ONTOLOGY REPORT - ANNOTATIONS
Term: cellular response to xenobiotic stimulus
Accession: GO:0071466
browse the term
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
Synonyms: related_synonym: cellular response to drug
alt_id: GO:0035690
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ABCA1
ATP binding cassette subfamily A member 1
ISO
pitavastatin, clofibrate, GW 6471
RGD
PMID:21554872
RGD:21408554
NCBI chr12:34,587,123...34,734,936
Ensembl chr12:34,587,118...34,731,642
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ABCB11
ATP binding cassette subfamily B member 11
ISO
RGD
PMID:27090119
RGD:15090804
NCBI chr10:54,458,283...54,575,943
Ensembl chr10:54,459,377...54,575,059
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ABCC2
ATP binding cassette subfamily C member 2
ISO
RGD
PMID:27090119
RGD:15090804
NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265
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ABCC9
ATP binding cassette subfamily C member 9
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:24037327)
MGI Ensembl
PMID:24037327
GO_REF:0000107
NCBI chr11:21,658,804...21,797,851
Ensembl chr11:21,658,794...21,797,263
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ACER2
alkaline ceramidase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:60,286,802...60,323,359
Ensembl chr12:60,283,174...60,321,817
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ADIPOQ
adiponectin, C1Q and collagen domain containing
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391
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ADM
adrenomedullin
ISO
RGD
PMID:12193565
RGD:628358
NCBI chr 1:54,518,359...54,520,683
Ensembl chr 1:54,518,358...54,520,686
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ADSS1
adenylosuccinate synthase 1
ISO
cyclosporin A
RGD
PMID:10636885
RGD:5135512
NCBI chr24:82,662,232...82,684,690
Ensembl chr24:82,662,319...82,684,874
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AGER
advanced glycosylation end-product specific receptor
ISO
losartan, metformin
RGD
PMID:22467055
RGD:7245559
NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127
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AIM2
absent in melanoma 2
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:19158679)
MGI Ensembl
PMID:19158679
GO_REF:0000107
NCBI chr20:4,759,746...4,884,460
Ensembl chr20:4,873,008...4,884,764
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AKAP5
A-kinase anchoring protein 5
acts_upstream_of_or_within
ISO
(PMID:23259949)
MGI
PMID:23259949
NCBI chr24:41,669,206...41,678,205
Ensembl chr24:41,672,098...41,673,381
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ANKRD1
ankyrin repeat domain 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:84,248,133...84,257,276
Ensembl chr 9:84,247,241...84,257,170
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ASIC2
acid sensing ion channel subunit 2
ISO
amiloride
RGD
PMID:12736332
RGD:1298620
NCBI chr16:26,547,878...27,674,909
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BCL2L1
BCL2 like 1
ISO
carboplatin
RGD
PMID:18483861
RGD:2293312
NCBI chr 2:36,059,024...36,118,332
Ensembl chr 2:36,058,919...36,116,470
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BLM
BLM RecQ like helicase
acts_upstream_of_or_within
ISO
(PMID:25520194)
MGI
PMID:25520194
NCBI chr29:9,046,485...9,152,320
Ensembl chr29:9,045,373...9,152,254
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BRAF
B-Raf proto-oncogene, serine/threonine kinase
acts_upstream_of_or_within
ISO
(PMID:22628551)
MGI
PMID:22628551
NCBI chr21:109,495,525...109,690,261
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BRAF
B-Raf proto-oncogene, serine/threonine kinase
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr21:109,545,491...109,690,195
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CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
ISO
N-phosphonoacetyl-L-aspartate
RGD
PMID:8548770
RGD:5132280
NCBI chr14:80,371,154...80,399,193
Ensembl chr14:80,371,096...80,398,914
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CCL2
C-C motif chemokine ligand 2
ISO
nifedipine
RGD
PMID:16331110
RGD:2298662
NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416
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CD69
CD69 molecule
involved_in
ISO
(PMID:19109165)
UniProt
PMID:19109165
NCBI chr11:9,659,154...9,666,342
Ensembl chr11:9,659,029...9,665,914
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CDH13
cadherin 13
ISO
RGD
PMID:12559965
RGD:632357
NCBI chr 5:68,048,655...69,213,102
Ensembl chr 5:68,451,894...69,211,534
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CEBPA
CCAAT enhancer binding protein alpha
ISO
rosiglitazone
RGD
PMID:1377818
RGD:69946
NCBI chr 6:28,342,506...28,345,759
Ensembl chr 6:28,343,907...28,344,977
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CERS1
ceramide synthase 1
involved_in
ISO
(PMID:19800881)
UniProt
PMID:19800881
