kinase
RGD ID: 11770874
Description: ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN B cell affinity maturation (ortholog); cell maturation (ortholog); cellular response to interleukin-7 (ortholog); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Adenoviridae Infections (ortholog); agammaglobulinemia (ortholog); agammaglobulinemia 1 (ortholog); FOUND IN cytosol (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase BTK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X100,684,017 - 100,720,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,684,017 - 100,725,187 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X90,551,874 - 90,588,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
B cell affinity maturation  (IEA,ISO)
B cell receptor signaling pathway  (IEA)
cell maturation  (IEA,ISO)
cellular response to interleukin-7  (IEA,ISO)
cellular response to molecule of fungal origin  (ISO)
cellular response to reactive oxygen species  (ISO)
eosinophil homeostasis  (ISO)
histamine secretion by mast cell  (ISO)
I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
intracellular signal transduction  (IEA)
monocyte proliferation  (ISO)
negative regulation of B cell activation  (ISO)
negative regulation of B cell proliferation  (IEA,ISO)
negative regulation of cytokine production  (IEA)
negative regulation of interleukin-10 production  (ISO)
negative regulation of leukocyte proliferation  (ISO)
neutrophil homeostasis  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
phosphorylation  (IEA)
positive regulation of B cell proliferation  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-17A production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA)
positive regulation of phagocytosis  (ISO)
positive regulation of synoviocyte proliferation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I hypersensitivity  (ISO)
positive regulation of type III hypersensitivity  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (IEA,ISO)
proteoglycan catabolic process  (ISO)
response to lipopolysaccharide  (ISO)
response to organic substance  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
BTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X100,684,017 - 100,720,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,684,017 - 100,725,187 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X90,551,874 - 90,588,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,349,450 - 101,390,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX101,349,338 - 101,390,796 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,604,438 - 100,645,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,491,098 - 100,527,838 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X100,410,586 - 100,447,327NCBI
CeleraX101,123,894 - 101,160,669 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,410,583 - 90,447,505 (-)NCBIHuRef
CHM1_1X100,497,918 - 100,534,692 (-)NCBICHM1_1
T2T-CHM13v2.0X99,793,571 - 99,834,908 (-)NCBIT2T-CHM13v2.0
Btk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,443,083 - 133,484,366 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,443,085 - 133,484,319 (-)EnsemblGRCm39 Ensembl
GRCm38X134,542,334 - 134,583,628 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,542,336 - 134,583,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,076,880 - 131,117,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,888,761 - 129,929,466 (-)NCBIMGSCv36mm8
CeleraX117,421,885 - 117,462,725 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.18NCBI
Btk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X97,722,796 - 97,762,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,722,802 - 97,761,853 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,397,016 - 99,436,088 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X102,907,749 - 102,946,794 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X100,410,180 - 100,449,237 (-)NCBIRnor_WKY
Rnor_6.0X105,360,922 - 105,390,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,360,922 - 105,390,580 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,250,666 - 105,279,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X121,998,935 - 122,030,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X122,072,367 - 122,103,722 (-)NCBI
CeleraX98,764,036 - 98,794,122 (-)NCBICelera
Cytogenetic MapXq32NCBI
Btk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,482,793 - 7,515,120 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555037,483,819 - 7,515,085 (-)NCBIChiLan1.0ChiLan1.0
BTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,270,952 - 75,302,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,270,979 - 75,302,562 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,691,359 - 76,723,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,691,367 - 76,723,042 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,255,464 - 74,287,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,915,885 - 75,947,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,678,325 - 75,710,045 (-)NCBIUU_Cfam_GSD_1.0
Btk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X63,007,672 - 63,045,710 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936813429,224 - 463,441 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936813429,400 - 467,481 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX82,981,515 - 83,014,573 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X82,981,512 - 83,014,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,690,569 - 89,727,420 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606514,609,796 - 14,647,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,182,682 - 1,216,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,173,101 - 1,216,662 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000054380   ⟹   ENSPPAP00000031515
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX100,684,017 - 100,720,868 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000054389   ⟹   ENSPPAP00000031524
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX100,684,452 - 100,725,187 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000054398   ⟹   ENSPPAP00000031533
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX100,684,452 - 100,709,959 (-)Ensembl
RefSeq Acc Id: XM_003810410   ⟹   XP_003810458
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X100,684,017 - 100,720,868 (-)NCBI
Mhudiblu_PPA_v0X90,552,012 - 90,588,786 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034950432   ⟹   XP_034806323
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0X90,551,874 - 90,578,066 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003810458 (Get FASTA)   NCBI Sequence Viewer  
  XP_034806323 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003810458   ⟸   XM_003810410
- Peptide Label: isoform X2
- UniProtKB: A0A2I3RVY9 (UniProtKB/TrEMBL),   A0A2R9BPC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034806323   ⟸   XM_034950432
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000031524   ⟸   ENSPPAT00000054389
RefSeq Acc Id: ENSPPAP00000031515   ⟸   ENSPPAT00000054380
RefSeq Acc Id: ENSPPAP00000031533   ⟸   ENSPPAT00000054398
Protein Domains
PH   Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038664 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000031515 ENTREZGENE
  ENSPPAP00000031515.1 UniProtKB/TrEMBL
  ENSPPAP00000031524.1 UniProtKB/TrEMBL
  ENSPPAP00000031533.1 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000054380.1 UniProtKB/TrEMBL
  ENSPPAT00000054389.1 UniProtKB/TrEMBL
  ENSPPAT00000054398.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro BTK_SH3 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/TrEMBL
KEGG Report pps:100992723 UniProtKB/TrEMBL
NCBI Gene BTK ENTREZGENE
Pfam BTK UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TECBTKDOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_BTK UniProtKB/TrEMBL
SMART BTK UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2I3RVY9 ENTREZGENE
  A0A2R9BPC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BQ26_PANPA UniProtKB/TrEMBL
  A0A2R9BSW7_PANPA UniProtKB/TrEMBL