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Gene: CYP46A1 (cytochrome P450 family 46 subfamily A member 1) Chlorocebus sabaeus

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Symbol:

CYP46A1

Name:

cytochrome P450 family 46 subfamily A member 1

RGD ID:

18654306

Description:

ENCODES a protein that exhibits cholesterol 24-hydroxylase activity (inferred); heme binding (inferred); iron ion binding (inferred); INVOLVED IN protein localization to membrane raft (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN dendrite (inferred); endoplasmic reticulum membrane (inferred); postsynapse (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cholesterol 24-hydroxylase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	77,641,068 - 77,684,722 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	77,641,034 - 77,684,741 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	64,780,651 - 64,824,401 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

chronic obstructive pulmonary disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol catabolic process (IEA)

progesterone metabolic process (IEA)

protein localization to membrane raft (IEA,ISO)

regulation of long-term synaptic potentiation (IEA)

xenobiotic metabolic process (IEA)

Cellular Component

dendrite (IEA)

endoplasmic reticulum membrane (IEA)

postsynapse (IEA)

presynapse (IEA)

Molecular Function

cholesterol 24-hydroxylase activity (IEA)

heme binding (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

steroid hydroxylase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid biosynthetic pathway (ISO)

cerebrotendinous xanthomatosis pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

familial hypercholanemia pathway (ISO)

Zellweger syndrome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CYP46A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	77,641,068 - 77,684,722 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	77,641,034 - 77,684,741 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	64,780,651 - 64,824,401 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CYP46A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	99,684,298 - 99,727,301 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	99,684,298 - 99,727,301 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	100,150,635 - 100,193,638 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	99,220,508 - 99,263,391 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	99,220,507 - 99,263,390	NCBI
Celera	14	80,205,602 - 80,248,517 (+)	NCBI		Celera
Cytogenetic Map	14	q32.2	NCBI
HuRef	14	80,333,998 - 80,376,909 (+)	NCBI		HuRef
CHM1_1	14	100,088,519 - 100,131,398 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	93,915,741 - 93,958,738 (+)	NCBI		T2T-CHM13v2.0

Cyp46a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	108,300,568 - 108,328,497 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	108,300,640 - 108,328,493 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	108,334,268 - 108,362,234 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	108,334,381 - 108,362,234 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	109,572,591 - 109,600,444 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	108,782,188 - 108,810,041 (+)	NCBI		MGSCv36	mm8
Celera	12	109,576,067 - 109,604,342 (+)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI
cM Map	12	59.41	NCBI

Cyp46a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	133,011,948 - 133,039,167 (+)	NCBI		GRCr8
mRatBN7.2	6	127,247,543 - 127,274,765 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	127,243,315 - 127,274,760 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	127,372,445 - 127,399,673 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	127,667,502 - 127,694,730 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	127,025,379 - 127,052,595 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	132,242,328 - 132,273,788 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	132,242,328 - 132,273,787 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	141,412,601 - 141,443,684 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	132,700,554 - 132,731,982 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	132,711,108 - 132,737,620 (+)	NCBI
Celera	6	124,801,923 - 124,833,398 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

LOC102030124
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	20,961,365 - 20,985,749 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	20,961,621 - 20,986,260 (+)	NCBI	ChiLan1.0	ChiLan1.0

CYP46A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	100,840,224 - 100,882,729 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	100,056,722 - 100,099,224 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	80,309,698 - 80,352,181 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	99,628,511 - 99,671,218 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	99,628,511 - 99,671,218 (+)	Ensembl	panpan1.1		panPan2

CYP46A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	68,064,898 - 68,095,537 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	68,041,344 - 68,095,212 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	67,588,798 - 67,617,580 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	68,352,536 - 68,381,116 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	68,352,532 - 68,381,111 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	68,013,336 - 68,042,112 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	68,079,753 - 68,108,514 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	68,477,349 - 68,506,246 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101961079
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	6,591,776 - 6,630,640 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936604	3,451,842 - 3,491,159 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936604	3,451,853 - 3,490,688 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYP46A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	120,661,111 - 120,695,016 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	120,658,781 - 120,695,031 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	128,276,297 - 128,302,580 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC101708822
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	4,242,511 - 4,266,975 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	4,242,070 - 4,267,027 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	18	34	34	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007987804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000008497 ⟹ ENSCSAP00000006644

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	24	77,641,034 - 77,684,741 (+)	Ensembl

RefSeq Acc Id:

XM_007987804 ⟹ XP_007985995

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	24	77,641,068 - 77,684,722 (+)	NCBI
Vero_WHO_p1.0	NW_023666053	64,780,651 - 64,824,401 (+)	NCBI