NCBI chr 6:17,331,021...17,351,542
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CERS1
ceramide synthase 1
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr 6:17,331,107...17,351,496
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CHEK2
checkpoint kinase 2
ISO
alpha-difluoromethylornithine
RGD
PMID:21745814
RGD:10401653
NCBI chr19:11,567,529...11,621,180
Ensembl chr19:11,567,528...11,604,792
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CRHBP
corticotropin releasing hormone binding protein
involved_in
ISO
(PMID:15976007)
UniProt
PMID:15976007
NCBI chr 4:71,203,335...71,223,179
Ensembl chr 4:71,205,932...71,223,172
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CXCR4
C-X-C motif chemokine receptor 4
ISO
RGD
PMID:20613717
RGD:11352688
NCBI chr10:20,336,470...20,340,308
Ensembl chr10:20,336,247...20,340,309
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DDC
dopa decarboxylase
ISO
L-DOPA
RGD
PMID:18602388
RGD:5129085
NCBI chr21:8,235,396...8,343,086
Ensembl chr21:8,235,343...8,343,361
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E2F1
E2F transcription factor 1
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:24726645)
MGI Ensembl
PMID:24726645
GO_REF:0000107
NCBI chr 2:37,968,541...37,980,461
Ensembl chr 2:37,968,556...37,980,326
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EDN1
endothelin 1
ISO
cyclosporine
RGD
PMID:8129032
RGD:8662286
NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198
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EEF1A1
eukaryotic translation elongation factor 1 alpha 1
ISO
cilostazol
RGD
PMID:21390260
RGD:10401124
NCBI chr17:1,626,701...1,630,445
Ensembl chr17:1,627,901...1,630,150
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EFTUD2
elongation factor Tu GTP binding domain containing 2
ISO
flutamide
RGD
PMID:24793618
RGD:10045571
NCBI chr16:61,505,796...61,549,720
Ensembl chr16:61,505,825...61,551,890
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EGFR
epidermal growth factor receptor
ISO
vorinostat NADPH oxidase inhibitors VAS2870, apocynin
RGD
PMID:21276422 PMID:21389970
RGD:5131459 RGD:5131479
NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239
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EGR1
early growth response 1
ISO
imipramine
RGD
PMID:21354245
RGD:5131879
NCBI chr23:41,139,636...41,143,598
Ensembl chr23:41,140,065...41,142,374
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EHMT2
euchromatic histone lysine methyltransferase 2
ISO
amitriptyline
RGD
PMID:22880885
RGD:9588218
NCBI chr17:40,123,935...40,141,942
Ensembl chr17:40,124,640...40,141,616
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EP300
E1A binding protein p300
ISO
valproic acid
RGD
PMID:20888352
RGD:7364728
NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979
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ESR2
estrogen receptor 2
ISO
tamoxifen
RGD
PMID:19279558
RGD:7364795
NCBI chr24:41,426,333...41,513,802
Ensembl chr24:41,447,224...41,512,486
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FANCB
FA complementation group B
acts_upstream_of_or_within
ISO
(PMID:25520194)
MGI
PMID:25520194
NCBI chr X:13,321,304...13,352,368
Ensembl chr X:13,321,527...13,342,478
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FBP1
fructose-bisphosphatase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:108,452,856...108,484,052
Ensembl chr12:108,453,156...108,483,775
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FGF21
fibroblast growth factor 21
ISO
RGD
PMID:23118742
RGD:10401886
NCBI chr 6:42,006,125...42,008,749
Ensembl chr 6:42,006,064...42,008,736
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GAS6
growth arrest specific 6
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr 3:91,720,882...91,738,069
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GPLD1
glycosylphosphatidylinositol specific phospholipase D1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:47,748,183...47,809,459
Ensembl chr17:47,765,699...47,804,378
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HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
isoproterenol
RGD
PMID:20193759
RGD:9068889
NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288
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HSF1
heat shock transcription factor 1
ISO
amlodipine besylate, amlodipine camsylate
RGD
PMID:21988238
RGD:10402816
NCBI chr 8:138,503,836...138,529,562
Ensembl chr 8:138,503,831...138,529,165
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HSPA5
heat shock protein family A (Hsp70) member 5
ISO
RGD
PMID:18757512
RGD:11354916
NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431
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HTR1B
5-hydroxytryptamine receptor 1B
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr13:2,143,646...2,145,943
Ensembl chr13:2,144,313...2,145,485
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IL1B
interleukin 1 beta
