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Gene: BTK (Bruton tyrosine kinase) Homo sapiens
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Symbol: BTK
Name: Bruton tyrosine kinase
Description: Exhibits identical protein binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation. Localizes to the cytosol; membrane raft; and plasma membrane. Implicated in X-linked agammaglobulinemia; agammaglobulinemia; isolated growth hormone deficiency type III; and mantle cell lymphoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: agammaglobulinaemia tyrosine kinase; AGMX1; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton's tyrosine kinase; dominant-negative kinase-deficient Brutons tyrosine kinase; IGHD3; IMD1; MGC126261; MGC126262; PSCTK1; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); XLA
Orthologs:
Mus musculus (house mouse) : Btk (Bruton agammaglobulinemia tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Btk (Bruton tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btk (Bruton tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : BTK (Bruton tyrosine kinase)
Canis lupus familiaris (dog) : BTK (Bruton tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btk (Bruton tyrosine kinase)
Sus scrofa (pig) : BTK (Bruton tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX101,349,447 - 101,390,796 (-)Ensembl
GRCh38X101,349,447 - 101,390,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X100,604,435 - 100,641,212 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,491,098 - 100,527,838 (-)NCBINCBI36hg18NCBI36
Build 34X100,410,586 - 100,447,327NCBI
CeleraX101,123,894 - 101,160,669 (-)NCBI
Cytogenetic MapXq22.1NCBI
HuRefX90,410,583 - 90,447,505 (-)NCBIHuRef
CHM1_1X100,497,918 - 100,539,264 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on BTK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1342660
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.