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ONTOLOGY REPORT - ANNOTATIONS


Term:canonical inflammasome complex assembly
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Accession:GO:0140632 term browser browse the term
Definition:The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex.



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negative regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd17a abhydrolase domain containing 17A, depalmitoylase involved_in ISO (PMID:38092000) RGD PMID:38092000 NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762
JBrowse link
G Cptp ceramide-1-phosphate transfer protein involved_in ISO
ISS
(PMID:29164996)
GO_REF:0000024
RGD
UniProt
PMID:29164996 GO_REF:0000024 NCBI chr 5:166,474,947...166,479,103
Ensembl chr 5:166,474,966...166,479,017
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:6787653|PMID:34615873)
UniProt
RGD
PMID:34615873 GO_REF:0000024 MGI:6787653 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
JBrowse link
G Fbxl2 F-box and leucine-rich repeat protein 2 involved_in ISO (PMID:26037928) RGD PMID:26037928 NCBI chr 8:113,916,660...113,965,137
Ensembl chr 8:113,913,373...113,965,066
JBrowse link
G Haus8l2 HAUS augmin-like complex, subunit 8 like 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr11:5,628,432...5,630,535
Ensembl chr11:5,628,427...5,630,533
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in ISO
IEA
(PMID:36586411)
GO_REF:0000107
RGD
Ensembl
PMID:36586411 GO_REF:0000107 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Irgm immunity-related GTPase M involved_in ISS
ISO
GO_REF:0000024
(MGI:6282153|PMID:30612879)
(PMID:30612879)
UniProt
RGD
PMID:30612879 GO_REF:0000024 MGI:6282153 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in ISO (PMID:36586411) RGD PMID:36586411 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Mefv MEFV innate immunity regulator, pyrin involved_in ISS
ISO
GO_REF:0000024
(PMID:26347139)
UniProt
RGD
PMID:26347139 GO_REF:0000024 NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (PMID:25277106) RGD PMID:25277106 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398
JBrowse link
G Sirt2 sirtuin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:23502856)
Ensembl
RGD
PMID:23502856 GO_REF:0000107 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within ISO (MGI:6391726|PMID:29887864)
(PMID:32514138)
RGD PMID:29887864 PMID:32514138 MGI:6391726 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Trim31 tripartite motif-containing 31 involved_in ISO (PMID:27929086)
(MGI:5907951|PMID:27929086)
RGD PMID:27929086 MGI:5907951 NCBI chr20:1,653,165...1,666,494
Ensembl chr20:1,653,165...1,666,494
JBrowse link
G Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:36586411)
UniProt
Ensembl
RGD
PMID:36586411 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:13,363,504...13,366,383
Ensembl chr 3:13,363,504...13,366,474
JBrowse link
NLRP1 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlrp1a NLR family, pyrin domain containing 1A involved_in ISO (PMID:22665479), (PMID:27662089), (PMID:31484767), (PMID:33243852), (PMID:33420028), (PMID:33420033), (PMID:33852854), (PMID:35594856) RGD PMID:22665479 PMID:27662089 PMID:31484767 PMID:33243852 PMID:33420028 More... NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
JBrowse link
NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atat1 alpha tubulin acetyltransferase 1 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
(PMID:23502856)
Ensembl
RGD
PMID:23502856 GO_REF:0000107 NCBI chr20:2,844,595...2,857,809
Ensembl chr20:2,844,616...2,861,964
JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 acts_upstream_of_or_within ISO MGI:2180015 (PMID:28928055) RGD PMID:28928055 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:5465108 (PMID:22753929)
(MGI:5492224|PMID:23582325), (MGI:5792478|PMID:27043286), (MGI:5913002|PMID:28716882), (MGI:5921465|PMID:28656979), (MGI:6106673|PMID:28943315), (MGI:6260219|PMID:30487600), (MGI:6787653|PMID:34615873), (MGI:6844859|PMID:34861190), (MGI:6859739|PMID:28465465), (PMID:26173909)
(PMID:17483456), (PMID:23582325), (PMID:25686105), (PMID:27043286), (PMID:27432880), (PMID:28465465), (PMID:28656979), (PMID:28943315), (PMID:30487600), (PMID:31189953), (PMID:33231615), (PMID:34554188), (PMID:34615873), (PMID:35114687), (PMID:35254907), (PMID:35559676), (PMID:36442502)
UniProt
RGD
PMID:17483456 PMID:22753929 PMID:23582325 PMID:25686105 PMID:26173909 More... GO_REF:0000024 MGI:5492224 MGI:5792478 MGI:5913002 MGI:5921465 MGI:6106673 MGI:6260219 MGI:6787653 MGI:6844859 MGI:6859739 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:27432880) RGD PMID:27432880 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Sirt2 sirtuin 2 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
(PMID:23502856)
Ensembl
RGD
PMID:23502856 GO_REF:0000107 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
NLRP6 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlrp6 NLR family, pyrin domain containing 6 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:6706628|PMID:32424362), (MGI:6833928|PMID:34678144)
(PMID:30674671), (PMID:31932628), (PMID:34678144)
UniProt
Ensembl
RGD
PMID:30674671 PMID:31932628 PMID:32424362 PMID:34678144 GO_REF:0000024 GO_REF:0000107 MGI:6706628 MGI:6833928 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113
JBrowse link
positive regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atat1 alpha tubulin acetyltransferase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:23502856)
Ensembl
RGD
PMID:23502856 GO_REF:0000107 NCBI chr20:2,844,595...2,857,809
Ensembl chr20:2,844,616...2,861,964
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex subunit 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:28943315)
(MGI:7387171|PMID:23246432)
UniProt
RGD
PMID:23246432 PMID:28943315 GO_REF:0000024 MGI:7387171 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