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:19158679)
MGI Ensembl
PMID:19158679
GO_REF:0000107
NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729
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ITGB3
integrin subunit beta 3
ISO
RGD
PMID:12242040
RGD:4999478
NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857
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KCNC1
potassium voltage-gated channel subfamily C member 1
ISO
fluoxetine
RGD
PMID:11543764
RGD:9685702
NCBI chr 1:47,189,485...47,237,093
Ensembl chr 1:47,190,806...47,236,775
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KCND2
potassium voltage-gated channel subfamily D member 2
ISO
RGD
PMID:17293496
RGD:7247436
NCBI chr21:89,091,939...89,575,464
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KCNE2
potassium voltage-gated channel subfamily E regulatory subunit 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:57,833,459...57,841,052
Ensembl chr 2:57,833,629...57,834,000
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KCNH2
potassium voltage-gated channel subfamily H member 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:119,123,601...119,156,985
Ensembl chr21:119,124,007...119,156,794
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KCNQ1
potassium voltage-gated channel subfamily Q member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:2,261,448...2,661,840
Ensembl chr 1:2,261,845...2,661,863
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KCNQ2
potassium voltage-gated channel subfamily Q member 2
acts_upstream_of_or_within
ISO
(PMID:23259949)
MGI
PMID:23259949
NCBI chr 2:739,965...803,575
Ensembl chr 2:761,952...802,999
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KCNQ3
potassium voltage-gated channel subfamily Q member 3
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:23259949)
MGI Ensembl
PMID:23259949
GO_REF:0000107
NCBI chr 8:126,566,288...126,921,354
Ensembl chr 8:126,566,545...126,622,712
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LOC103214855
growth arrest-specific protein 6
involved_in
ISO
(PMID:16359517) PMID:18374201
UniProt
PMID:16359517 PMID:18374201
RGD:8554638
NCBI chr 3:91,720,871...91,762,712
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LOC103222955
uncharacterized LOC103222955
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:29581031)
Ensembl MGI
PMID:29581031
GO_REF:0000107
NCBI chr19:4,855,633...4,889,674
Ensembl chr19:4,855,611...4,890,302
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LOC103223747
SLAM family member 8
acts_upstream_of_or_within
ISO
(PMID:22593622)
MGI
PMID:22593622
NCBI chr20:4,114,403...4,127,122
Ensembl chr20:4,116,630...4,124,988
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LOC103224275
glutathione S-transferase Mu 1
acts_upstream_of_or_within
ISO
(PMID:8512323)
MGI
PMID:8512323
NCBI chr20:23,854,969...23,861,634
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LOC103242912
nucleoside diphosphate kinase A
ISO
isoproterenol
RGD
PMID:11082283
RGD:2299080
NCBI chr16:42,186,039...42,195,608
Ensembl chr16:42,185,260...42,195,616
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MCM7
minichromosome maintenance complex component 7
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:24726645)
MGI Ensembl
PMID:24726645
GO_REF:0000107
NCBI chr28:12,976,487...12,985,354
Ensembl chr28:12,977,013...12,985,898
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MEF2C
myocyte enhancer factor 2C
involved_in
ISO
(PMID:16775627)
UniProt
PMID:16775627
NCBI chr 4:82,702,378...82,887,491
Ensembl chr 4:82,706,738...82,788,152
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MMP1
matrix metallopeptidase 1
ISO
ibuprophen
RGD
PMID:19847888
RGD:7207385
NCBI chr 1:94,167,507...94,177,357
Ensembl chr 1:94,167,219...94,176,767
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MYC
MYC proto-oncogene, bHLH transcription factor
involved_in
ISO IEA
emodin
RGD Ensembl
PMID:17886230
GO_REF:0000107 RGD:10059617
NCBI chr 8:122,282,989...122,288,392
Ensembl chr 8:122,282,630...122,288,384
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MYLK
myosin light chain kinase
acts_upstream_of_or_within
ISO
(PMID:18524939)
MGI
PMID:18524939
NCBI chr22:57,032,264...57,259,253
Ensembl chr22:57,065,331...57,257,464
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NFE2L2
NFE2 like bZIP transcription factor 2
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:24486487)
MGI Ensembl
PMID:24486487
GO_REF:0000107
NCBI chr10:62,789,647...62,825,651
Ensembl chr10:62,790,124...62,825,339
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NKX3-1
NK3 homeobox 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:21,792,069...21,797,258
Ensembl chr 8:21,791,422...21,796,319
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NOS2
nitric oxide synthase 2
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:24486487)
MGI Ensembl
PMID:24486487
GO_REF:0000107
NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257
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NR1H4
nuclear receptor subfamily 1 group H member 4
ISO
RGD
PMID:27090119 PMID:29235094
RGD:15042872 RGD:15090804
NCBI chr11:95,792,428...95,877,989
Ensembl chr11:95,792,996...95,878,293
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PAX6
paired box 6
ISO
pramipexole
RGD
PMID:19619535
RGD:8552332
NCBI chr 1:33,386,165...33,414,605
Ensembl chr 1:33,392,970...33,414,587
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PCNA
proliferating cell nuclear antigen
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:24726645)
Ensembl MGI
PMID:24726645
GO_REF:0000107
NCBI chr 2:32,936,600...32,953,635
Ensembl chr 2:32,948,196...32,953,991
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PDE2A
phosphodiesterase 2A
involved_in
ISO
(PMID:14687666)
UniProt
PMID:14687666
NCBI chr 1:63,812,877...63,912,602
Ensembl chr 1:63,812,840...63,880,492
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PDE4A
phosphodiesterase 4A
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:11267656)
MGI Ensembl
PMID:11267656
GO_REF:0000107
NCBI chr 6:9,455,471...9,503,809
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PDE4B
phosphodiesterase 4B
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:11267656)
Ensembl MGI
PMID:11267656
GO_REF:0000107
NCBI chr20:66,729,561...67,297,729
Ensembl chr20:66,728,664...66,771,691
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PPAT
phosphoribosyl pyrophosphate amidotransferase
ISO
malotilate
RGD
PMID:3012070
RGD:5135033
NCBI chr 7:12,201,434...12,242,418
Ensembl chr 7:12,191,784...12,243,488
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PPM1E
protein phosphatase, Mg2+/Mn2+ dependent 1E
involved_in
ISO
(PMID:20801214)
UniProt
PMID:20801214
NCBI chr16:34,433,918...34,647,076
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PPM1E
protein phosphatase, Mg2+/Mn2+ dependent 1E
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr16:34,434,865...34,461,449
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PPM1F
protein phosphatase, Mg2+/Mn2+ dependent 1F
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr19:4,167,925...4,200,550
Ensembl chr19:4,167,908...4,200,953
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PPP1R12A
protein phosphatase 1 regulatory subunit 12A
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:18524939)
Ensembl MGI
PMID:18524939
GO_REF:0000107
NCBI chr11:75,300,278...75,461,498
Ensembl chr11:75,319,962...75,461,438
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PPP1R14A
protein phosphatase 1 regulatory inhibitor subunit 14A
acts_upstream_of_or_within
ISO
(PMID:18524939)
MGI
PMID:18524939
NCBI chr 6:32,890,160...32,895,267
Ensembl chr 6:32,889,287...32,895,017
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PPP1R15A
protein phosphatase 1 regulatory subunit 15A
ISO
methapyrilene
RGD
PMID:23274394
RGD:9999168
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PPP1R9B
protein phosphatase 1 regulatory subunit 9B
ISO
haloperidol
RGD
PMID:16844384
RGD:10043796
NCBI chr16:43,188,400...43,205,621
Ensembl chr16:43,188,022...43,205,680
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PRKAA1
protein kinase AMP-activated catalytic subunit alpha 1
ISO
RGD
PMID:27090119
RGD:15090804
NCBI chr 4:39,516,307...39,553,627
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PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:23918774)
Ensembl MGI
PMID:23918774
GO_REF:0000107
NCBI chr20:76,258,063...76,319,512
Ensembl chr20:76,259,763...76,319,430
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PRNP
prion protein (Kanno blood group)
acts_upstream_of_or_within
ISO
(PMID:16254249)
MGI
PMID:16254249
NCBI chr 2:33,368,020...33,384,556
Ensembl chr 2:33,369,629...33,370,366
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QDPR
quinoid dihydropteridine reductase
ISO
theophylline
RGD
PMID:2484967
RGD:5128599
NCBI chr27:32,697,582...32,723,616
Ensembl chr27:32,697,599...32,723,016
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RANBP1
RAN binding protein 1
ISO
phenylephrine
RGD
PMID:25341891
RGD:9835001
NCBI chr19:5,611,968...5,622,414
Ensembl chr19:5,612,268...5,622,191
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RAP2A
RAP2A, member of RAS oncogene family
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:76,146,124...76,184,649
Ensembl chr 3:76,146,340...76,184,664
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RAPGEF3
Rap guanine nucleotide exchange factor 3
ISO
roflumilast
RGD
PMID:18276108
RGD:9835371
NCBI chr11:43,954,517...43,979,068
Ensembl chr11:43,957,425...43,978,047
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RB1
RB transcriptional corepressor 1
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:24726645)
MGI Ensembl
PMID:24726645
GO_REF:0000107
NCBI chr 3:26,220,783...26,393,671
Ensembl chr 3:26,220,803...26,394,546
