TXN (thioredoxin) - Rat Genome Database

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Gene: TXN (thioredoxin) Chlorocebus sabaeus
Analyze
Symbol: TXN
Name: thioredoxin
RGD ID: 18539830
Description: ENCODES a protein that exhibits enzyme binding (ortholog); protein homodimerization activity (ortholog); protein-disulfide reductase [NAD(P)H] activity (ortholog); INVOLVED IN cell redox homeostasis (ortholog); cellular detoxification of hydrogen peroxide (ortholog); cellular response to antibiotic (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Arterial Occlusive Diseases (ortholog); Breast Neoplasms (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11229,296,166 - 29,308,979 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603513,456,569 - 13,469,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TXNGreen Monkeyfetal akinesia deformation sequence syndrome 1  ISOTXN (Homo sapiens)8554872ClinVar Annotator: match by term: Fetal akinesia deformation sequence 1ClinVarPMID:28492532
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TXNGreen MonkeyAcute Lung Injury  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:16298680
TXNGreen MonkeyBreast Neoplasms  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30396169
TXNGreen Monkeybronchopulmonary dysplasia  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:20812253
TXNGreen Monkeycardiomyopathy  ISOTxn1 (Mus musculus)9068941CTD Direct Evidence: therapeuticCTDPMID:12221060
TXNGreen MonkeyCongenital Abnormalities  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:31310794
TXNGreen Monkeycontact dermatitis  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25724174
TXNGreen MonkeyDrug-Related Side Effects and Adverse Reactions  ISOTxn1 (Mus musculus)9068941CTD Direct Evidence: therapeuticCTDPMID:11462148
TXNGreen MonkeyExperimental Neoplasms  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28574600
TXNGreen Monkeyhydrocephalus  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:31310794
TXNGreen Monkeyliver disease  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:16996028
TXNGreen Monkeymalignant mesothelioma  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:27032653
TXNGreen MonkeyNeoplasm Invasiveness  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15048980
TXNGreen MonkeyNeoplasm Metastasis  ISOTXN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30396169
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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TXNGreen Monkeycell redox homeostasis acts_upstream_of_or_withinISOTxn1 (Mus musculus)9068941 PMID:18555775MGIPMID:18555775
TXNGreen Monkeycell redox homeostasis involved_inISOTXN (Homo sapiens)9068941 PMID:9108029UniProtPMID:9108029
TXNGreen Monkeycell redox homeostasis involved_inISOTXN (Homo sapiens)9068941 PMID:2176490UniProtPMID:2176490
TXNGreen Monkeycellular detoxification of hydrogen peroxide involved_inISOUniProtKB:Q994979068941 PMID:22492997ParkinsonsUK-UCLPMID:22492997
TXNGreen Monkeycellular response to antibiotic  ISOTxn1 (Rattus norvegicus)9068941minocyclineRGDPMID:21184825 and REF_RGD_ID:5133706
TXNGreen Monkeycellular response to glucose stimulus  ISOTxn1 (Rattus norvegicus)9068941 RGDPMID:20453393 and REF_RGD_ID:5133719
TXNGreen Monkeycellular response to hyperoxia  ISOTxn1 (Rattus norvegicus)9068941 RGDPMID:21505996 and REF_RGD_ID:5133704
TXNGreen Monkeycellular response to xenobiotic stimulus  ISOTxn1 (Rattus norvegicus)9068941dipyridamoleRGDPMID:20453393 and REF_RGD_ID:5133719
TXNGreen Monkeynegative regulation of protein export from nucleus acts_upstream_of_or_withinISOTxn1 (Mus musculus)9068941 PMID:18555775MGIPMID:18555775
TXNGreen Monkeynegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOMGI:1889549 and MGI:19300189068941 PMID:18555775MGIPMID:18555775
TXNGreen Monkeypositive regulation of peptidyl-cysteine S-nitrosylation involved_inISOTXN (Homo sapiens)9068941 PMID:16408020 more ...UniProtPMID:16408020 more ...
TXNGreen Monkeypositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_inISOTXN (Homo sapiens)9068941 PMID:22492997ParkinsonsUK-UCLPMID:22492997
TXNGreen Monkeyresponse to activity  ISOTxn1 (Rattus norvegicus)9068941 RGDPMID:20601738 and REF_RGD_ID:5133713
TXNGreen Monkeyresponse to axon injury  ISOTxn1 (Rattus norvegicus)9068941 RGDPMID:19833109 and REF_RGD_ID:5133729
TXNGreen Monkeyresponse to dexamethasone  ISOTxn1 (Rattus norvegicus)9068941 RGDPMID:20393169 and REF_RGD_ID:5133720
TXNGreen Monkeyresponse to nitric oxide involved_inISOTXN (Homo sapiens)9068941 PMID:16408020 and PMID:17606900UniProtPMID:16408020 and PMID:17606900
TXNGreen Monkeyresponse to radiation involved_inISOTXN (Homo sapiens)9068941 PMID:11118054 and PMID:9108029UniProtPMID:11118054 and PMID:9108029
TXNGreen Monkeyresponse to selenium ion  ISOTxn1 (Rattus norvegicus)9068941 RGDPMID:15792362 and REF_RGD_ID:5133718
TXNGreen Monkeyresponse to thyroxine  ISOTxn1 (Rattus norvegicus)9068941 RGDPMID:20729758 and REF_RGD_ID:5133711
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Cellular Component
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Molecular Function
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TXNGreen Monkeyenzyme binding  ISOTXNRD1 (Homo sapiens)9068941 RGDPMID:20536427 and REF_RGD_ID:5133715
TXNGreen Monkeyprotein binding enablesISOUniProtKB:Q998369068941 PMID:21988832IntActPMID:21988832
TXNGreen Monkeyprotein binding enablesISOPR:Q8BG609068941 PMID:18555775MGIPMID:18555775
TXNGreen Monkeyprotein binding enablesISOUniProtKB:P12814 more ...9068941 PMID:32296183IntActPMID:32296183
TXNGreen Monkeyprotein binding enablesISOUniProtKB:P42574 and UniProtKB:Q996839068941 PMID:15246877UniProtPMID:15246877
TXNGreen Monkeyprotein binding enablesISOUniProtKB:Q996839068941 PMID:19805025 and PMID:21771788IntActPMID:19805025 and PMID:21771788
TXNGreen Monkeyprotein binding enablesISOUniProtKB:G5E9A7 more ...9068941 PMID:32814053IntActPMID:32814053
TXNGreen Monkeyprotein binding enablesISOUniProtKB:P425749068941 PMID:17606900IntActPMID:17606900
TXNGreen Monkeyprotein binding enablesISOUniProtKB:Q9H3M79068941 PMID:10814541 more ...IntActPMID:10814541 more ...
TXNGreen Monkeyprotein binding enablesISOUniProtKB:P276959068941 PMID:11118054 and PMID:9108029UniProtPMID:11118054 and PMID:9108029
TXNGreen Monkeyprotein binding enablesISOUniProtKB:P005339068941 PMID:15657067 more ...IntActPMID:15657067 more ...
TXNGreen Monkeyprotein binding enablesISOUniProtKB:D0ZRB29068941 PMID:19690162GO_CentralPMID:19690162
TXNGreen Monkeyprotein binding enablesISOUniProtKB:Q929059068941 PMID:15480426 and PMID:21145461IntActPMID:15480426 and PMID:21145461
TXNGreen Monkeyprotein binding enablesISOUniProtKB:Q8ZQQ29068941 PMID:19690162UniProtPMID:19690162
TXNGreen Monkeyprotein binding enablesISOUniProtKB:P180319068941 PMID:24976139IntActPMID:24976139
TXNGreen Monkeyprotein binding enablesISOUniProtKB:P321199068941 PMID:17557078 and PMID:25402766IntActPMID:17557078 and PMID:25402766
TXNGreen Monkeyprotein homodimerization activity enablesISOTXN (Homo sapiens)9068941 PMID:17260951 and PMID:9369469UniProtPMID:17260951 and PMID:9369469
TXNGreen Monkeyprotein-disulfide reductase [NAD(P)H] activity enablesISOTXN (Homo sapiens)9068941 PMID:17182577UniProtPMID:17182577
TXNGreen Monkeyprotein-disulfide reductase activity enablesIEAInterPro:IPR005746150520179 InterProGO_REF:0000002
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Imported Annotations - SMPDB