JBrowse link
G Btk Bruton tyrosine kinase involved_in ISO (PMID:34554188)
(MGI:7276081|PMID:34554188)
RGD PMID:34554188 MGI:7276081 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G Casp4 caspase 4 involved_in ISO (MGI:5780643|PMID:26173909) RGD PMID:26173909 MGI:5780643 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Cd36 CD36 molecule involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5546292|PMID:23812099)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23812099 GO_REF:0000024 GO_REF:0000107 MGI:5546292 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cd36l1 CD36 molecule like 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (MGI:6368386|PMID:31511697) RGD PMID:31511697 MGI:6368386 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Dhx33 DEAH-box helicase 33 involved_in ISO (PMID:23871209) RGD PMID:23871209 NCBI chr10:55,708,102...55,724,618
Ensembl chr10:55,705,756...55,724,567
JBrowse link
G Gbp5 guanylate binding protein 5 involved_in ISO (PMID:22461501) RGD PMID:22461501 NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:28943315)
(MGI:6106673|PMID:28943315)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:28943315 GO_REF:0000024 GO_REF:0000107 MGI:6106673 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mark4 microtubule affinity regulating kinase 4 involved_in ISO (PMID:28656979)
(MGI:5921465|PMID:28656979)
RGD PMID:28656979 MGI:5921465 NCBI chr 1:79,075,353...79,108,882
Ensembl chr 1:79,068,904...79,108,556
JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in ISO (PMID:23582325)
(MGI:5492224|PMID:23582325)
RGD PMID:23582325 MGI:5492224 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
JBrowse link
G Mir21 microRNA 21 IDA RGD PMID:29084974 RGD:41404715 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor involved_in ISS
ISO
GO_REF:0000024
(PMID:33718825)
UniProt
RGD
PMID:33718825 GO_REF:0000024 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nek7 NIMA-related kinase 7 involved_in ISO
IEA
ISS
(MGI:5698271|PMID:26642356), (MGI:5751332|PMID:26814970)
(PMID:31189953), (PMID:36442502)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26642356 PMID:26814970 PMID:31189953 PMID:36442502 GO_REF:0000024 GO_REF:0000107 MGI:5698271 MGI:5751332 NCBI chr13:50,022,212...50,149,374
Ensembl chr13:50,022,218...50,149,296
JBrowse link
G Plcg2 phospholipase C, gamma 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:32514138)
GO_REF:0000107
RGD
Ensembl
PMID:32514138 GO_REF:0000107 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha involved_in ISS
ISO
GO_REF:0000024
(MGI:6859739|PMID:28465465)
UniProt
RGD
PMID:28465465 GO_REF:0000024 MGI:6859739 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Prkd1 protein kinase D1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5913002|PMID:28716882)
UniProt
RGD
PMID:28716882 GO_REF:0000024 MGI:5913002 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:27043286)
(MGI:5792478|PMID:27043286)
RGD PMID:27043286 MGI:5792478 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G Stmp1 short transmembrane mitochondrial protein 1 involved_in ISO (MGI:6384515|PMID:31836654) RGD PMID:31836654 MGI:6384515 NCBI chr 4:63,927,523...63,937,355 JBrowse link
G Tlr4 toll-like receptor 4 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:5546292|PMID:23812099)
UniProt
Ensembl
RGD
PMID:23812099 GO_REF:0000024 GO_REF:0000107 MGI:5546292 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO (MGI:5546292|PMID:23812099) RGD PMID:23812099 MGI:5546292 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Usp50 ubiquitin specific peptidase 50 acts_upstream_of_or_within ISO (PMID:28094437) RGD PMID:28094437 NCBI chr 3:114,012,104...114,035,468
Ensembl chr 3:114,011,702...114,035,476
JBrowse link
G Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 involved_in ISO (PMID:38092000) RGD PMID:38092000 NCBI chr 3:69,772,037...69,800,142
Ensembl chr 3:69,771,890...69,799,921
JBrowse link
regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5432942|PMID:22801494)
UniProt
RGD
PMID:22801494 GO_REF:0000024 MGI:5432942 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      cellular component organization or biogenesis 7217
        cellular component organization 6909
          cellular component assembly 3189
            protein-containing complex assembly 1621
              canonical inflammasome complex assembly 44
                CARD8 inflammasome complex assembly 0
                NLRP1 inflammasome complex assembly 1
                NLRP3 inflammasome complex assembly + 42
                NLRP6 inflammasome complex assembly 1
Path 2
Term Annotations click to browse term
  biological_process 20292
    response to stimulus 10871
      response to biotic stimulus 1884
        response to external biotic stimulus 1842
          response to other organism 1838
            defense response to other organism 1293
              defense response to symbiont 1151
                innate immune response 978
                  regulation of innate immune response 452
                    positive regulation of innate immune response 370
                      activation of innate immune response 301
                        innate immune response-activating signaling pathway 275
                          pattern recognition receptor signaling pathway 263
                            cytoplasmic pattern recognition receptor signaling pathway 167
                              inflammasome-mediated signaling pathway 46
                                canonical inflammasome complex assembly 44
                                  CARD8 inflammasome complex assembly 0
                                  NLRP1 inflammasome complex assembly 1
                                  NLRP3 inflammasome complex assembly + 42
                                  NLRP6 inflammasome complex assembly 1
paths to the root