Sequence:

show sequence

GGGCGGAGCCGAGCGGGCGGGGAGGGTGCTGGGTCGCGCCGGGCCTGGGGCCGAGGCGGCGCGC
GGCGCTGACAGCTGAGTCGGCTCGCGGCCTCCCGGCCCCCTCGGCGCCCGGCCCGACCCTGGCC
TGGCTTGCCCCGGAGCCATGAGCCCCGGGCTGCTGCTGCTCGGCAGCGCCGTCCTGCTCGCCTT
CGGCCTCTGCTGCACCTTCGTGCACCGCGCTCGCAGCCGCTACGAGCACATCCCCGGGCCGCCG
CGGCCCAGTTTCCTTCTAGGACACCTCCCCTGCTTTTGGAAAAAGGATGAGGTTGGTGGCCGTG
TGCTCCAAGATGTGTTTTTGGATTGGGCTAAGAAGTATGGACCTGTTGTGCGGGTCAACGTCTT
CCACAAAACCTCAGTCATCATCACGAGTCCCGAGTCGGTTAAGAAGTTCCTGATGTCAACCAAG
TACAACAAGGACTCCAAGATGTACCGTGCGCTCCAGACTGTGTTTGGTGAGAGACTCTTCGGCC
AAGGCTTGGTGTCCGAATGCAACTATGAGCGTTGGCACAAGCAGCGGAGAGTCATAGACCTGGC
CTTCAGCCGGAGCTCCTTGGTTAGCTTAATGGAAACATTCAACGAGAAGGCTGAGCAGCTGGTG
GAGATTCTAGAAGCCAAGGCAGATGGGCAGACCCCAGTGTCCATGCAGGACATGCTGACCTACA
CCGCCATGGACATCCTGGCCAAGGCAGCTTTTGGGATGGAGACCAGTATGCTGCTGGGTGCCCA
GAAGCCTCTGTCCCAGGCAGTGAAACTGATGTTGGAGGGAATCACCGCATCCCGCAACACTCTG
GCAAAGTTCCTGCCAGGGAAGAGGAAGCAGCTCCGGGAGGTCCGGGAGAGCATTCGCTTCCTGC
GCCAGGTGGGCAGGGACTGGGTCCAGCGCCGCCGGGAGGCCCTGAAGAGGGGCGAGGAGGTTCC
TGCCGACATCCTCACACAGATTCTCAAAGCTGAAGAGGGGGCCCAGGACGATGAGGGTCTGCTG
GACAACTTCGTCACCTTCTTCATTGCTGGTCACGAGACCTCTGCTAACCACTTGGCGTTCACAG
TGATGGAGCTGTCTCGCCAGCCGGAGATCGTGGCAAGGCTGCAGGCTGAGGTGGATGAGGTCAT
CGGTTCTAAGAGGTACCTGGATTTCGAGGACCTGGGGAGACTGCAGTACCTGTCCCAGGTCCTC
AAAGAGTCGCTGAGGCTGTACCCACCAGCGTGGGGCACCTTTCGCCTGCTGGAAGAGGAGACCT
TGATCGATGGGGTCAGAGTCCCCGGCAACACCCCGCTCTTGTTCAGCACCTATGTCATGGGGCG
GATGGACACATACTTTGAGGACCCGCTGACTTTCAACCCCGATCGCTTCGGCCCCGGAGCACCC
AAGCCACGGTTCACCTACTTCCCCTTCTCCCTGGGCCACCGCTCCTGCATCGGGCAGCAATTTG
CTCAGATGGAGGTAAAGGTGGTCATGGCAAAGCTGCTGCAGAGGCTGGAGTTCCGGCTGGTGCC
CGGGCAGCGCTTCGGGCTGCAGGAGCAGGCCACGCTCAAGCCACTGGACCCAGTGCTGTGCACC
CTGCGGCCCCGCGGCTGGCAGCCCACACCCCCACCGCCCCCCTGCTGAGGGGGCCTCCAGGCAG
GATGAGACTCCTCGGGCAAGGGCCGTGCCCGCCCACCTGTTGCCCACGGCCACCCACCCTTCTA
CCCTGTCCCATCCCCTGGGCCACCCTTCACGCTGGCTTCCAGCGGGCCCTCTGCCAACTGCCTG
CTTCACACCCCTCAGCGCTCCCTGTCACCTGCAGACTCCACGGCCCTTCCTGGACTGGCCCTTG
CCCAACTCTCAGCCACCACCATTGTCCCTACCACTGAGCCCTTGCACAGGCCACTTCCTCAGAT
GAGACACCCTAACTCTTGCTCACTCCCTAAAGCCCTCTTCAGGTGTCACCTCCTCCAAGAAGCC
CTCCTTGCCACCCCCAGCTGGGTCAGGGGCCCCTCCTCTGTGCTCCCTCAGTCACCTGTGCTAC
CTCTAACACCACACTGACCACACTGTATTGTGAGTGTCCGTTGATGTGACCAATTGCCCTCCCA
GGCTGTCAGCGCCTCAAGGGTAGGGTCTGTGTGTGATTCGTCTCTGAGCCCCCTGTGCCCACCC
GGGGCCCGGCACAGAGTCGATGCTCAATAAATGTGTGTTGACTGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007985995	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006644
	ENSCSAP00000006644.1

RefSeq Acc Id:	XP_007985995 ⟸ XM_007987804
- UniProtKB:	A0A0D9RDF5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000006644 ⟸ ENSCSAT00000008497

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000010408	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008497.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	CYP46A1	UniProtKB/TrEMBL
	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_E_grp-I	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
KEGG Report	csab:103229682	UniProtKB/TrEMBL
NCBI Gene	CYP46A1	ENTREZGENE
PANTHER	CHOLESTEROL 24-HYDROXYLASE	UniProtKB/TrEMBL
	PTHR24293	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PRINTS	EP450I	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A0D9RDF5	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:83404	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - CTD

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