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RBM22
RNA binding motif protein 22
involved_in
ISO
(PMID:21122810)
UniProt
PMID:21122810
NCBI chr23:53,302,697...53,312,382
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RECQL5
RecQ like helicase 5
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:25520194)
Ensembl MGI
PMID:25520194
GO_REF:0000107
NCBI chr16:46,013,100...46,052,713
Ensembl chr16:46,013,092...46,056,167
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REN
renin
ISO
secretagogue C4880
RGD
PMID:21963836
RGD:6892652
NCBI chr25:25,159,816...25,193,620
Ensembl chr25:25,183,037...25,193,420
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REST
RE1 silencing transcription factor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:11,749,312...11,776,103
Ensembl chr 7:11,749,168...11,773,340
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RNF149
ring finger protein 149
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:22628551)
Ensembl MGI
PMID:22628551
GO_REF:0000107
NCBI chr14:4,978,429...5,011,117
Ensembl chr14:4,979,126...5,011,083
G
SERPINE1
serpin family E member 1
ISO
valproic acid
RGD
PMID:23378038
RGD:8547945
NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202
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SLC10A1
solute carrier family 10 member 1
ISO
RGD
PMID:27090119
RGD:15090804
NCBI chr24:47,018,237...47,034,360
Ensembl chr24:47,017,414...47,033,940
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SLC18A2
solute carrier family 18 member A2
ISO
1-methyl-4-phenylpyridinium, acriflavine
RGD
PMID:20007701
RGD:5130957
NCBI chr 9:110,039,783...110,078,822
Ensembl chr 9:110,040,391...110,076,647
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SLCO1A2
solute carrier organic anion transporter family member 1A2
ISO
RGD
PMID:27090119
RGD:15090804
NCBI chr11:21,125,711...21,283,748
Ensembl chr11:21,128,062...21,283,796
G
SOX10
SRY-box transcription factor 10
ISO
arecaidine
RGD
PMID:24403178
RGD:12879828
NCBI chr19:20,673,053...20,685,506
G
TFRC
transferrin receptor
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:16254249)
MGI Ensembl
PMID:16254249
GO_REF:0000107
NCBI chr15:91,102,153...91,134,994
Ensembl chr15:91,102,817...91,135,584
G
TH
tyrosine hydroxylase
ISO
L-DOPA
RGD
PMID:18602388
RGD:5129085
NCBI chr 1:1,969,194...1,977,263
Ensembl chr 1:1,966,460...1,977,218
G
TLR3
toll like receptor 3
ISO
methimazole derivative C10
RGD
PMID:15661832
RGD:5128798
NCBI chr 7:131,991,068...132,014,366
Ensembl chr 7:131,991,029...132,016,232
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TP53
tumor protein p53
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223
G
TXN
thioredoxin
ISO
dipyridamole
RGD
PMID:20453393
RGD:5133719
NCBI chr12:29,296,166...29,308,979
G
UCHL1
ubiquitin C-terminal hydrolase L1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr27:9,074,961...9,086,606
Ensembl chr27:9,074,923...9,086,517
G
UMPS
uridine monophosphate synthetase
ISO
pyrazofurin
RGD
PMID:6134725
RGD:5132277
NCBI chr22:56,081,897...56,097,164
Ensembl chr22:56,082,103...56,097,105
G
VEGFA
vascular endothelial growth factor A
ISO
RGD
PMID:22326847
RGD:7421605
NCBI chr17:28,377,959...28,394,508
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WDR35
WD repeat domain 35
ISO
RGD
PMID:18472094
RGD:11553927
NCBI chr14:87,732,034...87,801,687
Ensembl chr14:87,732,049...87,801,852
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WNK4
WNK lysine deficient protein kinase 4
involved_in
ISO
(PMID:31496133)
MGI
PMID:31496133
NCBI chr16:63,494,090...63,512,068
G
AS3MT
arsenite methyltransferase
involved_in
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chr 9:95,911,465...95,939,554
Ensembl chr 9:95,912,086...95,939,375
G
N6AMT1
N-6 adenine-specific DNA methyltransferase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:63,348,897...63,363,709
Ensembl chr 2:63,348,745...63,363,090
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DNAJA2
DnaJ heat shock protein family (Hsp40) member A2
ISO
RGD
PMID:15270078
RGD:4891447
NCBI chr 5:32,815,641...32,834,385
G
CYP1A1
cytochrome P450 family 1 subfamily A member 1
ISO
2,3,7,8-tetrachlorodibenzo-p-dioxin
RGD
PMID:12914780 PMID:15812643
RGD:2306662 RGD:2306673
NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384
G
CYP1A1
cytochrome P450 family 1 subfamily A member 1
ISO
Deltamethrin (pyrethroid)
RGD
PMID:16169030
RGD:2306660
NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384
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ALDH2
aldehyde dehydrogenase 2 family member
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:107,019,015...107,060,784
Ensembl chr11:107,019,111...107,060,374
G
CYP1A2
cytochrome P450 family 1 subfamily A member 2
ISO
RGD
PMID:16520233
RGD:401900296
NCBI chr26:8,727,996...8,733,254
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ACAA1
acetyl-CoA acyltransferase 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr15:1,282,556...1,297,154
