RAPGEF3 (Rap guanine nucleotide exchange factor 3) - Rat Genome Database

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Gene: RAPGEF3 (Rap guanine nucleotide exchange factor 3) Chlorocebus sabaeus
Analyze
Symbol: RAPGEF3
Name: Rap guanine nucleotide exchange factor 3
RGD ID: 18658705
Description: ENCODES a protein that exhibits cAMP binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN artery development (ortholog); cellular response to L-dopa (ortholog); cellular response to organic cyclic compound (ortholog); PARTICIPATES IN adenosine signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); amyloidosis (ortholog); Arterial Injury (ortholog); FOUND IN apical part of cell (ortholog); axon terminus (ortholog); basal plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11143,954,517 - 43,979,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1143,957,425 - 43,978,047 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037202,402,390 - 202,425,041 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
artery development  (ISO)
associative learning  (IEA)
cellular response to cAMP  (IEA)
cellular response to L-dopa  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
dorsal root ganglion development  (ISO)
establishment of endothelial barrier  (IEA)
intracellular signal transduction  (IEA)
liver regeneration  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of syncytium formation by plasma membrane fusion  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of calcium ion transmembrane transport  (ISO)
positive regulation of cell size  (ISO)
positive regulation of GTP binding  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of potassium ion import across plasma membrane  (ISO)
positive regulation of protein export from nucleus  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of stress fiber assembly  (IEA)
positive regulation of syncytium formation by plasma membrane fusion  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
Rap protein signal transduction  (IEA)
Ras protein signal transduction  (IEA)
regulation of actin cytoskeleton organization  (IEA,ISO)
regulation of angiogenesis  (IEA)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
response to nicotine  (ISO)
small GTPase-mediated signal transduction  (IEA)
spinal cord development  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RAPGEF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11143,954,517 - 43,979,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1143,957,425 - 43,978,047 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037202,402,390 - 202,425,041 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
RAPGEF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,734,363 - 47,758,880 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1247,734,363 - 47,771,040 (-)EnsemblGRCh38hg38GRCh38
GRCh371248,128,146 - 48,152,663 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,417,293 - 46,438,952 (-)NCBINCBI36Build 36hg18NCBI36
Build 341246,417,293 - 46,438,822NCBI
Celera1246,925,923 - 46,950,362 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1245,159,564 - 45,184,005 (-)NCBIHuRef
CHM1_11248,094,358 - 48,118,798 (-)NCBICHM1_1
T2T-CHM13v2.01247,695,675 - 47,720,196 (-)NCBIT2T-CHM13v2.0
Rapgef3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,637,886 - 97,666,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1597,642,651 - 97,665,853 (-)EnsemblGRCm39 Ensembl
GRCm381597,744,770 - 97,768,419 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1597,744,770 - 97,767,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv371597,575,201 - 97,598,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361597,572,987 - 97,595,706 (-)NCBIMGSCv36mm8
Celera1599,871,753 - 99,894,632 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1553.74NCBI
Rapgef3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,754,883 - 130,777,303 (-)NCBIGRCr8
mRatBN7.27128,875,772 - 128,898,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,875,773 - 128,898,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7130,672,963 - 130,694,833 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07132,898,495 - 132,920,365 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07132,810,963 - 132,832,833 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07139,232,263 - 139,254,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,232,251 - 139,254,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,423,916 - 139,445,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,452,945 - 136,474,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17136,529,382 - 136,551,096 (-)NCBI
Celera7125,367,430 - 125,389,118 (-)NCBICelera
Cytogenetic Map7q36NCBI
Rapgef3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,655,056 - 6,674,311 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555006,655,056 - 6,674,311 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21046,409,026 - 46,433,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11246,405,818 - 46,430,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01240,974,756 - 40,999,471 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11241,836,354 - 41,873,252 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,848,785 - 41,873,252 (+)Ensemblpanpan1.1panPan2
RAPGEF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,993,452 - 7,030,372 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,993,452 - 7,017,316 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2739,291,724 - 39,314,353 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,060,331 - 7,082,948 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,060,331 - 7,082,947 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,997,147 - 7,019,732 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,032,603 - 7,055,256 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02739,580,125 - 39,602,733 (-)NCBIUU_Cfam_GSD_1.0
LOC101973720
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494567,505,399 - 67,557,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365125,608,659 - 5,627,513 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049365125,636,758 - 5,659,300 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365125,636,197 - 5,659,606 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,101,299 - 78,134,105 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,101,286 - 78,134,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Rapgef3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248164,496,856 - 4,519,911 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248164,496,848 - 4,519,782 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 19 35 35 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000004638   ⟹   ENSCSAP00000002884
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1143,957,425 - 43,978,047 (-)Ensembl
RefSeq Acc Id: XM_037997221   ⟹   XP_037853149
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037202,402,391 - 202,425,041 (+)NCBI
RefSeq Acc Id: XR_005239996
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037202,402,390 - 202,425,041 (+)NCBI
RefSeq Acc Id: XR_005239997
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037202,402,390 - 202,425,041 (+)NCBI
RefSeq Acc Id: XR_005239998
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037202,402,391 - 202,425,041 (+)NCBI
RefSeq Acc Id: XR_005239999
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037202,408,263 - 202,425,041 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037853149 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002884.1
Ensembl Acc Id: ENSCSAP00000002884   ⟸   ENSCSAT00000004638
RefSeq Acc Id: XP_037853149   ⟸   XM_037997221
- UniProtKB: A0A0D9R2P5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006671 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004638.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.8.1240 UniProtKB/TrEMBL
  1.10.840.10 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene RAPGEF3 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PRINTS CAMPKINASE UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF48366 UniProtKB/TrEMBL
  SSF51206 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A0D9R2P5 ENTREZGENE, UniProtKB/TrEMBL