RGD Reference Report - Role of Bruton's Tyrosine Kinase in Stage III Colorectal Cancer. - Rat Genome Database

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Role of Bruton's Tyrosine Kinase in Stage III Colorectal Cancer.

Authors: Basile, Debora  Gerratana, Lorenzo  Buonadonna, Angela  Garattini, Silvio Ken  Perin, Tiziana  Grassilli, Emanuela  Miolo, Gianmaria  Cerrito, Maria Grazia  Belluco, Claudio  Bertola, Giulio  De Paoli, Antonino  Cannizzaro, Renato  Lavitrano, Marialuisa  Puglisi, Fabio  Canzonieri, Vincenzo 
Citation: Basile D, etal., Cancers (Basel). 2019 Jun 24;11(6). pii: cancers11060880. doi: 10.3390/cancers11060880.
RGD ID: 151347852
Pubmed: PMID:31238520   (View Abstract at PubMed)
PMCID: PMC6627163   (View Article at PubMed Central)
DOI: DOI:10.3390/cancers11060880   (Journal Full-text)


BACKGROUND: Bruton's tyrosine kinase (BTK) is involved in the immune response and its deficiency impairs B cell maturation. We evaluated the expression of a novel BTK isoform, p65BTK, in colorectal cancer (CRC), to identify its impact on survival.
MATERIALS AND METHODS: This retrospective study evaluated 87 consecutive stage III CRC patients treated at the National Cancer Institute of Aviano (1999-2017). Multiple specimens were collected and analyzed for staining intensity and percentage of tumor cells positive for p65BTK. Prognostic impact was tested by univariate Cox regression analysis.
RESULTS: After a median follow-up of 82.59 months, median disease-free survival (DFS) and overall survival (OS) were 11.67 months and 31.33 months, respectively. Interestingly, 10% of patients did not express p65BTK. For the immunohistochemistry IHC intensity 1, the best cutoff point was 1% of p65BTK positivity; for IHC intensity 2, it was 50%; and for IHC intensity 3, it was 80%. Through univariate analysis, patients with highly expressed p65BTK (IHC intensity 3 and >=80%) were shown to have the worst prognosis in terms of DFS (HR: 6.23; p = 0.005; 95% C.I. 1.75-22.79) and OS (HR: 2.54; p = 0.025; 95% C.I. 1.12-5.76).
CONCLUSIONS: p65BTK is frequently expressed in CRC and, if highly expressed, is an unfavourable prognostic factor. However, further confirmation is needed and its potential targeting needs to be studied.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BTKHumancolorectal cancer exacerbatesIEP protein:increased expression:colorectum (human)RGD 
BtkRatcolorectal cancer exacerbatesISOBTK (Homo sapiens)protein:increased expression:colorectum (human)RGD 
BtkMousecolorectal cancer exacerbatesISOBTK (Homo sapiens)protein:increased expression:colorectum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Btk  (Bruton tyrosine kinase)

Genes (Mus musculus)
Btk  (Bruton agammaglobulinemia tyrosine kinase)

Genes (Homo sapiens)
BTK  (Bruton tyrosine kinase)


Additional Information