Ensembl chr15:1,282,650...1,297,832
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PON3
paraoxonase 3
ISO
RGD
PMID:12946270
RGD:1303961
NCBI chr21:53,645,406...53,675,066
Ensembl chr21:53,645,384...53,674,812
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SUFU
SUFU negative regulator of hedgehog signaling
ISO
RGD
PMID:30790292
RGD:150573813
NCBI chr 9:95,532,228...95,660,594
Ensembl chr 9:95,532,242...95,657,290
G
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
involved_in
ISO
(PMID:21795692)
BHF-UCL
PMID:21795692
NCBI chr12:1,020,556...1,050,568
Ensembl chr12:1,019,263...1,050,231
G
ABCC1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
ISO
RGD
PMID:15198509
RGD:2303058
NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567
G
PON3
paraoxonase 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:53,645,406...53,675,066
Ensembl chr21:53,645,384...53,674,812
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LPO
lactoperoxidase
involved_in
IEA
GOC
GO_REF:0000108
NCBI chr16:35,132,781...35,182,571
Ensembl chr16:35,133,311...35,158,976
G
LOC103235509
cytochrome P450 2F1
ISO
RGD
PMID:15987776
RGD:2301693
NCBI chr 6:35,270,229...35,286,326
G
ABCC2
ATP binding cassette subfamily C member 2
ISO
RGD
PMID:18088505
RGD:14700808
NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265
G
ACSL1
acyl-CoA synthetase long chain family member 1
ISO
RGD
PMID:10725307
RGD:2312871
NCBI chr 7:130,712,633...130,783,360
Ensembl chr 7:130,712,308...130,763,756
G
CRYZ
crystallin zeta
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:58,427,281...58,456,370
Ensembl chr20:58,435,671...58,456,408
G
CYP1A2
cytochrome P450 family 1 subfamily A member 2
involved_in
ISO
(PMID:18356043) (PMID:18619574)
BHF-UCL
PMID:18356043 PMID:18619574
NCBI chr26:8,727,996...8,733,254
G
CYP2B6
cytochrome P450 family 2 subfamily B member 6
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106
G
CYP2C19
cytochrome P450 family 2 subfamily C member 19
involved_in
ISO
(PMID:19029318)
BHF-UCL RGD
PMID:16039681 PMID:19029318
RGD:401965478
NCBI chr 9:87,981,300...88,025,007
G
CYP2C8
cytochrome P450 family 2 subfamily C member 8
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458
G
CYP2C9
cytochrome P450 family 2 subfamily C member 9
involved_in
ISO
(PMID:18356043) (PMID:18619574)
BHF-UCL
PMID:18356043 PMID:18619574
NCBI chr 9:88,082,124...88,125,390
G
CYP2C9
cytochrome P450 family 2 subfamily C member 9
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr 9:87,938,712...88,125,658
G
CYP2D6
cytochrome P450 family 2 subfamily D member 6
involved_in
ISO
(PMID:15039299)
BHF-UCL
PMID:15039299
NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513
G
CYP3A4
cytochrome P450 family 3 subfamily A member 4
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr28:13,313,930...13,331,832
G
CYP3A5
cytochrome P450 family 3 subfamily A member 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507
G
FMO4
flavin containing dimethylaniline monoxygenase 4
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:19262426)
MGI Ensembl
PMID:19262426
GO_REF:0000107
NCBI chr25:57,729,381...57,755,940
Ensembl chr25:57,728,614...57,755,259
G
GSTM3
glutathione S-transferase mu 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:23,797,794...23,802,910
Ensembl chr20:23,799,177...23,802,921
G
GSTO1
glutathione S-transferase omega 1
involved_in
ISO
(PMID:12928150)
UniProt
PMID:12928150
NCBI chr 9:97,305,094...97,317,892
G
LOC103224273
glutathione S-transferase Mu 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:23,885,520...23,891,229
Ensembl chr20:23,855,246...23,890,926
G
LOC103224275
glutathione S-transferase Mu 1
involved_in
ISO
PMID:17112229 (PMID:8373352)
CAFA BHF-UCL
PMID:8373352 PMID:17112229
RGD:12793043
NCBI chr20:23,854,969...23,861,634
G
LOC103246766
cytochrome P450 3A8
involved_in
ISO
(PMID:18356043) (PMID:15039299), (PMID:15327587), (PMID:18619574)
BHF-UCL
PMID:15039299 PMID:15327587 PMID:18356043 PMID:18619574
NCBI chr28:13,297,566...13,330,023
G
NOS1
nitric oxide synthase 1
acts_upstream_of_or_within
ISO
(PMID:11158245)
MGI
PMID:11158245
NCBI chr11:112,642,374...112,673,882
G
NR1I2
nuclear receptor subfamily 1 group I member 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr22:61,005,404...61,043,016
Ensembl chr22:61,006,667...61,040,832
G
NUDT15
nudix hydrolase 15
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:25,966,148...25,974,143
Ensembl chr 3:25,966,876...25,973,647
G
PRKCE
protein kinase C epsilon
involved_in
ISO
(PMID:18556656)
BHF-UCL
PMID:18556656
NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343
G
ABCB11
ATP binding cassette subfamily B member 11
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr10:54,458,283...54,575,943
Ensembl chr10:54,459,377...54,575,059
G
ABHD10
abhydrolase domain containing 10, depalmitoylase
involved_in
ISO
(PMID:22294686)
BHF-UCL
PMID:22294686
NCBI chr22:68,804,259...68,818,561
