GSTP1 (glutathione S-transferase pi 1) - Rat Genome Database

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Gene: GSTP1 (glutathione S-transferase pi 1) Chlorocebus sabaeus
Analyze
Symbol: GSTP1
Name: glutathione S-transferase pi 1
RGD ID: 18421980
Description: ENCODES a protein that exhibits dinitrosyl-iron complex binding (ortholog); fatty acid binding (ortholog); glutathione peroxidase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to cell-matrix adhesion (ortholog); cellular response to epidermal growth factor stimulus (ortholog); PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN mitochondrion (ortholog); protein-containing complex (ortholog); TRAF2-GSTP1 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutathione S-transferase P
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,676,897 - 6,679,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038103,955,106 - 103,991,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Aicardi-Goutieres Syndrome 3  (ISO)
Airway Obstruction  (ISO)
alcohol use disorder  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bone marrow disease  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchopulmonary dysplasia  (ISO)
bronchus carcinoma  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholangiocarcinoma  (ISO)
Cholangiofibrosis  (ISO)
cholestasis  (ISO)
Chromosome Aberrations  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
cocaine dependence  (ISO)
colorectal adenoma  (ISO)
congenital heart disease  (ISO)
conjunctivochalasis  (ISO)
contact dermatitis  (ISO)
Cough  (ISO)
diffuse large B-cell lymphoma  (ISO)
Disease Progression  (ISO)
drug allergy  (ISO)
Drug-Induced Leukopenia  (ISO)
Drug-induced Neutropenia  (ISO)
esophagus squamous cell carcinoma  (ISO)
essential tremor  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Seizures  (ISO)
Focal Nodular Hyperplasia  (ISO)
Gallbladder Neoplasms  (ISO)
Graves' disease  (ISO)
hematopoietic system disease  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (ISO)
immune system disease  (ISO)
intellectual disability  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
Kuhnt-Junius degeneration  (ISO)
Laryngeal Neoplasms  (ISO)
late onset Parkinson's disease  (ISO)
liver disease  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoid leukemia  (ISO)
malignant astrocytoma  (ISO)
melanoma  (ISO)
meningitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
mitochondrial metabolism disease  (ISO)
movement disease  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia  (ISO)
Myocardial Ischemia  (ISO)
Necrosis  (ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
peripheral nervous system disease  (ISO)
peritonitis  (ISO)
Plasmodium falciparum malaria  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Respiratory Sounds  (ISO)
respiratory system disease  (ISO)
sarcoma  (ISO)
senile cataract  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
substance-induced psychosis  (ISO)
testicular cancer  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
Ureteral Calculi  (ISO)
urinary bladder cancer  (ISO)
vestibular disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to cell-matrix adhesion  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
common myeloid progenitor cell proliferation  (ISO)
glutathione derivative biosynthetic process  (ISO)
glutathione metabolic process  (IEA,ISO)
hepoxilin biosynthetic process  (ISO)
inflammatory response  (ISO)
linoleic acid metabolic process  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of leukocyte proliferation  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of monocyte chemotactic protein-1 production  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of smooth muscle cell chemotaxis  (ISO)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
oligodendrocyte development  (ISO)
positive regulation of superoxide anion generation  (ISO)
prostaglandin metabolic process  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of stress-activated MAPK cascade  (ISO)
response to amino acid  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to L-ascorbic acid  (ISO)
response to nutrient levels  (ISO)
response to reactive oxygen species  (ISO)
response to toxic substance  (ISO)
xenobiotic metabolic process  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GSTP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,676,897 - 6,679,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038103,955,106 - 103,991,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GSTP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,583,812 - 67,586,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,583,742 - 67,586,656 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,351,283 - 67,354,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,107,862 - 67,110,699 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,107,861 - 67,110,699NCBI
Celera1164,685,527 - 64,688,585 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,680,236 - 63,683,230 (+)NCBIHuRef
CHM1_11167,234,118 - 67,237,177 (+)NCBICHM1_1
T2T-CHM13v2.01167,578,501 - 67,581,343 (+)NCBIT2T-CHM13v2.0
Gstp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,085,411 - 4,087,912 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,085,407 - 4,087,985 (-)EnsemblGRCm39 Ensembl
GRCm38194,035,411 - 4,037,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,035,407 - 4,037,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,035,411 - 4,037,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,035,411 - 4,037,912 (-)NCBIMGSCv36mm8
Celera193,906,327 - 3,908,828 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.75NCBI
Gstp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,767,237 - 210,770,242 (-)NCBIGRCr8
mRatBN7.21201,337,762 - 201,340,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,321,672 - 201,340,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,690,040 - 209,692,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,783,226 - 216,785,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,474,253 - 209,476,723 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,291,679 - 219,294,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,291,679 - 219,294,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,162,330 - 226,164,798 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,627,398 - 206,629,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,780,853 - 206,783,288 (-)NCBI
Celera1198,882,807 - 198,885,275 (-)NCBICelera
Cytogenetic Map1q43NCBI
Gstp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,914,305 - 17,917,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,914,228 - 17,916,918 (-)NCBIChiLan1.0ChiLan1.0
GSTP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,811,099 - 68,814,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,853,927 - 69,856,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,942,756 - 62,945,701 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,253,421 - 66,256,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,253,421 - 66,256,472 (+)Ensemblpanpan1.1panPan2
GSTP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,905,161 - 49,908,182 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,905,161 - 49,908,182 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,515,700 - 48,518,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,827,487 - 50,830,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,827,046 - 50,830,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,040,622 - 50,043,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,615,622 - 49,618,639 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,409,350 - 50,412,373 (-)NCBIUU_Cfam_GSD_1.0
Gstp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,755,332 - 5,758,293 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,197,634 - 2,201,050 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,197,681 - 2,200,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100739163
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.124,978,761 - 4,982,233 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,618,596 - 3,620,933 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in GSTP1
63 total Variants

Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_007964474   ⟹   XP_007962665
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.116,676,897 - 6,679,936 (-)NCBI
Vero_WHO_p1.0NW_023666038103,955,106 - 103,991,379 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007962665 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004943.1
RefSeq Acc Id: XP_007962665   ⟸   XM_007964474
- UniProtKB: A0A0D9R8K4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008684 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006748.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  GST_pi UniProtKB/TrEMBL
  GST_superfamily UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene GSTP1 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE P UniProtKB/TrEMBL
Pfam GST_C_3 UniProtKB/TrEMBL
PRINTS GSTRNSFRASEP UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
  GST_NTER UniProtKB/TrEMBL
Superfamily-SCOP GST C-terminal domain-like UniProtKB/TrEMBL
  Thioredoxin-like UniProtKB/TrEMBL
UniProt A0A0D9R8K4 ENTREZGENE, UniProtKB/TrEMBL