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TXNGreen Monkeyadenine phoshoribosyltransferase deficiency pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00535
TXNGreen Monkeyadenosine monophosphate deaminase deficiency pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00537
TXNGreen Monkeyadenylosuccinate lyase deficiency pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00167
TXNGreen MonkeyAICA-ribosuria pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00168
TXNGreen Monkeyazathioprine pharmacodynamics pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00427
TXNGreen MonkeyKelley-Seegmiller syndrome pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00365
TXNGreen MonkeyLesch-Nyhan syndrome pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00364
TXNGreen Monkeymercaptopurine pharmacodynamics pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00428
TXNGreen Monkeymolybdenum cofactor deficiency pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00203
TXNGreen Monkeypurine metabolic pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00050
TXNGreen Monkeypurine nucleoside phosphorylase deficiency pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00210
TXNGreen Monkeytioguanine pharmacodynamics pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00430
TXNGreen Monkeyxanthinuria type I pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00512
TXNGreen Monkeyxanthinuria pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00220
TXNGreen Monkeyxanthinuria type II pathway  ISOTXN (Homo sapiens)9068941 SMPDBSMP:00513
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Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TXNGreen Monkeyp38 MAPK signaling pathway   ISOTXN (Homo sapiens)9068941 PIDPID:200018
TXNGreen Monkeytumor necrosis factor mediated signaling pathway   ISOTXN (Homo sapiens)9068941 PIDPID:200102
PMID:22301074  



TXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11229,296,166 - 29,308,979 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603513,456,569 - 13,469,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389110,243,810 - 110,256,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9110,243,810 - 110,256,507 (-)EnsemblGRCh38hg38GRCh38
GRCh379113,006,090 - 113,018,787 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,046,131 - 112,058,599 (-)NCBINCBI36Build 36hg18NCBI36
Build 349110,085,864 - 110,098,333NCBI
Celera983,507,936 - 83,520,398 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef982,607,811 - 82,620,710 (-)NCBIHuRef
CHM1_19113,152,543 - 113,165,343 (-)NCBICHM1_1
T2T-CHM13v2.09122,413,340 - 122,426,045 (-)NCBIT2T-CHM13v2.0
Txn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39457,943,373 - 57,956,411 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm39 Ensembl
GRCm38457,943,373 - 57,956,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv37457,956,245 - 57,969,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,037,427 - 58,050,345 (-)NCBIMGSCv36mm8
Celera457,856,035 - 57,868,968 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
Txn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8577,507,455 - 77,519,685 (-)NCBIGRCr8
mRatBN7.2572,712,334 - 72,724,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl572,711,933 - 72,724,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,603,651 - 74,615,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0576,425,269 - 76,437,499 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0576,397,400 - 76,409,630 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0575,049,735 - 75,057,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,201,386 - 79,209,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,921,365 - 75,933,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1575,926,428 - 75,938,789 (-)NCBI
Celera571,558,162 - 71,570,393 (-)NCBICelera
RH 3.4 Map5494.0RGD
Cytogenetic Map5q24NCBI
TXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21129,150,207 - 29,162,897 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1929,152,695 - 29,165,262 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0981,399,056 - 81,411,607 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19109,565,557 - 109,578,311 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9109,565,557 - 109,578,311 (-)Ensemblpanpan1.1panPan2
LOC100687127
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,986,288 - 82,986,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX69,064,524 - 69,064,989 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X84,637,255 - 84,637,720 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X82,113,902 - 82,114,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,808,036 - 83,808,501 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X83,636,876 - 83,637,341 (-)NCBIUU_Cfam_GSD_1.0
Txn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947180,444,054 - 180,454,833 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365592,811,782 - 2,822,528 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365592,811,786 - 2,822,528 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,263,175 - 251,277,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,264,180 - 251,278,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21282,027,082 - 282,035,642 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1qNCBI
Txn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247581,318,529 - 1,329,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247581,318,108 - 1,329,011 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in TXN
310 total Variants





RefSeq Transcripts XM_007968459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_007968459   ⟹   XP_007966650
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11229,296,166 - 29,308,979 (+)NCBI
Vero_WHO_p1.0NW_02366603513,456,569 - 13,469,439 (-)NCBI
Sequence:
Protein RefSeqs XP_007966650 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000018404.1
  ENSCSAP00000018809.1
RefSeq Acc Id: XP_007966650   ⟸   XM_007968459
- UniProtKB: A0A0D9SC15 (UniProtKB/TrEMBL),   A0A0D9SD70 (UniProtKB/TrEMBL)



1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000018885 UniProtKB/TrEMBL
  ENSCSAG00000019299 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000018975.1 UniProtKB/TrEMBL
  ENSCSAT00000019389.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Thioredoxin UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report csab:103219027 UniProtKB/TrEMBL
  csab:103221232 UniProtKB/TrEMBL
NCBI Gene TXN ENTREZGENE
PANTHER THIOREDOXIN-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
PIRSF Thioredoxin UniProtKB/TrEMBL
PRINTS THIOREDOXIN UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A0D9SC15 ENTREZGENE, UniProtKB/TrEMBL
  A0A0D9SD70 ENTREZGENE, UniProtKB/TrEMBL
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