Ensembl chr22:68,802,251...68,818,722
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AHR
aryl hydrocarbon receptor
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr21:40,778,198...40,826,491
Ensembl chr21:40,778,218...40,826,478
G
AHRR
aryl-hydrocarbon receptor repressor
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr 4:220,523...329,973
Ensembl chr 4:243,026...326,722
G
AIP
aryl hydrocarbon receptor interacting protein
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:9083006)
MGI Ensembl
PMID:9083006
GO_REF:0000107
NCBI chr 1:6,774,648...6,783,095
Ensembl chr 1:6,773,364...6,783,318
G
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
ISO
RGD
PMID:18515330
RGD:2303526
NCBI chr14:80,371,154...80,399,193
Ensembl chr14:80,371,096...80,398,914
G
CBR1
carbonyl reductase 1
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr 2:80,096,955...80,102,721
G
CYP1A1
cytochrome P450 family 1 subfamily A member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384
G
CYP1A2
cytochrome P450 family 1 subfamily A member 2
involved_in acts_upstream_of_or_within
ISO
(PMID:15327587), (PMID:19219744) (PMID:8643688)
BHF-UCL MGI RGD
PMID:6772643 PMID:8643688 PMID:15327587 PMID:19219744
RGD:151347456
NCBI chr26:8,727,996...8,733,254
G
CYP1B1
cytochrome P450 family 1 subfamily B member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:69,318,713...69,327,277
Ensembl chr14:69,319,495...69,324,157
G
CYP26B1
cytochrome P450 family 26 subfamily B member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:35,030,011...35,057,164
Ensembl chr14:35,038,654...35,057,176
G
CYP2A23
cytochrome P450 family 2 subfamily A member 23
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:35,351,235...35,361,375
G
CYP2A23
cytochrome P450 family 2 subfamily A member 23
involved_in
IEA
TreeGrafter
GO_REF:0000118
Ensembl chr 6:35,353,932...35,361,085
G
CYP2A24
cytochrome P450 family 2 subfamily A member 24
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:35,314,507...35,322,700
Ensembl chr 6:35,314,764...35,321,400
G
CYP2A28
cytochrome P450 family 2 subfamily A member 28
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:35,452,676...35,461,063
Ensembl chr 6:35,453,288...35,460,823
G
CYP2B6
cytochrome P450 family 2 subfamily B member 6
involved_in
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chr 6:35,392,699...35,418,171
Ensembl chr 6:35,393,342...35,418,106
G
CYP2C19
cytochrome P450 family 2 subfamily C member 19
involved_in
ISO
(PMID:19219744), (PMID:19651758)
BHF-UCL
PMID:19219744 PMID:19651758
NCBI chr 9:87,981,300...88,025,007
G
CYP2C8
cytochrome P450 family 2 subfamily C member 8
involved_in
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458
G
CYP2C9
cytochrome P450 family 2 subfamily C member 9
involved_in
ISO
(PMID:21127708) (PMID:19219744), (PMID:19651758)
UniProt BHF-UCL
PMID:19219744 PMID:19651758 PMID:21127708
NCBI chr 9:88,082,124...88,125,390
G
CYP2C9
cytochrome P450 family 2 subfamily C member 9
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
Ensembl chr 9:87,938,712...88,125,658
G
CYP2D6
cytochrome P450 family 2 subfamily D member 6
involved_in
ISO IEA
RGD TreeGrafter
PMID:8910433
GO_REF:0000118 RGD:728177
NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513
G
CYP2D8
cytochrome P450 family 2 subfamily D member 8
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr19:24,683,186...24,689,557
Ensembl chr19:24,683,260...24,688,691
G
CYP2E1
cytochrome P450 family 2 subfamily E member 1
involved_in
ISO IEA
RGD Ensembl TreeGrafter
PMID:21187827
GO_REF:0000107 GO_REF:0000118 RGD:4892233
NCBI chr26:53,390,054...53,403,309
Ensembl chr26:53,390,089...53,404,211
G
CYP2G2
cytochrome P450 family 2 subfamily G member 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:35,423,727...35,436,361
Ensembl chr 6:35,424,076...35,435,896
G
CYP2J2
cytochrome P450 family 2 subfamily J member 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr20:73,083,312...73,115,174
Ensembl chr20:73,083,389...73,115,077
G
CYP2R1
cytochrome P450 family 2 subfamily R member 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:50,030,366...50,043,833
Ensembl chr 1:50,031,218...50,047,403
G
CYP2S1
cytochrome P450 family 2 subfamily S member 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
Ensembl chr 6:35,513,232...35,520,745
G
CYP2U1
cytochrome P450 family 2 subfamily U member 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 7:55,859,669...55,880,266
Ensembl chr 7:55,859,849...55,879,280
G
CYP2W1
cytochrome P450 family 2 subfamily W member 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr28:20,580,272...20,592,771
Ensembl chr28:20,582,287...20,591,497
G
CYP3A4
cytochrome P450 family 3 subfamily A member 4
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr28:13,313,930...13,331,832
G
CYP46A1
cytochrome P450 family 46 subfamily A member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr24:77,641,068...77,684,722
Ensembl chr24:77,641,034...77,684,741
G
FMO1
flavin containing dimethylaniline monoxygenase 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:19262426)
Ensembl MGI
PMID:19262426
GO_REF:0000107
NCBI chr25:57,781,273...57,819,787
Ensembl chr25:57,782,085...57,819,408
G
FMO2
flavin containing dimethylaniline monoxygenase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr25:57,869,866...57,892,359
Ensembl chr25:57,866,555...57,892,193
G
FMO3
flavin containing dimethylaniline monoxygenase 3
ISO
RGD
PMID:17173378
RGD:1626480
NCBI chr25:57,971,737...57,995,850
Ensembl chr25:57,969,234...57,995,613
G
FMO5
flavin containing dimethylaniline monoxygenase 5
involved_in
IEA
Ensembl
GO_REF:0000107
G
GSTA3
glutathione S-transferase alpha 3
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr17:19,655,717...19,666,454
G
GSTA4
glutathione S-transferase alpha 4
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr17:19,575,835...19,591,713
Ensembl chr17:19,575,876...19,591,919
G
GSTA5
glutathione S-transferase alpha 5
involved_in
IEA
TreeGrafter
GO_REF:0000118
Ensembl chr17:19,677,353...19,686,421
G
GSTO2
glutathione S-transferase omega 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:97,319,695...97,348,406
Ensembl chr 9:97,325,215...97,349,422
G
GSTP1
glutathione S-transferase pi 1
involved_in
ISO
(PMID:1540159)
UniProt
PMID:1540159
NCBI chr 1:6,676,897...6,679,936
G
GUK1
guanylate kinase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr25:1,579,382...1,587,623
Ensembl chr25:1,579,610...1,587,419
G
HNF4A
hepatocyte nuclear factor 4 alpha
involved_in acts_upstream_of_positive_effect
IEA ISO
(PMID:17827783)
Ensembl BHF-UCL
PMID:17827783
GO_REF:0000107
NCBI chr 2:19,390,870...19,466,300
Ensembl chr 2:19,388,891...19,421,664
G
LOC103216270
cytochrome P450 26A1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:86,310,142...86,328,622
Ensembl chr 9:86,325,401...86,328,775
G
LOC103217611
aldehyde oxidase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr10:86,077,939...86,165,503
Ensembl chr10:86,077,791...86,166,776
G
LOC103218526
carbonyl reductase [NADPH] 1
involved_in
ISO
(PMID:18449627)
UniProt
PMID:18449627
NCBI chr 2:80,096,743...80,099,982
G
LOC103221353
glutathione S-transferase A1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr17:19,759,896...19,771,765
G
LOC103221354
glutathione S-transferase A1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr17:19,726,261...19,743,939
Ensembl chr17:19,726,106...19,744,247
G
LOC103230462
sulfotransferase 1A3
involved_in
ISO
(PMID:20056724)
BHF-UCL
PMID:20056724
NCBI chr 5:26,469,450...26,474,416
G
LOC103241211
sulfotransferase 1C4
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:11,860,065...11,882,111
Ensembl chr14:11,861,211...11,871,767
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LOC103246766
cytochrome P450 3A8
involved_in
ISO
(PMID:19219744)
RGD BHF-UCL
PMID:12971802 PMID:19219744
RGD:5129544
NCBI chr28:13,297,566...13,330,023
G
NCEH1
neutral cholesterol ester hydrolase 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15840715)
Ensembl MGI
PMID:15840715
GO_REF:0000107
NCBI chr15:16,724,037...16,812,235
Ensembl chr15:16,723,664...16,812,329
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NR1I2
nuclear receptor subfamily 1 group I member 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr22:61,005,404...61,043,016
Ensembl chr22:61,006,667...61,040,832
G
RORA
RAR related orphan receptor A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr26:22,263,889...23,002,224
Ensembl chr26:22,812,445...22,993,021
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RORC
RAR related orphan receptor C
involved_in
ISO
(PMID:17666523)
UniProt
PMID:17666523
NCBI chr20:11,854,911...11,880,221
Ensembl chr20:11,855,005...11,879,717
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S100A12
S100 calcium binding protein A12
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:10,377,418...10,379,638
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SULT1B1
sulfotransferase family 1B member 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:18,202,215...18,239,443
Ensembl chr 7:18,203,827...18,238,794
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SULT1C3
sulfotransferase family 1C member 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:11,621,851...11,638,719
Ensembl chr14:11,622,043...11,636,652
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SULT2A1
sulfotransferase family 2A member 1
involved_in
ISO IEA
RGD Ensembl
PMID:16099924
GO_REF:0000107 RGD:5129555
NCBI chr 6:41,160,707...41,175,382
Ensembl chr 6:41,159,978...41,175,300
G
TPMT
thiopurine S-methyltransferase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:53,987,561...54,012,647
Ensembl chr17:53,987,559...54,014,650
G
VKORC1
vitamin K epoxide reductase complex subunit 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:27,778,553...27,782,639
Ensembl chr 5:27,776,416...27,782,640
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